Fosl2 (FOS like 2, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Fosl2 (FOS like 2, AP-1 transcription factor subunit) Rattus norvegicus
Analyze
Symbol: Fosl2
Name: FOS like 2, AP-1 transcription factor subunit
RGD ID: 2628
Description: Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in several processes, including conditioned taste aversion; response to forskolin; and response to progesterone. Predicted to be part of transcription factor AP-1 complex. Predicted to be active in nucleus. Biomarker of renal carcinoma. Orthologous to human FOSL2 (FOS like 2, AP-1 transcription factor subunit); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FOS like 2, AP-1 trancription factor subunit; Fos like antigen 2; fos-like antigen 2; fos-related antigen 2; FRA-2; Fra2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,017,952 - 30,039,269 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl630,021,916 - 30,039,406 (-)EnsemblGRCr8
mRatBN7.2624,297,898 - 24,319,219 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl624,300,956 - 24,320,034 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx624,601,426 - 24,618,764 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0624,917,309 - 24,934,650 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0624,406,268 - 24,423,562 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0625,598,936 - 25,616,995 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,598,936 - 25,616,995 (-)Ensemblrn6Rnor6.0
Rnor_5.0635,422,541 - 35,440,258 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera623,796,496 - 23,813,256 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-butoxyethanol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Bisphenol Z  (ISO)
butyric acid  (EXP)
C60 fullerene  (EXP)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
fluoranthene  (ISO)
formaldehyde  (ISO)
gemcitabine  (ISO)
geraniol  (ISO)
glucose  (ISO)
glycidol  (EXP)
GSK-J4  (ISO)
haloperidol  (EXP)
hexadecanoic acid  (ISO)
hydrogen chloride  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
mechlorethamine  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prostaglandin F2alpha  (EXP)
pyrrolidine dithiocarbamate  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
rimonabant  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alveolar secondary septum development  (ISO)
B cell differentiation  (ISO)
B cell proliferation  (ISO)
bone development  (ISO)
bone mineralization  (ISO)
cartilage development  (ISO)
cell morphogenesis  (ISO)
chondrocyte differentiation  (ISO)
chondrocyte proliferation  (ISO)
circadian rhythm  (IEP)
collagen biosynthetic process  (ISO)
collagen metabolic process  (ISO)
conditioned taste aversion  (IEP)
fat cell apoptotic process  (ISO)
fat cell differentiation  (ISO)
fat pad development  (ISO)
female pregnancy  (IEP)
gene expression  (ISO)
glucose homeostasis  (ISO)
growth plate cartilage development  (ISO)
homeostasis of number of cells  (ISO)
homeostasis of number of cells within a tissue  (ISO)
inflammatory response  (ISO)
inflammatory response to antigenic stimulus  (ISO)
innate immune response  (ISO)
insulin metabolic process  (ISO)
keratinocyte development  (ISO)
lung alveolus development  (ISO)
lung connective tissue development  (ISO)
lung development  (ISO)
macrophage differentiation  (ISO)
mucus secretion  (ISO)
multicellular organism growth  (ISO)
myofibroblast differentiation  (ISO)
neutrophil differentiation  (ISO)
NK T cell differentiation  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
osteoclast differentiation  (ISO)
photoperiodism  (IEP)
positive regulation of DNA-templated transcription  (IDA,IEA,ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of multicellular organism growth  (ISO)
regulation of myofibroblast differentiation  (ISO)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
response to bleomycin  (ISO)
response to cAMP  (IEP)
response to cytokine  (IEP)
response to estradiol  (IMP)
response to forskolin  (IEP)
response to glucocorticoid  (ISO)
response to Gram-positive bacterium  (ISO)
response to hypoxia  (IMP,ISO)
response to immobilization stress  (IEP)
response to interleukin-13  (ISO)
response to interleukin-7  (ISO)
response to leukemia inhibitory factor  (ISO)
response to light stimulus  (IEP)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (IEP)
response to peptide hormone  (IEP)
response to progesterone  (IEP)
response to toxic substance  (IEP)
response to xenobiotic stimulus  (ISO)
smooth muscle tissue development  (ISO)
T cell differentiation  (ISO)
T cell receptor signaling pathway  (ISO)
tissue remodeling  (ISO)
transcription by RNA polymerase II  (IMP)
transforming growth factor beta1 production  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Bcl-xL expression and regulation in the progression, recurrence, and cisplatin resistance of oral cancer. Alam M and Mishra R, Life Sci. 2021 Sep 1;280:119705. doi: 10.1016/j.lfs.2021.119705. Epub 2021 Jun 8.
2. Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. Babykutty S, etal., Clin Exp Metastasis. 2012 Jun;29(5):471-92. doi: 10.1007/s10585-012-9464-6. Epub 2012 Mar 15.
3. Circadian expression of transcription factor Fra-2 in the rat pineal gland. Baler R and Klein DC, J Biol Chem 1995 Nov 10;270(45):27319-25.
4. Temporal and regional expression of Fos-related proteins in response to ischemic injury. Butler TL and Pennypacker KR, Brain Res Bull. 2004 Mar 1;63(1):65-73.
5. The transcriptional response to hypoxic insult controlled by FRA-2. Butler TL and Pennypacker KR, Gene Expr. 2005;12(2):61-7.
6. Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism. Davies JS, etal., J Biol Chem. 2011 Apr 29;286(17):15227-39. doi: 10.1074/jbc.M110.201996. Epub 2011 Mar 2.
7. Is light-regulated AP-1 binding in the rat suprachiasmatic nucleus gated by the circadian clock? Francois-Bellan AM, etal., Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):161-70.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Adrenergic inducibility of AP-1 binding in the rat pineal gland depends on prior photoperiod. Guillaumond F, etal., J Neurochem 2002 Oct;83(1):157-66.
11. Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock's zeitgebers. Guillaumond F, etal., J Neurochem. 2000 Oct;75(4):1398-407.
12. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
13. Expression of AP-1 family transcription factors in the amygdala during conditioned taste aversion learning: role for Fra-2. Kwon B, etal., Brain Res. 2008 May 1;1207:128-41. Epub 2008 Feb 9.
14. Fos-like antigen 2 (FOSL2) promotes metastasis in colon cancer. Li S, etal., Exp Cell Res. 2018 Dec 15;373(1-2):57-61. doi: 10.1016/j.yexcr.2018.08.016. Epub 2018 Aug 13.
15. Circular RNA hsa_circ_0056836 functions an oncogenic gene in hepatocellular carcinoma through modulating miR-766-3p/FOSL2 axis. Li Z, etal., Aging (Albany NY). 2020 Feb 12;12(3):2485-2497. doi: 10.18632/aging.102756. Epub 2020 Feb 12.
16. Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway. Lian Y, etal., J Exp Clin Cancer Res. 2018 Oct 16;37(1):253. doi: 10.1186/s13046-018-0918-9.
17. Increased susceptibility to transcriptional changes with novel stressor in adrenal medulla of rats exposed to prolonged cold stress. Liu X, etal., Brain Res Mol Brain Res. 2005 Nov 18;141(1):19-29. Epub 2005 Sep 19.
18. Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression. Ma W, etal., Biochem Genet. 2022 Aug;60(4):1362-1379. doi: 10.1007/s10528-021-10148-6. Epub 2022 Jan 16.
19. Impaired activation of AP-1 and altered expression of constituent proteins in rat adrenal during ageing. Medicherla R, etal., Mech Ageing Dev. 2001 Aug;122(11):1169-86.
