Dpysl3 (dihydropyrimidinase-like 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Dpysl3 (dihydropyrimidinase-like 3) Rattus norvegicus
Analyze
Symbol: Dpysl3
Name: dihydropyrimidinase-like 3
RGD ID: 2410
Description: Enables SH3 domain binding activity; chondroitin sulfate binding activity; and identical protein binding activity. Involved in several processes, including actin filament organization; regulation of plasma membrane bounded cell projection organization; and response to axon injury. Located in several cellular components, including exocytic vesicle; growth cone; and lamellipodium. Part of filamentous actin. Is active in synapse. Orthologous to human DPYSL3 (dihydropyrimidinase like 3); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Collapsin response mediator protein 4; CRMP-4; Crmp4; dihydropyrimidinase-related protein 3; DRP-3; TOAD-64/Ulip/CRMP protein 4b; TUC-4b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81835,625,357 - 35,731,152 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1835,625,357 - 35,731,152 (-)EnsemblGRCr8
mRatBN7.21835,374,427 - 35,480,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1835,377,181 - 35,480,157 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1835,478,465 - 35,584,254 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01836,196,778 - 36,302,565 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01835,573,728 - 35,679,526 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01837,716,371 - 37,819,347 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1837,716,143 - 37,819,097 (-)Ensemblrn6Rnor6.0
Rnor_5.01837,372,407 - 37,475,307 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41836,620,669 - 36,680,355 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1834,966,806 - 35,026,066 (-)NCBICelera
RGSC_v3.11836,655,934 - 36,715,621 (-)NCBI
Cytogenetic Map18p11-q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-butoxyethanol  (ISO)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aconitine  (EXP)
acrylamide  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloroprene  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
manganese(II) chloride  (EXP,ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
quercetin  (EXP)
rotenone  (EXP,ISO)
S-nitrosoglutathione  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sterigmatocystin  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Identification of CRMP4 as a convergent regulator of axon outgrowth inhibition. Alabed YZ, etal., J Neurosci. 2007 Feb 14;27(7):1702-11.
2. Collapsin response mediator proteins of neonatal rat brain interact with chondroitin sulfate. Franken S, etal., J Biol Chem 2003 Jan 31;278(5):3241-50. Epub 2002 Nov 19.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Injury-induced CRMP4 expression in adult sensory neurons; a possible target gene for ciliary neurotrophic factor. Jang SY, etal., Neurosci Lett. 2010 Nov 12;485(1):37-42. doi: 10.1016/j.neulet.2010.08.058. Epub 2010 Aug 26.
6. Identification and verification of novel rodent postsynaptic density proteins. Jordan BA, etal., Mol Cell Proteomics. 2004 Sep;3(9):857-71. doi: 10.1074/mcp.M400045-MCP200. Epub 2004 May 28.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. TUC-4b, a novel TUC family variant, regulates neurite outgrowth and associates with vesicles in the growth cone. Quinn CC, etal., J Neurosci 2003 Apr 1;23(7):2815-23.
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Collapsin response mediator protein-4 regulates F-actin bundling. Rosslenbroich V, etal., Exp Cell Res. 2005 Nov 1;310(2):434-44. Epub 2005 Sep 21.
12. A family of rat CRMP genes is differentially expressed in the nervous system. Wang LH and Strittmatter SM, J Neurosci 1996 Oct 1;16(19):6197-207.
Additional References at PubMed
PMID:10956643   PMID:12687705   PMID:15865439   PMID:16987501   PMID:17845802   PMID:18053648   PMID:18313395   PMID:19639589   PMID:22871113   PMID:23988434   PMID:25358863   PMID:26064693  
PMID:27339813   PMID:28131823   PMID:38063003  


Genomics

Comparative Map Data
Dpysl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81835,625,357 - 35,731,152 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1835,625,357 - 35,731,152 (-)EnsemblGRCr8
mRatBN7.21835,374,427 - 35,480,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1835,377,181 - 35,480,157 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1835,478,465 - 35,584,254 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01836,196,778 - 36,302,565 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01835,573,728 - 35,679,526 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01837,716,371 - 37,819,347 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1837,716,143 - 37,819,097 (-)Ensemblrn6Rnor6.0
Rnor_5.01837,372,407 - 37,475,307 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41836,620,669 - 36,680,355 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1834,966,806 - 35,026,066 (-)NCBICelera
RGSC_v3.11836,655,934 - 36,715,621 (-)NCBI
Cytogenetic Map18p11-q11NCBI
DPYSL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385147,390,808 - 147,510,068 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5147,390,808 - 147,510,089 (-)Ensemblhg38GRCh38
