Gfi1 (growth factor independent 1 transcriptional repressor) - Rat Genome Database

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Gene: Gfi1 (growth factor independent 1 transcriptional repressor) Rattus norvegicus
Analyze
Symbol: Gfi1
Name: growth factor independent 1 transcriptional repressor
RGD ID: 2680
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and enzyme-substrate adaptor activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Predicted to act upstream of or within several processes, including inner ear development; negative regulation of double-strand break repair via homologous recombination; and regulation of cell fate specification. Predicted to be located in nuclear body and nuclear matrix. Predicted to be part of transcription repressor complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: growth factor independent 1; growth factor independent 1 transcription repressor; growth factor independent protein 1; Growth factor independent-1; zinc finger protein Gfi-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,185,489 - 2,204,191 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl142,187,286 - 2,196,730 (+)EnsemblGRCr8
mRatBN7.2142,040,576 - 2,056,874 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl142,042,434 - 2,051,814 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx141,920,954 - 1,930,312 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0143,222,742 - 3,232,132 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,919,439 - 1,928,836 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,058,035 - 3,073,332 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,058,993 - 3,068,371 (+)Ensemblrn6Rnor6.0
Rnor_5.0143,060,287 - 3,069,973 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4142,597,303 - 2,606,681 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera142,061,330 - 2,070,708 (+)NCBICelera
RGSC_v3.1142,597,302 - 2,606,681 (+)NCBI
RH 3.4 Map1437.2RGD
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nuclear body  (IEA,ISO)
nuclear matrix  (IEA,ISO)
nucleus  (IEA,ISO)
transcription repressor complex  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1. Basu S, etal., Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1433-8. doi: 10.1073/pnas.0804863106. Epub 2009 Jan 22.
2. Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1. Duan Z, etal., Mol Cell Biol. 2005 Dec;25(23):10338-51.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein. Gilks CB, etal., Mol Cell Biol 1993 Mar;13(3):1759-68.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The growth factor independence-1 (Gfi1) is overexpressed in chronic myelogenous leukemia. Huang M, etal., Acta Haematol. 2010;123(1):1-5. doi: 10.1159/000253856. Epub 2009 Nov 2.
7. CD34, RAB20, PU.1 and GFI1 mRNA expression in myelodysplastic syndrome. Huh HJ, etal., Int J Lab Hematol. 2009 Jun;31(3):344-51. doi: 10.1111/j.1751-553X.2008.01056.x. Epub 2008 Mar 25.
8. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Karsunky H, etal., Nat Genet. 2002 Mar;30(3):295-300. Epub 2002 Jan 28.
9. A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia. Khandanpour C, etal., Blood. 2010 Mar 25;115(12):2462-72. doi: 10.1182/blood-2009-08-239822. Epub 2010 Jan 14.
10. The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice. Khandanpour C, etal., Blood. 2012 Nov 8;120(19):4006-17. doi: 10.1182/blood-2011-02-334722. Epub 2012 Aug 28.
11. Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. Khandanpour C, etal., Stem Cells. 2011 Feb;29(2):376-85. doi: 10.1002/stem.575.
12. Low GFI1 expression in white blood cells of CP-CML patients at diagnosis is strongly associated with subsequent blastic transformation. Kok CH, etal., Leukemia. 2013 Jun;27(6):1427-30. doi: 10.1038/leu.2013.47. Epub 2013 Feb 15.
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
18. A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia. Ordonez-Rueda D, etal., Eur J Immunol. 2012 Sep;42(9):2395-408. doi: 10.1002/eji.201242589.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas. Shin MS, etal., Cancer Res. 2004 Jul 1;64(13):4419-27.
24. [Expression of growth-factor independence 1 in patients with leukemia and its significance]. Wang TT, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Aug;18(4):834-7.