20. Differential expression of activator protein-1 transcription factors in pregnant rat myometrium. Mitchell JA and Lye SJ, Biol Reprod. 2002 Jul;67(1):240-6.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes. Papachristou D, etal., Eur J Orthod. 2006 Feb;28(1):20-6. Epub 2005 Dec 22.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation. Sharma SC and Richards JS, J Biol Chem. 2000 Oct 27;275(43):33718-28.
26. Tissue-specific transgenic knockdown of Fos-related antigen 2 (Fra-2) expression mediated by dominant negative Fra-2. Smith M, etal., Mol Cell Biol 2001 Jun;21(11):3704-13.
27. Cyclic AMP-inducible genes respond uniformly to seasonal lighting conditions in the rat pineal gland. Spessert R, etal., Neuroscience. 2006 Dec 1;143(2):607-13. Epub 2006 Sep 8.
28. MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-β/Smad3 signaling pathway. Sun L, etal., Biomed Pharmacother. 2018 Nov;107:168-176. doi: 10.1016/j.biopha.2018.07.151. Epub 2018 Aug 6.
29. Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors. Szabo-Fresnais N, etal., Mol Cell Endocrinol. 2008 Mar 12;284(1-2):28-37. Epub 2008 Jan 8.
30. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
31. Gene expression profiling of testosterone and estradiol-17 beta-induced prostatic dysplasia in Noble rats and response to the antiestrogen ICI 182,780. Thompson CJ, etal., Endocrinology 2002 Jun;143(6):2093-105.
32. Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model. Urakami S, etal., Biochem Biophys Res Commun. 1997 Dec 8;241(1):24-30.
33. Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site. Varghese S, etal., Endocrinology. 2000 Jun;141(6):2185-91.
34. FOSL2 positively regulates TGF-beta1 signalling in non-small cell lung cancer. Wang J, etal., PLoS One. 2014 Nov 6;9(11):e112150. doi: 10.1371/journal.pone.0112150. eCollection 2014.
35. Restraint-induced fra-2 and c-fos expression in the rat forebrain: relationship to stress duration. Weinberg MS, etal., Neuroscience. 2007 Dec 5;150(2):478-86. Epub 2007 Sep 14.
36. Gene expression in the rat cerebral cortex: comparison of recovery sleep and hypnotic-induced sleep. Wisor JP, etal., Neuroscience. 2006 Aug 11;141(1):371-8. Epub 2006 May 11.
37. The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes. Won JS and Suh HW, Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):41-51.
38. The comparative analysis of proenkephalin mRNA expression induced by cholera toxin and pertussis toxin in primary cultured rat cortical astrocytes. Won JS and Suh HW, Brain Res Mol Brain Res. 2001 Mar 31;88(1-2):83-93.
Additional References at PubMed
PMID:7790908   PMID:7936655   PMID:11460264   PMID:11750070   PMID:13679379   PMID:15299028   PMID:19289495   PMID:19560520   PMID:20513656   PMID:20618447   PMID:21507338   PMID:21820506  
PMID:22585681   PMID:25547114  


Genomics

Comparative Map Data
Fosl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,017,952 - 30,039,269 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl630,021,916 - 30,039,406 (-)EnsemblGRCr8
mRatBN7.2624,297,898 - 24,319,219 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl624,300,956 - 24,320,034 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx624,601,426 - 24,618,764 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0624,917,309 - 24,934,650 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0624,406,268 - 24,423,562 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0625,598,936 - 25,616,995 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl625,598,936 - 25,616,995 (-)Ensemblrn6Rnor6.0
Rnor_5.0635,422,541 - 35,440,258 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera623,796,496 - 23,813,256 (-)NCBICelera
Cytogenetic Map6q14NCBI
FOSL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38228,392,858 - 28,417,317 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl228,392,448 - 28,417,317 (+)Ensemblhg38GRCh38
GRCh37228,615,725 - 28,640,184 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36228,469,283 - 28,491,020 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34228,527,429 - 28,549,165NCBI
Celera228,460,891 - 28,482,629 (+)NCBICelera
Cytogenetic Map2p23.2NCBI
HuRef228,356,103 - 28,377,836 (+)NCBIHuRef
CHM1_1228,546,510 - 28,568,245 (+)NCBICHM1_1
T2T-CHM13v2.0228,436,151 - 28,460,588 (+)NCBIT2T-CHM13v2.0
Fosl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39532,292,599 - 32,315,184 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl532,293,145 - 32,315,186 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38532,136,472 - 32,157,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl532,135,801 - 32,157,842 (+)Ensemblmm10GRCm38
