Dnase1 (deoxyribonuclease 1) - Rat Genome Database

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Gene: Dnase1 (deoxyribonuclease 1) Rattus norvegicus
Analyze
Symbol: Dnase1
Name: deoxyribonuclease 1
RGD ID: 2510
Description: Enables deoxyribonuclease I activity. Predicted to be involved in several processes, including DNA catabolic process; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Predicted to be located in extracellular region; nuclear envelope; and zymogen granule. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human DNASE1 (deoxyribonuclease 1); INTERACTS WITH 6-propyl-2-thiouracil; Allylamine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deoxyribonuclease I; deoxyribonuclease-1; DNase I; MGC108543
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81012,005,305 - 12,030,615 (-)NCBIGRCr8
mRatBN7.21011,498,930 - 11,505,151 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,498,931 - 11,501,869 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1016,206,518 - 16,209,457 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,695,347 - 15,698,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01011,364,678 - 11,367,617 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01011,757,681 - 11,760,672 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1011,757,682 - 11,760,620 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01010,512,148 - 10,515,131 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41011,762,570 - 11,765,509 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11011,762,569 - 11,765,509 (-)NCBI
Celera1010,455,483 - 10,458,422 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification and expression of deoxyribonuclease (DNase) I alternative transcripts in the rat. Basnakian AG, etal., Gene 2002 May 1;289(1-2):87-96.
2. Decreased serum DNase1-activity in patients with autoimmune liver diseases. Gatselis NK, etal., Autoimmunity. 2017 Mar;50(2):125-132. doi: 10.1080/08916934.2017.1279610. Epub 2017 Feb 14.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Host DNases prevent vascular occlusion by neutrophil extracellular traps. Jiménez-Alcázar M, etal., Science. 2017 Dec 1;358(6367):1202-1206. doi: 10.1126/science.aam8897.
6. DNase I primary transcript is alternatively spliced in both normal and apoptotic cells: no evidence of up-regulation in apoptosis. Liu QY, etal., DNA Cell Biol 1997 Aug;16(8):911-8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). Peitsch MC, etal., EMBO J. 1993 Jan;12(1):371-7.
11. Nucleotide sequence of a full length cDNA clone encoding the deoxyribonuclease I from the rat parotid gland. Polzar B and Mannherz HG, Nucleic Acids Res 1990 Dec 11;18(23):7151.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. DNase I is present in the chief cells of human and rat stomachs. Tsutsumi S, etal., Histochem J 2001 Sep-Oct;33(9-10):531-5.
Additional References at PubMed
PMID:12477932   PMID:15015938   PMID:15796714   PMID:23376485   PMID:23533145   PMID:33212932  


Genomics

Comparative Map Data
Dnase1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81012,005,305 - 12,030,615 (-)NCBIGRCr8
mRatBN7.21011,498,930 - 11,505,151 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,498,931 - 11,501,869 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1016,206,518 - 16,209,457 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,695,347 - 15,698,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01011,364,678 - 11,367,617 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01011,757,681 - 11,760,672 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1011,757,682 - 11,760,620 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01010,512,148 - 10,515,131 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41011,762,570 - 11,765,509 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11011,762,569 - 11,765,509 (-)NCBI
Celera1010,455,483 - 10,458,422 (-)NCBICelera
Cytogenetic Map10q12NCBI
DNASE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38163,611,760 - 3,665,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl163,611,728 - 3,680,143 (+)EnsemblGRCh38hg38GRCh38
GRCh37163,661,761 - 3,715,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36163,642,941 - 3,648,097 (+)NCBINCBI36Build 36hg18NCBI36
Build 34163,642,940 - 3,648,096NCBI
Celera163,909,706 - 3,914,804 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef163,671,995 - 3,677,205 (+)NCBIHuRef
CHM1_1163,702,960 - 3,708,116 (+)NCBICHM1_1
T2T-CHM13v2.0163,639,029 - 3,692,728 (+)NCBIT2T-CHM13v2.0
Dnase1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39163,855,007 - 3,857,888 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl163,854,806 - 3,857,888 (+)EnsemblGRCm39 Ensembl
GRCm38164,036,958 - 4,040,024 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,036,942 - 4,040,024 (+)EnsemblGRCm38mm10GRCm38
MGSCv37164,037,145 - 4,040,024 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36163,952,382 - 3,955,252 (+)NCBIMGSCv36mm8
Celera164,669,458 - 4,672,337 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.37NCBI
Dnase1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544213,733,107 - 13,736,527 (-)NCBIChiLan1.0ChiLan1.0
DNASE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2184,136,615 - 4,191,061 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1167,920,194 - 7,971,346 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0162,532,281 - 2,583,408 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1163,708,189 - 3,758,615 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl163,708,189 - 3,758,615 (+)Ensemblpanpan1.1panPan2
DNASE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1637,596,735 - 37,599,953 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl637,595,911 - 37,599,827 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha638,925,673 - 38,928,375 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0637,811,866 - 37,814,684 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl637,811,867 - 37,814,566 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1637,595,076 - 37,597,778 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0637,488,193 - 37,490,895 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0637,898,900 - 37,901,602 (-)NCBIUU_Cfam_GSD_1.0
Dnase1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,988,982 - 106,004,515 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936694704,692 - 710,501 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936694704,948 - 715,846 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNASE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl338,586,602 - 38,646,833 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1338,590,045 - 38,646,852 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2339,859,278 - 39,914,463 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNASE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.153,310,853 - 3,352,483 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl53,310,824 - 3,339,870 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606827,475,814 - 27,507,119 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnase1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248241,443,451 - 1,446,881 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248241,429,078 - 1,446,881 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnase1
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:87
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000009283
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat

Markers in Region
RH129035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21011,498,936 - 11,499,117 (+)MAPPERmRatBN7.2
Rnor_6.01011,757,688 - 11,757,868NCBIRnor6.0
Rnor_5.01010,512,155 - 10,512,335UniSTSRnor5.0
RGSC_v3.41011,762,577 - 11,762,757UniSTSRGSC3.4
Celera1010,455,490 - 10,455,670UniSTS
Cytogenetic Map10q12UniSTS
RH94863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21011,498,754 - 11,498,992 (+)MAPPERmRatBN7.2
Rnor_6.01011,757,506 - 11,757,743NCBIRnor6.0
Rnor_5.01010,511,973 - 10,512,210UniSTSRnor5.0
RGSC_v3.41011,762,395 - 11,762,632UniSTSRGSC3.4
Celera1010,455,308 - 10,455,545UniSTS
Cytogenetic Map10q12UniSTS
RH140196  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21011,498,541 - 11,498,883 (+)MAPPERmRatBN7.2
Rnor_6.01011,757,293 - 11,757,634NCBIRnor6.0
Rnor_5.01010,511,760 - 10,512,101UniSTSRnor5.0
RGSC_v3.41011,762,182 - 11,762,523UniSTSRGSC3.4
Celera1010,455,095 - 10,455,436UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 23
Low 2 8 27 11 19 11 8 8 72 12 32 10 8
Below cutoff 35 28 28 28 3 2 9 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB057442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF397149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF397150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF397151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U76635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000009283   ⟹   ENSRNOP00000009283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1011,498,931 - 11,501,869 (-)Ensembl
Rnor_6.0 Ensembl1011,757,682 - 11,760,620 (-)Ensembl
RefSeq Acc Id: NM_013097   ⟹   NP_037229
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81012,005,305 - 12,008,244 (-)NCBI
mRatBN7.21011,498,930 - 11,501,869 (-)NCBI
Rnor_6.01011,757,681 - 11,760,620 (-)NCBI
Rnor_5.01010,512,148 - 10,515,131 (-)NCBI
RGSC_v3.41011,762,570 - 11,765,509 (-)RGD
Celera1010,455,483 - 10,458,422 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085292   ⟹   XP_038941220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81012,005,305 - 12,030,615 (-)NCBI
mRatBN7.21011,499,079 - 11,505,151 (-)NCBI
RefSeq Acc Id: XM_039085293   ⟹   XP_038941221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81012,005,305 - 12,030,615 (-)NCBI
mRatBN7.21011,499,079 - 11,505,151 (-)NCBI
RefSeq Acc Id: XM_063268482   ⟹   XP_063124552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81012,005,305 - 12,030,615 (-)NCBI
RefSeq Acc Id: XM_063268483   ⟹   XP_063124553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81012,005,305 - 12,030,615 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_037229   ⟸   NM_013097
- Peptide Label: precursor
- UniProtKB: Q5FVU6 (UniProtKB/Swiss-Prot),   P21704 (UniProtKB/Swiss-Prot),   A6K4T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009283   ⟸   ENSRNOT00000009283
RefSeq Acc Id: XP_038941221   ⟸   XM_039085293
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941220   ⟸   XM_039085292
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124553   ⟸   XM_063268483
- Peptide Label: isoform X2
- UniProtKB: Q5FVU6 (UniProtKB/Swiss-Prot),   P21704 (UniProtKB/Swiss-Prot),   A6K4T9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124552   ⟸   XM_063268482
- Peptide Label: isoform X2
- UniProtKB: Q5FVU6 (UniProtKB/Swiss-Prot),   P21704 (UniProtKB/Swiss-Prot),   A6K4T9 (UniProtKB/TrEMBL)
Protein Domains
Endonuclease/exonuclease/phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21704-F1-model_v2 AlphaFold P21704 1-284 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696981
Promoter ID:EPDNEW_R7506
Type:initiation region
Name:Dnase1_1
Description:deoxyribonuclease 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01011,760,632 - 11,760,692EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2510 AgrOrtholog
BioCyc Gene G2FUF-26000 BioCyc
Ensembl Genes ENSRNOG00000006873 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055024422 UniProtKB/Swiss-Prot
  ENSRNOG00060009080 UniProtKB/Swiss-Prot
  ENSRNOG00065009562 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009283 ENTREZGENE
  ENSRNOT00000009283.5 UniProtKB/Swiss-Prot
  ENSRNOT00055041974 UniProtKB/Swiss-Prot
  ENSRNOT00060015258 UniProtKB/Swiss-Prot
  ENSRNOT00065015317 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130586 IMAGE-MGC_LOAD
InterPro Deoxyribonuclease-1_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNase_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNASE_I_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endo/exonu/phosph_ase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25633 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108543 IMAGE-MGC_LOAD
NCBI Gene 25633 ENTREZGENE
PANTHER DEOXYRIBONUCLEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEOXYRIBONUCLEASE-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Exo_endo_phos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dnase1 PhenoGen
PIRSF DNase_I_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS DNASEI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DNASE_I_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNASE_I_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006873 RatGTEx
  ENSRNOG00055024422 RatGTEx
  ENSRNOG00060009080 RatGTEx
  ENSRNOG00065009562 RatGTEx
SMART DNaseIc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP DNase I-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC219197
UniProt A6K4T9 ENTREZGENE, UniProtKB/TrEMBL
  DNAS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FVU6 ENTREZGENE
  Q924T1_RAT UniProtKB/TrEMBL
UniProt Secondary Q5FVU6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-27 Dnase1  deoxyribonuclease 1  Dnase1  deoxyribonuclease I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Dnase1  Deoxyribonuclease I      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the cytoplasm of chief cells of the rat pars glandularis 1298887
gene_expression expressed principally in tissues of the digestive system 619702
gene_function cleaves DNA endonucleolytically to yield primarily 5'-phosphodinucleotide and oligonucleotide end products 1300414
gene_homology bovine homologue binds actin 1298889
gene_process may not be involved in apoptosis-induced DNA degradation 1298887
gene_process role in digestive tissues is to hydrolyze DNA 619702
gene_process role in tissues other than those involved in digestion is uncertain 619702
gene_transcript produces alternative transcripts 619702