Gdf11 (growth differentiation factor 11) - Rat Genome Database

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Gene: Gdf11 (growth differentiation factor 11) Rattus norvegicus
Analyze
Symbol: Gdf11
Name: growth differentiation factor 11
RGD ID: 2673
Description: Predicted to enable cytokine activity. Involved in negative regulation of neuron differentiation. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in vertebral hypersegmentation and orofacial anomalies. Orthologous to human GDF11 (growth differentiation factor 11); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BMP-11; bone morphogenetic protein 11; GDF-11; growth/differentiation factor 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,896,229 - 1,909,147 (-)NCBIGRCr8
mRatBN7.271,311,732 - 1,325,211 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,311,732 - 1,320,725 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx74,076,094 - 4,085,087 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,951,755 - 5,960,748 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,253,020 - 6,262,013 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,306,863 - 3,315,856 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,306,863 - 3,315,856 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,277,923 - 3,286,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,182,467 - 2,191,454 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.172,185,253 - 2,191,265 (-)NCBI
Celera71,182,487 - 1,191,452 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells. Ge G, etal., Mol Cell Biol. 2005 Jul;25(14):5846-58.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury. Magga J, etal., Mol Ther. 2019 Mar 6;27(3):600-610. doi: 10.1016/j.ymthe.2019.01.013. Epub 2019 Jan 24.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Expression of growth/differentiation factor 11, a new member of the BMP/TGFbeta superfamily during mouse embryogenesis. Nakashima M, etal., Mech Dev 1999 Feb;80(2):185-9.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10391213   PMID:12729564   PMID:15548585   PMID:15976303   PMID:16790475   PMID:16845371   PMID:23918385   PMID:24019467   PMID:26001423   PMID:27653860   PMID:28257634   PMID:29448002  
PMID:29463625   PMID:29783655   PMID:31096010   PMID:32220534   PMID:35033112   PMID:35461108   PMID:36293138   PMID:36749472   PMID:37220327   PMID:37827256  


Genomics

Comparative Map Data
Gdf11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,896,229 - 1,909,147 (-)NCBIGRCr8
mRatBN7.271,311,732 - 1,325,211 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,311,732 - 1,320,725 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx74,076,094 - 4,085,087 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,951,755 - 5,960,748 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,253,020 - 6,262,013 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,306,863 - 3,315,856 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,306,863 - 3,315,856 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,277,923 - 3,286,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,182,467 - 2,191,454 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.172,185,253 - 2,191,265 (-)NCBI
Celera71,182,487 - 1,191,452 (-)NCBICelera
Cytogenetic Map7q11NCBI
GDF11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,743,122 - 55,757,264 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,743,122 - 55,757,264 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,136,906 - 56,151,048 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,423,331 - 54,430,332 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,423,333 - 54,430,332NCBI
Celera1255,789,534 - 55,799,135 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,175,916 - 53,185,626 (+)NCBIHuRef
CHM1_11256,103,813 - 56,113,414 (+)NCBICHM1_1
T2T-CHM13v2.01255,709,757 - 55,723,906 (+)NCBIT2T-CHM13v2.0
Gdf11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,716,393 - 128,727,587 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,718,164 - 128,727,587 (-)EnsemblGRCm39 Ensembl
GRCm3810128,880,524 - 128,891,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,882,295 - 128,891,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,321,602 - 128,328,774 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610128,287,495 - 128,294,634 (-)NCBIMGSCv36mm8
Celera10131,277,119 - 131,314,308 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.18NCBI
Gdf11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,388,402 - 3,398,040 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,388,402 - 3,398,040 (+)NCBIChiLan1.0ChiLan1.0
GDF11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,571,240 - 38,585,080 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,568,010 - 38,581,811 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01233,154,530 - 33,168,427 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,879,143 - 33,893,027 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,879,180 - 33,893,252 (-)Ensemblpanpan1.1panPan2
GDF11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110142,039 - 152,537 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10145,036 - 148,373 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10202,146 - 211,966 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010147,013 - 159,810 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10147,013 - 153,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110124,694 - 137,481 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010367,790 - 377,596 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010491,709 - 504,497 (+)NCBIUU_Cfam_GSD_1.0
Gdf11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,643,209 - 58,655,134 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646216,946 - 224,321 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646215,101 - 227,296 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,191,251 - 21,201,804 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,191,322 - 21,199,024 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2522,671,244 - 22,678,880 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GDF11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,693,664 - 51,702,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1151,693,717 - 51,700,278 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037194,292,055 - 194,300,722 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gdf11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480212,259,971 - 12,269,440 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gdf11
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:39
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000010035
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat

Markers in Region
MARC_41381-41054:1084804684:3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,320,288 - 1,320,701 (+)MAPPERmRatBN7.2
Rnor_6.073,315,420 - 3,315,832NCBIRnor6.0
Rnor_5.073,286,480 - 3,286,892UniSTSRnor5.0
RGSC_v3.472,191,024 - 2,191,436UniSTSRGSC3.4
Cytogenetic Map7q11UniSTS
Gdf11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,314,728 - 1,315,838 (+)MAPPERmRatBN7.2
Rnor_6.073,309,860 - 3,310,969NCBIRnor6.0
Rnor_5.073,280,920 - 3,282,029UniSTSRnor5.0
RGSC_v3.472,185,464 - 2,186,573UniSTSRGSC3.4
Celera71,185,484 - 1,186,593UniSTS
Cytogenetic Map7q11UniSTS
UniSTS:498329  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,320,257 - 1,320,416 (+)MAPPERmRatBN7.2
Rnor_6.073,315,389 - 3,315,547NCBIRnor6.0
Rnor_5.073,286,449 - 3,286,607UniSTSRnor5.0
RGSC_v3.472,190,993 - 2,191,151UniSTSRGSC3.4
Celera71,191,013 - 1,191,171UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 4 4 4 74 20 27
Low 3 31 46 30 19 30 8 11 15 14 11 8
Below cutoff 7 7 7

Sequence


RefSeq Acc Id: ENSRNOT00000010035   ⟹   ENSRNOP00000010035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl71,311,732 - 1,320,725 (-)Ensembl
Rnor_6.0 Ensembl73,306,863 - 3,315,856 (-)Ensembl
RefSeq Acc Id: NM_017203   ⟹   NP_058899
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,896,229 - 1,905,222 (-)NCBI
mRatBN7.271,311,732 - 1,320,725 (-)NCBI
Rnor_6.073,306,863 - 3,315,856 (-)NCBI
Rnor_5.073,277,923 - 3,286,916 (-)NCBI
Celera71,182,487 - 1,191,452 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078581   ⟹   XP_038934509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,896,231 - 1,909,147 (-)NCBI
mRatBN7.271,311,734 - 1,324,962 (-)NCBI
Protein Sequences
Protein RefSeqs NP_058899 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934509 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD05266 (Get FASTA)   NCBI Sequence Viewer  
  EDL84790 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010035
  ENSRNOP00000010035.2
  ENSRNOP00055020296
  ENSRNOP00060039719
  ENSRNOP00065016526
GenBank Protein Q9Z217 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058899   ⟸   NM_017203
- Peptide Label: precursor
- UniProtKB: G3V6Y2 (UniProtKB/Swiss-Prot),   Q9Z217 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010035   ⟸   ENSRNOT00000010035
RefSeq Acc Id: XP_038934509   ⟸   XM_039078581
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z217-F1-model_v2 AlphaFold Q9Z217 1-405 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2673 AgrOrtholog
BioCyc Gene G2FUF-35327 BioCyc
Ensembl Genes ENSRNOG00000007610 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055014477 UniProtKB/Swiss-Prot
  ENSRNOG00060027537 UniProtKB/Swiss-Prot
  ENSRNOG00065013036 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010035 ENTREZGENE
  ENSRNOT00000010035.4 UniProtKB/Swiss-Prot
  ENSRNOT00055024841 UniProtKB/Swiss-Prot
  ENSRNOT00060047757 UniProtKB/Swiss-Prot
  ENSRNOT00065021368 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.970 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-b_propeptide UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:29454 UniProtKB/Swiss-Prot
NCBI Gene 29454 ENTREZGENE
PANTHER GROWTH/DIFFERENTIATION FACTOR 11 UniProtKB/Swiss-Prot
  PTHR11848 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
  TGFb_propeptide UniProtKB/Swiss-Prot
PharmGKB GDF11 RGD
PhenoGen Gdf11 PhenoGen
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007610 RatGTEx
  ENSRNOG00055014477 RatGTEx
  ENSRNOG00060027537 RatGTEx
  ENSRNOG00065013036 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
TIGR TC238415
UniProt G3V6Y2 ENTREZGENE
  GDF11_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V6Y2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gdf11  growth differentiation factor 11       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in adult dental pulp and brain 69843
gene_product member of the bone morphogenetic protein/transforming growth factor beta (BMP/TGFbeta) superfamily 69843