Cyp4b1 (cytochrome P450, family 4, subfamily b, polypeptide 1) - Rat Genome Database

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Gene: Cyp4b1 (cytochrome P450, family 4, subfamily b, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp4b1
Name: cytochrome P450, family 4, subfamily b, polypeptide 1
RGD ID: 2480
Description: Enables heterocyclic compound binding activity. Involved in biphenyl metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP4B1 (cytochrome P450 family 4 subfamily B member 1); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYPIVB1; cytochrome P450 4B1; cytochrome P450 isozyme 5; cytochrome P450 L-2; Cytochrome P450 subfamily IVB polypeptide 1; Cytochrome P450 subfamily IVB polypeptide 1 see also D5M4Rp1; cytochrome P450, subfamily 4B, polypeptide 1; Cytochrome P450, subfamily IVB, polypeptide 1; P450 L-2; P450-isozyme 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,375,807 - 134,413,635 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5134,375,807 - 134,393,116 (-)EnsemblGRCr8
mRatBN7.25129,139,019 - 129,176,860 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,139,038 - 129,156,348 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5131,749,529 - 131,766,903 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,504,409 - 133,521,783 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,526,563 - 133,543,937 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,508,728 - 134,526,103 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,508,730 - 134,526,089 (-)Ensemblrn6Rnor6.0
Rnor_5.05138,299,551 - 138,316,860 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45135,917,327 - 135,934,636 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5127,676,727 - 127,694,036 (-)NCBICelera
RGSC_v3.15135,922,552 - 135,939,862 (-)NCBI
RH 3.4 Map5823.3RGD
Cytogenetic Map5q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-naphthylamine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3'-Dichlorobenzidine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylbenzyl alcohol  (EXP)
3-methylcholanthrene  (EXP)
3-methyleneindolenine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-Ipomeanol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dodecanoic acid  (ISO)
elemental selenium  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
glycidol  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
ketoconazole  (EXP)
kojic acid  (EXP,ISO)
lead diacetate  (ISO)
levofloxacin  (EXP)
m-tolualdehyde  (EXP)
m-xylene  (EXP)
methimazole  (EXP)
methylparaben  (ISO)
mifepristone  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nevirapine  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propylparaben  (ISO)
resveratrol  (ISO)
ritonavir  (EXP)
rotenone  (EXP)
selenium atom  (EXP)
silicon dioxide  (ISO)
skatole  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulindac  (EXP)
tamoxifen  (ISO)
terephthalic acid  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
VX nerve agent  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB. Gasser R and Philpot RM, Mol Pharmacol 1989 May;35(5):617-25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family. Hardwick JP, etal., J Biol Chem 1987 Jan 15;262(2):801-10.
5. Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa. Imaoka S, etal., Biochem Pharmacol. 1997 Sep 15;54(6):677-83.
6. Androgen regulation of CYP4B1 responsible for mutagenic activation of bladder carcinogens in the rat bladder: detection of CYP4B1 mRNA by competitive reverse transcription-polymerase chain reaction. Imaoka S, etal., Cancer Lett 2001 May 26;166(2):119-23.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element. Kimura S, etal., DNA 1989 Sep;8(7):503-16.
9. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. CYP4B1 activates 4-ipomeanol in rat lung. Verschoyle RD, etal., Toxicol Appl Pharmacol. 1993 Dec;123(2):193-8.
Additional References at PubMed
PMID:2229008   PMID:15489334   PMID:16788951  


