Dnase1 (deoxyribonuclease 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Dnase1 (deoxyribonuclease 1) Rattus norvegicus
Analyze
Symbol: Dnase1
Name: deoxyribonuclease 1
RGD ID: 2510
Description: Enables deoxyribonuclease I activity. Predicted to be involved in several processes, including DNA catabolic process; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Located in cytoplasm. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human DNASE1 (deoxyribonuclease 1); INTERACTS WITH 6-propyl-2-thiouracil; Allylamine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deoxyribonuclease I; deoxyribonuclease-1; DNase I; MGC108543
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81012,005,305 - 12,030,615 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1012,005,306 - 12,010,497 (-)EnsemblGRCr8
mRatBN7.21011,498,930 - 11,505,151 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,498,931 - 11,501,869 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1016,206,518 - 16,209,457 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,695,347 - 15,698,286 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01011,364,678 - 11,367,617 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01011,757,681 - 11,760,672 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1011,757,682 - 11,760,620 (-)Ensemblrn6Rnor6.0
Rnor_5.01010,512,148 - 10,515,131 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41011,762,570 - 11,765,509 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1010,455,483 - 10,458,422 (-)NCBICelera
RGSC_v3.11011,762,569 - 11,765,509 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification and expression of deoxyribonuclease (DNase) I alternative transcripts in the rat. Basnakian AG, etal., Gene 2002 May 1;289(1-2):87-96.
2. Decreased serum DNase1-activity in patients with autoimmune liver diseases. Gatselis NK, etal., Autoimmunity. 2017 Mar;50(2):125-132. doi: 10.1080/08916934.2017.1279610. Epub 2017 Feb 14.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Host DNases prevent vascular occlusion by neutrophil extracellular traps. Jiménez-Alcázar M, etal., Science. 2017 Dec 1;358(6367):1202-1206. doi: 10.1126/science.aam8897.
6. DNase I primary transcript is alternatively spliced in both normal and apoptotic cells: no evidence of up-regulation in apoptosis. Liu QY, etal., DNA Cell Biol 1997 Aug;16(8):911-8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). Peitsch MC, etal., EMBO J. 1993 Jan;12(1):371-7.
11. Nucleotide sequence of a full length cDNA clone encoding the deoxyribonuclease I from the rat parotid gland. Polzar B and Mannherz HG, Nucleic Acids Res 1990 Dec 11;18(23):7151.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. DNase I is present in the chief cells of human and rat stomachs. Tsutsumi S, etal., Histochem J 2001 Sep-Oct;33(9-10):531-5.
16. Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition. Udayanga KG, etal., Histol Histopathol. 2011 Jul;26(7):811-20. doi: 10.14670/HH-26.811.
Additional References at PubMed
PMID:12477932   PMID:15015938   PMID:15796714   PMID:23376485   PMID:23533145   PMID:33212932  


Genomics

Comparative Map Data
Dnase1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81012,005,305 - 12,030,615 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1012,005,306 - 12,010,497 (-)EnsemblGRCr8
mRatBN7.21011,498,930 - 11,505,151 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,498,931 - 11,501,869 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1016,206,518 - 16,209,457 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,695,347 - 15,698,286 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01011,364,678 - 11,367,617 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01011,757,681 - 11,760,672 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1011,757,682 - 11,760,620 (-)Ensemblrn6Rnor6.0
Rnor_5.01010,512,148 - 10,515,131 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41011,762,570 - 11,765,509 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1010,455,483 - 10,458,422 (-)NCBICelera
RGSC_v3.11011,762,569 - 11,765,509 (-)NCBI
Cytogenetic Map10q12NCBI
DNASE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38163,611,760 - 3,665,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl163,611,728 - 3,680,143 (+)Ensemblhg38GRCh38
GRCh37163,661,761 - 3,715,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36163,642,941 - 3,648,097 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34163,642,940 - 3,648,096NCBI
Celera163,909,706 - 3,914,804 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef163,671,995 - 3,677,205 (+)NCBIHuRef
CHM1_1163,702,960 - 3,708,116 (+)NCBICHM1_1
T2T-CHM13v2.0163,639,029 - 3,692,728 (+)NCBIT2T-CHM13v2.0
