Gls (glutaminase) - Rat Genome Database

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Gene: Gls (glutaminase) Rattus norvegicus
Analyze
Symbol: Gls
Name: glutaminase
RGD ID: 2707
Description: Predicted to enable glutaminase activity and identical protein binding activity. Predicted to be involved in glutamine family amino acid metabolic process; intracellular glutamate homeostasis; and protein homotetramerization. Predicted to act upstream of or within chemical synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and suckling behavior. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (glutaminase); PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; arginine and proline metabolic pathway; D-glutamine and D-glutamate metabolic pathway; INTERACTS WITH (R)-lipoic acid; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Glut; glutaminase kidney isoform, mitochondrial; K-glutaminase; kidney-type glutaminase; L-glutamine amidohydrolase; RATGLUT
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,836,584 - 56,908,861 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl956,836,584 - 56,908,861 (+)EnsemblGRCr8
mRatBN7.2949,344,616 - 49,416,900 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,344,781 - 49,416,900 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx957,894,412 - 57,966,467 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,017,246 - 63,089,303 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,313,233 - 61,385,290 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,212,622 - 54,284,879 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,212,767 - 54,284,872 (+)Ensemblrn6Rnor6.0
Rnor_5.0953,923,145 - 53,995,543 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4946,380,165 - 46,452,974 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera947,008,653 - 47,080,221 (+)NCBICelera
RGSC_v3.1946,381,578 - 46,454,381 (+)NCBI
Cytogenetic Map9q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
Abemaciclib  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitraz  (EXP)
ammonia  (ISO)
ammonium chloride  (EXP,ISO)
amphotericin B  (ISO)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (EXP,ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
erianin  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Heliotrine  (ISO)
hexadecanoic acid  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
idazoxan  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactacystin  (ISO)
lanthanum trichloride  (EXP)
lead(0)  (EXP,ISO)
linuron  (EXP)
lipoic acid  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
motexafin gadolinium  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naphthalenes  (EXP)
nickel atom  (ISO)
Nutlin-3  (ISO)
O-palmitoylcarnitine  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenylarsonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
quartz  (ISO)
quercetin  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
theophylline  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
mitochondrial matrix  (IEA)
mitochondrion  (IEA,ISO)
synapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels. Buschdorf JP, etal., J Cell Sci. 2006 Aug 15;119(Pt 16):3337-50.
2. Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons. Buschdorf JP, etal., PLoS One. 2008 Jul 16;3(7):e2686. doi: 10.1371/journal.pone.0002686.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis. Krencz I, etal., Hum Pathol. 2018 Sep;79:199-207. doi: 10.1016/j.humpath.2018.05.018. Epub 2018 Jun 6.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Complexity and species variation of the kidney-type glutaminase gene. Porter LD, etal., Physiol Genomics 2002;9(3):157-66.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Isolation, characterization, and in vitro expression of a cDNA that encodes the kidney isoenzyme of the mitochondrial glutaminase. Shapiro RA, etal., J Biol Chem 1991 Oct 5;266(28):18792-6.
14. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
Additional References at PubMed
PMID:1991024   PMID:3401701   PMID:14686922   PMID:16219914   PMID:16641247   PMID:17986214   PMID:21734190   PMID:22049910   PMID:22225880   PMID:22228304   PMID:24086752   PMID:25297978  
PMID:27514492   PMID:28770953   PMID:30239721   PMID:31344597   PMID:36915976  


Genomics

Comparative Map Data
Gls
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,836,584 - 56,908,861 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl956,836,584 - 56,908,861 (+)EnsemblGRCr8
mRatBN7.2949,344,616 - 49,416,900 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,344,781 - 49,416,900 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx957,894,412 - 57,966,467 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,017,246 - 63,089,303 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,313,233 - 61,385,290 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,212,622 - 54,284,879 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,212,767 - 54,284,872 (+)Ensemblrn6Rnor6.0
Rnor_5.0953,923,145 - 53,995,543 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4946,380,165 - 46,452,974 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera947,008,653 - 47,080,221 (+)NCBICelera
RGSC_v3.1946,381,578 - 46,454,381 (+)NCBI
Cytogenetic Map9q22NCBI
GLS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,880,821 - 190,965,552 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,880,821 - 190,965,552 (+)Ensemblhg38GRCh38
GRCh372191,745,547 - 191,830,278 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,453,792 - 191,538,021 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342191,571,102 - 191,655,771NCBI
Celera2185,340,136 - 185,424,375 (+)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2183,605,181 - 183,689,941 (+)NCBIHuRef
CHM1_12191,751,387 - 191,836,127 (+)NCBICHM1_1
T2T-CHM13v2.02191,369,931 - 191,454,659 (+)NCBIT2T-CHM13v2.0
Gls
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,202,608 - 52,274,168 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,202,607 - 52,272,391 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38152,163,449 - 52,235,009 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,163,448 - 52,233,232 (-)Ensemblmm10GRCm38
MGSCv37152,220,293 - 52,290,076 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36152,110,128 - 52,177,777 (-)NCBIMGSCv36mm8
Celera152,701,920 - 52,771,737 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.86NCBI
Gls
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,195,255 - 8,261,402 (-)Ensembl
ChiLan1.0NW_0049554038,195,241 - 8,261,402 (-)NCBIChiLan1.0ChiLan1.0
GLS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21393,562,487 - 93,647,465 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,577,451 - 93,662,449 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B78,182,117 - 78,267,071 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B196,098,910 - 196,183,332 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,098,910 - 196,183,323 (+)EnsemblpanPan2panpan1.1
GLS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,433,640 - 1,508,347 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,433,398 - 1,508,146 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha372,381,805 - 2,456,538 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0371,321,277 - 1,395,855 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,321,033 - 1,397,358 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,330,931 - 1,405,450 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,298,679 - 1,373,454 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,327,448 - 1,402,011 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gls
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303149,524,201 - 149,600,982 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,237,099 - 7,313,976 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,237,099 - 7,314,011 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,513,446 - 95,598,311 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11595,513,414 - 95,606,029 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215106,832,208 - 106,866,986 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11076,402,201 - 76,489,063 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,402,195 - 76,486,498 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040122,988,383 - 123,074,691 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gls
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,108,566 - 5,202,240 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248545,106,419 - 5,202,445 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gls
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14123,193,339 - 123,264,201 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gls
469 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000032525
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
D9Wox15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,415,692 - 49,415,876 (+)MAPPERmRatBN7.2
Rnor_6.0954,283,672 - 54,283,855NCBIRnor6.0
Rnor_5.0953,994,336 - 53,994,519UniSTSRnor5.0
RGSC_v3.4946,451,767 - 46,451,950UniSTSRGSC3.4
Celera947,079,018 - 47,079,197UniSTS
Cytogenetic Map9q31-q32UniSTS
RH143479  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,395,321 - 49,395,464 (+)MAPPERmRatBN7.2
Rnor_6.0954,263,304 - 54,263,446NCBIRnor6.0
Rnor_5.0953,973,965 - 53,974,107UniSTSRnor5.0
RGSC_v3.4946,431,395 - 46,431,537UniSTSRGSC3.4
Celera947,059,485 - 47,059,627UniSTS
Cytogenetic Map9q31-q32UniSTS
RH135102  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,343,952 - 49,344,132 (+)MAPPERmRatBN7.2
Rnor_6.0954,211,939 - 54,212,118NCBIRnor6.0
Rnor_5.0953,922,132 - 53,922,311UniSTSRnor5.0
Rnor_5.0953,816,470 - 53,816,649UniSTSRnor5.0
RGSC_v3.4946,379,337 - 46,379,516UniSTSRGSC3.4
Celera947,007,825 - 47,008,004UniSTS
Cytogenetic Map9q31-q32UniSTS
RH137240  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,392,381 - 49,392,566 (+)MAPPERmRatBN7.2
Rnor_6.0954,260,364 - 54,260,548NCBIRnor6.0
Rnor_5.0953,971,025 - 53,971,209UniSTSRnor5.0
RGSC_v3.4946,428,455 - 46,428,639UniSTSRGSC3.4
Celera947,056,545 - 47,056,729UniSTS
Cytogenetic Map9q31-q32UniSTS
RH139095  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,395,440 - 49,395,663 (+)MAPPERmRatBN7.2
Rnor_6.0954,263,423 - 54,263,645NCBIRnor6.0
Rnor_5.0953,974,084 - 53,974,306UniSTSRnor5.0
RGSC_v3.4946,431,514 - 46,431,736UniSTSRGSC3.4
Celera947,059,604 - 47,059,826UniSTS
Cytogenetic Map9q31-q32UniSTS
Gls  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,414,585 - 49,415,449 (+)MAPPERmRatBN7.2
Rnor_6.0954,282,565 - 54,283,428NCBIRnor6.0
Rnor_5.0953,993,229 - 53,994,092UniSTSRnor5.0
RGSC_v3.4946,450,660 - 46,451,523UniSTSRGSC3.4
Celera947,077,911 - 47,078,774UniSTS
Cytogenetic Map9q31-q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF302091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY083459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB776615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M65150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000078073   ⟹   ENSRNOP00000075466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl956,836,584 - 56,884,768 (+)Ensembl
mRatBN7.2 Ensembl949,344,781 - 49,392,804 (+)Ensembl
Rnor_6.0 Ensembl954,212,767 - 54,260,786 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090026   ⟹   ENSRNOP00000071972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl956,836,584 - 56,908,861 (+)Ensembl
mRatBN7.2 Ensembl949,344,781 - 49,416,900 (+)Ensembl
Rnor_6.0 Ensembl954,212,767 - 54,284,872 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110936   ⟹   ENSRNOP00000093636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl956,836,584 - 56,908,861 (+)Ensembl
mRatBN7.2 Ensembl949,344,781 - 49,416,900 (+)Ensembl
RefSeq Acc Id: NM_001109968   ⟹   NP_001103438
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,836,584 - 56,884,768 (+)NCBI
mRatBN7.2949,344,616 - 49,392,804 (+)NCBI
Rnor_6.0954,212,767 - 54,260,786 (+)NCBI
Rnor_5.0953,923,145 - 53,995,543 (+)NCBI
RGSC_v3.4946,380,165 - 46,452,974 (+)RGD
Celera947,008,653 - 47,056,967 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012569   ⟹   NP_036701
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,836,584 - 56,908,861 (+)NCBI
mRatBN7.2949,344,616 - 49,416,900 (+)NCBI
Rnor_6.0954,212,767 - 54,284,879 (+)NCBI
Rnor_5.0953,923,145 - 53,995,543 (+)NCBI
RGSC_v3.4946,380,165 - 46,452,974 (+)RGD
Celera947,008,653 - 47,080,221 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767075   ⟹   XP_008765297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,836,584 - 56,884,768 (+)NCBI
mRatBN7.2949,344,634 - 49,392,804 (+)NCBI
Rnor_6.0954,212,622 - 54,260,786 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083004   ⟹   XP_038938932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,851,527 - 56,908,861 (+)NCBI
mRatBN7.2949,359,552 - 49,414,641 (+)NCBI
RefSeq Acc Id: XM_039083005   ⟹   XP_038938933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,836,584 - 56,878,934 (+)NCBI
mRatBN7.2949,344,633 - 49,387,035 (+)NCBI
RefSeq Acc Id: XM_039083006   ⟹   XP_038938934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,836,584 - 56,872,713 (+)NCBI
mRatBN7.2949,344,632 - 49,380,531 (+)NCBI
RefSeq Acc Id: XM_039083007   ⟹   XP_038938935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,836,584 - 56,870,559 (+)NCBI
mRatBN7.2949,344,633 - 49,376,277 (+)NCBI
RefSeq Acc Id: XM_039083009   ⟹   XP_038938937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,868,351 - 56,908,861 (+)NCBI
mRatBN7.2949,376,386 - 49,414,641 (+)NCBI
RefSeq Acc Id: XM_039083010   ⟹   XP_038938938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,868,186 - 56,908,861 (+)NCBI
mRatBN7.2949,376,217 - 49,414,641 (+)NCBI
RefSeq Acc Id: XR_010054565
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,836,584 - 56,875,952 (+)NCBI
RefSeq Acc Id: XR_010054566
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,836,584 - 56,872,859 (+)NCBI
RefSeq Acc Id: XR_010054567
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,836,584 - 56,872,840 (+)NCBI
RefSeq Acc Id: XR_010054568
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,836,584 - 56,872,859 (+)NCBI
RefSeq Acc Id: NP_036701   ⟸   NM_012569
- Peptide Label: isoform a
- UniProtKB: Q8R421 (UniProtKB/Swiss-Prot),   P13264 (UniProtKB/Swiss-Prot),   A0A0G2K1T0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103438   ⟸   NM_001109968
- Peptide Label: isoform b
- UniProtKB: Q8R421 (UniProtKB/Swiss-Prot),   P13264 (UniProtKB/Swiss-Prot),   A0A0G2KAN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765297   ⟸   XM_008767075
- Peptide Label: isoform X1
- UniProtKB: Q8R421 (UniProtKB/Swiss-Prot),   P13264 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071972   ⟸   ENSRNOT00000090026
Ensembl Acc Id: ENSRNOP00000075466   ⟸   ENSRNOT00000078073
RefSeq Acc Id: XP_038938934   ⟸   XM_039083006
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038938933   ⟸   XM_039083005
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038938935   ⟸   XM_039083007
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038938932   ⟸   XM_039083004
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038938938   ⟸   XM_039083010
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038938937   ⟸   XM_039083009
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000093636   ⟸   ENSRNOT00000110936
Protein Domains
Glutaminase EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13264-F1-model_v2 AlphaFold P13264 1-674 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2707 AgrOrtholog
BioCyc Gene G2FUF-27608 BioCyc
BioCyc Pathway CITRULBIO-PWY [L-citrulline biosynthesis] BioCyc
  GLUTAMINDEG-PWY [L-glutamine degradation I] BioCyc
  PWY-5921 [glutaminyl-tRNAgln biosynthesis via transamidation] BioCyc
BioCyc Pathway Image CITRULBIO-PWY BioCyc
  GLUTAMINDEG-PWY BioCyc
  PWY-5921 BioCyc
Ensembl Genes ENSRNOG00000056246 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000078073 ENTREZGENE
  ENSRNOT00000090026 ENTREZGENE
Gene3D-CATH 1.10.238.210 UniProtKB/Swiss-Prot
  1.25.40.20 UniProtKB/Swiss-Prot
  3.40.710.10 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  Beta-lactam/transpept-like UniProtKB/Swiss-Prot
  Glutaminase UniProtKB/Swiss-Prot
  Glutaminase_EF-hand UniProtKB/Swiss-Prot
KEGG Report rno:24398 UniProtKB/Swiss-Prot
NCBI Gene 24398 ENTREZGENE
PANTHER GLUTAMINASE KIDNEY ISOFORM, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR12544 UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  EF-hand_14 UniProtKB/Swiss-Prot
  Glutaminase UniProtKB/Swiss-Prot
PhenoGen Gls PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000056246 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
  SSF56601 UniProtKB/Swiss-Prot
UniProt A0A0G2K1T0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KAN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AXB6_RAT UniProtKB/TrEMBL
  A6INW6_RAT UniProtKB/TrEMBL
  A6INW7_RAT UniProtKB/TrEMBL
  GLSK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8R421 ENTREZGENE
UniProt Secondary Q8R421 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gls  glutaminase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function synthesizes glutamate from glutamine  
gene_process implicated in behavior disturbances in which glutamate acts as a neurotransmitter