Cdkl5 (cyclin-dependent kinase-like 5)

Gene: Cdkl5 (cyclin-dependent kinase-like 5) Rattus norvegicus

Analyze

Symbol:

Cdkl5

Name:

cyclin-dependent kinase-like 5

RGD ID:

2324133

Description:

Enables small GTPase binding activity. Involved in neuron migration; positive regulation of dendritic spine development; and positive regulation of neurogenesis. Located in dendrite cytoplasm; dendritic growth cone; and perinuclear region of cytoplasm. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with ruffle membrane. Human ortholog(s) of this gene implicated in Rett syndrome; developmental and epileptic encephalopathy 2; intellectual disability; and visual epilepsy. Orthologous to human CDKL5 (cyclin dependent kinase like 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC100362725

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CDKL5 (cyclin dependent kinase like 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Cdkl5 (cyclin dependent kinase like 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cdkl5 (cyclin dependent kinase like 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CDKL5 (cyclin dependent kinase like 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CDKL5 (cyclin dependent kinase like 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cdkl5 (cyclin dependent kinase like 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CDKL5 (cyclin dependent kinase like 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CDKL5 (cyclin dependent kinase like 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cdkl5 (cyclin dependent kinase like 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CDKL5 (cyclin dependent kinase like 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cdkl5 (cyclin dependent kinase like 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cdkl5 (cyclin-dependent kinase-like 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cdkl5	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	37,566,320 - 37,796,766 (+)	NCBI		GRCr8
mRatBN7.2	X	33,757,605 - 33,988,075 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	33,821,257 - 33,986,582 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	35,536,396 - 35,773,204 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	35,599,258 - 35,771,711 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	35,864,921 - 36,102,409 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	55,033,499 - 55,228,646 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	34,451,035 - 34,675,154 (+)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Angelman syndrome (ISO)

autistic disorder (ISO)

Christianson syndrome (ISO)

Coffin-Lowry syndrome (ISO)

developmental and epileptic encephalopathy 1 (ISO)

developmental and epileptic encephalopathy 2 (ISO,ISS)

developmental and epileptic encephalopathy 4 (ISO)

Developmental Disabilities (ISO)

epilepsy (ISO)

focal epilepsy (ISO)

fundus dystrophy (ISO)

Generalized Epilepsy (ISO)

genetic disease (ISO)

glycogen storage disease IXA (ISO)

intellectual disability (ISO)

Nance-Horan syndrome (ISO)

Nervous System Malformations (ISO)

NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES (ISO)

Neurodevelopmental Disorders (ISO)

Nicolaides-Baraitser syndrome (ISO)

Pyruvate Dehydrogenase E1 Alpha Deficiency (ISO)

retinoschisis (ISO)

Rett syndrome (ISO)

Rett Syndrome, Atypical (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

visual epilepsy (ISO)

West syndrome (ISO)

X-linked juvenile retinoschisis 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

amphotericin B (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

clobetasol (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

dioxygen (ISO)

doxorubicin (ISO)

FR900359 (ISO)

gentamycin (EXP)

leflunomide (ISO)

methimazole (EXP)

nickel sulfate (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

potassium chromate (ISO)

potassium dichromate (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (EXP)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

modulation of chemical synaptic transmission (ISO)

neuron migration (IMP)

positive regulation of axon extension (IBA,IMP)

positive regulation of dendrite morphogenesis (IMP)

positive regulation of dendritic spine development (IMP)

protein localization to nucleus (ISO)

regulation of cilium assembly (ISO)

regulation of dendrite development (IBA,IMP)

regulation of postsynapse organization (ISO)

Cellular Component

centrosome (ISO)

ciliary basal body (ISO)

ciliary tip (ISO)

dendrite cytoplasm (IBA,IDA)

dendritic growth cone (IDA)

glutamatergic synapse (IDA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO)

perinuclear region of cytoplasm (IDA)

postsynaptic density, intracellular component (IDA)

ruffle membrane (IDA)

Molecular Function

ATP binding (ISO)

kinase activity (ISO)

protein binding (IPI,ISO)

protein kinase activity (IBA,ISO)

protein serine/threonine kinase activity (IEA)

small GTPase binding (IPI)