Additional References at PubMed
PMID:11060035   PMID:12441305   PMID:12721361   PMID:12874834   PMID:15131254   PMID:15947108   PMID:16230531   PMID:19026687   PMID:19506020   PMID:20153336   PMID:20190815   PMID:20547752  


Genomics

Comparative Map Data
Gfi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,185,489 - 2,204,191 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl142,187,286 - 2,196,730 (+)EnsemblGRCr8
mRatBN7.2142,040,576 - 2,056,874 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl142,042,434 - 2,051,814 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx141,920,954 - 1,930,312 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0143,222,742 - 3,232,132 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,919,439 - 1,928,836 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,058,035 - 3,073,332 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,058,993 - 3,068,371 (+)Ensemblrn6Rnor6.0
Rnor_5.0143,060,287 - 3,069,973 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4142,597,303 - 2,606,681 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera142,061,330 - 2,070,708 (+)NCBICelera
RGSC_v3.1142,597,302 - 2,606,681 (+)NCBI
RH 3.4 Map1437.2RGD
Cytogenetic Map14p22NCBI
GFI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,473,043 - 92,486,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,472,360 - 92,486,925 (-)Ensemblhg38GRCh38
GRCh37192,938,600 - 92,952,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,712,909 - 92,725,021 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34192,652,341 - 92,664,451NCBI
Celera191,193,179 - 91,205,211 (-)NCBICelera
Cytogenetic Map1p22.1NCBI
HuRef191,061,525 - 91,073,603 (-)NCBIHuRef
CHM1_1193,055,130 - 93,067,261 (-)NCBICHM1_1
T2T-CHM13v2.0192,317,932 - 92,331,836 (-)NCBIT2T-CHM13v2.0
Gfi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395107,864,521 - 107,873,671 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5107,864,523 - 107,873,902 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385107,716,655 - 107,725,805 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5107,716,657 - 107,726,036 (-)Ensemblmm10GRCm38
MGSCv375108,145,674 - 108,153,363 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365107,956,961 - 107,964,646 (-)NCBIMGSCv36mm8
Celera5104,829,261 - 104,836,969 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map552.23NCBI
Gfi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554232,022,417 - 2,033,149 (+)Ensembl
ChiLan1.0NW_0049554232,024,084 - 2,032,530 (+)NCBIChiLan1.0ChiLan1.0
GFI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21134,538,355 - 134,547,424 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11133,689,661 - 133,703,553 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,139,171 - 95,151,054 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,875,880 - 93,883,558 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,876,245 - 93,883,528 (-)EnsemblpanPan2panpan1.1
GFI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1656,473,032 - 56,484,422 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl656,256,305 - 56,484,422 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha659,174,527 - 59,183,663 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0656,849,754 - 56,861,112 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl656,852,003 - 56,861,112 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1656,531,815 - 56,540,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0656,510,728 - 56,519,864 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0656,970,884 - 56,980,018 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gfi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058102,328,318 - 102,337,410 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365376,610,565 - 6,618,450 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365376,610,565 - 6,618,509 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GFI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4124,621,261 - 124,629,638 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14124,619,887 - 124,629,638 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GFI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12040,771,238 - 40,786,008 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2040,776,816 - 40,783,717 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603377,232,569 - 77,242,841 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gfi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247425,261,537 - 5,270,695 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247425,260,651 - 5,271,908 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gfi1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11117,485,285 - 17,498,525 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gfi1
64 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:372
