Phf6 (PHD finger protein 6) - Rat Genome Database

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Gene: Phf6 (PHD finger protein 6) Rattus norvegicus
Analyze
Symbol: Phf6
Name: PHD finger protein 6
RGD ID: 2323526
Description: Predicted to enable several functions, including histone binding activity; histone deacetylase binding activity; and scaffold protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Borjeson-Forssman-Lehmann syndrome; acute myeloid leukemia; and congestive heart failure. Orthologous to human PHF6 (PHD finger protein 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; thioacetamide; (-)-demecolcine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100359714; LOC103690175
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,576,214 - 137,619,297 (+)NCBIGRCr8
mRatBN7.2X132,656,658 - 132,699,720 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX132,656,672 - 132,699,127 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,816,738 - 134,859,802 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X138,399,577 - 138,442,639 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X135,965,278 - 136,008,343 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X158,698,353 - 158,739,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,698,356 - 158,739,838 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,268,653 - 158,288,109 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X152,890,577 - 152,930,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X153,324,996 - 153,366,506 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X139,850,136 - 139,890,670NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Phf6Ratacute myeloid leukemia severityISOPHF6 (Homo sapiens)155260286DNA:mutations:multiple (human)RGD 
Phf6Ratcolorectal carcinoma  ISOPHF6 (Homo sapiens)150524297mRNA:increased expression:colorectal mucosa (human)RGD 
Phf6Ratcongestive heart failure disease_progressionISOPHF6 (Homo sapiens)155630627DNA:mutations: :RGD 
Phf6Rathepatocellular carcinoma  ISOPHF6 (Homo sapiens)155260288mRNA:increased expression:liver (human)RGD 
Phf6Rathepatocellular carcinoma exacerbatesISOPHF6 (Homo sapiens)155260308mRNA:increased expression:liver (human)RGD 
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Phf6Ratautistic disorder  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Phf6Ratautosomal hemophilia A  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: AUTOSOMAL HEMOPHILIA AClinVarPMID:31690835
Phf6RatBorjeson-Forssman-Lehmann syndrome  ISOPHF6 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12415272 more ...
Phf6RatBorjeson-Forssman-Lehmann syndrome  ISOPHF6 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12415272 more ...
Phf6RatDevelopmental Disabilities  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVar 
Phf6RatDevelopmental Disease  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:25741868
Phf6Ratfactor VIII deficiency  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Factor 8 deficiency and congenitalClinVarPMID:31690835
Phf6Ratgenetic disease  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:12415272 more ...
Phf6Rathereditary spastic paraplegia 4  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary spastic paraplegia 4ClinVarPMID:12415272 more ...
Phf6RatHirsutism  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: HirsutismClinVar 
Phf6RatHRPT-related hyperuricemia  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Partial hypoxanthine-guanine phosphoribosyltransferase deficiencyClinVarPMID:11018746 more ...
Phf6Ratintellectual disability  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868
Phf6Ratnephroblastoma  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Wilms tumor 1ClinVarPMID:10402475 more ...
Phf6Ratneuroblastoma  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: NeuroblastomaClinVarPMID:26822237
Phf6RatPulmonary Arterial Hypertension  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Pulmonary arterial hypertensionClinVarPMID:25741868
Phf6Ratsyndromic X-linked intellectual disability Lubs type  ISOPHF6 (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Phf6RatBorjeson-Forssman-Lehmann syndrome  ISOPHF6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Phf6RatT-cell acute lymphoblastic leukemia  ISOPHF6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20228800
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Phf6RatBorjeson-Forssman-Lehmann syndrome  ISSPhf6 (Mus musculus)13592920OMIM:301900MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Phf6RatBorjeson-Forssman-Lehmann syndrome  ISOPHF6 (Homo sapiens)7240710 OMIM 

