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Gene: Tiam2 (TIAM Rac1 associated GEF 2) Rattus norvegicus

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Symbol:

Tiam2

Name:

TIAM Rac1 associated GEF 2

RGD ID:

2324148

Description:

Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of axonogenesis and small GTPase-mediated signal transduction. Predicted to be located in cytoplasm. Predicted to be active in membrane and synapse. Orthologous to human TIAM2 (TIAM Rac1 associated GEF 2); INTERACTS WITH 4,4'-sulfonyldiphenol; bisphenol A; bisphenol F.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC100362710; rho guanine nucleotide exchange factor TIAM2; T-cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TIAM2 (TIAM Rac1 associated GEF 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Tiam2 (T cell lymphoma invasion and metastasis 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tiam2 (TIAM Rac1 associated GEF 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TIAM2 (TIAM Rac1 associated GEF 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TIAM2 (TIAM Rac1 associated GEF 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tiam2 (TIAM Rac1 associated GEF 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TIAM2 (TIAM Rac1 associated GEF 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TIAM2 (TIAM Rac1 associated GEF 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tiam2 (TIAM Rac1 associated GEF 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tiam2 (TIAM Rac1 associated GEF 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TFB1M (transcription factor B1, mitochondrial)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Tiam2 (T cell lymphoma invasion and metastasis 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TIAM2 (TIAM Rac1 associated GEF 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tiam2a (T cell lymphoma invasion and metastasis 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tiam-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	sif	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	46,323,450 - 46,524,769 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	46,323,456 - 46,524,769 (+)	Ensembl				GRCr8
mRatBN7.2	1	43,918,179 - 44,119,499 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	43,918,174 - 44,119,493 (+)	Ensembl				mRatBN7.2
Dahl_SR_JrHsd	1	45,938,232 - 46,137,711 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	1	45,277,622 - 45,477,098 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	1	46,438,949 - 46,638,442 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	1	44,715,463 - 44,914,947 (+)	NCBI		F344_StmMcwi
Rnor_6.0	1	44,232,520 - 44,433,450 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	44,311,513 - 44,433,193 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	45,562,714 - 45,763,294 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	38,479,385 - 38,514,359 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	39,555,701 - 39,754,110 (+)	NCBI		Celera
Cytogenetic Map	1	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

substance-related disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

amosite asbestos (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium dichloride (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

cocaine (EXP)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

diquat (ISO)

doxorubicin (ISO)

endosulfan (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

genistein (EXP)

gentamycin (EXP)

inulin (ISO)

ivermectin (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

serpentine asbestos (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

Triptolide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (IEA)

positive regulation of axonogenesis (IBA)

signal transduction (IEA)

small GTPase-mediated signal transduction (IBA,IEA)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (IEA,ISO)

fibrillar center (IEA,ISO)

membrane (IBA,IEA,ISO)

nucleoplasm (IEA,ISO)

synapse (IBA)

Molecular Function

GTPase activator activity (IEA,ISO)

guanyl-nucleotide exchange factor activity (IBA,IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10364228	PMID:11707441	PMID:15723051	PMID:19056867	PMID:21460187

Genomics

Comparative Map Data

Tiam2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	46,323,450 - 46,524,769 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	46,323,456 - 46,524,769 (+)	Ensembl				GRCr8
mRatBN7.2	1	43,918,179 - 44,119,499 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	43,918,174 - 44,119,493 (+)	Ensembl				mRatBN7.2
Dahl_SR_JrHsd	1	45,938,232 - 46,137,711 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	1	45,277,622 - 45,477,098 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	1	46,438,949 - 46,638,442 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	1	44,715,463 - 44,914,947 (+)	NCBI		F344_StmMcwi
Rnor_6.0	1	44,232,520 - 44,433,450 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	44,311,513 - 44,433,193 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	45,562,714 - 45,763,294 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	38,479,385 - 38,514,359 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	39,555,701 - 39,754,110 (+)	NCBI		Celera
Cytogenetic Map	1	q11	NCBI

TIAM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	154,995,315 - 155,257,723 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	154,832,697 - 155,257,723 (+)	Ensembl			hg38	GRCh38
GRCh37	6	155,316,449 - 155,578,857 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	155,453,115 - 155,620,549 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	155,540,736 - 155,670,437	NCBI
Celera	6	156,145,600 - 156,313,154 (+)	NCBI		Celera
Cytogenetic Map	6	q25.2-q25.3	NCBI
HuRef	6	152,973,625 - 153,141,133 (+)	NCBI		HuRef
CHM1_1	6	155,674,081 - 155,841,472 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	156,197,278 - 156,459,744 (+)	NCBI		T2T-CHM13v2.0