References

References - curated

#	Reference Title	Reference Citation
1.	Recurrent mutations in the CDKL5 gene: genotype-phenotype relationships.	Bahi-Buisson N, etal., Am J Med Genet A. 2012 Jul;158A(7):1612-9. doi: 10.1002/ajmg.a.35401. Epub 2012 Jun 7.
2.	CDKL5, a protein associated with rett syndrome, regulates neuronal morphogenesis via Rac1 signaling.	Chen Q, etal., J Neurosci. 2010 Sep 22;30(38):12777-86. doi: 10.1523/JNEUROSCI.1102-10.2010.
3.	Novel mutations in cyclin-dependent kinase-like 5 (CDKL5) gene in Indian cases of Rett syndrome.	Das DK, etal., Neuromolecular Med. 2013 Mar;15(1):218-25. doi: 10.1007/s12017-012-8212-z. Epub 2012 Dec 15.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Historic, clinical, and prognostic features of epileptic encephalopathies caused by CDKL5 mutations.	Moseley BD, etal., Pediatr Neurol. 2012 Feb;46(2):101-5. doi: 10.1016/j.pediatrneurol.2011.11.007.
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Neurodevelopmental and neurobehavioral characteristics in males and females with CDKL5 duplications.	Szafranski P, etal., Eur J Hum Genet. 2015 Jul;23(7):915-21. doi: 10.1038/ejhg.2014.217. Epub 2014 Oct 15.
10.	Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development.	Zhu YC, etal., Proc Natl Acad Sci U S A. 2013 May 28;110(22):9118-23. doi: 10.1073/pnas.1300003110. Epub 2013 May 13.

Additional References at PubMed

PMID:15917271	PMID:16935860	PMID:20211261	PMID:22922712	PMID:25931508	PMID:27940108	PMID:29420175	PMID:30288694	PMID:36759195

Genomics

Comparative Map Data

Cdkl5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	37,566,320 - 37,796,766 (+)	NCBI		GRCr8
mRatBN7.2	X	33,757,605 - 33,988,075 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	33,821,257 - 33,986,582 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	35,536,396 - 35,773,204 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	35,599,258 - 35,771,711 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	35,864,921 - 36,102,409 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	55,033,499 - 55,228,646 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	34,451,035 - 34,675,154 (+)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

CDKL5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	18,425,608 - 18,653,629 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	18,425,583 - 18,653,629 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	18,443,728 - 18,671,749 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	18,353,646 - 18,581,670 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	18,203,413 - 18,431,402	NCBI
Celera	X	22,563,823 - 22,791,841 (+)	NCBI		Celera
Cytogenetic Map	X	p22.13	NCBI
HuRef	X	16,199,185 - 16,425,423 (+)	NCBI		HuRef
CHM1_1	X	18,474,049 - 18,702,829 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	18,008,223 - 18,236,232 (+)	NCBI		T2T-CHM13v2.0

Cdkl5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	159,567,241 - 159,777,673 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	159,554,919 - 159,777,700 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	160,784,308 - 160,994,681 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	160,771,923 - 160,994,704 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	157,222,240 - 157,432,613 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
Celera	X	144,024,211 - 144,235,023 (-)	NCBI		Celera
Cytogenetic Map	X	F4	NCBI
cM Map	X	73.95	NCBI

Cdkl5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955586	809,386 - 997,485 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955586	791,886 - 997,713 (-)	NCBI	ChiLan1.0	ChiLan1.0

CDKL5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	20,222,401 - 20,431,439 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	20,225,793 - 20,434,831 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	11,047,357 - 11,261,172 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	18,412,018 - 18,638,735 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	18,492,329 - 18,638,735 (+)	Ensembl	panpan1.1		panPan2

CDKL5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	14,512,226 - 14,725,348 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	14,512,178 - 14,725,233 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	14,472,365 - 14,691,693 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	14,472,377 - 14,692,899 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	14,539,994 - 14,752,603 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	14,533,192 - 14,745,807 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	14,596,867 - 14,809,610 (+)	NCBI		UU_Cfam_GSD_1.0