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Phf6Rat(-)-demecolcine decreases expressionISOPHF6 (Homo sapiens)6480464Demecolcine results in decreased expression of PHF6 mRNACTDPMID:23649840
Phf6Rat1,2-dimethylhydrazine increases expressionISOPhf6 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of PHF6 mRNACTDPMID:22206623
Phf6Rat1,2-dimethylhydrazine multiple interactionsISOPhf6 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PHF6 mRNACTDPMID:22206623
Phf6Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOPHF6 (Homo sapiens)6480464Dihydrotestosterone results in increased expression of PHF6 mRNACTDPMID:29581250
Phf6Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOPhf6 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Phf6Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOPhf6 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Phf6Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPhf6 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PHF6 mRNACTDPMID:21570461
Phf6Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PHF6 mRNACTDPMID:33387578
Phf6Rat3,4-methylenedioxymethamphetamine increases expressionISOPhf6 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PHF6 mRNACTDPMID:20188158
Phf6Rat3,4-methylenedioxymethamphetamine decreases expressionISOPhf6 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PHF6 mRNACTDPMID:26251327
Phf6Rat4-hydroxyphenyl retinamide increases expressionISOPhf6 (Mus musculus)6480464Fenretinide results in increased expression of PHF6 mRNACTDPMID:28973697
Phf6Ratacetohydrazide decreases expressionISOPhf6 (Mus musculus)6480464acetylhydrazine results in decreased expression of PHF6 mRNACTDPMID:15282401
Phf6Rataflatoxin B1 decreases methylationISOPHF6 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of PHF6 intronCTDPMID:30157460
Phf6Ratall-trans-retinoic acid decreases expressionISOPHF6 (Homo sapiens)6480464Tretinoin results in decreased expression of PHF6 mRNACTDPMID:33167477
Phf6Ratarsenite(3-) multiple interactionsISOPHF6 (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to PHF6 mRNA]CTDPMID:32406909
Phf6Ratbenzo[a]pyrene increases expressionISOPhf6 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of PHF6 mRNACTDPMID:22228805
Phf6Ratbenzo[a]pyrene affects methylationISOPHF6 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of PHF6 5' UTR more ...CTDPMID:27901495
Phf6Ratbisphenol A decreases expressionISOPHF6 (Homo sapiens)6480464bisphenol A results in decreased expression of PHF6 proteinCTDPMID:37567409
Phf6Ratcadmium dichloride increases expressionISOPHF6 (Homo sapiens)6480464Cadmium Chloride results in increased expression of PHF6 mRNACTDPMID:26472689
Phf6Ratcadmium dichloride decreases expressionISOPHF6 (Homo sapiens)6480464Cadmium Chloride results in decreased expression of PHF6 mRNACTDPMID:38568856

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Biological Process

  
Object Symbol
Species
Term
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Reference
Notes
Source
Original Reference(s)
Phf6Ratbiological_process  ND 159840709/2022:no relevant rat dataRGD 
Phf6Ratblastocyst hatching acts_upstream_of_or_withinISOPhf6 (Mus musculus)1624291 PMID:27869233RGDPMID:27869233
Phf6Ratnegative regulation of transcription by RNA polymerase II involved_inISOPHF6 (Homo sapiens)1624291 PMID:24554700RGDPMID:24554700

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Phf6Ratnucleolus located_inISOPHF6 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Phf6Ratnucleolus located_inISOPHF6 (Homo sapiens)1624291 PMID:22720776RGDPMID:22720776
Phf6Ratnucleoplasm located_inISOPHF6 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Phf6Ratnucleoplasm located_inISOPHF6 (Homo sapiens)1624291 PMID:22720776RGDPMID:22720776
Phf6Ratnucleus is_active_inIBAFB:FBgn0031091 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Phf6Ratnucleus located_inISOPhf6 (Mus musculus)1624291 PMID:17698420RGDPMID:17698420

Molecular Function
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality. Kiefer KC, etal., ESC Heart Fail. 2021 Jun;8(3):1873-1884. doi: 10.1002/ehf2.13297. Epub 2021 Mar 28.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. Slattery ML, etal., Genes Chromosomes Cancer. 2017 Nov;56(11):769-787. doi: 10.1002/gcc.22481. Epub 2017 Jul 30.
8. Downregulation of PHF6 Inhibits Cell Proliferation and Migration in Hepatocellular Carcinoma. Yu Q, etal., Cancer Biother Radiopharm. 2019 May;34(4):245-251. doi: 10.1089/cbr.2018.2671. Epub 2019 Mar 19.
9. MicroRNA-214 suppresses cell proliferation and migration and cell metabolism by targeting PDK2 and PHF6 in hepatocellular carcinoma. Yu Q, etal., Cell Biol Int. 2019 Jul 22. doi: 10.1002/cbin.11207.
10. High expression of microRNA-500 is associated with poor prognosis in patients with acute myeloid leukemia receiving allogeneic hematopoietic stem cell transplantation. Zhang G, etal., Oncol Lett. 2019 Jun;17(6):5815-5820. doi: 10.3892/ol.2019.10250. Epub 2019 Apr 15.
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PMID:17698420   PMID:22658674   PMID:22720776   PMID:24554700   PMID:27869233  