Count of miRNA genes:224
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000002807
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat

Markers in Region
RH94680  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2142,051,254 - 2,051,357 (+)MAPPERmRatBN7.2
Rnor_6.0143,067,812 - 3,067,914NCBIRnor6.0
Rnor_5.0143,069,262 - 3,069,364UniSTSRnor5.0
RGSC_v3.4142,606,122 - 2,606,224UniSTSRGSC3.4
Celera142,070,149 - 2,070,251UniSTS
RH 3.4 Map1437.2UniSTS
Cytogenetic Map14p22UniSTS
D1S3707E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2142,047,083 - 2,047,202 (+)MAPPERmRatBN7.2
Rnor_6.0143,063,643 - 3,063,761NCBIRnor6.0
Rnor_5.0143,065,094 - 3,065,212UniSTSRnor5.0
RGSC_v3.4142,601,953 - 2,602,071UniSTSRGSC3.4
Celera142,065,980 - 2,066,098UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 7 42 61 83 84 53 92 53 6 299 159 11 35 65 89 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000002807   ⟹   ENSRNOP00000002807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl142,187,286 - 2,196,730 (+)Ensembl
mRatBN7.2 Ensembl142,042,434 - 2,051,814 (+)Ensembl
Rnor_6.0 Ensembl143,058,993 - 3,068,371 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102102   ⟹   ENSRNOP00000088098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl142,187,620 - 2,196,730 (+)Ensembl
mRatBN7.2 Ensembl142,042,705 - 2,051,814 (+)Ensembl
RefSeq Acc Id: NM_012566   ⟹   NP_036698
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,187,349 - 2,196,727 (+)NCBI
mRatBN7.2142,042,434 - 2,051,814 (+)NCBI
Rnor_6.0143,058,993 - 3,068,371 (+)NCBI
Rnor_5.0143,060,287 - 3,069,973 (+)NCBI
RGSC_v3.4142,597,303 - 2,606,681 (+)RGD
Celera142,061,330 - 2,070,708 (+)RGD
Sequence:
RefSeq Acc Id: XM_008769917   ⟹   XP_008768139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,185,493 - 2,196,734 (+)NCBI
mRatBN7.2142,040,576 - 2,051,821 (+)NCBI
Rnor_6.0143,058,035 - 3,068,375 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769918   ⟹   XP_008768140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,187,861 - 2,196,734 (+)NCBI
mRatBN7.2142,042,941 - 2,051,821 (+)NCBI
Rnor_6.0143,059,499 - 3,068,375 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769920   ⟹   XP_008768142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,185,489 - 2,204,191 (+)NCBI
mRatBN7.2142,042,302 - 2,056,874 (+)NCBI
Rnor_6.0143,058,035 - 3,073,332 (+)NCBI
Sequence:
RefSeq Acc Id: XR_359278
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,185,493 - 2,196,734 (+)NCBI
mRatBN7.2142,042,302 - 2,051,821 (+)NCBI
Rnor_6.0143,058,035 - 3,068,375 (+)NCBI
Rnor_5.0143,060,287 - 3,069,973 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036698   ⟸   NM_012566
- UniProtKB: Q07120 (UniProtKB/Swiss-Prot),   A6KPI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768142   ⟸   XM_008769920
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008768139   ⟸   XM_008769917
- Peptide Label: isoform X1
- UniProtKB: Q07120 (UniProtKB/Swiss-Prot),   A6KPI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768140   ⟸   XM_008769918
- Peptide Label: isoform X1
- UniProtKB: Q07120 (UniProtKB/Swiss-Prot),   A6KPI0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002807   ⟸   ENSRNOT00000002807
Ensembl Acc Id: ENSRNOP00000088098   ⟸   ENSRNOT00000102102
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07120-F1-model_v2 AlphaFold Q07120 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699156
Promoter ID:EPDNEW_R9681
Type:single initiation site
Name:Gfi1_1
Description:growth factor independent 1 transcriptional repressor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0143,058,940 - 3,059,000EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2680 AgrOrtholog
BioCyc Gene G2FUF-16627 BioCyc
Ensembl Genes ENSRNOG00000002042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002807 ENTREZGENE
  ENSRNOT00000002807.4 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro C2H2-ZF_Transcription_Reg UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report rno:24388 UniProtKB/Swiss-Prot
NCBI Gene 24388 ENTREZGENE
PANTHER ODD-SKIPPED - RELATED UniProtKB/Swiss-Prot
  ZINC FINGER PROTEIN 208-LIKE UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Gfi1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002042 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt A0A8I6A753_RAT UniProtKB/TrEMBL
  A6KPI0 ENTREZGENE, UniProtKB/TrEMBL
  GFI1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Gfi1  growth factor independent 1 transcriptional repressor  Gfi1  growth factor independent 1 transcription repressor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Gfi1  growth factor independent 1 transcription repressor  Gfi1  growth factor independent 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gfi1  Growth factor independent-1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is expressed in thymus, spleen and testis in adult animals 728614