Tiam2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	3,376,675 - 3,569,672 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	3,376,848 - 3,581,619 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	3,326,313 - 3,519,397 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	3,326,573 - 3,531,344 (+)	Ensembl			mm10	GRCm38
MGSCv37	17	3,326,573 - 3,519,397 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	3,353,689 - 3,475,879 (+)	NCBI		MGSCv36	mm8
Celera	17	3,867,789 - 4,054,192 (+)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI
cM Map	17	1.99	NCBI

Tiam2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	6,939,563 - 7,067,507 (-)	Ensembl
ChiLan1.0	NW_004955439	6,942,702 - 7,147,145 (-)	NCBI	ChiLan1.0	ChiLan1.0

TIAM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	175,016,172 - 175,281,087 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	172,907,831 - 173,172,685 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	152,809,716 - 153,074,427 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	158,774,096 - 159,038,777 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	158,902,783 - 159,038,777 (+)	Ensembl			panPan2	panpan1.1

TIAM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	44,897,699 - 45,001,094 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	44,870,103 - 45,002,684 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	45,707,011 - 45,838,149 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	45,062,854 - 45,184,503 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	45,053,768 - 45,184,501 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	44,920,794 - 45,051,675 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	44,792,357 - 44,923,421 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	45,357,659 - 45,479,661 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tiam2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	140,110,602 - 140,212,560 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936489	7,362,598 - 7,465,076 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936489	7,336,078 - 7,464,553 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TIAM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	11,648,508 - 11,759,348 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	11,648,506 - 11,897,869 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	13,622,596 - 13,664,877 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TIAM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	82,537,021 - 82,823,525 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	82,688,773 - 82,822,949 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	54,926,150 - 55,198,751 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tiam2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624785	3,086,449 - 3,192,680 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624785	3,085,876 - 3,303,006 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tiam2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	195,244,365 - 195,366,076 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tiam2
1191 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	54
Count of miRNA genes:	50
Interacting mature miRNAs:	52
Transcripts:	ENSRNOT00000065386
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	43457837	87558729	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	7746118	52746118	Rat
1357397	Bw41	Body weight QTL 41	4.19	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	29409279	74409279	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	46302615	91302615	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	43457837	87558729	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	46302615	91302615	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	42122968	87122968	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
7421626	Bp360	Blood pressure QTL 360		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	6941022	51941022	Rat
1357401	Bw43	Body weight QTL 43	3.75		body mass (VT:0001259)	body weight (CMO:0000012)	1	6909353	51909353	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
631494	Bp95	Blood pressure QTL 95	40	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	17315378	51816258	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	46302615	91302615	Rat
5684998	Bss101	Bone structure and strength QTL 101	3.6		tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	1	6909353	51909353	Rat
5684999	Bss102	Bone structure and strength QTL 102	5.5	7e-07	tibia strength trait (VT:1000284)	tibia stiffness (CMO:0001735)	1	6909353	51909353	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	43457837	87558729	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	46302615	91302615	Rat
1578756	Iddm22	Insulin dependent diabetes mellitus QTL 22	2.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	20508326	65508326	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	30708375	87558729	Rat
631508	Sald1	Serum aldosterone level QTL 1	3.7		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	1	11684464	56684464	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	34565726	79565726	Rat
4889451	Eae29	Experimental allergic encephalomyelitis QTL 29	5.51		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	1	7746121	52746121	Rat
1558642	Prcr2	Prostate cancer resistance QTL 2	4.3		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	1	10379492	55379492	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	46302615	91302615	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	43509952	88509952	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	42122968	87122968	Rat
2302038	Pia31	Pristane induced arthritis QTL 31	5.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	1	12820494	57820494	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	46302615	91302615	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat
634353	Rends2	Renal damage susceptibility QTL 2		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	1	20656420	65656420	Rat

Markers in Region

D15Rat45

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	44,095,638 - 44,095,856 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	44,409,585 - 44,409,802	NCBI	Rnor6.0
Rnor_5.0	1	45,739,429 - 45,739,646	UniSTS	Rnor5.0
RGSC_v3.4	1	38,490,284 - 38,490,502	RGD	RGSC3.4
RGSC_v3.4	1	38,490,285 - 38,490,502	UniSTS	RGSC3.4
Celera	1	39,730,228 - 39,730,445	UniSTS
RGSC_v3.1	1	38,493,229 - 38,493,447	RGD
FHH x ACI Map	15	19.6699	UniSTS
FHH x ACI Map	15	19.6699	RGD

