Gja5 (gap junction protein, alpha 5) - Rat Genome Database

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Gene: Gja5 (gap junction protein, alpha 5) Rattus norvegicus
Analyze
Symbol: Gja5
Name: gap junction protein, alpha 5
RGD ID: 2692
Description: Enables connexin binding activity; disordered domain specific binding activity; and gap junction channel activity. Involved in several processes, including blood vessel diameter maintenance; cell communication by chemical coupling; and regulation of blood pressure. Located in cell projection. Part of connexin complex. Used to study hypertension. Biomarker of artery disease (multiple); glomerulonephritis; obesity; overactive bladder syndrome; and ureteral obstruction. Human ortholog(s) of this gene implicated in atrial fibrillation; atrial standstill 1; familial atrial fibrillation; and tetralogy of Fallot. Orthologous to human GJA5 (gap junction protein alpha 5); PARTICIPATES IN connexin signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; acadesine; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: connexin 40; connexin i; connexin-40; Cx40; Cxni; gap junction alpha-5 protein; gap junction membrane channel protein alpha 5; gap junction membrane channel protein alpha 5 (connexin 40)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Gja5em1Mcwi  
Genetic Models: WKY-Gja5em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,291,227 - 187,310,770 (+)NCBIGRCr8
mRatBN7.22184,602,407 - 184,621,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,564,475 - 184,621,952 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2192,244,465 - 192,263,988 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02190,042,684 - 190,062,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,877,034 - 184,896,564 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02199,162,745 - 199,184,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,162,745 - 199,184,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,648,368 - 218,669,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,824,118 - 191,843,867 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,786,871 - 191,806,619 (+)NCBI
Celera2177,098,223 - 177,117,685 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Gja5Ratatrial fibrillation  ISOGJA5 (Homo sapiens)7207850 RGD 
Gja5Ratatrial fibrillation  ISOGJA5 (Homo sapiens)1580393 RGD 
Gja5RatBrain Injuries  IEP 7207391protein:increased expression:cerebral arteryRGD 
Gja5RatExperimental Diabetes Mellitus treatmentIDA 7207415 RGD 
Gja5Ratglomerulonephritis  IEP 7207390 RGD 
Gja5RatHemorrhagic Shock  IEP 7207423 RGD 
Gja5Rathypertension treatmentIDA 7207417 RGD 
Gja5Rathypertension  IEP 7207848protein:decreased expression:artery endothelium RGD 
Gja5Ratmyocardial infarction treatmentIEP 13592597 RGD 
Gja5Ratobesity  IEP 7207466mRNA and protein:decreased expression:mesenteric arteryRGD 
Gja5Ratoveractive bladder syndrome  IEP 7207474mRNA:increased expression:urinary bladderRGD 
Gja5Ratrenovascular hypertension  IEP 7207851 RGD 
Gja5RatSepsis  IEP 7207815mRNA and protein:increased expression:aorta endothelium RGD 
Gja5Rattetralogy of Fallot  ISOGJA5 (Homo sapiens)7207464DNA:duplicationsRGD 
Gja5Ratureteral obstruction  IEP 7207847mRNA:increased expression:kidneyRGD 
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Gja5Ratatrial fibrillation  ISOGJA5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16790700 more ...
Gja5Ratatrial standstill 1  ISOGJA5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16790700 more ...
Gja5Ratautism spectrum disorder  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:21844811 more ...
Gja5Ratcataract 1 multiple types  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Cataract 1 multiple typesClinVarPMID:17601931 more ...
Gja5Ratcataract 46 juvenile-onset  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Cataract 46 juvenile-onsetClinVarPMID:29464339 and PMID:31690835
Gja5Ratchromosome 1q21.1 deletion syndrome  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 1q21.1 deletion syndromeClinVarPMID:25741868 and PMID:28492532
Gja5Ratchromosome 1q21.1 duplication syndrome  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 1q21.1 duplication syndromeClinVar 
Gja5Ratfamilial atrial fibrillation  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial atrial fibrillationClinVarPMID:12522116 more ...