Cdkl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	7,612,076 - 7,808,649 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936844	160,833 - 271,901 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936844	101,815 - 271,254 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDKL5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	14,952,225 - 15,078,855 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	14,858,826 - 15,096,969 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	16,199,743 - 16,304,073 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDKL5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	16,955,540 - 17,101,513 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666056	18,759,157 - 18,974,830 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cdkl5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624829	3,356,580 - 3,472,832 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624829	3,288,239 - 3,479,620 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cdkl5
770 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	92
Count of miRNA genes:	73
Interacting mature miRNAs:	77
Transcripts:	ENSRNOT00000005061, ENSRNOT00000072627
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
71116	Niddm16	Non-insulin dependent diabetes mellitus QTL 16	7.81		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	15297802	60297802	Rat
1598873	Memor2	Memory QTL 2	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	X	20990947	41052531	Rat
2290375	Gluco34	Glucose level QTL 34	2.75		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	20990947	41203591	Rat

Markers in Region

DXRat87

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	33,865,542 - 33,865,693 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	35,640,424 - 35,640,574	NCBI	Rnor6.0
Rnor_5.0	X	35,968,452 - 35,968,602	UniSTS	Rnor5.0
RGSC_v3.4	X	55,143,817 - 55,143,967	UniSTS	RGSC3.4
RGSC_v3.4	X	55,143,816 - 55,143,967	RGD	RGSC3.4
RGSC_v3.1	X	55,197,285 - 55,197,436	RGD
Celera	X	34,553,241 - 34,553,391	UniSTS
RH 3.4 Map	X	490.8	RGD
RH 3.4 Map	X	490.8	UniSTS
RH 2.0 Map	21	394.4	RGD
SHRSP x BN Map	X	13.77	RGD

DXGot31

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	33,971,379 - 33,971,534 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	35,757,676 - 35,757,830	NCBI	Rnor6.0
Rnor_5.0	X	36,085,492 - 36,085,646	UniSTS	Rnor5.0
RGSC_v3.4	X	55,250,372 - 55,250,527	RGD	RGSC3.4
RGSC_v3.4	X	55,250,373 - 55,250,527	UniSTS	RGSC3.4
RGSC_v3.1	X	55,303,841 - 55,303,996	RGD
Celera	X	34,658,491 - 34,658,645	UniSTS

AU048188

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	33,808,623 - 33,808,895 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	35,586,631 - 35,586,902	NCBI	Rnor6.0
Rnor_5.0	X	35,915,155 - 35,915,426	UniSTS	Rnor5.0
RGSC_v3.4	X	55,085,126 - 55,085,397	UniSTS	RGSC3.4
Celera	X	34,501,867 - 34,502,138	UniSTS

RH136752

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	33,969,877 - 33,970,038 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	35,756,174 - 35,756,334	NCBI	Rnor6.0
Rnor_5.0	X	36,083,990 - 36,084,150	UniSTS	Rnor5.0
RGSC_v3.4	X	55,248,871 - 55,249,031	UniSTS	RGSC3.4
Celera	X	34,656,989 - 34,657,149	UniSTS

RH137814

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	33,941,749 - 33,941,953 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	35,716,998 - 35,717,201	NCBI	Rnor6.0
Rnor_5.0	X	36,045,026 - 36,045,229	UniSTS	Rnor5.0
RGSC_v3.4	X	55,220,260 - 55,220,463	UniSTS	RGSC3.4
Celera	X	34,629,098 - 34,629,301	UniSTS
RH 3.4 Map	X	503.01	UniSTS

AI577388

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	33,959,355 - 33,959,465 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	35,745,469 - 35,745,578	NCBI	Rnor6.0
Rnor_5.0	X	36,073,285 - 36,073,394	UniSTS	Rnor5.0
RGSC_v3.4	X	55,238,356 - 55,238,465	UniSTS	RGSC3.4
Celera	X	34,646,626 - 34,646,735	UniSTS
RH 3.4 Map	X	490.3	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			2						40		9	10
Low	1	43	55	41	19	41	8	8	34	35	32	1	8
Below cutoff	2							3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001421533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039100454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039100455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279693	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	FJ807484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GU351881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000005061 ⟹ ENSRNOP00000005061

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	33,821,257 - 33,986,582 (+)	Ensembl
Rnor_6.0 Ensembl	X	35,599,291 - 35,771,711 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000072627 ⟹ ENSRNOP00000067316

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	33,821,257 - 33,986,582 (+)	Ensembl
Rnor_6.0 Ensembl	X	35,599,258 - 35,771,711 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095927 ⟹ ENSRNOP00000088060