BE118732

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	44,097,687 - 44,097,847 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	44,411,639 - 44,411,798	NCBI	Rnor6.0
Rnor_5.0	1	45,741,483 - 45,741,642	UniSTS	Rnor5.0
RGSC_v3.4	1	38,492,232 - 38,492,391	UniSTS	RGSC3.4
Celera	1	39,732,277 - 39,732,436	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	160	89	88	57	89	57	6	350	189	11	139	80	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001427474	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006222901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006222904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006227904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008758738	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008774327	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282703	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000065386 ⟹ ENSRNOP00000060330

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	46,323,456 - 46,524,769 (+)	Ensembl
mRatBN7.2 Ensembl	1	43,918,174 - 44,119,493 (+)	Ensembl
Rnor_6.0 Ensembl	1	44,311,513 - 44,433,193 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000136443 ⟹ ENSRNOP00000111842

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	46,401,508 - 46,524,765 (+)	Ensembl

RefSeq Acc Id:

NM_001427473 ⟹ NP_001414402

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	46,400,865 - 46,524,769 (+)	NCBI
Dahl_SR_JrHsd	1	46,014,784 - 46,137,711 (+)	NCBI
Lyon_Normotensive	1	45,354,174 - 45,477,098 (+)	NCBI
Lyon_Hypertensive	1	46,515,510 - 46,638,442 (+)	NCBI
F344_StmMcwi	1	44,792,012 - 44,914,947 (+)	NCBI

RefSeq Acc Id:

NM_001427474 ⟹ NP_001414403

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	46,323,456 - 46,524,769 (+)	NCBI
Dahl_SR_JrHsd	1	45,938,232 - 46,137,711 (+)	NCBI
Lyon_Normotensive	1	45,277,622 - 45,477,098 (+)	NCBI
Lyon_Hypertensive	1	46,438,949 - 46,638,442 (+)	NCBI
F344_StmMcwi	1	44,715,463 - 44,914,947 (+)	NCBI

RefSeq Acc Id:

XM_006227904 ⟹ XP_006227966

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	46,489,773 - 46,524,769 (+)	NCBI
mRatBN7.2	1	44,084,514 - 44,119,499 (+)	NCBI
Rnor_6.0	1	44,398,406 - 44,433,450 (+)	NCBI
Rnor_5.0	1	45,562,714 - 45,763,294 (+)	NCBI

Sequence:

