Ces1c (carboxylesterase 1C) - Rat Genome Database

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Gene: Ces1c (carboxylesterase 1C) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ces1c
Name: carboxylesterase 1C
RGD ID: 2571
Description: Enables carboxylesterase activity and protein homodimerization activity. Predicted to be involved in short-chain fatty acid catabolic process. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum and lipid droplet. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: carboxyesterase ES-1; E1; ES-THET; Es1; Es2; esterase 1; esterase 2; Esterase 2 member of carboxylesterase-cluster 1; esterase 2, member of carboxylesterase-cluster 1; esterase-2; liver carboxylesterase 1; LOC100365275; MGC109055; microsomal carboxyesterase E1-like; neutral retinyl ester hydrolase; NREH; REH; retinyl ester hydrolase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Is Marker For: QTLs:   Scl12  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,099,383 - 30,128,531 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1930,099,323 - 30,128,528 (+)EnsemblGRCr8
mRatBN7.21913,926,401 - 13,955,527 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,926,260 - 13,955,524 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1915,622,205 - 15,650,818 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01920,816,969 - 20,845,585 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,762,552 - 23,791,164 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1923,962,648 - 23,991,098 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1922,079,345 - 22,107,955 (+)NCBILyon_Normotensive
Lyon_Hypertensive1923,933,643 - 23,962,093 (+)NCBILyon_Hypertensive
F344_StmMcwi1921,768,339 - 21,796,949 (+)NCBIF344_StmMcwi
Rnor_6.01915,294,524 - 15,335,005 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,081,158 - 15,335,002 (+)Ensemblrn6Rnor6.0
Rnor_5.01926,391,608 - 26,431,928 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41914,981,499 - 15,021,203 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1913,863,624 - 13,879,860 (+)NCBICelera
RGSC_v3.11914,986,402 - 15,025,950 (+)NCBI
Cytogenetic Map19p11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and identification of a rat serum carboxylesterase expressed in the liver. Alexson SE, etal., J Biol Chem 1994 Jun 24;269(25):17118-24.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Biosynthesis and localization of rat liver microsomal carboxyesterase E1. Harano T, etal., J Biochem. 1988 Jan;103(1):149-55. doi: 10.1093/oxfordjournals.jbchem.a122221.
4. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
5. Rat liver carboxylesterase: cDNA cloning, sequencing, and evidence for a multigene family. Long RM, etal., Biochem Biophys Res Commun 1988 Oct 31;156(2):866-73.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Molecular cloning and nucleotide sequence of cDNA of microsomal carboxyesterase E1 of rat liver. Takagi Y, etal., J Biochem (Tokyo) 1988 Nov;104(5):801-6.
Additional References at PubMed
PMID:9305911   PMID:12477932   PMID:15489334   PMID:15794950  


Genomics

Variants

.
Variants in Ces1c
198 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:105
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000024622
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat

Markers in Region
CES2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21913,837,454 - 13,837,605 (+)MAPPERmRatBN7.2
mRatBN7.21913,926,882 - 13,927,033 (+)MAPPERmRatBN7.2
Rnor_6.01915,294,979 - 15,295,129NCBIRnor6.0
Rnor_6.01915,158,908 - 15,159,058NCBIRnor6.0
Rnor_5.01926,263,742 - 26,263,892UniSTSRnor5.0
Rnor_5.01926,392,061 - 26,392,211UniSTSRnor5.0
RGSC_v3.41914,892,454 - 14,892,604UniSTSRGSC3.4
RGSC_v3.41914,981,939 - 14,982,089UniSTSRGSC3.4
Celera1913,771,227 - 13,771,377UniSTS
Cytogenetic Map19p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 10 20 29 53 56 37 19 37 140 49 22 36 50 19 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000024187   ⟹   ENSRNOP00000024187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,796,623 - 13,822,110 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000024622   ⟹   ENSRNOP00000024622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1930,099,323 - 30,128,528 (+)Ensembl
mRatBN7.2 Ensembl1913,926,260 - 13,955,524 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078874   ⟹   ENSRNOP00000072835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,833,154 - 13,912,035 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083500   ⟹   ENSRNOP00000075184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,837,042 - 13,869,627 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085762   ⟹   ENSRNOP00000070163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,796,623 - 13,869,627 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090865   ⟹   ENSRNOP00000070536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1930,046,449 - 30,085,449 (+)Ensembl
mRatBN7.2 Ensembl1913,873,490 - 13,912,035 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101266   ⟹   ENSRNOP00000082621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,800,079 - 13,822,111 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103881   ⟹   ENSRNOP00000088578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,833,154 - 13,869,627 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110686   ⟹   ENSRNOP00000096820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,800,986 - 13,822,111 (+)Ensembl
RefSeq Acc Id: NM_017004   ⟹   NP_058700
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81930,099,447 - 30,128,531 (+)NCBI
mRatBN7.21913,926,443 - 13,955,527 (+)NCBI
Dahl_SR_JrHsd1923,962,648 - 23,991,098 (+)NCBI
Lyon_Normotensive1922,079,345 - 22,107,955 (+)NCBI
Lyon_Hypertensive1923,933,643 - 23,962,093 (+)NCBI
F344_StmMcwi1921,768,339 - 21,796,949 (+)NCBI
Rnor_6.01915,294,539 - 15,335,005 (+)NCBI
Rnor_5.01926,391,608 - 26,431,928 (+)NCBI
RGSC_v3.41914,981,499 - 15,021,203 (+)RGD
Celera1913,863,624 - 13,879,860 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255172   ⟹   XP_006255234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81930,099,383 - 30,128,531 (+)NCBI
mRatBN7.21913,926,401 - 13,955,527 (+)NCBI
Rnor_6.01915,294,524 - 15,335,005 (+)NCBI
Rnor_5.01926,391,608 - 26,431,928 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058700   ⟸   NM_017004
- Peptide Label: precursor
- UniProtKB: Q64626 (UniProtKB/Swiss-Prot),   Q63106 (UniProtKB/Swiss-Prot),   Q5I0K0 (UniProtKB/Swiss-Prot),   P10959 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255234   ⟸   XM_006255172
- Peptide Label: isoform X1
- UniProtKB: Q64626 (UniProtKB/Swiss-Prot),   Q63106 (UniProtKB/Swiss-Prot),   Q5I0K0 (UniProtKB/Swiss-Prot),   P10959 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024622   ⟸   ENSRNOT00000024622
Ensembl Acc Id: ENSRNOP00000096820   ⟸   ENSRNOT00000110686
Ensembl Acc Id: ENSRNOP00000024187   ⟸   ENSRNOT00000024187
Ensembl Acc Id: ENSRNOP00000070163   ⟸   ENSRNOT00000085762
Ensembl Acc Id: ENSRNOP00000075184   ⟸   ENSRNOT00000083500
Ensembl Acc Id: ENSRNOP00000082621   ⟸   ENSRNOT00000101266
Ensembl Acc Id: ENSRNOP00000070536   ⟸   ENSRNOT00000090865
Ensembl Acc Id: ENSRNOP00000088578   ⟸   ENSRNOT00000103881
Ensembl Acc Id: ENSRNOP00000072835   ⟸   ENSRNOT00000078874

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10959-F1-model_v2 AlphaFold P10959 1-549 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2571 AgrOrtholog
BioCyc Gene G2FUF-6405 BioCyc
BioCyc Pathway PWY-6857 [retinol biosynthesis] BioCyc
BioCyc Pathway Image PWY-6857 BioCyc
Ensembl Genes ENSRNOG00000015438 Ensembl
  ENSRNOG00000069004 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024622 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7371252 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  CarbesteraseB UniProtKB/Swiss-Prot
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot
  Type-B_Carboxylest/Lipase UniProtKB/Swiss-Prot
KEGG Report rno:24346 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109055 IMAGE-MGC_LOAD
NCBI Gene 24346 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/Swiss-Prot
Pfam COesterase UniProtKB/Swiss-Prot
PhenoGen Ces1c PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015438 RatGTEx
  ENSRNOG00000069004 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt D3ZGK7_RAT UniProtKB/TrEMBL
  EST1C_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5I0K0 ENTREZGENE
  Q63106 ENTREZGENE
  Q64626 ENTREZGENE
UniProt Secondary Q5I0K0 UniProtKB/Swiss-Prot
  Q63106 UniProtKB/Swiss-Prot
  Q64626 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Ces1c  carboxylesterase 1C  LOC100365275  microsomal carboxyesterase E1-like  Data merged from RGD:2319399 737654 PROVISIONAL
2010-11-18 Ces1c  carboxylesterase 1C  Es1  esterase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100365275  microsomal carboxyesterase E1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-15 Es1  esterase 1  Es2  esterase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 Es2  esterase 2  LOC684025  similar to esterase 2  Data merged from RGD:1595219 1643240 APPROVED
2006-11-20 LOC684025  similar to esterase 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Es2  Esterase 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 632748
gene_protein 531 amino acids with a predicted molecular weight of 58 kDa 632748