Genomics

Comparative Map Data
Cyp4b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,375,807 - 134,413,635 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5134,375,807 - 134,393,116 (-)EnsemblGRCr8
mRatBN7.25129,139,019 - 129,176,860 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,139,038 - 129,156,348 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5131,749,529 - 131,766,903 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05133,504,409 - 133,521,783 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,526,563 - 133,543,937 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05134,508,728 - 134,526,103 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5134,508,730 - 134,526,089 (-)Ensemblrn6Rnor6.0
Rnor_5.05138,299,551 - 138,316,860 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45135,917,327 - 135,934,636 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5127,676,727 - 127,694,036 (-)NCBICelera
RGSC_v3.15135,922,552 - 135,939,862 (-)NCBI
RH 3.4 Map5823.3RGD
Cytogenetic Map5q35NCBI
CYP4B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,799,046 - 46,819,413 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,757,838 - 46,819,413 (+)Ensemblhg38GRCh38
GRCh37147,264,718 - 47,285,085 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36147,037,257 - 47,057,608 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34146,976,761 - 46,997,105NCBI
Celera145,552,027 - 45,572,396 (+)NCBICelera
Cytogenetic Map1p33NCBI
HuRef145,380,284 - 45,400,633 (+)NCBIHuRef
CHM1_1147,381,383 - 47,401,714 (+)NCBICHM1_1
T2T-CHM13v2.0146,676,425 - 46,696,812 (+)NCBIT2T-CHM13v2.0
Cyp4b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394115,481,895 - 115,504,918 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4115,481,922 - 115,504,920 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384115,624,698 - 115,647,721 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4115,624,725 - 115,647,723 (-)Ensemblmm10GRCm38
MGSCv374115,297,333 - 115,320,310 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364115,122,660 - 115,145,637 (-)NCBIMGSCv36mm8
Celera4114,360,727 - 114,383,719 (-)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.06NCBI
LOC102012414
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546411,378,980 - 11,556,544 (-)Ensembl
ChiLan1.0NW_00495546411,539,467 - 11,556,519 (-)NCBIChiLan1.0ChiLan1.0
CYP4B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21179,984,908 - 180,003,684 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,126,616 - 179,145,387 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0146,107,787 - 46,127,162 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1147,462,178 - 47,481,502 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl147,462,178 - 47,481,502 (+)EnsemblpanPan2panpan1.1
CYP4B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11513,676,631 - 13,694,483 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1513,676,371 - 13,694,705 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1513,796,940 - 13,814,798 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01513,826,980 - 13,844,834 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1513,826,737 - 13,844,877 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11513,628,060 - 13,645,902 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01513,696,377 - 13,714,240 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01513,765,891 - 13,783,754 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101955242
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505861,881,092 - 61,957,546 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647427,767,371 - 27,782,008 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647427,705,874 - 27,782,328 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP4B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6164,718,444 - 164,737,552 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16164,718,393 - 164,737,693 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26152,210,031 - 152,229,243 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP4B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12085,997,796 - 86,018,649 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2085,996,269 - 86,018,055 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603330,987,875 - 31,007,108 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101725929
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249062,663,940 - 2,684,171 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249062,664,057 - 2,683,527 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116898076
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1139,349,162 - 39,366,808 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyp4b1
127 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:129
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000012681, ENSRNOT00000013321, ENSRNOT00000045571
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133308734140009902Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5M4Rp1   No map positions available.
D5Rat200  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85134,377,722 - 134,377,922 (+)Marker Load Pipeline
mRatBN7.25129,140,953 - 129,141,153 (+)MAPPERmRatBN7.2
Rnor_6.05134,510,644 - 134,510,843NCBIRnor6.0
Rnor_5.05138,301,467 - 138,301,666UniSTSRnor5.0
RGSC_v3.45135,919,242 - 135,919,442RGDRGSC3.4
RGSC_v3.45135,919,243 - 135,919,442UniSTSRGSC3.4
Celera5127,678,643 - 127,678,842UniSTS
RGSC_v3.15135,924,370 - 135,924,698RGD
SHRSP x BN Map568.3499UniSTS
SHRSP x BN Map568.3499RGD
Cytogenetic Map5q36UniSTS
RH142421  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map5823.3UniSTS
Cytogenetic Map5q36UniSTS
RH137159  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,139,100 - 129,139,251 (+)MAPPERmRatBN7.2
Rnor_6.05134,508,791 - 134,508,941NCBIRnor6.0
Rnor_5.05138,299,614 - 138,299,764UniSTSRnor5.0
RGSC_v3.45135,917,390 - 135,917,540UniSTSRGSC3.4
Celera5127,676,790 - 127,676,940UniSTS
RH 3.4 Map5837.8UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 115 91 90 59 38 59 6 300 136 11 87 81 91 31 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000013321   ⟹   ENSRNOP00000013321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5134,375,807 - 134,393,116 (-)Ensembl
mRatBN7.2 Ensembl5129,139,038 - 129,156,348 (-)Ensembl
Rnor_6.0 Ensembl5134,508,730 - 134,526,089 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000163904   ⟹   ENSRNOP00000108173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5134,375,807 - 134,388,399 (-)Ensembl
RefSeq Acc Id: NM_016999   ⟹   NP_058695
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,375,807 - 134,393,116 (-)NCBI
mRatBN7.25129,139,038 - 129,156,348 (-)NCBI
Rnor_6.05134,508,728 - 134,526,037 (-)NCBI
Rnor_5.05138,299,551 - 138,316,860 (-)NCBI
RGSC_v3.45135,917,327 - 135,934,636 (-)RGD
Celera5127,676,727 - 127,694,036 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109255   ⟹   XP_038965183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,375,818 - 134,413,635 (-)NCBI
mRatBN7.25129,139,019 - 129,176,860 (-)NCBI
RefSeq Acc Id: XR_001837834
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,376,306 - 134,393,158 (-)NCBI
mRatBN7.25129,139,537 - 129,156,386 (-)NCBI
Rnor_6.05134,509,279 - 134,526,103 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058695 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965183 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41778 (Get FASTA)   NCBI Sequence Viewer  
  AAH74012 (Get FASTA)   NCBI Sequence Viewer  
  EDL90309 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013321
  ENSRNOP00000013321.4
GenBank Protein P15129 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058695   ⟸   NM_016999
- UniProtKB: P15129 (UniProtKB/Swiss-Prot),   A6JZ44 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013321   ⟸   ENSRNOT00000013321
RefSeq Acc Id: XP_038965183   ⟸   XM_039109255
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000108173   ⟸   ENSRNOT00000163904

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15129-F1-model_v2 AlphaFold P15129 1-511 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693922
Promoter ID:EPDNEW_R4447
Type:single initiation site
Name:Cyp4b1_1
Description:cytochrome P450, family 4, subfamily b, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05134,526,065 - 134,526,125EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2480 AgrOrtholog
BioCyc Gene G2FUF-40281 BioCyc
Ensembl Genes ENSRNOG00000055078 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013321 ENTREZGENE
  ENSRNOT00000013321.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100197 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_Monoox UniProtKB/Swiss-Prot
KEGG Report rno:24307 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91453 IMAGE-MGC_LOAD
NCBI Gene 24307 ENTREZGENE
PANTHER CYTOCHROME P450 4B1 UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp4b1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000055078 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0ABK0M0U8_RAT UniProtKB/TrEMBL
  A6JZ44 ENTREZGENE, UniProtKB/TrEMBL
  CP4B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp4b1  cytochrome P450, family 4, subfamily b, polypeptide 1    cytochrome P450, subfamily 4B, polypeptide 1  Name updated 1299863 APPROVED
2002-11-06 Cyp4b1  cytochrome P450, subfamily 4B, polypeptide 1    Cytochrome P450, subfamily IVB, polypeptide 1  Name updated 625702 APPROVED
2002-06-10 Cyp4b1  Cytochrome P450, subfamily IVB, polypeptide 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is induced by androgens 729927