show sequence

GACCTCAAGGTGTGTTAAGCGGTTTCCCCACAGACAAGCCACTCGAGTACTGGAGACTGTCAGT
GGACATATGGTACTTAGCGAATCTGTTGTCCCTGCATCTGCTGTAACCTCCTGGTGCCTCTTCA
GAGCAGGCAGGCTCACAGTTTGGGGTAGGAATCTAGTGGAAGGGCGTGTACCTTCTCCAGGCAG
CAGGGAAAGAGCGTGGTGACGCTAGGGCGTCCTTGTGGATGTGACAGAAGAACAGTTTGCGATT
TTTCCCCCATTTCATTGCCTGGTGATGAGAGCTGAAGGAGATGCATTGCCTTCCATACTCTCCA
GCAGCAGTGGCCTGTAGCCGGCTTCCTTCTCCAGCACTGAGAAGGAACAGGTGCCTCTGAATCT
CTCCTTTTCATGTACAGGCGTAGTGCTGAGCAGATTGTGGAGCTCTGCAGAGGCACCACCAGTA
TGGAAGCACCGACAGACAGCCGCGACCCGCCTCCCAGGCCTCTGGCTCGTCACCTCTCAGATGC
AGACCGCCTCCGAAAAGTCATCCAGGAGCTTGTAGACACCGAGAAGTCTTACGTGAAGGATCTG
AGCTGCCTCTTTGAACTGTACTTGGAGCCCCTTCAGAACGAGACCTTTCTTACCCAAGATGAGA
TGGAGTCACTTTTTGGGAGCTTGCCAGAGATGCTGGAATTTCAAAAGGTGTTCCTGGAGACTCT
GGAGGATGGGATCTCTGCTTCCTCAGACTTTAGTGTCCTGGAAACCCCCTCACAGTTTCGGAAA
TTGCTGTTCTCTCTCGGAGGCTCTTTCCTCTACTACGCAGATCACTTTAAACTGTACAGTGGAT
TCTGCGCCAACCACATTAAAGTACAGAAGGTCCTAGAGCGAGCTAAAACCGACAGAGCTTTCAA
GGCTTTTCTGGACGCGCGGAACCCCACGAAGCAGCACTCCTCCACGCTGGAGTCATATCTCATC
AAGCCTGTTCAGAGAGTGCTCAAGTATCCTCTGCTCCTCAAGGAGCTCGTGTCACTGACTGACC
ATGAGAGCGAAGAACACTATCACCTGACAGAAGCTCTAAAGGCCATGGAAAAAGTAGCCAGTCA
CATCAATGAGATGCAGAAGATCTACGAGGACTATGGGACGGTGTTTGACCAGCTGGTGGCAGAG
CAGAGTGGCACAGAGAAGGAGGTAACAGAGCTGTCCATGGGGGAACTTCTGATGCACTCTACAG
TTTCCTGGTTGAATCCGTTCCTGTCTCTGGGAAAAGCCAGGAAGGACATTGAGCTCACAGTGTT
TGTTTTTAAGAGAGCTGTCATACTGGTTTATAAAGAAAACTGCAAGCTGAAAAAGAAACTGCCC
TCCAATTCCCGGCCTGCTCACAACTCTGCTGACTTGGACCCATTTAAATTCCGCTGGTTGATCC
CCATATCTGCGCTTCAAGTTAGACTGGGGAACACGGCAGGGACTGAAAACAATTCCACCTGGGA
GCTGATTCATACCAAGTCAGAAATTGAAGGACGGCCAGAGACCATCTTTCAACTGTGCTGCAGT
GACAGCGAGAGCAAAACCAGCATCGTTAAGGTGATCCGTTCTATTCTGAGAGAGAACTTCAGGC
GCCACATAAAGTGTGAGTTACCAATGGAGAAGACATGTAAGGACCGGCTGGTACCTCTTAAGAA
CCGAGTTCCTGTTTCAGCCAAATTAGCCTCATCCAGGTCTTTGAAGGTCCTCAGAACATCCTCC
AGCAGCGAGTGGCCCAGCGACCCCAGCAAGGGCAACTCACTGGACTCGGATGAGTGCAGCCTGA
GCAGTGGCACCCAGAGCAGTGGCTGCCCAGTAGCTGAGAGCAGACAAGACTGTAAGAGCACCGT
GCTGGAGAAAGACGCTCATGAGGTCCTGGCAGAGTTTCCAGATGGTCTCATCAAAGAAAGCGAC
ATTCTAAGTGATGAAGAGGAGGACTTCCACCACCCTCTGAAACAGGGCAGCCCTACTAAGGACA
TTGAGCTTCAGTTCCAGAGACTGCGAATCTCTGAGGAACCCGATATGCACTCAACTGGGCAGCA
GCCGCCTCTCACAGGGCCGGGTGAACAGCCCAAGCTGGTCAGGGGCCACTTTTGCCCCATTAAG
CGTAAAGCAAACAGCACTAAGAGGGGCCGAGGAACTTTGCTCAAGGCGCAGACACGTCACCAGT
CCCTGGACAGCCACCCGGAAACCGCCAGCATCGATCTAAATTTGGTTCTGGAGAGAGAATTCAG
TGTCCAGAGCTTAACTTCAGTTGTTAATGAGGAGTGTTTTTATGAAACACAGAGCCATGGCAAA
TCCTAGTGTGATCTGTATGGCGTGGTTACAATGCTCATTTTCAAATTGGTGGAAAATAGAAACT
GCAGGAAAACTGTTCATGTTTGGGTTTTATGCAGTATATAATTTTCCACAAAACCTGTAAAGAT
TTAAGTTATTTTAATTTATTGTGAATCAGAAAACTAGATTTAGTTGGTCAGAATCTGTAAATTA
CTAGCTTCTATCCCTTTTGAGCAGGAATCAAATGATTTTTAGTCTTGTAATAAAATTGCATTCT
AATTATTTTAAGTTATGTGGGATAAGATTGGGAACGTTGTGATTAATAGCTTTTAAAGGCCCCT
CCCCCCAGTCCTTTGGGCATTTTCTTTGCGCTGTTAGTTTTTGCTTCATTTAAAGCACATTTAT
GTTTACATGGTTTAGGGGCACAATGTGCAGACATTTCATTTTGGAAGGTTGTAATAAATGCTGT
TTATACTAAA

hide sequence

RefSeq Acc Id:

XM_039099650 ⟹ XP_038955578

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	46,323,450 - 46,524,769 (+)	NCBI
mRatBN7.2	1	43,918,179 - 44,119,499 (+)	NCBI

RefSeq Acc Id:

XM_063282703 ⟹ XP_063138773

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	46,416,018 - 46,524,769 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414402	(Get FASTA)	NCBI Sequence Viewer
	NP_001414403	(Get FASTA)	NCBI Sequence Viewer
	XP_006227966	(Get FASTA)	NCBI Sequence Viewer
	XP_038955578	(Get FASTA)	NCBI Sequence Viewer
	XP_063138773	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000060330
	ENSRNOP00000060330.2
	ENSRNOP00000111842
	ENSRNOP00000111842.1

RefSeq Acc Id:

XP_006227966 ⟸ XM_006227904

- Peptide Label:

isoform X3

- Sequence:

show sequence

MYRRSAEQIVELCRGTTSMEAPTDSRDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCL
FELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFSVLETPSQFRKLLF
SLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDRAFKAFLDARNPTKQHSSTLESYLIKPV
QRVLKYPLLLKELVSLTDHESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSG
TEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDIELTVFVFKRAVILVYKENCKLKKKLPSNS
RPAHNSADLDPFKFRWLIPISALQVRLGNTAGTENNSTWELIHTKSEIEGRPETIFQLCCSDSE
SKTSIVKVIRSILRENFRRHIKCELPMEKTCKDRLVPLKNRVPVSAKLASSRSLKVLRTSSSSE
WPSDPSKGNSLDSDECSLSSGTQSSGCPVAESRQDCKSTVLEKDAHEVLAEFPDGLIKESDILS
DEEEDFHHPLKQGSPTKDIELQFQRLRISEEPDMHSTGQQPPLTGPGEQPKLVRGHFCPIKRKA
NSTKRGRGTLLKAQTRHQSLDSHPETASIDLNLVLEREFSVQSLTSVVNEECFYETQSHGKS

hide sequence

Ensembl Acc Id:

ENSRNOP00000060330 ⟸ ENSRNOT00000065386

RefSeq Acc Id:	XP_038955578 ⟸ XM_039099650
- Peptide Label:	isoform X2

RefSeq Acc Id:	NP_001414403 ⟸ NM_001427474
- UniProtKB:	D3ZMS5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001414402 ⟸ NM_001427473
- UniProtKB:	D3ZMS5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138773 ⟸ XM_063282703
- Peptide Label:	isoform X1
- UniProtKB:	D3ZMS5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000111842 ⟸ ENSRNOT00000136443

Protein Domains

DH PDZ PH RBD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZMS5-F1-model_v2	AlphaFold	D3ZMS5	1-1714	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2324148	AgrOrtholog
BioCyc Gene	G2FUF-61665	BioCyc
Ensembl Genes	ENSRNOG00000016728	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000065386	ENTREZGENE
	ENSRNOT00000065386.5	UniProtKB/TrEMBL
	ENSRNOT00000136443	ENTREZGENE
	ENSRNOT00000136443.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.900.10	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
	2.30.42.10	UniProtKB/TrEMBL
	6.10.140.680	UniProtKB/TrEMBL
InterPro	DBL_dom_sf	UniProtKB/TrEMBL
	DH-domain	UniProtKB/TrEMBL
	GDS_CDC24_CS	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
	PH_Tiam1/2	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
	Raf-like_ras-bd	UniProtKB/TrEMBL
	Tiam1/Tiam2/Sif	UniProtKB/TrEMBL
	TIAM1_CC-Ex	UniProtKB/TrEMBL
NCBI Gene	100362710	ENTREZGENE
PANTHER	PTHR46001	UniProtKB/TrEMBL
	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM2	UniProtKB/TrEMBL
Pfam	PDZ	UniProtKB/TrEMBL
	PF00169	UniProtKB/TrEMBL
	PH_Tiam1	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
	Tiam_CC_Ex	UniProtKB/TrEMBL
PhenoGen	Tiam2	PhenoGen
PROSITE	DH_1	UniProtKB/TrEMBL
	DH_2	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/TrEMBL
	RBD	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016728	RatGTEx
SMART	PDZ	UniProtKB/TrEMBL
	RBD	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	DH-domain	UniProtKB/TrEMBL
	PDZ	UniProtKB/TrEMBL
	PH domain-like	UniProtKB/TrEMBL
UniProt	A0ABK0M0Z9_RAT	UniProtKB/TrEMBL
	D3ZMS5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-09-13	Tiam2	TIAM Rac1 associated GEF 2	Tiam2	T-cell lymphoma invasion and metastasis 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-08-30	Tiam2	T-cell lymphoma invasion and metastasis 2	LOC100362710	T-cell lymphoma invasion and metastasis 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-06	LOC100362710	T-cell lymphoma invasion and metastasis 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD