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Gene: Zfp457 (zinc finger protein 457) Rattus norvegicus

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Symbol:

Zfp457

Name:

zinc finger protein 457

RGD ID:

2322273

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF845 (zinc finger protein 845); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine (ortholog); arsane (ortholog); arsenic atom (ortholog).

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC100360380; zinc finger protein 457-like; zinc finger protein 728-like

RGD Orthologs

Human

Mouse

Bonobo

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ZNF845 (zinc finger protein 845)	HGNC	Ensembl, OrthoDB
Mus musculus (house mouse):	Zfp457 (zinc finger protein 457)	RGD	RGD
Pan paniscus (bonobo/pygmy chimpanzee):	ZNF850 (zinc finger protein 850)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	USE1 (unconventional SNARE in the ER 1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Zfp595 (zinc finger protein 595)	Alliance	DIOPT (OMA\|OrthoFinder\|SonicParanoid)
Mus musculus (house mouse):	Zfp759 (zinc finger protein 759)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Homo sapiens (human):	ZNF845 (zinc finger protein 845)	Alliance	DIOPT (Ensembl Compara\|HGNC)
Caenorhabditis elegans (roundworm):	Y55F3AM.14	Alliance	DIOPT (Hieranoid\|InParanoid\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ZAP1	Alliance	DIOPT (Hieranoid\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	86,333,770 - 86,350,883 (+)	NCBI		GRCr8
mRatBN7.2	2	84,625,360 - 84,642,535 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	84,608,705 - 84,684,942 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	2	86,880,806 - 86,922,446 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	86,891,092 - 87,038,833 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	106,552,765 - 106,594,127 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	86,105,917 - 86,109,927 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	80,011,859 - 80,030,069 (+)	NCBI		Celera
Celera	2	80,036,718 - 80,053,611 (+)	NCBI		Celera
Cytogenetic Map	2	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

Dibutyl phosphate (ISO)

folic acid (ISO)

fulvestrant (ISO)

ozone (ISO)

perfluorooctane-1-sulfonic acid (ISO)

temozolomide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

trovafloxacin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of transcription by RNA polymerase II (IEA)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

nucleus (IBA,IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IBA)

metal ion binding (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Zfp457
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	86,333,770 - 86,350,883 (+)	NCBI		GRCr8
mRatBN7.2	2	84,625,360 - 84,642,535 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	84,608,705 - 84,684,942 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	2	86,880,806 - 86,922,446 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	86,891,092 - 87,038,833 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	106,552,765 - 106,594,127 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	86,105,917 - 86,109,927 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	80,011,859 - 80,030,069 (+)	NCBI		Celera
Celera	2	80,036,718 - 80,053,611 (+)	NCBI		Celera
Cytogenetic Map	2	q23	NCBI

ZNF845
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	53,333,749 - 53,356,906 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	53,333,749 - 53,356,906 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	53,837,002 - 53,860,159 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	58,528,814 - 58,549,934 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	50,878,376 - 50,899,500 (+)	NCBI		Celera
Cytogenetic Map	19	q13.42	NCBI
HuRef	19	50,157,300 - 50,178,426 (+)	NCBI		HuRef
CHM1_1	19	53,838,576 - 53,859,701 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	56,413,246 - 56,436,414 (+)	NCBI		T2T-CHM13v2.0

Zfp457
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	67,440,514 - 67,454,476 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	67,436,202 - 67,454,549 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	67,288,137 - 67,306,412 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	67,288,138 - 67,306,485 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	67,393,386 - 67,407,348 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	67,791,547 - 67,805,509 (-)	NCBI		MGSCv36	mm8
Celera	13	70,003,822 - 70,015,596 (+)	NCBI		Celera
Cytogenetic Map	13	B3	NCBI
cM Map	13	34.54	NCBI

ZNF850
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	42,880,024 - 42,915,034 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	44,771,743 - 44,799,298 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	33,704,185 - 33,733,659 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	43,034,645 - 43,063,711 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

