Fmo1 (flavin containing dimethylaniline monoxygenase 1) - Rat Genome Database

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Gene: Fmo1 (flavin containing dimethylaniline monoxygenase 1) Rattus norvegicus
Analyze
Symbol: Fmo1
Name: flavin containing dimethylaniline monoxygenase 1
RGD ID: 2622
Description: Enables N,N-dimethylaniline monooxygenase activity and trimethylamine monooxygenase activity. Involved in response to lipopolysaccharide. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human FMO1 (flavin containing dimethylaniline monoxygenase 1); PARTICIPATES IN tamoxifen pharmacodynamics pathway; tamoxifen pharmacokinetics pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dimethylaniline monooxygenase [N-oxide-forming] 1; dimethylaniline oxidase 1; flavin containing monooxygenase 1; Flavin-containing monooxygenase 1; FMO 1; hepatic flavin-containing monooxygenase 1; RFMO1A; trimethylamine monooxygenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,715,405 - 77,747,666 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1377,715,402 - 77,747,874 (-)EnsemblGRCr8
mRatBN7.21375,182,184 - 75,214,439 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,182,176 - 75,214,647 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1377,760,307 - 77,792,478 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,060,879 - 79,093,009 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,320,740 - 76,352,870 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,712,885 - 80,745,095 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,712,882 - 80,745,347 (-)Ensemblrn6Rnor6.0
Rnor_5.01385,607,539 - 85,639,778 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41378,503,770 - 78,536,359 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1374,919,415 - 74,951,610 (-)NCBICelera
RGSC_v3.11378,517,957 - 78,550,547 (-)NCBI
Cytogenetic Map13q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminophenol  (ISO)
4-fluoroaniline  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
Actein  (EXP)
aminoguanidine  (EXP)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
Aroclor 1254  (ISO)
atazanavir sulfate  (ISO)
Azoxymethane  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzydamine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromoacetate  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (EXP)
chrysene  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
Clozapine N-oxide  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
coumarin  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-penicillamine  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dihydroxyacetone  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP,ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
eugenol  (EXP)
fenofibrate  (EXP)
fenthion  (ISO)
fentin chloride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
glafenine  (EXP)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP,ISO)
Heptachlor epoxide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
lipopolysaccharide  (EXP,ISO)
maleic acid  (ISO)
methimazole  (EXP,ISO)
methiocarb  (ISO)
methiocarb-sulfoxide  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
NCX-4040  (ISO)
nefazodone  (ISO)
nevirapine  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitroglycerin  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
phlorizin  (ISO)
phosgene  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
pyrazinecarboxamide  (EXP)
pyrimidin-2-amine  (EXP)
quercetin  (ISO)
resveratrol  (EXP)
rifampicin  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP,ISO)
sulfadimethoxine  (EXP)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc pyrithione  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model. Ekuni D, etal., Am J Pathol. 2009 Oct;175(4):1398-409. Epub 2009 Sep 24.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat liver flavin-containing monooxygenase (FMO): cDNA cloning and expression in yeast. Itoh K, etal., Biochim Biophys Acta 1993 May 28;1173(2):165-71.
5. Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney. Lattard V, etal., Biochem Pharmacol 2002 Apr 15;63(8):1453-64.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes. Novick RM, etal., J Pharmacol Exp Ther. 2009 Jun;329(3):1148-55. Epub 2009 Mar 23.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Effect of hyperosmotic conditions on flavin-containing monooxygenase activity, protein and mRNA expression in rat kidney. Rodriguez-Fuentes G, etal., Toxicol Lett. 2009 Jun 1;187(2):115-8. Epub 2009 Feb 20.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9094723   PMID:15144220   PMID:15465034   PMID:15489334   PMID:19262426   PMID:24440618  