Phf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,576,214 - 137,619,297 (+)NCBIGRCr8
mRatBN7.2X132,656,658 - 132,699,720 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX132,656,672 - 132,699,127 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,816,738 - 134,859,802 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X138,399,577 - 138,442,639 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X135,965,278 - 136,008,343 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X158,698,353 - 158,739,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,698,356 - 158,739,838 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,268,653 - 158,288,109 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X152,890,577 - 152,930,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X153,324,996 - 153,366,506 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X139,850,136 - 139,890,670NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapXq36NCBI
PHF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X134,373,312 - 134,428,790 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX134,373,288 - 134,428,791 (+)EnsemblGRCh38hg38GRCh38
GRCh37X133,507,342 - 133,562,820 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X133,335,008 - 133,390,488 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X133,232,861 - 133,288,339NCBI
CeleraX133,894,183 - 133,949,652 (+)NCBICelera
Cytogenetic MapXq26.2NCBI
HuRefX122,905,958 - 122,961,468 (+)NCBIHuRef
CHM1_1X133,419,127 - 133,474,595 (+)NCBICHM1_1
T2T-CHM13v2.0X132,698,463 - 132,753,940 (+)NCBIT2T-CHM13v2.0
Phf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X52,001,091 - 52,045,838 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX52,001,143 - 52,045,820 (+)EnsemblGRCm39 Ensembl
GRCm38X52,912,214 - 52,956,961 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX52,912,266 - 52,956,943 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X50,265,443 - 50,310,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X49,156,893 - 49,201,570 (+)NCBIMGSCv36mm8
CeleraX40,338,044 - 40,382,845 (+)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX29.28NCBI
Phf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955473527,005 - 586,627 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955473527,005 - 586,589 (-)NCBIChiLan1.0ChiLan1.0
PHF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X133,808,035 - 133,864,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X133,811,627 - 133,867,947 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X123,521,956 - 123,578,256 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X133,822,260 - 133,877,452 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX133,822,260 - 133,873,990 (+)Ensemblpanpan1.1panPan2
PHF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X105,044,232 - 105,093,663 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX105,043,556 - 105,091,795 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX91,154,612 - 91,205,687 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X106,904,096 - 106,955,183 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX106,904,172 - 106,955,712 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X104,317,141 - 104,368,210 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X106,183,139 - 106,234,213 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X105,974,494 - 106,025,566 (+)NCBIUU_Cfam_GSD_1.0
Phf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X103,189,381 - 103,240,634 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936691716,697 - 768,016 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936691716,723 - 767,960 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX110,249,010 - 110,303,017 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X110,249,010 - 110,311,503 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X126,334,888 - 126,353,998 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PHF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X109,531,700 - 109,595,136 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX109,531,726 - 109,593,854 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606547,136,942 - 47,193,137 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479714,081,302 - 14,128,487 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479714,081,381 - 14,140,180 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Phf6
15 total Variants

The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

DXGot147  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X132,678,804 - 132,678,960 (-)MAPPERmRatBN7.2
Rnor_6.0X158,286,030 - 158,286,183NCBIRnor6.0
Rnor_6.0X158,719,113 - 158,719,266NCBIRnor6.0
Rnor_5.0X153,345,756 - 153,345,909UniSTSRnor5.0
Rnor_5.0X152,911,337 - 152,911,490UniSTSRnor5.0
RGSC_v3.4X139,872,279 - 139,872,432UniSTSRGSC3.4
Cytogenetic MapX RGD
AW549906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X132,699,109 - 132,699,250 (-)MAPPERmRatBN7.2
Rnor_6.0X158,265,740 - 158,265,880NCBIRnor6.0
Rnor_6.0X158,698,823 - 158,698,963NCBIRnor6.0
Rnor_5.0X153,325,466 - 153,325,606UniSTSRnor5.0
Rnor_5.0X152,891,047 - 152,891,187UniSTSRnor5.0
RGSC_v3.4X139,892,582 - 139,892,722UniSTSRGSC3.4
RH139307  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X132,685,648 - 132,685,847 (-)MAPPERmRatBN7.2
Rnor_6.0X158,279,143 - 158,279,341NCBIRnor6.0
Rnor_6.0X158,712,226 - 158,712,424NCBIRnor6.0
Rnor_5.0X153,338,869 - 153,339,067UniSTSRnor5.0
Rnor_5.0X152,904,450 - 152,904,648UniSTSRnor5.0
RGSC_v3.4X139,879,121 - 139,879,319UniSTSRGSC3.4