GRCh375146,770,371 - 146,889,631 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365146,750,564 - 146,813,453 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345146,750,565 - 146,813,453NCBI
Celera5142,852,394 - 142,915,278 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5141,917,546 - 142,036,676 (-)NCBIHuRef
CHM1_15146,202,682 - 146,322,042 (-)NCBICHM1_1
T2T-CHM13v2.05147,926,586 - 148,045,847 (-)NCBIT2T-CHM13v2.0
Dpysl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391843,454,044 - 43,571,354 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1843,454,049 - 43,571,351 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381843,320,979 - 43,438,286 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1843,320,984 - 43,438,286 (-)Ensemblmm10GRCm38
MGSCv371843,483,881 - 43,552,985 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361843,449,613 - 43,518,664 (-)NCBIMGSCv36mm8
Celera1844,709,412 - 44,773,911 (-)NCBICelera
Cytogenetic Map18B3NCBI
Dpysl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554156,702,768 - 6,814,097 (+)Ensembl
ChiLan1.0NW_0049554156,703,212 - 6,813,906 (+)NCBIChiLan1.0ChiLan1.0
DPYSL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24142,643,607 - 142,763,113 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15140,783,158 - 140,902,554 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05142,839,385 - 142,958,774 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15148,850,102 - 148,969,606 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5148,850,102 - 148,969,606 (-)EnsemblpanPan2panpan1.1
DPYSL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1241,687,725 - 41,809,402 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl241,690,845 - 41,802,376 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha238,729,489 - 38,849,072 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0242,142,973 - 42,262,444 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,142,980 - 42,263,107 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,218,903 - 39,339,535 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0240,029,019 - 40,148,731 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0240,851,053 - 40,970,669 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dpysl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213145,687,381 - 145,794,511 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365047,261,524 - 7,365,168 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365047,261,334 - 7,365,828 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYSL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2148,662,051 - 148,776,619 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12148,663,563 - 148,777,055 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22155,127,544 - 155,234,332 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DPYSL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12349,941,799 - 50,060,696 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2349,945,023 - 50,060,392 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603427,706,225 - 27,824,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dpysl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247746,835,299 - 6,943,552 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247746,836,198 - 6,943,528 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dpysl3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1151,617,667 - 1,680,326 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dpysl3
668 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:40
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000025880
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat

Markers in Region
D18Mit202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21835,436,351 - 35,436,496 (+)MAPPERmRatBN7.2
Rnor_6.01837,775,242 - 37,775,386NCBIRnor6.0
Rnor_5.01837,431,202 - 37,431,346UniSTSRnor5.0
RGSC_v3.41836,679,144 - 36,679,288UniSTSRGSC3.4
Celera1835,024,855 - 35,024,999UniSTS
Cytogenetic Map18p11UniSTS
RH143255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21835,392,237 - 35,392,358 (+)MAPPERmRatBN7.2
Rnor_6.01837,731,128 - 37,731,248NCBIRnor6.0
Rnor_5.01837,387,088 - 37,387,208UniSTSRnor5.0
RGSC_v3.41836,635,030 - 36,635,150UniSTSRGSC3.4
Celera1834,981,170 - 34,981,290UniSTS
Cytogenetic Map18p11UniSTS
RH140106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21835,437,942 - 35,438,130 (+)MAPPERmRatBN7.2
Rnor_6.01837,776,833 - 37,777,020NCBIRnor6.0
Rnor_5.01837,432,793 - 37,432,980UniSTSRnor5.0
RGSC_v3.41836,680,735 - 36,680,922UniSTSRGSC3.4
Celera1835,026,446 - 35,026,633UniSTS
Cytogenetic Map18p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 44 59 6 308 144 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025880   ⟹   ENSRNOP00000025880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1835,625,357 - 35,731,152 (-)Ensembl
mRatBN7.2 Ensembl1835,377,181 - 35,480,157 (-)Ensembl
Rnor_6.0 Ensembl1837,716,143 - 37,819,097 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087876   ⟹   ENSRNOP00000070679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1835,625,357 - 35,688,511 (-)Ensembl
mRatBN7.2 Ensembl1835,377,181 - 35,437,563 (-)Ensembl