Gja5RatFamilial Atrial Fibrillation 11  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Atrial fibrillation more ...ClinVarPMID:16790700 more ...
Gja5Ratgastrointestinal stromal tumor  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Gja5Ratgenetic disease  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Gja5Rathypertrophic cardiomyopathy  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathyClinVar 
Gja5RatNeurodevelopmental Disorders  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Gja5Ratparathyroid carcinoma  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Gja5Ratschizophrenia  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
Gja5Ratthrombocytopenia-absent radius syndrome  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Radial aplasia-thrombocytopenia syndromeClinVar 
Gja5RatWolff-Parkinson-White syndrome  ISOGJA5 (Homo sapiens)8554872ClinVar Annotator: match by term: Wolff-Parkinson-White patternClinVar 
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Gja5Ratatrial fibrillation  ISOGJA5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29892015 and PMID:30061737
Gja5Ratatrial standstill 1  ISOGJA5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Gja5Ratchromosome 1q21.1 deletion syndrome  ISOGJA5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Gja5Rathypertension  ISOGJA5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19109587
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Gja5Rattetralogy of Fallot  ISSGja5 (Mus musculus)13592920OMIM:187500MouseDO 
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Gja5Ratatrial standstill 1  ISOGJA5 (Homo sapiens)7240710 OMIM 
Gja5RatFamilial Atrial Fibrillation 11  ISOGJA5 (Homo sapiens)7240710 OMIM 

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Gja5Rat1,2-dichloroethane increases expressionISOGja5 (Mus musculus)6480464ethylene dichloride results in increased expression of GJA5 mRNACTDPMID:28189721 and PMID:28960355
Gja5Rat1,2-dimethylhydrazine affects expressionISOGja5 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of GJA5 mRNACTDPMID:22206623
Gja5Rat17beta-estradiol multiple interactionsISOGJA5 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of GJA5 mRNACTDPMID:30165855
Gja5Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOGja5 (Mus musculus)64804642 more ...CTDPMID:38648751
Gja5Rat4,4'-diaminodiphenylmethane increases expressionISOGja5 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of GJA5 mRNACTDPMID:18648102
Gja5Rat4,4'-sulfonyldiphenol increases expressionISOGja5 (Mus musculus)6480464bisphenol S results in increased expression of GJA5 mRNACTDPMID:30951980
Gja5Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of GJA5 mRNACTDPMID:22504374
Gja5Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of GJA5 mRNACTDPMID:24780913
Gja5Ratacadesine multiple interactionsEXP 6480464acadesine inhibits the reaction [AGT protein results in decreased expression of GJA5 protein]CTDPMID:33676887
Gja5Rataflatoxin B1 increases methylationISOGJA5 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of GJA5 geneCTDPMID:27153756
Gja5Ratall-trans-retinoic acid increases expressionISOGJA5 (Homo sapiens)6480464Tretinoin results in increased expression of GJA5 mRNACTDPMID:21934132
Gja5Ratall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of GJA5 mRNACTDPMID:20488242
Gja5Ratamiodarone increases expressionISOGJA5 (Homo sapiens)6480464Amiodarone results in increased expression of GJA5 mRNACTDPMID:19774075
Gja5Ratamitrole increases expressionEXP 6480464Amitrole results in increased expression of GJA5 mRNACTDPMID:30047161
Gja5Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of GJA5 mRNACTDPMID:16483693
Gja5Ratarsenous acid decreases expressionEXP 6480464Arsenic Trioxide results in decreased expression of GJA5 proteinCTDPMID:17559834
Gja5Ratbenzo[a]pyrene decreases expressionISOGja5 (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of GJA5 mRNACTDPMID:21569818
Gja5Ratbenzo[a]pyrene decreases expressionEXP 6480464Benzo(a)pyrene results in decreased expression of GJA5 mRNACTDPMID:34283317
Gja5Ratbenzo[a]pyrene affects methylationISOGJA5 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of GJA5 5' UTR and Benzo(a)pyrene affects the methylation of GJA5 promoterCTDPMID:27901495
Gja5Ratbenzo[a]pyrene increases expressionISOGja5 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of GJA5 mRNACTDPMID:22228805

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Biological Process
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Gja5Ratangiogenesis involved_inISOGJA5 (Homo sapiens)1624291 PMID:11866539RGDPMID:11866539
Gja5Ratangiogenesis involved_inIEAUniProtKB:P36382 and ensembl:ENSP000004638511600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratartery morphogenesis involved_inISOGja5 (Mus musculus)1624291 PMID:20530546RGDPMID:20530546
Gja5Ratartery morphogenesis involved_inIEAUniProtKB:Q01231 and ensembl:ENSMUSP000000882641600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratatrial cardiac muscle cell to AV node cell communication by electrical coupling involved_inISOGJA5 (Homo sapiens)1624291 PMID:16790700 more ...RGDPMID:16790700 more ...