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 11 43 82 57 60 41 19 41 160 73 74 35 41 19



Ensembl Acc Id: ENSRNOT00000003091   ⟹   ENSRNOP00000003091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX132,656,716 - 132,699,127 (+)Ensembl
Rnor_6.0 EnsemblX158,698,356 - 158,739,838 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000072527   ⟹   ENSRNOP00000064143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX132,656,672 - 132,699,127 (+)Ensembl
Rnor_6.0 EnsemblX158,268,653 - 158,288,109 (-)Ensembl
RefSeq Acc Id: NM_001402228   ⟹   NP_001389157
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,576,240 - 137,619,297 (+)NCBI
mRatBN7.2X132,656,659 - 132,699,720 (+)NCBI
RefSeq Acc Id: XM_017602432   ⟹   XP_017457921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,576,254 - 137,619,297 (+)NCBI
mRatBN7.2X132,656,658 - 132,699,720 (+)NCBI
Rnor_6.0X158,698,353 - 158,739,854 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039100498   ⟹   XP_038956426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,576,214 - 137,619,297 (+)NCBI
mRatBN7.2X132,656,658 - 132,699,720 (+)NCBI
Protein RefSeqs NP_001389157 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457921 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956426 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL84495 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003091.3
  ENSRNOP00000064143.2
RefSeq Acc Id: XP_017457921   ⟸   XM_017602432
- Peptide Label: isoform X2
- UniProtKB: M0R464 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038956426   ⟸   XM_039100498
- Peptide Label: isoform X1
- UniProtKB: D3ZQV8 (UniProtKB/TrEMBL),   A6KUK6 (UniProtKB/TrEMBL),   M0R464 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000003091   ⟸   ENSRNOT00000003091
Ensembl Acc Id: ENSRNOP00000064143   ⟸   ENSRNOT00000072527
RefSeq Acc Id: NP_001389157   ⟸   NM_001402228
- UniProtKB: D3ZQV8 (UniProtKB/TrEMBL),   A6KUK6 (UniProtKB/TrEMBL),   M0R464 (UniProtKB/TrEMBL)
PHD-type

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQV8-F1-model_v2 AlphaFold D3ZQV8 1-364 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13702072
Promoter ID:EPDNEW_R12590
Type:multiple initiation site
Name:LOC103690175_1
Description:PHD finger protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X158,739,815 - 158,739,875EPDNEW


1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-1008 BioCyc
Ensembl Genes ENSRNOG00000002276 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000048650 Ensembl
Ensembl Transcript ENSRNOT00000003091.6 UniProtKB/TrEMBL
  ENSRNOT00000072527.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro EPHD UniProtKB/TrEMBL
  PHD-type_Zinc_Finger UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene 100359714 ENTREZGENE
PANTHER PHD FINGER PROTEIN UniProtKB/TrEMBL
  PHD FINGER PROTEIN 6 UniProtKB/TrEMBL
Pfam zf-HC5HC2H UniProtKB/TrEMBL
PhenoGen Phf6 PhenoGen
PROSITE EPHD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002276 RatGTEx
  ENSRNOG00000048650 RatGTEx
SMART PHD UniProtKB/TrEMBL
UniProt A6KUK6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQV8 ENTREZGENE, UniProtKB/TrEMBL
  M0R464 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Phf6  PHD finger protein 6  LOC103690175  PHD finger protein 6  Data merged from RGD:9471618 737654 PROVISIONAL
2014-08-25 LOC103690175  PHD finger protein 6      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-24 Phf6  PHD finger protein 6  LOC100359714  PHD finger protein 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100359714  PHD finger protein 6      Symbol and Name status set to provisional 70820 PROVISIONAL