Rnor_6.0 Ensembl1837,716,559 - 37,776,453 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098686   ⟹   ENSRNOP00000096224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1835,625,357 - 35,669,691 (-)Ensembl
mRatBN7.2 Ensembl1835,377,181 - 35,418,741 (-)Ensembl
RefSeq Acc Id: NM_001398556   ⟹   NP_001385485
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81835,625,357 - 35,731,152 (-)NCBI
mRatBN7.21835,374,427 - 35,480,228 (-)NCBI
RefSeq Acc Id: NM_012934   ⟹   NP_037066
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81835,625,357 - 35,688,511 (-)NCBI
mRatBN7.21835,374,427 - 35,437,583 (-)NCBI
Rnor_6.01837,716,559 - 37,776,453 (-)NCBI
Rnor_5.01837,372,407 - 37,475,307 (-)NCBI
RGSC_v3.41836,620,669 - 36,680,355 (-)RGD
Celera1834,966,806 - 35,026,066 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254671   ⟹   XP_006254733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81835,625,360 - 35,669,653 (-)NCBI
mRatBN7.21835,374,429 - 35,418,615 (-)NCBI
Rnor_6.01837,716,371 - 37,757,649 (-)NCBI
Rnor_5.01837,372,407 - 37,475,307 (-)NCBI
Sequence:
RefSeq Acc Id: NP_037066   ⟸   NM_012934
- Peptide Label: isoform 1
- UniProtKB: Q8K4H3 (UniProtKB/Swiss-Prot),   Q91XM8 (UniProtKB/Swiss-Prot),   Q62952 (UniProtKB/Swiss-Prot),   A6J3L8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254733   ⟸   XM_006254671
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AUS8 (UniProtKB/TrEMBL),   A6J3L9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070679   ⟸   ENSRNOT00000087876
Ensembl Acc Id: ENSRNOP00000025880   ⟸   ENSRNOT00000025880
Ensembl Acc Id: ENSRNOP00000096224   ⟸   ENSRNOT00000098686
RefSeq Acc Id: NP_001385485   ⟸   NM_001398556
- Peptide Label: isoform 2
- UniProtKB: A6J3L7 (UniProtKB/TrEMBL)
Protein Domains
Amidohydrolase-related

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62952-F1-model_v2 AlphaFold Q62952 1-570 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700752
Promoter ID:EPDNEW_R11276
Type:initiation region
Name:Dpysl3_2
Description:dihydropyrimidinase-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11277  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01837,776,450 - 37,776,510EPDNEW
RGD ID:13700759
Promoter ID:EPDNEW_R11277
Type:initiation region
Name:Dpysl3_1
Description:dihydropyrimidinase-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11276  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01837,819,113 - 37,819,173EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2410 AgrOrtholog
BioCyc Gene G2FUF-7685 BioCyc
BioCyc Pathway PWY-3982 [uracil degradation I (reductive)] BioCyc
  PWY-6430 [thymine degradation] BioCyc
BioCyc Pathway Image PWY-3982 BioCyc
  PWY-6430 BioCyc
Ensembl Genes ENSRNOG00000018992 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025880 ENTREZGENE
  ENSRNOT00000025880.6 UniProtKB/Swiss-Prot
  ENSRNOT00000087876 ENTREZGENE
  ENSRNOT00000087876.2 UniProtKB/Swiss-Prot
  ENSRNOT00000098686 ENTREZGENE
Gene3D-CATH 2.30.40.10 UniProtKB/Swiss-Prot
  Metal-dependent hydrolases UniProtKB/Swiss-Prot
InterPro Amidohydro-rel UniProtKB/Swiss-Prot
  Hydantoinase/dihydroPyrase UniProtKB/Swiss-Prot
  Metal-dep_hydrolase_composite UniProtKB/Swiss-Prot
  Metal_Hydrolase UniProtKB/Swiss-Prot
  Metallo-dep_Hydrolases_sf UniProtKB/Swiss-Prot
KEGG Report rno:25418 UniProtKB/Swiss-Prot
NCBI Gene 25418 ENTREZGENE
PANTHER HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER UniProtKB/Swiss-Prot
  PTHR11647:SF57 UniProtKB/Swiss-Prot
Pfam Amidohydro_1 UniProtKB/Swiss-Prot
PhenoGen Dpysl3 PhenoGen
RatGTEx ENSRNOG00000018992 RatGTEx
Superfamily-SCOP SSF51338 UniProtKB/Swiss-Prot
  SSF51556 UniProtKB/Swiss-Prot
UniProt A0A8I6AUS8 ENTREZGENE, UniProtKB/TrEMBL
  A6J3L6_RAT UniProtKB/TrEMBL
  A6J3L7 ENTREZGENE, UniProtKB/TrEMBL
  A6J3L8 ENTREZGENE, UniProtKB/TrEMBL
  A6J3L9 ENTREZGENE, UniProtKB/TrEMBL
  DPYL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8K4H3 ENTREZGENE
  Q91XM8 ENTREZGENE
UniProt Secondary Q8K4H3 UniProtKB/Swiss-Prot
  Q91XM8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Dpysl3  dihydropyrimidinase-like 3  Crmp4    Symbol updated 1299863 APPROVED
2003-04-09 Crmp4  dihydropyrimidinase-like 3    Collapsin response mediator protein 4  Symbol and Name updated 629477 APPROVED
2002-06-10 Crmp4  Collapsin response mediator protein 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to synaptic vesicle protein 2-positive vesicles in growth cone of neural cells 1298810
gene_expression expressed mainly in nervous system during development 1298809
gene_homology most closely homologous to chick CRMP-62 1298809
gene_homology homologous to C. elegans unc-33, which is involved in axon guidance and extension 1298810
gene_mutations_overexpression overexpression in cultured cells results in increased neurite length and branching 1298810
gene_other released by a ligand of extracellular matrix in brain during development, possibly after cell death 1298811
gene_physical_interaction interacts with Src homology 3A domain of intersectin 1298810
gene_process may play a role in neurite growth and extension by regulation of growth cone vesicle transport 1298810
gene_process may be involved in neuronal plasticity by transducing signals from semaphorins 1298809