Gja5Ratatrial cardiac muscle cell to AV node cell communication by electrical coupling involved_inIEAUniProtKB:Q01231 and ensembl:ENSMUSP000000882641600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratatrial cardiac muscle cell to AV node cell communication by electrical coupling involved_inIEAUniProtKB:P36382 and ensembl:ENSP000004638511600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratatrial cardiac muscle cell to AV node cell communication by electrical coupling involved_inISOGja5 (Mus musculus)1624291 PMID:10515563RGDPMID:10515563
Gja5Ratatrial cardiac muscle cell to AV node cell communication by electrical coupling involved_inIBAMGI:95716 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gja5Ratatrial septum development involved_inISOGJA5 (Homo sapiens)1624291 PMID:22199024RGDPMID:22199024
Gja5Ratatrial septum development involved_inIEAUniProtKB:P36382 and ensembl:ENSP000004638511600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratatrial septum morphogenesis acts_upstream_of_or_withinISOGja5 (Mus musculus)1624291MGI:2445238 PMID:10969038RGDPMID:10969038
Gja5Ratatrial septum morphogenesis acts_upstream_of_or_withinIEAUniProtKB:Q01231 and ensembl:ENSMUSP000000882641600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratatrial ventricular junction remodeling acts_upstream_of_or_withinISOGja5 (Mus musculus)1624291MGI:2445238 PMID:10969038RGDPMID:10969038
Gja5Ratatrial ventricular junction remodeling acts_upstream_of_or_withinIEAUniProtKB:Q01231 and ensembl:ENSMUSP000000882641600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5RatAV node cell to bundle of His cell communication acts_upstream_of_or_withinIEAUniProtKB:Q01231 and ensembl:ENSMUSP000000882641600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5RatAV node cell to bundle of His cell communication acts_upstream_of_or_withinISOGja5 (Mus musculus)1624291MGI:2445238 PMID:10515563RGDPMID:10515563
Gja5RatAV node cell to bundle of His cell communication by electrical coupling involved_inISOGja5 (Mus musculus)1624291 PMID:10515563RGDPMID:10515563
Gja5RatAV node cell to bundle of His cell communication by electrical coupling involved_inIEAUniProtKB:Q01231 and ensembl:ENSMUSP000000882641600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5RatAV node cell to bundle of His cell communication by electrical coupling involved_inIEAUniProtKB:P36382 and ensembl:ENSP000004638511600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Gja5Ratanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Gja5Ratcell projection  IDA 7207813 RGD 
Gja5Ratconnexin complex  IDA 728713 RGD 
Gja5Ratconnexin complex part_ofIEAUniProtKB:P36382 and ensembl:ENSP000004638511600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratconnexin complex part_ofIBAMGI:2384150 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gja5Ratconnexin complex part_ofIEAInterPro:IPR000500 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Gja5Ratconnexin complex part_ofISOGJA5 (Homo sapiens)1624291 PMID:22247482RGDPMID:22247482
Gja5Ratconnexin complex part_ofISOGJA5 (Canis lupus familiaris)1624291 PMID:7930207RGDPMID:7930207
Gja5Ratconnexin complex part_ofIMP 12793009PMID:19808665CAFA 
Gja5Ratconnexin complex  IDA 1598435 RGD 
Gja5Ratgap junction located_inISOGJA5 (Homo sapiens)1624291 PMID:23348765RGDPMID:23348765
Gja5Ratgap junction located_inIEAUniProtKB-SubCell:SL-01241600115GO_REF:0000044UniProtGO_REF:0000044
Gja5Ratgap junction located_inISOGja5 (Mus musculus)1624291 PMID:9501070RGDPMID:9501070
