Mir30e (microRNA 30e) - Rat Genome Database

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Gene: Mir30e (microRNA 30e) Rattus norvegicus
Analyze
Symbol: Mir30e
Name: microRNA 30e
RGD ID: 2325460
Description: Predicted to enable mRNA base-pairing post-transcriptional repressor activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; negative regulation of cardiac muscle contraction; and regulation of G protein-coupled receptor signaling pathway. Predicted to be part of RISC complex. Biomarker of cardiomyopathy; congestive heart failure; and myocardial infarction. Human ortholog(s) of this gene implicated in primary hyperparathyroidism and schizophrenia. Orthologous to human MIR30E (microRNA 30e); INTERACTS WITH (+)-schisandrin B; aflatoxin B1; bis(2-ethylhexyl) phthalate.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-30e
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85139,637,450 - 139,637,541 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5139,637,450 - 139,637,541 (+)EnsemblGRCr8
mRatBN7.25134,352,232 - 134,352,323 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5134,352,232 - 134,352,323 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5137,079,723 - 137,079,814 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05138,836,194 - 138,836,285 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05138,856,809 - 138,856,900 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5139,276,268 - 139,276,359 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive5141,253,912 - 141,254,003 (-)NCBILyon_Normotensive
Lyon_Hypertensive5140,441,140 - 140,441,231 (-)NCBILyon_Hypertensive
F344_StmMcwi5134,021,485 - 134,021,576 (-)NCBIF344_StmMcwi
Rnor_6.05139,702,872 - 139,702,963 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,702,872 - 139,702,963 (-)Ensemblrn6Rnor6.0
Rnor_5.05143,497,752 - 143,497,843 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera5132,906,563 - 132,906,654 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MiRNA-30e mediated cardioprotection of ACE2 in rats with Doxorubicin-induced heart failure through inhibiting cardiomyocytes autophagy. Lai L, etal., Life Sci. 2017 Jan 15;169:69-75. doi: 10.1016/j.lfs.2016.09.006. Epub 2016 Sep 12.
2. Association Between hsa-miR-30e Polymorphisms and Sporadic Primary Hyperparathyroidism Risk. Mizamtsidi M, etal., In Vivo. 2019 Jul-Aug;33(4):1263-1269. doi: 10.21873/invivo.11598.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in beta-adrenergic signaling and enhances apoptosis. Roca-Alonso L, etal., Cell Death Dis. 2015 May 7;6:e1754. doi: 10.1038/cddis.2015.89.
5. Circulating MicroRNA-188, -30a, and -30e as Early Biomarkers for Contrast-Induced Acute Kidney Injury. Sun SQ, etal., J Am Heart Assoc. 2016 Aug 15;5(8). pii: JAHA.116.004138. doi: 10.1161/JAHA.116.004138.
6. MiR‑30e and miR‑92a are related to atherosclerosis by targeting ABCA1. Wang Z, etal., Mol Med Rep. 2019 Apr;19(4):3298-3304. doi: 10.3892/mmr.2019.9983. Epub 2019 Feb 25.
7. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. Xu Y, etal., Schizophr Res. 2010 Jun;119(1-3):219-27. doi: 10.1016/j.schres.2010.02.1070. Epub 2010 Mar 27.
8. MiR-30e Attenuates Isoproterenol-induced Cardiac Fibrosis Through Suppressing Snai1/TGF-β Signaling. Zhang W, etal., J Cardiovasc Pharmacol. 2017 Dec;70(6):362-368. doi: 10.1097/FJC.0000000000000526.
Additional References at PubMed
PMID:16381832   PMID:16766679   PMID:17604727   PMID:19091803   PMID:19188439   PMID:20403161   PMID:20548288   PMID:21993888   PMID:23515048   PMID:24205035   PMID:25858512   PMID:26208845  
PMID:27199283   PMID:32879888   PMID:33180227   PMID:33293097  