MGSCv37532,438,845 - 32,460,213 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36532,413,115 - 32,434,421 (+)NCBIMGSCv36mm8
MGSCv36530,804,839 - 30,826,510 (+)NCBIMGSCv36mm8
Celera529,588,696 - 29,629,647 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.33NCBI
Fosl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546910,297,179 - 10,319,180 (+)Ensembl
ChiLan1.0NW_00495546910,297,179 - 10,319,180 (+)NCBIChiLan1.0ChiLan1.0
FOSL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21298,097,276 - 98,121,829 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A98,100,630 - 98,125,163 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A28,392,328 - 28,416,838 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A28,485,271 - 28,498,815 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A28,485,613 - 28,498,397 (+)EnsemblpanPan2panpan1.1
FOSL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11722,340,469 - 22,364,994 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1722,341,322 - 22,361,772 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1722,136,634 - 22,160,204 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01722,904,688 - 22,928,247 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1722,904,806 - 22,928,863 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11722,204,175 - 22,227,721 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01722,256,447 - 22,279,983 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01722,372,895 - 22,396,457 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fosl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629266,512,413 - 66,535,167 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364934,304,395 - 4,327,179 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364934,308,683 - 4,327,102 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOSL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3110,823,666 - 110,843,068 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13110,820,403 - 110,842,903 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23117,487,534 - 117,495,043 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOSL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11479,201,128 - 79,222,363 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1479,201,649 - 79,222,373 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604532,919,208 - 32,943,579 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fosl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473810,370,103 - 10,391,623 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473810,370,479 - 10,391,623 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fosl2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1722,014,455 - 22,032,039 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fosl2
24 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:62
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000071237, ENSRNOT00000074887
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat

Markers in Region
RH135236  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2624,307,470 - 24,307,665 (+)MAPPERmRatBN7.2
Rnor_6.0625,604,094 - 25,604,288NCBIRnor6.0
Rnor_5.0635,427,357 - 35,427,551UniSTSRnor5.0
Celera623,801,570 - 23,801,764UniSTS
UniSTS:235160  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera623,796,242 - 23,796,440UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000077894   ⟹   ENSRNOP00000070970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl625,598,936 - 25,616,995 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107475   ⟹   ENSRNOP00000091217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl630,021,916 - 30,039,269 (-)Ensembl
mRatBN7.2 Ensembl624,300,956 - 24,319,157 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113775   ⟹   ENSRNOP00000089057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl630,021,916 - 30,039,406 (-)Ensembl
mRatBN7.2 Ensembl624,300,956 - 24,320,034 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119558   ⟹   ENSRNOP00000091751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl624,300,956 - 24,310,481 (-)Ensembl
RefSeq Acc Id: NM_001013146   ⟹   NP_001013164
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8630,021,916 - 30,039,269 (-)NCBI
mRatBN7.2624,301,862 - 24,319,219 (-)NCBI
Rnor_6.0625,598,936 - 25,616,995 (-)NCBI
Rnor_5.0635,422,541 - 35,440,258 (-)NCBI
Celera623,796,496 - 23,813,256 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012954   ⟹   NP_037086
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8630,021,916 - 30,039,269 (-)NCBI
mRatBN7.2624,301,862 - 24,319,219 (-)NCBI
Rnor_6.0625,598,936 - 25,616,995 (-)NCBI
Rnor_5.0635,422,541 - 35,440,258 (-)NCBI
Celera623,796,496 - 23,813,256 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111806   ⟹   XP_038967734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8630,017,952 - 30,034,506 (-)NCBI
mRatBN7.2624,297,898 - 24,310,428 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001013164 (Get FASTA)   NCBI Sequence Viewer  
  NP_037086 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967734 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA61951 (Get FASTA)   NCBI Sequence Viewer  
  AAC52310 (Get FASTA)   NCBI Sequence Viewer  
  AAT52165 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000089057
  ENSRNOP00000091217
GenBank Protein P51145 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037086   ⟸   NM_012954
- Peptide Label: isoform 1
- UniProtKB: P51145 (UniProtKB/Swiss-Prot),   Q6GXE4 (UniProtKB/Swiss-Prot),   A0A8I6AAS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001013164   ⟸   NM_001013146
- Peptide Label: isoform 2
- UniProtKB: Q62738 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070970   ⟸   ENSRNOT00000077894
RefSeq Acc Id: XP_038967734   ⟸   XM_039111806
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJV9 (UniProtKB/TrEMBL),   A0A8I6AAS5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091217   ⟸   ENSRNOT00000107475
Ensembl Acc Id: ENSRNOP00000089057   ⟸   ENSRNOT00000113775
Ensembl Acc Id: ENSRNOP00000091751   ⟸   ENSRNOT00000119558
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51145-F1-model_v2 AlphaFold P51145 1-326 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2628 AgrOrtholog
BioCyc Gene G2FUF-38372 BioCyc
Ensembl Genes ENSRNOG00000052357 Ensembl
  ENSRNOG00000068412 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000107475 ENTREZGENE
  ENSRNOT00000113775 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
InterPro AP-1 UniProtKB/Swiss-Prot
  bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
KEGG Report rno:25446 UniProtKB/Swiss-Prot
NCBI Gene 25446 ENTREZGENE
PANTHER PTHR23351 UniProtKB/Swiss-Prot
  PTHR23351:SF25 UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot
PhenoGen Fosl2 PhenoGen
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000052357 RatGTEx
  ENSRNOG00000068412 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
TIGR TC219905
UniProt A0A8I6AAS5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJV9 ENTREZGENE
  FOSL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62738 ENTREZGENE, UniProtKB/TrEMBL
  Q6GXE4 ENTREZGENE
UniProt Secondary Q6GXE4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Fosl2  FOS like 2, AP-1 transcription factor subunit  Fosl2  FOS like 2, AP-1 trancription factor subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-11 Fosl2  FOS like 2, AP-1 trancription factor subunit  Fosl2  fos-like antigen 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Fosl2  Fos like antigen 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA and protein are expressed in pineal gland only at night on a circadian basis 632679
gene_expression expressed selectively in the pineal gland 628507
gene_function transcription factor 628507
gene_physical_interaction forms heterodimeric complexes with Jun proteins, which control gene expression through interaction with the activator protein 1 (AP-1) DNA consensus element; also forms heterodimers with some ATF/CREB family members 628507
gene_process regulates the arylalkylamine-N-acetyltransferase (Aanat) an enzyme in the melatonin biosynthetic pathway 628507
gene_process major stable protein expressed over the circadian period 628397
gene_process two gene targets of transcription regulation are type II iodothyronine deiodinase and nectadrin (CD24) 628507
gene_product member of the fos family of transcription factors 632679
gene_product member of the Fos family of transcription factors 628507
gene_protein protein is 42/46 kDa in size 632679
gene_regulation adrenergic-cyclic AMP mediates the regulation 632679
gene_regulation expression is induced by second messengers, including cyclic AMP (cAMP) and Ca2+ 628507
gene_regulation circadian regulation mediated by an adrenergic to cyclic AMP mechanism 632679
gene_regulation mRNA level is proportional to the level ofactivating protein 628507