Genomics

Comparative Map Data
Fmo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,715,405 - 77,747,666 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1377,715,402 - 77,747,874 (-)EnsemblGRCr8
mRatBN7.21375,182,184 - 75,214,439 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,182,176 - 75,214,647 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1377,760,307 - 77,792,478 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,060,879 - 79,093,009 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,320,740 - 76,352,870 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,712,885 - 80,745,095 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,712,882 - 80,745,347 (-)Ensemblrn6Rnor6.0
Rnor_5.01385,607,539 - 85,639,778 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41378,503,770 - 78,536,359 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1374,919,415 - 74,951,610 (-)NCBICelera
RGSC_v3.11378,517,957 - 78,550,547 (-)NCBI
Cytogenetic Map13q22NCBI
FMO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,248,494 - 171,285,978 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,248,471 - 171,285,978 (+)Ensemblhg38GRCh38
GRCh371171,217,633 - 171,255,117 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,484,287 - 169,521,737 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341167,949,320 - 167,986,769NCBI
Celera1144,327,502 - 144,364,465 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,440,949 - 142,478,265 (+)NCBIHuRef
CHM1_11172,639,801 - 172,677,227 (+)NCBICHM1_1
T2T-CHM13v2.01170,604,793 - 170,642,278 (+)NCBIT2T-CHM13v2.0
Fmo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,657,130 - 162,694,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,657,130 - 162,694,179 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381162,829,561 - 162,866,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,829,561 - 162,866,610 (-)Ensemblmm10GRCm38
MGSCv371164,759,692 - 164,796,679 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361164,666,236 - 164,703,223 (-)NCBIMGSCv36mm8
Celera1165,273,712 - 165,303,556 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.34NCBI
Fmo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540611,881,882 - 11,916,323 (+)Ensembl
ChiLan1.0NW_00495540611,882,656 - 11,915,875 (+)NCBIChiLan1.0ChiLan1.0
FMO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2178,472,277 - 78,498,941 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1178,146,459 - 78,173,131 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,742,505 - 146,778,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11150,456,729 - 150,492,527 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,456,729 - 150,492,527 (+)EnsemblpanPan2panpan1.1
FMO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,599,230 - 27,623,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,599,267 - 27,618,237 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha727,120,190 - 27,139,165 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0727,400,502 - 27,424,539 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,400,510 - 27,424,542 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1727,251,218 - 27,270,180 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,285,744 - 27,304,928 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,528,093 - 27,546,971 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
FMO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl963,868,064 - 63,895,076 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1963,860,957 - 63,895,086 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,137,610 - 70,171,700 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,781,273 - 57,819,787 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2557,782,085 - 57,819,408 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605559,419,669 - 59,462,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fmo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477110,357,210 - 10,386,005 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477110,358,422 - 10,386,015 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fmo1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11042,094,309 - 42,119,698 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fmo1
187 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:60
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000041908
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH128136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21375,182,238 - 75,182,438 (+)MAPPERmRatBN7.2
Rnor_6.01380,712,940 - 80,713,139NCBIRnor6.0
Rnor_5.01385,607,599 - 85,607,798UniSTSRnor5.0
RGSC_v3.41378,503,823 - 78,504,022UniSTSRGSC3.4
Celera1374,919,468 - 74,919,667UniSTS
Cytogenetic Map13q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 12 61 140 91 90 59 31 59 6 284 125 11 118 81 92 31 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000041908   ⟹   ENSRNOP00000044613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1377,715,402 - 77,747,874 (-)Ensembl
mRatBN7.2 Ensembl1375,182,176 - 75,214,647 (-)Ensembl
Rnor_6.0 Ensembl1380,712,882 - 80,745,347 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081551   ⟹   ENSRNOP00000073105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1377,715,402 - 77,747,874 (-)Ensembl
mRatBN7.2 Ensembl1375,182,176 - 75,214,647 (-)Ensembl
Rnor_6.0 Ensembl1380,712,885 - 80,738,634 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000132259   ⟹   ENSRNOP00000104371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1377,715,402 - 77,747,874 (-)Ensembl
RefSeq Acc Id: NM_012792   ⟹   NP_036924
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,715,412 - 77,747,666 (-)NCBI
mRatBN7.21375,182,186 - 75,214,439 (-)NCBI
Rnor_6.01380,712,887 - 80,745,095 (-)NCBI
Rnor_5.01385,607,539 - 85,639,778 (-)NCBI
RGSC_v3.41378,503,770 - 78,536,359 (-)RGD
Celera1374,919,415 - 74,951,610 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250145   ⟹   XP_006250207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,715,405 - 77,741,334 (-)NCBI
mRatBN7.21375,182,184 - 75,208,111 (-)NCBI
Rnor_6.01380,713,286 - 80,738,763 (-)NCBI
Rnor_5.01385,607,539 - 85,639,778 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036924   ⟸   NM_012792
- UniProtKB: A0A8L2R702 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250207   ⟸   XM_006250145
- Peptide Label: isoform X1
- UniProtKB: Q6P7Q5 (UniProtKB/Swiss-Prot),   P36365 (UniProtKB/Swiss-Prot),   A6IDA3 (UniProtKB/TrEMBL),   A0A8L2R702 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044613   ⟸   ENSRNOT00000041908
Ensembl Acc Id: ENSRNOP00000073105   ⟸   ENSRNOT00000081551
Ensembl Acc Id: ENSRNOP00000104371   ⟸   ENSRNOT00000132259

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36365-F1-model_v2 AlphaFold P36365 1-532 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698943
Promoter ID:EPDNEW_R9468
Type:initiation region
Name:Fmo1_1
Description:flavin containing monooxygenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01380,745,300 - 80,745,360EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2622 AgrOrtholog
BioCyc Gene G2FUF-17638 BioCyc
Ensembl Genes ENSRNOG00000034191 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041908 ENTREZGENE
  ENSRNOT00000041908.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6887467 IMAGE-MGC_LOAD
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot
  Flavin_mOase UniProtKB/Swiss-Prot
  Flavin_mOase-like UniProtKB/Swiss-Prot
  Flavin_mOase_1 UniProtKB/Swiss-Prot
  FMO UniProtKB/Swiss-Prot
KEGG Report rno:25256 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72920 IMAGE-MGC_LOAD
NCBI Gene 25256 ENTREZGENE
PANTHER DIMETHYLANILINE MONOOXYGENASE UniProtKB/Swiss-Prot
Pfam FMO-like UniProtKB/Swiss-Prot
PharmGKB FMO1 RGD
PhenoGen Fmo1 PhenoGen
PIRSF FMO UniProtKB/Swiss-Prot
PRINTS FMOXYGENASE UniProtKB/Swiss-Prot
  FMOXYGENASE1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000034191 RatGTEx
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot
TIGR TC206326
UniProt A0A8L2R702 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LFY6_RAT UniProtKB/TrEMBL
  A6IDA3 ENTREZGENE, UniProtKB/TrEMBL
  FMO1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P7Q5 ENTREZGENE
UniProt Secondary Q6P7Q5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-09 Fmo1  flavin containing dimethylaniline monoxygenase 1  Fmo1  flavin containing monooxygenase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Fmo1  Flavin-containing monooxygenase 1      Symbol and Name status set to approved 70586 APPROVED