Mir125b1 (microRNA 125b-1) - Rat Genome Database

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Gene: Mir125b1 (microRNA 125b-1) Rattus norvegicus
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Symbol: Mir125b1
Name: microRNA 125b-1
RGD ID: 2325457
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing post-transcriptional repressor activity. Predicted to be involved in several processes, including negative regulation of gene expression; negative regulation of signal transduction; and positive regulation of cell differentiation. Predicted to act upstream of or within several processes, including cellular response to cytokine stimulus; cellular response to estrogen stimulus; and cellular response to mechanical stimulus. Predicted to be located in extracellular exosome. Predicted to be part of RISC complex. Orthologous to human MIR125B1 (microRNA 125b-1); INTERACTS WITH 2-acetamidofluorene; atrazine; cadmium atom.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-125b-1; Mir125b-1; rno-mir-125b-1
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8850,850,036 - 50,850,122 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl850,850,036 - 50,850,122 (+)EnsemblGRCr8
mRatBN7.2841,952,966 - 41,953,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl841,952,966 - 41,953,052 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx847,445,457 - 47,445,543 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0845,724,100 - 45,724,186 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0843,591,670 - 43,591,756 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd851,664,782 - 51,664,868 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive853,860,741 - 53,860,827 (+)NCBILyon_Normotensive
Lyon_Hypertensive852,292,052 - 52,292,138 (+)NCBILyon_Hypertensive
F344_StmMcwi843,705,100 - 43,705,186 (+)NCBIF344_StmMcwi
Rnor_6.0845,798,260 - 45,798,346 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl845,798,260 - 45,798,346 (+)Ensemblrn6Rnor6.0
Rnor_5.0844,272,846 - 44,272,932 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera841,551,438 - 41,551,524 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to estrogen stimulus  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vitamin D  (ISO)
common myeloid progenitor cell proliferation  (ISO)
hematopoietic stem cell differentiation  (ISO)
juxtaglomerular apparatus development  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of interleukin-6-mediated signaling pathway  (ISO)
negative regulation of keratinocyte proliferation  (ISO)
negative regulation of monocyte differentiation  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of receptor signaling pathway via STAT  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
ossification  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of keratinocyte differentiation  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:16381832   PMID:16766679   PMID:17604727   PMID:17805466   PMID:18791161   PMID:19188425   PMID:20403161   PMID:20439489   PMID:20660734   PMID:21993888  
PMID:23536218   PMID:23646144   PMID:25751060   PMID:25858512   PMID:25959411   PMID:26248331   PMID:26729468   PMID:27979484   PMID:28281528   PMID:28522697   PMID:29122578   PMID:29510389  
PMID:31000329   PMID:31548167   PMID:32415544   PMID:33909769   PMID:34563514   PMID:34889563   PMID:37166139   PMID:37858031   PMID:37958999   PMID:39117291   PMID:39135278  


Genomics

Comparative Map Data
Mir125b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8850,850,036 - 50,850,122 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl850,850,036 - 50,850,122 (+)EnsemblGRCr8
mRatBN7.2841,952,966 - 41,953,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl841,952,966 - 41,953,052 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx847,445,457 - 47,445,543 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0845,724,100 - 45,724,186 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0843,591,670 - 43,591,756 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd851,664,782 - 51,664,868 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive853,860,741 - 53,860,827 (+)NCBILyon_Normotensive
Lyon_Hypertensive852,292,052 - 52,292,138 (+)NCBILyon_Hypertensive
F344_StmMcwi843,705,100 - 43,705,186 (+)NCBIF344_StmMcwi
Rnor_6.0845,798,260 - 45,798,346 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl845,798,260 - 45,798,346 (+)Ensemblrn6Rnor6.0
Rnor_5.0844,272,846 - 44,272,932 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera841,551,438 - 41,551,524 (+)NCBICelera
Cytogenetic Map8q22NCBI
MIR125B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811122,099,757 - 122,099,844 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11122,099,757 - 122,099,844 (-)Ensemblhg38GRCh38
GRCh3711121,970,465 - 121,970,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611121,475,674 - 121,475,761 (-)NCBIBuild 36Build 36hg18NCBI36
Celera11119,131,144 - 119,131,231 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11117,917,003 - 117,917,090 (-)NCBIHuRef
CHM1_111121,857,766 - 121,857,853 (-)NCBICHM1_1
T2T-CHM13v2.011122,128,759 - 122,128,846 (-)NCBIT2T-CHM13v2.0
Mir125b-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39941,493,222 - 41,493,298 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl941,493,222 - 41,493,298 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38941,581,926 - 41,582,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl941,581,926 - 41,582,002 (+)Ensemblmm10GRCm38
MGSCv37941,390,009 - 41,390,085 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera938,821,699 - 38,821,775 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map923.41NCBI
MIR125B-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1512,097,672 - 12,097,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl512,097,658 - 12,097,745 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha512,152,730 - 12,152,790 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0512,047,627 - 12,047,687 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl512,047,613 - 12,047,700 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1512,151,360 - 12,151,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0512,090,768 - 12,090,828 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0512,129,464 - 12,129,524 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MIR125B-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,109,435 - 49,109,514 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1949,109,435 - 49,109,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2954,334,908 - 54,334,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mir125b1
1 total Variants
miRNA Target Status (No longer updated)

Predicted Targets
Summary Value
Count of predictions:7491
Count of gene targets:4925
Count of transcripts:5223
Interacting mature miRNAs:rno-miR-125b-1-3p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625851589833Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 5 11 66 14 17 3 10 3 45 27 60 9 22 14

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl850,850,036 - 50,850,122 (+)Ensembl
mRatBN7.2 Ensembl841,952,966 - 41,953,052 (+)Ensembl
Rnor_6.0 Ensembl845,798,260 - 45,798,346 (+)Ensembl
RefSeq Acc Id: NR_031869
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8850,850,036 - 50,850,122 (+)NCBI
mRatBN7.2841,952,966 - 41,953,052 (+)NCBI
Dahl_SR_JrHsd851,664,782 - 51,664,868 (+)NCBI
Lyon_Normotensive853,860,741 - 53,860,827 (+)NCBI
Lyon_Hypertensive852,292,052 - 52,292,138 (+)NCBI
F344_StmMcwi843,705,100 - 43,705,186 (+)NCBI
Rnor_6.0845,798,260 - 45,798,346 (+)NCBI
Rnor_5.0844,272,846 - 44,272,932 (+)NCBI
Celera841,551,438 - 41,551,524 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325457 AgrOrtholog
BioCyc Gene G2FUF-30795 BioCyc
Ensembl Genes ENSRNOG00000035550 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053673 ENTREZGENE
miRBase MI0000896 ENTREZGENE
NCBI Gene 100314156 ENTREZGENE
PhenoGen Mir125b1 PhenoGen
RatGTEx ENSRNOG00000035550 RatGTEx
RNAcentral URS0000209905 RNACentral
  URS00002DABEA RNACentral
  URS000075BEA4 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir125b1  microRNA 125b-1  Mir125b-1  microRNA mir-125b-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir125b-1  microRNA mir-125b-1      Symbol and Name status set to provisional 70820 PROVISIONAL