Dnase1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39163,855,007 - 3,857,888 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl163,854,806 - 3,857,888 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38164,036,958 - 4,040,024 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,036,942 - 4,040,024 (+)Ensemblmm10GRCm38
MGSCv37164,037,145 - 4,040,024 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36163,952,382 - 3,955,252 (+)NCBIMGSCv36mm8
Celera164,669,458 - 4,672,337 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.37NCBI
Dnase1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544213,733,107 - 13,736,527 (-)NCBIChiLan1.0ChiLan1.0
DNASE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2184,136,615 - 4,191,061 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1167,920,194 - 7,971,346 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0162,532,281 - 2,583,408 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1163,708,189 - 3,758,615 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl163,708,189 - 3,758,615 (+)EnsemblpanPan2panpan1.1
DNASE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1637,596,735 - 37,599,953 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl637,595,911 - 37,599,827 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha638,925,673 - 38,928,375 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0637,811,866 - 37,814,684 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl637,811,867 - 37,814,566 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1637,595,076 - 37,597,778 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0637,488,193 - 37,490,895 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0637,898,900 - 37,901,602 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dnase1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,988,982 - 106,004,515 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936694704,692 - 710,501 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936694704,948 - 715,846 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNASE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl338,586,602 - 38,646,833 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1338,590,045 - 38,646,852 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2339,859,278 - 39,914,463 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNASE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.153,310,853 - 3,352,483 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl53,310,824 - 3,339,870 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606827,475,814 - 27,507,119 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnase1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248241,443,451 - 1,446,881 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248241,429,078 - 1,446,881 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dnase1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1917,816,478 - 17,819,759 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dnase1
344 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:87
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000009283
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH129035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21011,498,936 - 11,499,117 (+)MAPPERmRatBN7.2
Rnor_6.01011,757,688 - 11,757,868NCBIRnor6.0
Rnor_5.01010,512,155 - 10,512,335UniSTSRnor5.0
RGSC_v3.41011,762,577 - 11,762,757UniSTSRGSC3.4
Celera1010,455,490 - 10,455,670UniSTS
Cytogenetic Map10q12UniSTS
RH94863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21011,498,754 - 11,498,992 (+)MAPPERmRatBN7.2
Rnor_6.01011,757,506 - 11,757,743NCBIRnor6.0
Rnor_5.01010,511,973 - 10,512,210UniSTSRnor5.0
RGSC_v3.41011,762,395 - 11,762,632UniSTSRGSC3.4
Celera1010,455,308 - 10,455,545UniSTS
Cytogenetic Map10q12UniSTS
RH140196  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81012,004,916 - 12,005,258 (+)Marker Load Pipeline
mRatBN7.21011,498,541 - 11,498,883 (+)MAPPERmRatBN7.2
Rnor_6.01011,757,293 - 11,757,634NCBIRnor6.0
Rnor_5.01010,511,760 - 10,512,101UniSTSRnor5.0
RGSC_v3.41011,762,182 - 11,762,523UniSTSRGSC3.4
Celera1010,455,095 - 10,455,436UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 63 155 88 87 56 84 56 6 341 180 11 133 81 88 31 15 15

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB057442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF397149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF397150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF397151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U76635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000009283   ⟹   ENSRNOP00000009283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1012,005,306 - 12,008,244 (-)Ensembl