Gja5Ratgap junction located_inIEAUniProtKB:P36382 and ensembl:ENSP000004638511600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratgap junction located_inIEAUniProtKB-KW:KW-03031600115GO_REF:0000043UniProtGO_REF:0000043
Gja5Ratgap junction located_inIEAARBA:ARBA000283601600115GO_REF:0000117UniProtGO_REF:0000117
Gja5Ratgap junction located_inIEAUniProtKB:Q01231 and ensembl:ENSMUSP000000882641600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratintercalated disc located_inISOGJA5 (Homo sapiens)1624291 PMID:16790700RGDPMID:16790700
Gja5Ratintercalated disc located_inIEAUniProtKB:P36382 and ensembl:ENSP000004638511600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Gja5Ratconnexin binding  IPIGja1 (Rattus norvegicus)7207849 RGD 
Gja5Ratdisordered domain specific binding enablesIPIUniProtKB:P0805012793009PMID:19808665CAFA 
Gja5Ratgap junction channel activity  IDA 728713 RGD 
Gja5Ratgap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling enablesISOGJA5 (Homo sapiens)1624291 PMID:16790700 more ...RGDPMID:16790700 more ...
Gja5Ratgap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling enablesIEAUniProtKB:P36382 and ensembl:ENSP000004638511600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratgap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling enablesIBAPANTHER:PTN002633691 and UniProtKB:P363821600115GO_REF:0000033GO_CentralGO_REF:0000033
Gja5Ratgap junction channel activity involved in AV node cell-bundle of His cell electrical coupling enablesISOGJA5 (Homo sapiens)1624291 PMID:22247482RGDPMID:22247482
Gja5Ratgap junction channel activity involved in AV node cell-bundle of His cell electrical coupling enablesIEAUniProtKB:P36382 and ensembl:ENSP000004638511600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratgap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling enablesISOGja5 (Mus musculus)1624291 PMID:26786475RGDPMID:26786475
Gja5Ratgap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling enablesIEAUniProtKB:P36382 and ensembl:ENSP000004638511600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratgap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling enablesIEAUniProtKB:Q01231 and ensembl:ENSMUSP000000882641600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratgap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling enablesISOGJA5 (Homo sapiens)1624291 PMID:22247482RGDPMID:22247482
Gja5Ratgap junction channel activity involved in cardiac conduction electrical coupling enablesISOGJA5 (Homo sapiens)1624291 PMID:16790700 and PMID:23348765RGDPMID:16790700 and PMID:23348765
Gja5Ratgap junction channel activity involved in cardiac conduction electrical coupling enablesIEAUniProtKB:P36382 and ensembl:ENSP000004638511600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratgap junction hemi-channel activity enablesISOGJA5 (Homo sapiens)1624291 PMID:23348765RGDPMID:23348765
Gja5Ratgap junction hemi-channel activity enablesIEAUniProtKB:P36382 and ensembl:ENSP000004638511600115GO_REF:0000107EnsemblGO_REF:0000107
Gja5Ratprotein binding enablesISOGJA5 (Homo sapiens)1624291UniProtKB:O15243 more ...RGDPMID:32296183 and PMID:32814053
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RGD Manual Annotations


  
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Original Reference(s)
Gja5Ratconnexin signaling pathway  ISOGJA5 (Homo sapiens)1580398 RGD 

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Reference Title
Reference Citation
1. Cerebrovascular connexin expression: effects of traumatic brain injury. Avila MA, etal., J Neurotrauma. 2011 Sep;28(9):1803-11. doi: 10.1089/neu.2011.1900. Epub 2011 Sep 6.
