Gja6 (gap junction protein, alpha 6) - Rat Genome Database

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Gene: Gja6 (gap junction protein, alpha 6) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gja6
Name: gap junction protein, alpha 6
RGD ID: 2693
Description: Predicted to enable gap junction channel activity. Predicted to be involved in cell communication by electrical coupling; cell-cell signaling; and heart development. Predicted to be located in gap junction and plasma membrane. Predicted to be part of connexin complex; INTERACTS WITH bisphenol A; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: connexin 33; connexin k2; connexin-33; cx33; cxn-33; Cxnk2; gap junction alpha-6 protein; gap junction membrane channel protein alpha 6
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X37,649,393 - 37,654,289 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2X33,840,689 - 33,845,585 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX33,840,549 - 33,845,614 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX35,011,296 - 35,012,156 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X38,473,317 - 38,474,177 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X36,148,440 - 36,149,300 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X35,621,805 - 35,622,665 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X35,946,791 - 35,951,162 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X55,120,709 - 55,121,569 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX34,536,416 - 34,537,276 (+)NCBICelera
RGSC_v3.1X55,174,177 - 55,175,038 (+)NCBI
Cytogenetic MapXq14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. Haefliger JA, etal., J Biol Chem 1992 Jan 25;267(3):2057-64.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15331631   PMID:16236818  


Genomics

Variants

.
Variants in Gja6
37 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2447036044931007Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2447036045082063Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
1 1 10 15 41 20 4 12 20 6 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000115489   ⟹   ENSRNOP00000085747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX33,840,549 - 33,845,614 (+)Ensembl
RefSeq Acc Id: NM_019308   ⟹   NP_062181
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X37,649,393 - 37,654,289 (+)NCBI
mRatBN7.2X33,840,689 - 33,845,585 (+)NCBI
Rnor_6.0X35,621,805 - 35,622,665 (+)NCBI
Rnor_5.0X35,946,791 - 35,951,162 (+)NCBI
RGSC_v3.4X55,120,709 - 55,121,569 (+)RGD
CeleraX34,536,416 - 34,537,276 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062181 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40998 (Get FASTA)   NCBI Sequence Viewer  
  EDL96158 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000085747.1
GenBank Protein P28233 (Get FASTA)   NCBI Sequence Viewer  
  VZP20204 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062181   ⟸   NM_019308
- UniProtKB: P28233 (UniProtKB/Swiss-Prot),   A0A654ID76 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000085747   ⟸   ENSRNOT00000115489
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28233-F1-model_v2 AlphaFold P28233 1-286 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2693 AgrOrtholog
BioCyc Gene G2FUF-2510 BioCyc
Ensembl Genes ENSRNOG00000069341 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000115489.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot
InterPro Connexin UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
  Connexin_CS UniProtKB/Swiss-Prot
  Connexin_N UniProtKB/Swiss-Prot
  Connexin_N_sf UniProtKB/Swiss-Prot
KEGG Report rno:54256 UniProtKB/Swiss-Prot
NCBI Gene 54256 ENTREZGENE
PANTHER GAP JUNCTION ALPHA-6 PROTEIN UniProtKB/Swiss-Prot
  PTHR11984 UniProtKB/Swiss-Prot
Pfam Connexin UniProtKB/Swiss-Prot
PhenoGen Gja6 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot
  CONNEXINS_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000069341 RatGTEx
SMART CNX UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
UniProt A0A654ID76 ENTREZGENE, UniProtKB/TrEMBL
  CXA6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-25 Gja6  gap junction protein, alpha 6  Gja6  gap junction membrane channel protein alpha 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gja6  gap junction membrane channel protein alpha 6      Name updated 70584 APPROVED