Variants

Variants in Zfp457
84 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	59846005	104846005	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	81018907	126018907	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	82345893	130923501	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
2293676	Bmd19	Bone mineral density QTL 19	10.7	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	43162366	111362592	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	18960362	228801039	Rat
2293682	Bmd24	Bone mineral density QTL 24	8.9	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	43162366	111362592	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	38573329	122609194	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	76539322	150540526	Rat
61465	Bp13	Blood pressure QTL 13	3.3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	76539322	102785628	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	40067944	102785628	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	59324377	103795077	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	74786664	94359546	Rat
7411551	Bw131	Body weight QTL 131	29.6	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	67942638	112942638	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	78665616	143657569	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	35134841	88029593	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	59324719	102755241	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	80270434	125270434	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	59324377	103795077	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	72532993	157142209	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	59134147	127460910	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	64366971	109366971	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	28484589	169504100	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	28484589	169504100	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	59324377	141596857	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat

Markers in Region

RH140885

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	84,642,240 - 84,642,421 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	86,922,152 - 86,922,332	NCBI	Rnor6.0
Rnor_5.0	2	106,593,833 - 106,594,013	UniSTS	Rnor5.0
RGSC_v3.4	2	86,113,071 - 86,113,251	UniSTS	RGSC3.4
Celera	2	80,053,317 - 80,053,497	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008760845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103573	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010064166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010064167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010064168	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000077162 ⟹ ENSRNOP00000075268

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	84,634,183 - 84,684,473 (+)	Ensembl
Rnor_6.0 Ensembl	2	86,891,092 - 86,918,780 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000081966 ⟹ ENSRNOP00000072605

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	84,608,705 - 84,639,007 (+)	Ensembl
Rnor_6.0 Ensembl	2	86,914,995 - 86,918,609 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083066 ⟹ ENSRNOP00000074610

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	84,608,705 - 84,639,097 (+)	Ensembl
Rnor_6.0 Ensembl	2	86,891,101 - 87,038,833 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085164 ⟹ ENSRNOP00000074964

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	84,608,705 - 84,684,473 (+)	Ensembl
Rnor_6.0 Ensembl	2	86,914,989 - 86,918,831 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103291 ⟹ ENSRNOP00000077354

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	84,625,648 - 84,684,038 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108131 ⟹ ENSRNOP00000088387

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	84,608,705 - 84,684,646 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110977 ⟹ ENSRNOP00000095849

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	84,635,087 - 84,684,942 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111251 ⟹ ENSRNOP00000084200

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	84,608,705 - 84,684,473 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112313 ⟹ ENSRNOP00000081426

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	84,634,525 - 84,684,038 (+)	Ensembl

RefSeq Acc Id:

XM_039103573 ⟹ XP_038959501

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	86,333,770 - 86,350,883 (+)	NCBI
mRatBN7.2	2	84,625,360 - 84,642,535 (+)	NCBI

RefSeq Acc Id:

XR_010064166

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	86,333,770 - 86,350,883 (+)	NCBI

RefSeq Acc Id:

XR_010064167

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	86,333,770 - 86,350,883 (+)	NCBI

RefSeq Acc Id:

XR_010064168

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	86,333,770 - 86,350,883 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_038959501	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072605.2
	ENSRNOP00000074610.2
	ENSRNOP00000074964.2
	ENSRNOP00000075268.2
	ENSRNOP00000077354.1
	ENSRNOP00000081426.1
	ENSRNOP00000084200.1
	ENSRNOP00000088387.1
	ENSRNOP00000095849.1

Ensembl Acc Id:

ENSRNOP00000075268 ⟸ ENSRNOT00000077162

Ensembl Acc Id:

ENSRNOP00000074964 ⟸ ENSRNOT00000085164

Ensembl Acc Id:

ENSRNOP00000074610 ⟸ ENSRNOT00000083066

Ensembl Acc Id:

ENSRNOP00000072605 ⟸ ENSRNOT00000081966

RefSeq Acc Id:

XP_038959501 ⟸ XM_039103573

Ensembl Acc Id:

ENSRNOP00000084200 ⟸ ENSRNOT00000111251

Ensembl Acc Id:

ENSRNOP00000081426 ⟸ ENSRNOT00000112313

Ensembl Acc Id:

ENSRNOP00000095849 ⟸ ENSRNOT00000110977

Ensembl Acc Id:

ENSRNOP00000088387 ⟸ ENSRNOT00000108131

Ensembl Acc Id:

ENSRNOP00000077354 ⟸ ENSRNOT00000103291

Protein Domains

C2H2-type KRAB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2KA56-F1-model_v2	AlphaFold	A0A0G2KA56	1-623	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2322273	AgrOrtholog
BioCyc Gene	G2FUF-53831	BioCyc
Ensembl Genes	ENSRNOG00000051606	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000077162.2	UniProtKB/TrEMBL
	ENSRNOT00000081966.2	UniProtKB/TrEMBL
	ENSRNOT00000083066.2	UniProtKB/TrEMBL
	ENSRNOT00000085164.2	UniProtKB/TrEMBL
	ENSRNOT00000103291.1	UniProtKB/TrEMBL
	ENSRNOT00000108131.1	UniProtKB/TrEMBL
	ENSRNOT00000110977.1	UniProtKB/TrEMBL
	ENSRNOT00000111251.1	UniProtKB/TrEMBL
	ENSRNOT00000112313.1	UniProtKB/TrEMBL
Gene3D-CATH	6.10.140.140	UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	KRAB	UniProtKB/TrEMBL
	KRAB_dom_sf	UniProtKB/TrEMBL
	Krueppel_C2H2_ZnF	UniProtKB/TrEMBL
	Snail/Krueppel_Znf	UniProtKB/TrEMBL
	Znf_C2H2-type	UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/TrEMBL
NCBI Gene	100360380	ENTREZGENE
PANTHER	COMBGAP, ISOFORM L-RELATED	UniProtKB/TrEMBL
	GENE 10130-RELATED	UniProtKB/TrEMBL
	KRAB DOMAIN C2H2 ZINC FINGER	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN 281-RELATED	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN 60-LIKE	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN 726	UniProtKB/TrEMBL
	ZNF44 PROTEIN	UniProtKB/TrEMBL
Pfam	KRAB	UniProtKB/TrEMBL
	zf-C2H2	UniProtKB/TrEMBL
	zf-C2H2_6	UniProtKB/TrEMBL
	zf-C2HC_2	UniProtKB/TrEMBL
PhenoGen	Zfp457	PhenoGen
PROSITE	KRAB	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000051606	RatGTEx
SMART	KRAB	UniProtKB/TrEMBL
	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF109640	UniProtKB/TrEMBL
	SSF57667	UniProtKB/TrEMBL
UniProt	A0A0G2K3E5_RAT	UniProtKB/TrEMBL
	A0A0G2K8H5_RAT	UniProtKB/TrEMBL
	A0A0G2K9E2_RAT	UniProtKB/TrEMBL
	A0A0G2KA56_RAT	UniProtKB/TrEMBL
	A0A8I5Y5Q2_RAT	UniProtKB/TrEMBL
	A0A8I5ZSI3_RAT	UniProtKB/TrEMBL
	A0A8I6A6E9_RAT	UniProtKB/TrEMBL
	A0A8I6AQK0_RAT	UniProtKB/TrEMBL
	A0A8I6GBK7_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-05-26	Zfp457	zinc finger protein 457	LOC100360380	zinc finger protein 457-like	Name and Symbol changed	629549	APPROVED
2010-05-06	LOC100360380	zinc finger protein 457-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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