2. Unique conductance, gating, and selective permeability properties of gap junction channels formed by connexin40. Beblo DA, etal., Circ Res. 1995 Oct;77(4):813-22.
3. Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle. Beyer EC, etal., J Membr Biol 1992 Apr;127(1):69-76.
4. Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension. Billaud M, etal., Respir Res. 2011 Mar 17;12:30. doi: 10.1186/1465-9921-12-30.
5. Characterization of the structure and intermolecular interactions between the connexin40 and connexin43 carboxyl-terminal and cytoplasmic loop domains. Bouvier D, etal., J Biol Chem. 2009 Dec 4;284(49):34257-71. doi: 10.1074/jbc.M109.039594. Epub 2009 Oct 5.
6. Connexins: gaps in our knowledge of vascular function. Figueroa XF, etal., Physiology (Bethesda). 2004 Oct;19:277-84.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. Gollob MH, etal., N Engl J Med. 2006 Jun 22;354(25):2677-88.
10. Endothelial coordination of cerebral vasomotion via myoendothelial gap junctions containing connexins 37 and 40. Haddock RE, etal., Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2047-56. Epub 2006 Jun 30.
11. Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. Haefliger JA, etal., J Biol Chem 1992 Jan 25;267(3):2057-64.
12. Connexins 40 and 43 are differentially regulated within the kidneys of rats with renovascular hypertension. Haefliger JA, etal., Kidney Int. 2001 Jul;60(1):190-201.
13. Cardiac myocytes express multiple gap junction proteins. Kanter HL, etal., Circ Res 1992 Feb;70(2):438-44.
14. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
15. Changes of gap junctional cell-cell communication in overactive detrusor in rats. Li L, etal., Am J Physiol Cell Physiol. 2007 Nov;293(5):C1627-35. Epub 2007 Sep 13.
16. Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure. Ma J, etal., Biomed Pharmacother. 2018 Apr;100:156-167. doi: 10.1016/j.biopha.2018.02.013. Epub 2018 Feb 8.
17. Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells. Martin PE, etal., Br J Pharmacol. 2005 Mar;144(5):617-27.
18. Rapid endothelial cell-selective loading of connexin 40 antibody blocks endothelium-derived hyperpolarizing factor dilation in rat small mesenteric arteries. Mather S, etal., Circ Res. 2005 Aug 19;97(4):399-407. Epub 2005 Jul 21.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Regulatory effects of myoendothelial gap junction on vascular reactivity after hemorrhagic shock in rats. Ming J, etal., Shock. 2009 Jan;31(1):80-6. doi: 10.1097/SHK.0b013e31817d3eF2-11.
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PMID:7930207   PMID:9501069   PMID:9501070   PMID:9709407   PMID:10515563   PMID:10747000   PMID:10969038   PMID:11046183   PMID:11866539   PMID:12435353   PMID:14693688   PMID:14732399  
PMID:15016632   PMID:15489334   PMID:15923624   PMID:16284078   PMID:16352648   PMID:17255527   PMID:17546509   PMID:17584645   PMID:17632690   PMID:18239136   PMID:18599871   PMID:19129462  
PMID:19465552   PMID:19588758   PMID:20530546   PMID:20606116   PMID:20805582   PMID:21543330   PMID:22203979   PMID:22247482   PMID:22336507   PMID:22403875   PMID:23348765   PMID:26927369  
PMID:27304225   PMID:28157110   PMID:28457700   PMID:28870649  



Gja5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,291,227 - 187,310,770 (+)NCBIGRCr8
mRatBN7.22184,602,407 - 184,621,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,564,475 - 184,621,952 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2192,244,465 - 192,263,988 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02190,042,684 - 190,062,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,877,034 - 184,896,564 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02199,162,745 - 199,184,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,162,745 - 199,184,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,648,368 - 218,669,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,824,118 - 191,843,867 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,786,871 - 191,806,619 (+)NCBI
Celera2177,098,223 - 177,117,685 (+)NCBICelera
Cytogenetic Map2q34NCBI