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	33,821,257 - 33,960,174 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104285 ⟹ ENSRNOP00000078764

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	33,821,290 - 33,986,582 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107431 ⟹ ENSRNOP00000082790

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	33,821,257 - 33,960,174 (+)	Ensembl

RefSeq Acc Id:

NM_001421533 ⟹ NP_001408462

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	37,566,378 - 37,765,738 (+)	NCBI
mRatBN7.2	X	33,757,663 - 33,957,044 (+)	NCBI

RefSeq Acc Id:

XM_017602290 ⟹ XP_017457779

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	37,566,320 - 37,765,738 (+)	NCBI
mRatBN7.2	X	33,757,605 - 33,957,044 (+)	NCBI
Rnor_6.0	X	35,536,396 - 35,725,432 (+)	NCBI

Sequence:

show sequence

AGGTTTCGATTACTTGTCGCTACCGCTAGGGAGAAGGTAAAGCGGTGACGGCGGCCGCCGGAGT
GGAGGCTTCCCCGGTAGAGGTGGGGGACTCAGTAGGGGACTCATTTAATACTTCACAGTTGAAC
AAATGTATGAACGTTCCTTGCCAACCATTGAGAATTTCTTCGTTGGGACATTTTTTTCCTGCAT
ACTGAATAACTGGTTTAGAAGTCCCTTTTTTGGTGCCATGTTCTGTGGCTTGAATCAAAAGAGG
AGTTTGTCTTCATGAAGATTCCTAACATTGGTAATGTGATGAATAAATTTGAGATCCTTGGGGT
TGTTGGTGAAGGAGCCTATGGAGTTGTACTTAAATGCAGACACAAGGAAACACATGAAATTGTG
GCAATCAAGAAATTCAAGGACAGTGAAGAAAATGAAGAAGTCAAGGAGACGACTTTACGAGAGC
TTAAAATGCTTCGCACTCTCAAGCAGGAAAACATTGTGGAGCTGAAGGAAGCTTTTCGTCGGAG
AGGAAAACTATACCTGGTGTTTGAATATGTTGAGAAAAATATGCTTGAATTGCTGGAAGAGATG
CCAAACGGAGTTCCACCTGAAAAGGTTAAAAGCTATATCTACCAACTAATCAAAGCCATCCACT
GGTGCCACAAGAACGACATTGTCCACAGAGATATAAAGCCTGAAAATCTCTTAATCAGCCACAA
TGATGTCCTGAAACTGTGTGACTTTGGTTTTGCTCGGAATCTCTCAGAAGGAAACAATGCTAAT
TACACAGAATACGTGGCTACTCGGTGGTACCGATCTCCAGAACTGCTACTTGGAGCCCCCTATG
GAAAGTCAGTGGACATGTGGTCAGTGGGCTGTATTCTTGGAGAGCTCAGTGATGGACAGCCCTT
ATTTCCTGGGGAAAGTGAAATTGACCAACTCTTTACTATTCAGAAGGTGCTAGGACCACTTCCG
TCTGAGCAGATGAAGCTCTTCTACAGTAATCCTCGTTTCCATGGGCTCCGGTTTCCAGCTGTTA
ACCATCCTCAGTCATTAGAGAGACGATACCTTGGAATTTTAAATAGTGTTTTACTTGACCTAAT
GAAGAATTTACTGAAGTTGGACCCAGCTGACAGATACTTGACGGAGCAGTGTTTGAATCACCCT
ACATTTCAAACTCAGAGACTTTTGGACCGGTCTCCTTCAAGGTCAACAAAAAGGAAGCCTTACC
ATGTGGAAAGCAGCACACTGTCTAATAGAAGCCAATCCACCAAGGGTGGTGCTTTACAGACTCA
TCACAGATCCAACAGCAAGGACATTCAGAACTTAAGTGTGGGTCTGCCCAGAGCTGAGGAAGGC