mRatBN7.2 Ensembl1011,498,931 - 11,501,869 (-)Ensembl
Rnor_6.0 Ensembl1011,757,682 - 11,760,620 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000124780   ⟹   ENSRNOP00000103381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1012,005,306 - 12,010,497 (-)Ensembl
RefSeq Acc Id: NM_013097   ⟹   NP_037229
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81012,005,305 - 12,008,244 (-)NCBI
mRatBN7.21011,498,930 - 11,501,869 (-)NCBI
Rnor_6.01011,757,681 - 11,760,620 (-)NCBI
Rnor_5.01010,512,148 - 10,515,131 (-)NCBI
RGSC_v3.41011,762,570 - 11,765,509 (-)RGD
Celera1010,455,483 - 10,458,422 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085292   ⟹   XP_038941220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81012,005,305 - 12,030,615 (-)NCBI
mRatBN7.21011,499,079 - 11,505,151 (-)NCBI
RefSeq Acc Id: XM_039085293   ⟹   XP_038941221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81012,005,305 - 12,030,615 (-)NCBI
mRatBN7.21011,499,079 - 11,505,151 (-)NCBI
RefSeq Acc Id: XM_063268482   ⟹   XP_063124552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81012,005,305 - 12,030,615 (-)NCBI
RefSeq Acc Id: XM_063268483   ⟹   XP_063124553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81012,005,305 - 12,030,615 (-)NCBI
RefSeq Acc Id: NP_037229   ⟸   NM_013097
- Peptide Label: precursor
- UniProtKB: Q5FVU6 (UniProtKB/Swiss-Prot),   P21704 (UniProtKB/Swiss-Prot),   A6K4T9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009283   ⟸   ENSRNOT00000009283
RefSeq Acc Id: XP_038941221   ⟸   XM_039085293
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941220   ⟸   XM_039085292
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124553   ⟸   XM_063268483
- Peptide Label: isoform X2
- UniProtKB: Q5FVU6 (UniProtKB/Swiss-Prot),   P21704 (UniProtKB/Swiss-Prot),   A6K4T9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124552   ⟸   XM_063268482
- Peptide Label: isoform X2
- UniProtKB: Q5FVU6 (UniProtKB/Swiss-Prot),   P21704 (UniProtKB/Swiss-Prot),   A6K4T9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103381   ⟸   ENSRNOT00000124780
Protein Domains
Endonuclease/exonuclease/phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21704-F1-model_v2 AlphaFold P21704 1-284 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696981
Promoter ID:EPDNEW_R7506
Type:initiation region
Name:Dnase1_1
Description:deoxyribonuclease 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01011,760,632 - 11,760,692EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2510 AgrOrtholog
BioCyc Gene G2FUF-26000 BioCyc
Ensembl Genes ENSRNOG00000006873 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009283 ENTREZGENE
  ENSRNOT00000009283.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130586 IMAGE-MGC_LOAD
InterPro Deoxyribonuclease-1_AS UniProtKB/Swiss-Prot
  DNase_I UniProtKB/Swiss-Prot
  DNASE_I_2 UniProtKB/Swiss-Prot
  Endo/exonu/phosph_ase_sf UniProtKB/Swiss-Prot
  Endo/exonuclease/phosphatase UniProtKB/Swiss-Prot
KEGG Report rno:25633 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108543 IMAGE-MGC_LOAD
NCBI Gene 25633 ENTREZGENE
PANTHER DEOXYRIBONUCLEASE UniProtKB/Swiss-Prot
  DEOXYRIBONUCLEASE-1 UniProtKB/Swiss-Prot
Pfam Exo_endo_phos UniProtKB/Swiss-Prot
PhenoGen Dnase1 PhenoGen
PIRSF DNase_I_euk UniProtKB/Swiss-Prot
PRINTS DNASEI UniProtKB/Swiss-Prot
PROSITE DNASE_I_1 UniProtKB/Swiss-Prot
  DNASE_I_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006873 RatGTEx
SMART DNaseIc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56219 UniProtKB/Swiss-Prot
TIGR TC219197
UniProt A0ABK0LQD0_RAT UniProtKB/TrEMBL
  A6K4T9 ENTREZGENE, UniProtKB/TrEMBL
  DNAS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FVU6 ENTREZGENE
  Q924T1_RAT UniProtKB/TrEMBL
UniProt Secondary Q5FVU6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-27 Dnase1  deoxyribonuclease 1  Dnase1  deoxyribonuclease I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Dnase1  Deoxyribonuclease I      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the cytoplasm of chief cells of the rat pars glandularis 1298887
gene_expression expressed principally in tissues of the digestive system 619702
gene_function cleaves DNA endonucleolytically to yield primarily 5'-phosphodinucleotide and oligonucleotide end products 1300414
gene_homology bovine homologue binds actin 1298889
gene_process may not be involved in apoptosis-induced DNA degradation 1298887
gene_process role in digestive tissues is to hydrolyze DNA 619702
gene_process role in tissues other than those involved in digestion is uncertain 619702
gene_transcript produces alternative transcripts 619702