GJA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,756,199 - 147,773,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,756,199 - 147,773,362 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,228,332 - 147,245,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,694,956 - 145,712,108 (-)NCBINCBI36Build 36hg18NCBI36
Build 341144,453,708 - 144,457,501NCBI
Celera1121,738,476 - 121,755,641 (+)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1120,641,850 - 120,658,997 (-)NCBIHuRef
CHM1_11149,124,325 - 149,141,488 (-)NCBICHM1_1
T2T-CHM13v2.01147,034,309 - 147,051,468 (+)NCBIT2T-CHM13v2.0
Gja5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,939,718 - 96,960,950 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,812,009 - 96,984,732 (+)EnsemblGRCm39 Ensembl
GRCm38397,032,402 - 97,053,634 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,904,693 - 97,077,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,836,339 - 96,857,557 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36397,117,821 - 97,139,039 (+)NCBIMGSCv36mm8
Celera398,439,607 - 98,460,828 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map342.04NCBI
Gja5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568635,042 - 653,349 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955568635,319 - 652,692 (+)NCBIChiLan1.0ChiLan1.0
GJA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21101,927,011 - 101,952,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11101,515,393 - 101,539,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01123,200,111 - 123,224,626 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11112,306,880 - 112,331,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1112,328,337 - 112,329,413 (+)Ensemblpanpan1.1panPan2
GJA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,289,327 - 58,305,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,289,327 - 58,305,315 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1757,757,715 - 57,773,685 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01759,286,062 - 59,301,971 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,285,495 - 59,302,023 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,159,018 - 58,175,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,219,654 - 58,235,621 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01758,946,248 - 58,962,243 (-)NCBIUU_Cfam_GSD_1.0
Gja5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,393,289 - 20,403,471 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936867269,477 - 279,549 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,854,392 - 99,871,286 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24109,687,517 - 109,704,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GJA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603814,460,790 - 14,478,590 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gja5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477216,813,011 - 16,814,084 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477216,810,723 - 16,828,328 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Gja5
76 total Variants

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:161
Interacting mature miRNAs:194
Transcripts:ENSRNOT00000023488
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 69 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat

1 to 10 of 69 rows
Gja5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22184,619,868 - 184,620,068 (+)MAPPERmRatBN7.2
Rnor_6.02199,182,858 - 199,183,057NCBIRnor6.0
Rnor_5.02218,667,271 - 218,667,470UniSTSRnor5.0
RGSC_v3.42191,841,784 - 191,841,983UniSTSRGSC3.4
Celera2177,115,694 - 177,115,893UniSTS
Cytogenetic Map2q34UniSTS
D2Wox62  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82187,310,130 - 187,310,342 (+)Marker Load Pipeline
mRatBN7.22184,621,312 - 184,621,524 (+)MAPPERmRatBN7.2
Rnor_6.02199,184,302 - 199,184,513NCBIRnor6.0
Rnor_5.02218,668,715 - 218,668,926UniSTSRnor5.0
RGSC_v3.42191,843,228 - 191,843,439UniSTSRGSC3.4
Celera2177,117,138 - 177,117,257UniSTS
Cytogenetic Map2q34UniSTS
RH134117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22184,621,613 - 184,621,795 (+)MAPPERmRatBN7.2
Rnor_6.02199,184,603 - 199,184,784NCBIRnor6.0
Rnor_5.02218,669,016 - 218,669,197UniSTSRnor5.0