Genomics

Comparative Map Data
Mir30e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85139,637,450 - 139,637,541 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5139,637,450 - 139,637,541 (+)EnsemblGRCr8
mRatBN7.25134,352,232 - 134,352,323 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5134,352,232 - 134,352,323 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5137,079,723 - 137,079,814 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05138,836,194 - 138,836,285 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05138,856,809 - 138,856,900 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5139,276,268 - 139,276,359 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive5141,253,912 - 141,254,003 (-)NCBILyon_Normotensive
Lyon_Hypertensive5140,441,140 - 140,441,231 (-)NCBILyon_Hypertensive
F344_StmMcwi5134,021,485 - 134,021,576 (-)NCBIF344_StmMcwi
Rnor_6.05139,702,872 - 139,702,963 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5139,702,872 - 139,702,963 (-)Ensemblrn6Rnor6.0
Rnor_5.05143,497,752 - 143,497,843 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera5132,906,563 - 132,906,654 (-)NCBICelera
Cytogenetic Map5q36NCBI
MIR30E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38140,754,355 - 40,754,446 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl140,754,355 - 40,754,446 (+)Ensemblhg38GRCh38
GRCh37141,220,027 - 41,220,118 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,992,613 - 40,992,704 (+)NCBIBuild 36Build 36hg18NCBI36
Celera139,502,227 - 39,502,318 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef139,338,148 - 39,338,239 (+)NCBIHuRef
CHM1_1141,335,858 - 41,335,949 (+)NCBICHM1_1
T2T-CHM13v2.0140,623,565 - 40,623,656 (+)NCBIT2T-CHM13v2.0
Mir30e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394120,629,803 - 120,629,894 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4120,629,803 - 120,629,894 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384120,772,606 - 120,772,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4120,772,606 - 120,772,697 (-)Ensemblmm10GRCm38
MGSCv374120,445,211 - 120,445,302 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera4119,490,804 - 119,490,895 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map456.52NCBI
MIR30E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,283,306 - 2,283,369 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl152,283,306 - 2,283,369 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha152,541,606 - 2,541,669 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0152,372,685 - 2,372,748 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl152,372,685 - 2,372,748 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1152,278,149 - 2,278,212 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0152,338,221 - 2,338,284 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,354,057 - 2,354,120 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MIR30E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6170,429,841 - 170,429,920 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16170,429,841 - 170,429,920 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26157,476,655 - 157,476,734 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mir30e
7 total Variants
miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Syt4rno-miR-30e-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:12291
Count of gene targets:6986
Count of transcripts:7497
Interacting mature miRNAs:rno-miR-30e-3p, rno-miR-30e-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133308734140009902Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 8 9 18 23 23 6 18 6 63 35 10 12 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000053763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5139,637,450 - 139,637,541 (+)Ensembl
mRatBN7.2 Ensembl5134,352,232 - 134,352,323 (+)Ensembl
Rnor_6.0 Ensembl5139,702,872 - 139,702,963 (-)Ensembl
RefSeq Acc Id: NR_031840
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85139,637,450 - 139,637,541 (-)NCBI
mRatBN7.25134,352,232 - 134,352,323 (-)NCBI
Dahl_SR_JrHsd5139,276,268 - 139,276,359 (-)NCBI
Lyon_Normotensive5141,253,912 - 141,254,003 (-)NCBI
Lyon_Hypertensive5140,441,140 - 140,441,231 (-)NCBI
F344_StmMcwi5134,021,485 - 134,021,576 (-)NCBI
Rnor_6.05139,702,872 - 139,702,963 (-)NCBI
Rnor_5.05143,497,752 - 143,497,843 (-)NCBI
Celera5132,906,563 - 132,906,654 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325460 AgrOrtholog
BioCyc Gene G2FUF-40053 BioCyc
Ensembl Genes ENSRNOG00000035640 Ensembl
miRBase MI0000867 ENTREZGENE
NCBI Gene 100314153 ENTREZGENE
PhenoGen Mir30e PhenoGen
RatGTEx ENSRNOG00000035640 RatGTEx
RNAcentral URS00001DE669 RNACentral
  URS00004DC6A5 RNACentral
  URS0000759D99 RNACentral
  URS000075B1E9 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir30e  microRNA 30e  Mir30e  microRNA mir-30e  Name updated 61478 APPROVED
2010-06-02 Mir30e  microRNA mir-30e      Symbol and Name status set to provisional 70820 PROVISIONAL