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Gene: Gjb5 (gap junction protein, beta 5) Rattus norvegicus

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Symbol:

Gjb5

Name:

gap junction protein, beta 5

RGD ID:

2696

Description:

Predicted to enable gap junction channel activity. Involved in epididymis development. Predicted to be located in gap junction and plasma membrane. Predicted to be part of connexin complex. Orthologous to human GJB5 (gap junction protein beta 5); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

connexin 31.1; connexin a; connexin-31.1; Cx31.1; Cxna; gap junction beta-5 protein; gap junction membrane channel protein beta 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GJB5 (gap junction protein beta 5)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther, PhylomeDB
Mus musculus (house mouse):	Gjb5 (gap junction protein, beta 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gjb5 (gap junction protein beta 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GJB5 (gap junction protein beta 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GJB5 (gap junction protein beta 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gjb5 (gap junction protein beta 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GJB5 (gap junction protein beta 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GJB5 (gap junction protein beta 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gjb5 (gap junction protein beta 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gjb5 (gap junction protein beta 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GJB4 (gap junction protein beta 4)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	GJB5 (gap junction protein beta 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gjb5 (gap junction protein, beta 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cx34.4 (connexin 34.4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Danio rerio (zebrafish):	cx28.6 (connexin 28.6)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	cx28.6 (connexin 28.6)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cx30.9 (connexin 30.9)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	cx30.9 (connexin 30.9)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gjb4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gjb4	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	LOC101734565	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	144,965,133 - 144,968,051 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	144,964,751 - 144,984,021 (-)	Ensembl				GRCr8
mRatBN7.2	5	139,680,670 - 139,683,588 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	139,680,671 - 139,683,583 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	142,376,076 - 142,376,891 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	144,146,067 - 144,146,882 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	144,146,880 - 144,147,695 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	145,422,034 - 145,440,558 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	145,422,357 - 145,423,172 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	149,190,009 - 149,193,107 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	146,802,849 - 146,803,664 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	138,175,690 - 138,176,505 (-)	NCBI		Celera
RGSC_v3.1	5	146,812,887 - 146,813,703 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Skin Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trimethylbenzene (EXP)

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (EXP,ISO)

Benzoyl peroxide (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

cisplatin (ISO)

cocaine (EXP)

cyproconazole (ISO)

DDE (ISO)

decabromodiphenyl ether (EXP)

folic acid (ISO)

genistein (ISO)

graphite (EXP)

hexaconazole (ISO)

manganese(II) chloride (EXP)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (EXP)

naphthalene (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

paraquat (EXP)

phenobarbital (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

propanal (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

thiram (ISO)

titanium dioxide (ISO)

undecane (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell communication (IEA)

cell-cell signaling (IBA)

epididymis development (IEP)

labyrinthine layer morphogenesis (ISO)

spongiotrophoblast differentiation (ISO)

transmembrane transport (IEA)

trophoblast giant cell differentiation (ISO)

Cellular Component

connexin complex (IBA,IEA)

gap junction (IEA)

plasma membrane (IEA)

Molecular Function

gap junction channel activity (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression of multiple connexins in the rat epididymis indicates a complex regulation of gap junctional communication.	Dufresne J, etal., Am J Physiol Cell Physiol 2003 Jan;284(1):C33-43.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.	Haefliger JA, etal., J Biol Chem 1992 Jan 25;267(3):2057-64.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:17961533	PMID:24866916

Genomics

Comparative Map Data

Gjb5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	144,965,133 - 144,968,051 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	144,964,751 - 144,984,021 (-)	Ensembl				GRCr8
mRatBN7.2	5	139,680,670 - 139,683,588 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	139,680,671 - 139,683,583 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	142,376,076 - 142,376,891 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	144,146,067 - 144,146,882 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	144,146,880 - 144,147,695 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	145,422,034 - 145,440,558 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	145,422,357 - 145,423,172 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	149,190,009 - 149,193,107 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	146,802,849 - 146,803,664 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	138,175,690 - 138,176,505 (-)	NCBI		Celera
RGSC_v3.1	5	146,812,887 - 146,813,703 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

GJB5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	34,755,047 - 34,758,512 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	34,755,034 - 34,758,512 (+)	Ensembl			hg38	GRCh38
GRCh37	1	35,220,648 - 35,224,113 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	34,993,308 - 34,996,699 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	34,889,813 - 34,893,205	NCBI
Celera	1	33,494,445 - 33,497,836 (+)	NCBI		Celera
Cytogenetic Map	1	p34.3	NCBI
HuRef	1	33,338,163 - 33,341,628 (+)	NCBI		HuRef
CHM1_1	1	35,336,342 - 35,339,807 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	34,617,685 - 34,621,150 (+)	NCBI		T2T-CHM13v2.0