RGSC_v3.42191,843,529 - 191,843,710UniSTSRGSC3.4
Celera2177,117,347 - 177,117,528UniSTS
RH 3.4 Map21247.3UniSTS
Cytogenetic Map2q34UniSTS
UniSTS:275686  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22184,618,959 - 184,619,214 (+)MAPPERmRatBN7.2
Rnor_6.02199,181,949 - 199,182,203NCBIRnor6.0
Rnor_5.02218,666,362 - 218,666,616UniSTSRnor5.0
RGSC_v3.42191,840,875 - 191,841,129UniSTSRGSC3.4
Celera2177,114,785 - 177,115,039UniSTS
Cytogenetic Map2q34UniSTS


This gene Gja5 is modified in the following models/strains:
WKY-Gja5em1Mcwi    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000023488   ⟹   ENSRNOP00000023488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2184,607,596 - 184,621,952 (+)Ensembl
Rnor_6.0 Ensembl2199,162,745 - 199,184,939 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108116   ⟹   ENSRNOP00000076921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2184,602,293 - 184,621,952 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115241   ⟹   ENSRNOP00000080221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2184,564,475 - 184,621,952 (+)Ensembl
RefSeq Acc Id: NM_019280   ⟹   NP_062153
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,291,227 - 187,310,770 (+)NCBI
mRatBN7.22184,602,408 - 184,621,952 (+)NCBI
Rnor_6.02199,162,745 - 199,184,942 (+)NCBI
Rnor_5.02218,648,368 - 218,669,354 (+)NCBI
RGSC_v3.42191,824,118 - 191,843,867 (+)RGD
Celera2177,098,223 - 177,117,685 (+)RGD
Sequence:
RefSeq Acc Id: XM_063282415   ⟹   XP_063138485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,295,920 - 187,310,770 (+)NCBI
RefSeq Acc Id: NP_062153   ⟸   NM_019280
- UniProtKB: P28234 (UniProtKB/Swiss-Prot),   A6K3A5 (UniProtKB/TrEMBL),   A0A654ICD7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023488   ⟸   ENSRNOT00000023488
Ensembl Acc Id: ENSRNOP00000080221   ⟸   ENSRNOT00000115241
Ensembl Acc Id: ENSRNOP00000076921   ⟸   ENSRNOT00000108116
RefSeq Acc Id: XP_063138485   ⟸   XM_063282415
- Peptide Label: isoform X1
- UniProtKB: P28234 (UniProtKB/Swiss-Prot),   A6K3A5 (UniProtKB/TrEMBL),   A0A654ICD7 (UniProtKB/TrEMBL)
Connexin N-terminal   Gap junction protein cysteine-rich

Name Modeler Protein Id AA Range Protein Structure
AF-P28234-F1-model_v2 AlphaFold P28234 1-356 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691593
Promoter ID:EPDNEW_R2117
Type:multiple initiation site
Name:Gja5_1
Description:gap junction protein, alpha 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02199,162,718 - 199,162,778EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-51953 BioCyc
Ensembl Genes ENSRNOG00000017484 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023488.7 UniProtKB/Swiss-Prot
  ENSRNOT00000108116 ENTREZGENE
  ENSRNOT00000108116.1 UniProtKB/Swiss-Prot
  ENSRNOT00000115241 ENTREZGENE
  ENSRNOT00000115241.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7097997 IMAGE-MGC_LOAD
InterPro Connexin UniProtKB/Swiss-Prot
  Connexin40 UniProtKB/Swiss-Prot
  Connexin_C UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
  Connexin_CS UniProtKB/Swiss-Prot
  Connexin_N UniProtKB/Swiss-Prot
  Connexin_N_sf UniProtKB/Swiss-Prot
  Cx40_C UniProtKB/Swiss-Prot
KEGG Report rno:50563 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91719 IMAGE-MGC_LOAD
NCBI Gene 50563 ENTREZGENE
PANTHER PTHR11984 UniProtKB/Swiss-Prot
  PTHR11984:SF13 UniProtKB/Swiss-Prot
Pfam Connexin UniProtKB/Swiss-Prot
  Connexin40_C UniProtKB/Swiss-Prot
PharmGKB GJA5 RGD
PhenoGen Gja5 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot
  CONNEXINA5 UniProtKB/Swiss-Prot
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot
  CONNEXINS_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017484 RatGTEx
SMART CNX UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF118220 UniProtKB/Swiss-Prot
TIGR TC218949
UniProt A0A654ICD7 ENTREZGENE, UniProtKB/TrEMBL
  A6K3A5 ENTREZGENE, UniProtKB/TrEMBL
  CXA5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Gja5  gap junction protein, alpha 5  Gja5  gap junction membrane channel protein alpha 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gja5  gap junction membrane channel protein alpha 5      Name updated 70584 APPROVED