Ftl1l2 (ferritin light chain 1 like 2) - Rat Genome Database

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Gene: Ftl1l2 (ferritin light chain 1 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ftl1l2
Name: ferritin light chain 1 like 2
RGD ID: 2325062
Description: Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain); INTERACTS WITH cadmium atom.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ferritin light chain 1-like; ferritin light chain 2; LOC100359668
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,977,712 - 78,987,254 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl678,974,639 - 79,002,430 (-)EnsemblGRCr8
GRCr8 Ensembl263,270,578 - 63,305,917 (-)EnsemblGRCr8
mRatBN7.2673,242,612 - 73,243,527 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl673,242,608 - 73,253,291 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl261,543,323 - 61,578,556 (-)EnsemblmRatBN7.2
Rnor_6.0676,652,033 - 76,652,975 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,652,206 - 76,652,757 (-)Ensemblrn6Rnor6.0
Rnor_5.0686,184,248 - 86,185,190 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4676,152,983 - 76,153,826 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera672,075,615 - 72,076,557 (-)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
cadmium atom  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ftl1l2
77 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:49
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000042177
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 3 50 117 74 73 48 84 48 6 302 162 10 99 75 85 25 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000042177   ⟹   ENSRNOP00000042311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl678,976,893 - 79,002,430 (-)Ensembl
mRatBN7.2 Ensembl673,242,618 - 73,252,261 (-)Ensembl
Rnor_6.0 Ensembl676,652,206 - 76,652,757 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096014   ⟹   ENSRNOP00000090717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl263,270,578 - 63,305,917 (-)Ensembl
mRatBN7.2 Ensembl261,543,323 - 61,578,556 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106144   ⟹   ENSRNOP00000095589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl673,242,608 - 73,253,291 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145241   ⟹   ENSRNOP00000107547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl678,977,191 - 79,002,189 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148687   ⟹   ENSRNOP00000102077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl263,270,586 - 63,271,493 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000153469   ⟹   ENSRNOP00000109088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl263,270,592 - 63,300,110 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170958   ⟹   ENSRNOP00000103057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl678,974,639 - 78,978,635 (-)Ensembl
RefSeq Acc Id: XM_039113181   ⟹   XP_038969109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8678,977,712 - 78,987,254 (-)NCBI
mRatBN7.2673,242,612 - 73,243,527 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038969109 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042311.3
  ENSRNOP00000090717.1
  ENSRNOP00000095589.1
  ENSRNOP00000102077.1
  ENSRNOP00000103057
  ENSRNOP00000103057.1
  ENSRNOP00000107547.1
  ENSRNOP00000109088.1
Ensembl Acc Id: ENSRNOP00000042311   ⟸   ENSRNOT00000042177
RefSeq Acc Id: XP_038969109   ⟸   XM_039113181
- UniProtKB: F1M5T1 (UniProtKB/TrEMBL),   A0A8I6GIG4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095589   ⟸   ENSRNOT00000106144
Ensembl Acc Id: ENSRNOP00000090717   ⟸   ENSRNOT00000096014
Ensembl Acc Id: ENSRNOP00000103057   ⟸   ENSRNOT00000170958
Ensembl Acc Id: ENSRNOP00000107547   ⟸   ENSRNOT00000145241
Ensembl Acc Id: ENSRNOP00000109088   ⟸   ENSRNOT00000153469
Ensembl Acc Id: ENSRNOP00000102077   ⟸   ENSRNOT00000148687
Protein Domains
Ferritin-like diiron

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M5T1-F1-model_v2 AlphaFold F1M5T1 1-183 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325062 AgrOrtholog
BioCyc Gene G2FUF-37482 BioCyc
Ensembl Genes ENSRNOG00000033776 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000065602 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042177.5 UniProtKB/TrEMBL
  ENSRNOT00000096014.2 UniProtKB/TrEMBL
  ENSRNOT00000106144.1 UniProtKB/TrEMBL
  ENSRNOT00000145241.1 UniProtKB/TrEMBL
  ENSRNOT00000148687.1 UniProtKB/TrEMBL
  ENSRNOT00000153469.1 UniProtKB/TrEMBL
  ENSRNOT00000170958 ENTREZGENE
  ENSRNOT00000170958.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.10 UniProtKB/TrEMBL
InterPro Ferritin UniProtKB/TrEMBL
  Ferritin-like_diiron UniProtKB/TrEMBL
  Ferritin-like_SF UniProtKB/TrEMBL
  Ferritin-rel UniProtKB/TrEMBL
  Ferritin_CS UniProtKB/TrEMBL
  Ferritin_DPS_dom UniProtKB/TrEMBL
NCBI Gene 100359668 ENTREZGENE
PANTHER FERRITIN LIGHT CHAIN UniProtKB/TrEMBL
  PTHR11431 UniProtKB/TrEMBL
Pfam Ferritin UniProtKB/TrEMBL
PhenoGen Ftl1l2 PhenoGen
PROSITE FERRITIN_1 UniProtKB/TrEMBL
  FERRITIN_2 UniProtKB/TrEMBL
  FERRITIN_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033776 RatGTEx
  ENSRNOG00000065602 RatGTEx
Superfamily-SCOP Ferritin/RR_like UniProtKB/TrEMBL
UniProt A0A8I6GIG4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L171_RAT UniProtKB/TrEMBL
  F1M5T1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Ftl1l2  ferritin light chain 1 like 2  LOC100359668  ferritin light chain 2  Symbol and Name Changed 1299863 APPROVED
2010-05-20 LOC100359668  ferritin light chain 2      Symbol and Name status set to provisional 70820 PROVISIONAL