Gjb5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	127,248,600 - 127,251,957 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	127,248,602 - 127,251,974 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	127,354,809 - 127,358,164 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	127,354,809 - 127,358,181 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	127,032,053 - 127,035,408 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	126,857,113 - 126,860,468 (-)	NCBI		MGSCv36	mm8
Celera	4	125,689,190 - 125,692,545 (-)	NCBI		Celera
Cytogenetic Map	4	D2.2	NCBI
cM Map	4	61.51	NCBI

Gjb5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	12,867,200 - 12,870,427 (+)	Ensembl
ChiLan1.0	NW_004955452	12,867,200 - 12,870,427 (+)	NCBI	ChiLan1.0	ChiLan1.0

GJB5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	192,087,232 - 192,090,729 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	191,208,376 - 191,211,883 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	34,022,109 - 34,025,606 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	35,203,658 - 35,207,134 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	35,205,953 - 35,206,774 (+)	Ensembl			panPan2	panpan1.1

GJB5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	7,196,720 - 7,199,652 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	7,436,219 - 7,439,149 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	7,342,877 - 7,345,807 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	7,343,120 - 7,343,941 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	7,205,189 - 7,208,117 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	7,253,201 - 7,256,124 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	7,267,421 - 7,270,351 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gjb5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	51,577,747 - 51,581,737 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	17,405,000 - 17,405,809 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	17,402,804 - 17,406,080 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GJB5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	91,002,163 - 91,002,984 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	90,999,514 - 91,003,301 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	78,819,323 - 78,823,093 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GJB5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	98,128,901 - 98,132,640 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	98,129,262 - 98,130,083 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	18,708,932 - 18,712,511 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gjb5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	17,808,161 - 17,811,372 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624764	17,807,943 - 17,811,404 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gjb5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	30,925,601 - 30,926,756 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gjb5
32 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	135
Count of miRNA genes:	102
Interacting mature miRNAs:	112
Transcripts:	ENSRNOT00000019315
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
2303586	Gluco52	Glucose level QTL 52	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	100826632	145826632	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300122	Wbc1	White blood cell count QTL 1	2.75		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	5	130678987	145274255	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
2303618	Vencon1	Ventilatory control QTL 1	3.8		respiration trait (VT:0001943)	oxygen consumption (CMO:0002169)	5	100826632	145826632	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

RH130895

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	139,680,891 - 139,681,096 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	145,422,256 - 145,422,460	NCBI	Rnor6.0
Rnor_5.0	5	149,190,231 - 149,190,435	UniSTS	Rnor5.0
RGSC_v3.4	5	146,802,748 - 146,802,952	UniSTS	RGSC3.4
Celera	5	138,175,589 - 138,175,793	UniSTS
RH 3.4 Map	5	934.8	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	4	23	116	36	40	11	9	11	6	155	56	11	94	69	89	29	8	8

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019241	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC133802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LT990394	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M76533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000081919 ⟹ ENSRNOP00000075127

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	144,964,751 - 144,968,072 (-)	Ensembl
mRatBN7.2 Ensembl	5	139,680,671 - 139,683,583 (-)	Ensembl
Rnor_6.0 Ensembl	5	145,422,357 - 145,423,172 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000155672 ⟹ ENSRNOP00000103451

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	144,965,167 - 144,984,021 (-)	Ensembl

RefSeq Acc Id:

NM_019241 ⟹ NP_062114

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	144,965,133 - 144,968,051 (-)	NCBI
mRatBN7.2	5	139,680,670 - 139,683,588 (-)	NCBI
Rnor_6.0	5	145,422,357 - 145,423,172 (-)	NCBI
Rnor_5.0	5	149,190,009 - 149,193,107 (-)	NCBI
RGSC_v3.4	5	146,802,849 - 146,803,664 (-)	RGD
Celera	5	138,175,690 - 138,176,505 (-)	RGD