CTGCCTGCAAATGAAAGCTTCCTAAATGGAAACCTTGCTGGAGCAACTCTCAGTCCAATGCACA
CCAAAACGTACCAAGCAAGTACCCAGCCTGGGTCTTCCAGCAAAGATCTCACAAACAACAATAT
ACCGCACCTTCTCAGTCCAAAAGAAGCCAAGTCCAAAACAGAGTTTGACTTCAATATTGACCCA
AAGCCTTCAGAAGGTCCAGGCACAAAGTACCTCAAGTCCAGCACCAGATCTCAACAGAACAGAC
ACTCATTCATGGAAAGTTCCCAGAGCAAAGCTGGGACACTGCAGCCTAGTGAGAAGCAGAGTCG
GCACAGCTATATTGACACCATCCCCCAGTCTTCCAGGAGTCCATCCTACAGGACAAAGGCCAAA
AGCCATGGGGCTTTGAGTGACTCCAAGTCTGTGAGCAACCTTTCAGAAGCCAGAGCCCAAATCA
CAGAGACTAATACCAGTAGATATTTCCCATCCAGTTGTTTGGACTTGAACTCTCCCACCAGCCC
AACACCCACCAGGCACACTGATACGAGAACTTTGCTCAGCCCTTCCGGGAGAAATAATCGAAAT
GAGGGCACTCTGGACTCCCGGCGAACCACCACCAGACACTCAAAAACCATGGAAGAGTTGAAGC
TGCCTGAACACATGGATAGCAGCCATTCACATTCGCTGTCTGCACCTCATGAATCATTTTCTTA
TGGGCTAGGCTATACCAGCCCCTTCTCCTCTCAACAACGTCCTCACAGGCATTCCATGTATGTG
ACCCGGGACAAAGTGAGAGCTAAAGGCATTGACGGAAGCTTGAGCATAGGGCAAGGGATGGCAG
CCAGAGCCAACAGCTTGCAGCTGTTATCACCCCAGCCTGGAGAACAGCTTCCTCCAGAAATGAC
TGTGGCAAGACCTTCTGTAAAAGAGTCCTCCCGAGAAGGCACCTCTTCGTTCCACACCCGTCAG
AAATCTGAGGGTGGAGTATACCATGACCCACACTCTGACGACGGCACGGCTCCCAAAGAAAATC
GGCATCTGTACAATGATCCTGTCCCAAGGAGAGTTGGTAGCTTTTATAGAGTGCCATCTCCACG
ACCAGACAATTCTTTCCATGAAAATAATGTGTCCACTCGAGTTTCTTCTCTGCCATCGGATAGT
AGTTCTGGCACAAATCATTCAAAAAGACAACCAGGATTTGATCCGTGGAAAAGTCCTGAAAACA
TTAGTCATTCCGATCAACTCAAAGAAAAGGAGAAGCAAGGCTTTTTCAGGTCAATGAAAAAGAA
AAAGAAGAAAACTCAAACAACAGACTCCACCAACGGGGAGAATCCAAGCATCAAGAAATCCCTC
TTCCCTCTTTTTAATTCAAAGAACCATTTAAAGCATAGTTCTTCTTTGAAAAAGCTTCCTGTAG
TCACTCCACCCATGGTGCCCAACACTGATGGTCCTGATTTATTGACCTTACAGAAAGCCATTCA
TTCTTCTAGCACTGCAAGCAGCAGACCAAAGGAGTGGCGACCTGAAAAGCTTTCAGATCTACAG
ACCCAGAGCCAACCACTAAAATCCCTTCGCAAGCTGCTGCATCTTTCTTCGTCAACCAATCACC
CGGCTTCTTCAGATCCTCGGTTCCAGCCGTTAACAGCTCAACAAGCCAAAAATTCCTTCTCAGA
AATTCGGATTCACCCTCTGAGTCAGGCCTCTGGTGGGAGCAGCAACATCCGGCAGGAGCCTACA
CCAAAAGGCAGACCAGCCCTTCAGCTGCCAGGTCAGATGGATCCTGGTTGGCACGTGTCCTCTG
TGACCAGGAGTGCCACAGAGGGGCCTTCCTATTCTGAACAGCTAGGTGCCAAGAGTGGGCCAAA
CGGGCACCCTTATAACAGAACAAATCGCTCACGAATGCCAAATCTGAATGATTTAAAAGAAACA
GCCTTGTAATTTATGCTGGGATGGAGTGTGTGTGGGGGGTGGGGTGGGGGTGGGGAG

hide sequence

RefSeq Acc Id:

XM_039100454 ⟹ XP_038956382

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	37,579,479 - 37,765,738 (+)	NCBI
mRatBN7.2	X	33,770,763 - 33,957,044 (+)	NCBI

RefSeq Acc Id:

XM_039100455 ⟹ XP_038956383

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	37,566,320 - 37,796,766 (+)	NCBI
mRatBN7.2	X	33,757,605 - 33,988,075 (+)	NCBI

RefSeq Acc Id:

XM_063279693 ⟹ XP_063135763

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	37,583,974 - 37,796,766 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001408462	(Get FASTA)	NCBI Sequence Viewer
	XP_017457779	(Get FASTA)	NCBI Sequence Viewer
	XP_038956382	(Get FASTA)	NCBI Sequence Viewer
	XP_038956383	(Get FASTA)	NCBI Sequence Viewer
	XP_063135763	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ACY73182	(Get FASTA)	NCBI Sequence Viewer
	ADK77880	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005061.6
	ENSRNOP00000067316.1
	ENSRNOP00000078764.1
	ENSRNOP00000082790
	ENSRNOP00000082790.1
	ENSRNOP00000088060.1

RefSeq Acc Id:	XP_017457779 ⟸ XM_017602290
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZVL4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKML RTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSV DMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQ SLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSTKRKPYHVES STLSNRSQSTKGGALQTHHRSNSKDIQNLSVGLPRAEEGLPANESFLNGNLAGATLSPMHTKTY QASTQPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSSTRSQQNRHSFM ESSQSKAGTLQPSEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQITETN TSRYFPSSCLDLNSPTSPTPTRHTDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEH MDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGIDGSLSIGQGMAARAN SLQLLSPQPGEQLPPEMTVARPSVKESSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLY NDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSDSSSGTNHSKRQPGFDPWKSPENISHS DQLKEKEKQGFFRSMKKKKKKTQTTDSTNGENPSIKKSLFPLFNSKNHLKHSSSLKKLPVVTPP MVPNTDGPDLLTLQKAIHSSSTASSRPKEWRPEKLSDLQTQSQPLKSLRKLLHLSSSTNHPASS DPRFQPLTAQQAKNSFSEIRIHPLSQASGGSSNIRQEPTPKGRPALQLPGQMDPGWHVSSVTRS ATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL hide sequence

RefSeq Acc Id:

ENSRNOP00000067316 ⟸ ENSRNOT00000072627

RefSeq Acc Id:

ENSRNOP00000005061 ⟸ ENSRNOT00000005061

RefSeq Acc Id:	XP_038956383 ⟸ XM_039100455
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZVL4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038956382 ⟸ XM_039100454
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZVL4 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000082790 ⟸ ENSRNOT00000107431

RefSeq Acc Id:

ENSRNOP00000078764 ⟸ ENSRNOT00000104285

RefSeq Acc Id:

ENSRNOP00000088060 ⟸ ENSRNOT00000095927

RefSeq Acc Id:	NP_001408462 ⟸ NM_001421533
- UniProtKB:	A0A8I6A725 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063135763 ⟸ XM_063279693
- Peptide Label:	isoform X3

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZG85-F1-model_v2	AlphaFold	D3ZG85	1-934	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2324133	AgrOrtholog
BioCyc Gene	G2FUF-2511	BioCyc
Ensembl Genes	ENSRNOG00000003742	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005061.7	UniProtKB/TrEMBL
	ENSRNOT00000072627.4	UniProtKB/TrEMBL
	ENSRNOT00000095927.1	UniProtKB/TrEMBL
	ENSRNOT00000104285.1	UniProtKB/TrEMBL
	ENSRNOT00000107431	ENTREZGENE
	ENSRNOT00000107431.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_prot_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	100362725	ENTREZGENE
PANTHER	CELL DIVISION PROTEIN KINASE	UniProtKB/TrEMBL
	CYCLIN-DEPENDENT KINASE-LIKE 5	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PhenoGen	Cdkl5	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003742	RatGTEx
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZVL4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A725	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G3S6_RAT	UniProtKB/TrEMBL
	D3ZG85_RAT	UniProtKB/TrEMBL
	E2E1S0_RAT	UniProtKB/TrEMBL
UniProt Secondary	E1U7Q0	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-08-30	Cdkl5	cyclin-dependent kinase-like 5	LOC100362725	cyclin-dependent kinase-like 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-06	LOC100362725	cyclin-dependent kinase-like 5			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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