Sequence:

show sequence

ATGAACTGGAGCGTCTTTGAGGGGCTCCTAAGTGGGGTCAACAAGTACTCCACAGCCTTTGGTC
GCATCTGGCTGTCTCTGGTCTTTGTCTTCCGTGTGCTGGTGTACCTGGTGACAGCCGAGCGTGT
GTGGGGTGACGACCAGAAGGACTTTGACTGCAACACTAGGCAACCCGGCTGTACCAACGTCTGC
TATGATGAGTTCTTCCCTGTGTCCCACGTGCGCCTCTGGGCCCTGCAGCTCATCCTGGTCACAT
GCCCCTCCTTGCTTGTCGTCATGCATGTGGCCTATAGAAAGGCTCGAGAGAAGAAGTACCAGCA
AGAAGTTGGCAAAGGGTACCTCTACCCAAACCCCGGCAAGAAGCGAGGCGGACTCTGGTGGACA
TACGTCTGCAGCCTGTTGTTCAAGGCCACCATAGATATTATTTTCCTCTACCTTTTCCATGCAT
TCTACCCCAGATATACCCTCCCGTCTATGGTCAAGTGCCATTCGGCACCATGTCCCAACACAGT
GGACTGCTTCATCGCCAAGCCCTCAGAGAAGAACATCTTCATTGTCTTCATGTTGGTCACGGCC
ATCGTCTGCATCCTGCTTAACCTTGTGGAGCTGCTCTACTTGGTGATCAAGCGGTGTTCTGAGT
GTGCACCAGCGAAGAGACCGCCCACTGCACACGCAAAGAATGACCCAAACTGGGCCAACCCTTC
CAGCAAAGAGAAGGACTTCCTCTCAAGCGACCTCATCTTTCTGGGCTCGGACACTCACCCACCT
CTGTTACCTGATCGCCCTCGAGCCCACGTGAAGAAAACCATTCTGTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_062114	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB38538	(Get FASTA)	NCBI Sequence Viewer
	EDL80484	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075127
	ENSRNOP00000075127.1
GenBank Protein	P28232	(Get FASTA)	NCBI Sequence Viewer
	VZP20194	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_062114 ⟸ NM_019241

- UniProtKB:

P28232 (UniProtKB/Swiss-Prot), A0A654ID63 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNWSVFEGLLSGVNKYSTAFGRIWLSLVFVFRVLVYLVTAERVWGDDQKDFDCNTRQPGCTNVC
YDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYRKAREKKYQQEVGKGYLYPNPGKKRGGLWWT
YVCSLLFKATIDIIFLYLFHAFYPRYTLPSMVKCHSAPCPNTVDCFIAKPSEKNIFIVFMLVTA
IVCILLNLVELLYLVIKRCSECAPAKRPPTAHAKNDPNWANPSSKEKDFLSSDLIFLGSDTHPP
LLPDRPRAHVKKTIL

hide sequence

Ensembl Acc Id:

ENSRNOP00000075127 ⟸ ENSRNOT00000081919

Ensembl Acc Id:

ENSRNOP00000103451 ⟸ ENSRNOT00000155672

Protein Domains

Connexin N-terminal Gap junction protein cysteine-rich

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P28232-F1-model_v2	AlphaFold	P28232	1-271	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2696	AgrOrtholog
BioCyc Gene	G2FUF-39850	BioCyc
Ensembl Genes	ENSRNOG00000059897	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000081919	ENTREZGENE
	ENSRNOT00000081919.2	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1440.80	UniProtKB/Swiss-Prot
InterPro	Connexin	UniProtKB/Swiss-Prot
	Connexin303	UniProtKB/Swiss-Prot
	Connexin_CCC	UniProtKB/Swiss-Prot
	Connexin_CS	UniProtKB/Swiss-Prot
	Connexin_N	UniProtKB/Swiss-Prot
	Connexin_N_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:29586	UniProtKB/Swiss-Prot
NCBI Gene	29586	ENTREZGENE
PANTHER	GAP JUNCTION BETA-5 PROTEIN	UniProtKB/Swiss-Prot
	PTHR11984	UniProtKB/Swiss-Prot
Pfam	Connexin	UniProtKB/Swiss-Prot
PhenoGen	Gjb5	PhenoGen
PRINTS	CONNEXIN	UniProtKB/Swiss-Prot
	CONNEXINB4	UniProtKB/Swiss-Prot
PROSITE	CONNEXINS_1	UniProtKB/Swiss-Prot
	CONNEXINS_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000059897	RatGTEx
SMART	CNX	UniProtKB/Swiss-Prot
	Connexin_CCC	UniProtKB/Swiss-Prot
TIGR	TC209054
UniProt	A0A654ID63	ENTREZGENE, UniProtKB/TrEMBL
	CXB5_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-05-20	Gjb5	gap junction protein, beta 5	Gjb5	gap junction membrane channel protein beta 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Gjb5	gap junction membrane channel protein beta 5			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in adult epididymis	628541
gene_expression	mRNA levels in the caput-corpus epididymidis are low on days until day 21 and increase thereafter to peak at day 49 and subsequently decrease until day 91	628541

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD