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Gene: Hsf3 (heat shock transcription factor 3) Rattus norvegicus

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Symbol:

Hsf3

Name:

heat shock transcription factor 3

RGD ID:

2321468

Description:

Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular response to heat. Predicted to be located in cytoplasm. Predicted to be active in nucleus; INTERACTS WITH vinclozolin; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 1,2-dichloroethane (ortholog).

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

heat shock factor protein 3-like; LOC100360790

RGD Orthologs

Mouse

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	65,190,675 - 65,243,358 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	65,191,009 - 65,305,178 (-)	Ensembl				GRCr8
mRatBN7.2	X	61,181,376 - 61,233,724 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	61,182,298 - 61,295,686 (-)	Ensembl				mRatBN7.2
Rnor_6.0	X	65,412,241 - 65,468,572 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	65,411,161 - 65,559,785 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	66,246,594 - 66,298,797 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	83,910,544 - 83,962,333 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	61,595,020 - 61,648,286 (-)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

PCB138 (ISO)

titanium dioxide (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to heat (ISO)

DNA-templated transcription (IEA)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of DNA-templated transcription (IEA)

Cellular Component

cytoplasm (ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

chromatin DNA binding (ISO)

DNA binding (IEA)

DNA-binding transcription factor activity (IBA,IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

sequence-specific DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19864465

Genomics

Comparative Map Data

Hsf3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	65,190,675 - 65,243,358 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	65,191,009 - 65,305,178 (-)	Ensembl				GRCr8
mRatBN7.2	X	61,181,376 - 61,233,724 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	61,182,298 - 61,295,686 (-)	Ensembl				mRatBN7.2
Rnor_6.0	X	65,412,241 - 65,468,572 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	65,411,161 - 65,559,785 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	66,246,594 - 66,298,797 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	83,910,544 - 83,962,333 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	61,595,020 - 61,648,286 (-)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

Hsf3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	95,349,781 - 95,499,900 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	95,349,784 - 95,499,900 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	96,306,178 - 96,456,294 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	96,306,178 - 96,456,294 (-)	Ensembl			mm10	GRCm38
MGSCv37	X	93,502,206 - 93,552,579 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	92,508,897 - 92,659,013 (-)	NCBI		MGSCv36	mm8
Celera	X	83,312,283 - 83,357,256 (-)	NCBI		Celera
Cytogenetic Map	X	C3	NCBI
cM Map	X	42.69	NCBI

Variants

Variants in Hsf3
76 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	104
Count of miRNA genes:	87
Interacting mature miRNAs:	90
Transcripts:	ENSRNOT00000041963
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	45182909	117740458	Rat
70221	Bp56	Blood pressure QTL 56	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	61035856	67175160	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	44930883	89930883	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	9	17	40	32	34	10	32	10	2	119	64	1	26	24	64	24	6	6

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003752067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003754771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000041963

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	65,191,009 - 65,243,422 (-)	Ensembl
mRatBN7.2 Ensembl	X	61,182,298 - 61,233,827 (-)	Ensembl
Rnor_6.0 Ensembl	X	65,412,493 - 65,467,073 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076937

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	65,192,288 - 65,305,178 (-)	Ensembl
mRatBN7.2 Ensembl	X	61,182,792 - 61,295,686 (-)	Ensembl
Rnor_6.0 Ensembl	X	65,412,325 - 65,559,774 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076968

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	65,192,288 - 65,243,422 (-)	Ensembl
mRatBN7.2 Ensembl	X	61,182,792 - 61,233,827 (-)	Ensembl
Rnor_6.0 Ensembl	X	65,411,161 - 65,559,785 (-)	Ensembl

RefSeq Acc Id:

XM_003752067 ⟹ XP_003752115

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	65,190,675 - 65,243,358 (-)	NCBI
mRatBN7.2	X	61,181,376 - 61,233,724 (-)	NCBI
Rnor_6.0	X	65,412,241 - 65,468,572 (-)	NCBI
Rnor_5.0	X	66,246,594 - 66,298,797 (-)	NCBI

Sequence:

show sequence

TTTCTCTTTAAATATTTAAAACCTATAATCATTTTTCTTCCATATGCTCTTAAAAGTTACTCAA
AATAAAGTCAATGTAAAATATAAGTTTGATAGCCCCTGCTGTTGTTCATTGCTATTATAATAAA
TTTTATCTTCAATATGAAAAAGAATATAAAATTTCAAAGCTCAATTTAACCCAAGGAGATACAA
AAGATTTAAGAAGACAATTAGCATTCCAACCATTCACGATTTATGGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGCATTTTGATGTATGTGTATGTACAGGGAAATCAGGGTTCCTGTTGTTC
TTCAGAAGCCATTCACCTTGTTTATTGAGACAAGGCATCTCAGGCCTGGGGTTCACCAAATGAG
CTAAGGTGAATGACCAATTGGCCCCAGAACTACGCCTGCCCATGCTTCCTCAGCTCTGTGATTA
GAGGACAGGTACTACTTTCACCCTTTATGTGGCTGGTGGGGATTGAACTCAGATATGCATGCTT
GCATGGTAATCACTTTATGAGTGTGCTACCTGTCCGGCCCCTCACCAAACTATTTTCTAATGAA
AGAAGAAATAAGAAAACAACAAAAATTCTGTATGTTTTTAGGCAAACTTCTTTCTTCTTAGTTT
CCTTCCAACCTTATCATGAGAAAAAGTAAATGCTCTAATATTCTTGGAGTGTTTCACTTCACCA
AGATGCATGCCAAGCATTTTTACCAGCCATGTGTGGTGGCACACATCTTTAATCCCAAGACTAG
GGAAGCAGAGGCAGGTAGATTTCTGAGTTCAGGAACTGTCTGATACATAAATAATGAGTTCTGG
CCAGCTGAGGCTGTCTGGTGAGATTCTGGAGGAAAACAAAAACAAAGAGCTAAACAAACAAACA
AATCAAAACAAAAACCAAACACTTATCATCTTTCCAGAGACCAGGTCAAAACCACGCACTGCTG
TAAAGTTTTGCCTTGTAATAGTTACCAAGCTATAATCAACATCAAGTTAATTCAGTGATAACCT
AGTGCAGTGTCACACCACTTGGTTGCCTGGCCGTGACTGTGTAAAACTATTACTAAAGCACTTA
TAGCCAGAAAAGCAACAGAGAAAACATCAAAAGTAGTGCCCCCTACTGCTTTGCTCATGGCTCG
TTTCTCCTCACGGCTCGTTTTACCTCACGGCTCGTTTTACCTCACGACTCGTTTTACCTCACAC
TATAAAGGTGTTCCTCTACCGGAAGTTCCCCAATAGTCACGTGCCAGAGGCCCTGCAATCACGG
TACTATAGCCAGCCAATGAGAATTGTCCCCTTGGCAATTAAGACCCGCCCCCAAGCCAAGTTCT
GAGGGAGGGCCGGTTATCGGCTTTGTGTCACAGAAAGCTGCTGCTTGACCAGACGTGGTTTTGC
TCTCCAAGTGGTAATGGACTAGCTCAGGTTTTCCTTGCTGCCTACAATTGTCCAGGACTGACAT
TTTCTTGAGGCATTGACACCCTAAAACATGGAGCACTTCCGCAAGACAGTGGTTCCTCACTTTC
TCACTAAACTCTGGGTGTTAGTAGACGACGCTCTCTTGGACCATGTGATTCGCTGGAGCAAGGA
TGGTCACAGCTTTCAGATTGTGAATGAAGAGACCTTTGCCAAAGAAGTACTACCAAAATACTTC
AAACATAACAAAATAGCAAGCTTTGTTCGACAGCTCAACATGTATGGTTTCCGAAAAGTTATTG
CACTGCAGAGTGAAAAGACTAGCCTGGAGAATAAAATAACTATTGAATTTCAGCATCCACTTTT
CAAAAAGGGAGAAGCCTTCCTTCTTGCAAACATTAAGCGAAAGGTGCCAACGATAAAAACTGAA
GATGCCAACCTCTGCTCTGATGAGTATCAGAAAATTATGGCTGAAATACAAGAGTTCAAAGACA
TGCAGAAGAACATGGATACCAGATATGCACAAATGAAACAAGACTATTCCAATCTATGTCTTGA
AGTTACAAACCTAAGAAAGAAGTACTGTGAGCAACAACAACTGTTGACACAGGTACTCCATTTT
ATCTTGAATTTGATGAGTGAAAACCATACAGTACTAAAAAAGAGGAAAAGGTCATTATCATTCA
TATCTGAAGCCTCAGATTCTGAATTGGATCATCAGTATCTCCATATTCCAGACGACAAGAAAAA
GGAAGCTATGGAGATATTAAAAGATGGTTATGAACTTATTGAAGACAAATATAAAAGTCTCCTT
GATAGAGTCTTACCAATTTTAAAAGAACCCAAAAGTTTAATTTCATCTGCAGACCAGCCAAGTG
GGGATGATGGAGAACACGCTGAAGTGTCCGTTCAGGATAAACCTACAGATGAAGAGTCGCTGAC
CATTCAGTTGGATTTGACCATACCAGTTTTACCAGAACAAATAACTCAAGAATCCGTTGAACAA
GAACCTAAGGATATTTCTTTGGAATTAGATCTTTCTTCCCAGGATTCACCTTTGATGAAAGATG
ACTCAGACAATCTGTATAACAATATAATTAACAGGGATAAAATGAATGTGAATCATACTGAAGG
AAATTTGTTAGAGCTAAATTCGATACTATCTTGGAAGGGAGTGGATTATGATTCTGATCATTTC
AGTGAGAGTCTAAATCTGATGCAAAATGAAGAAGAGAAAAGTCCGCTTGATCCCAATGGGGGAA
AAGACAAACATATGGTACAATGCATGGAAAAACCAGAGCTTTTCCTTTTGGATGGGACACCAAT
ATGTGACTTTGGAGAAAATCTTCAAGATTATGACATACTTTTGGATGATCTGAAGGACCCCCCA
AATGTCATATCAGCTTTGTGCGACCATGATTATGTAACCTCCAATATTTCCACTCTGCAAGAAG
ATAATATTGAAAATGATGCTCCCCCATTTTGTATGGAAGCCAATGGGGAATCCAGTGTGTTCCC
TTTTCTCTTTCTTAACCCTGTTAGTAATATTTTTTGAAAAGCATATCGAAACCAATCTTCTGTT
ACAATTTATTTTAAGTCTCAGTGAATCGCATTTCCTCTGGGGAAACAGATATTCCATGGCTGCT
TGCTAGTGTATGCATCTTCATTTGGAAATATCTGTAACTTAAAGACTGTGTTCAAATTACATCC
TCCCAGTATCTAGGCAAGTTTTGGCAACTAGGATGAAATTCAGACCACAAAAAAACATAAGTAA
TATATCCAAATTTTAATATAATAAGAAGTTAAT

hide sequence

Protein Sequences


Protein RefSeqs	XP_003752115	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000079623.2
	ENSRNOP00000086201
	ENSRNOP00000086201.1
	ENSRNOP00000093307.1

RefSeq Acc Id:

XP_003752115 ⟸ XM_003752067

- UniProtKB:

A0A8I6A0S5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEHFRKTVVPHFLTKLWVLVDDALLDHVIRWSKDGHSFQIVNEETFAKEVLPKYFKHNKIASFV
RQLNMYGFRKVIALQSEKTSLENKITIEFQHPLFKKGEAFLLANIKRKVPTIKTEDANLCSDEY
QKIMAEIQEFKDMQKNMDTRYAQMKQDYSNLCLEVTNLRKKYCEQQQLLTQVLHFILNLMSENH
TVLKKRKRSLSFISEASDSELDHQYLHIPDDKKKEAMEILKDGYELIEDKYKSLLDRVLPILKE
PKSLISSADQPSGDDGEHAEVSVQDKPTDEESLTIQLDLTIPVLPEQITQESVEQEPKDISLEL
DLSSQDSPLMKDDSDNLYNNIINRDKMNVNHTEGNLLELNSILSWKGVDYDSDHFSESLNLMQN
EEEKSPLDPNGGKDKHMVQCMEKPELFLLDGTPICDFGENLQDYDILLDDLKDPPNVISALCDH
DYVTSNISTLQEDNIENDAPPFCMEANGESSVFPFLFLNPVSNIF

hide sequence

Protein Domains

HSF-type DNA-binding

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2321468	AgrOrtholog
BioCyc Gene	G2FUF-2183	BioCyc
Ensembl Genes	ENSRNOG00000021694	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000041963	ENTREZGENE
	ENSRNOT00000041963.5	UniProtKB/TrEMBL
	ENSRNOT00000076937.4	UniProtKB/TrEMBL
	ENSRNOT00000076968.4	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
InterPro	HSF_DNA-bd	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:100360790	UniProtKB/TrEMBL
NCBI Gene	100360790	ENTREZGENE
PANTHER	HEAT SHOCK FACTOR PROTEIN 3	UniProtKB/TrEMBL
	PTHR10015	UniProtKB/TrEMBL
Pfam	HSF_DNA-bind	UniProtKB/TrEMBL
PhenoGen	Hsf3	PhenoGen
PRINTS	HSFDOMAIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000021694	RatGTEx
SMART	HSF	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
UniProt	A0A8I5ZNG5_RAT	UniProtKB/TrEMBL
	A0A8I6A0S5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AFK6_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-05-05	Hsf3	heat shock transcription factor 3	LOC100360790	heat shock transcription factor 3	Symbol changed	629549	APPROVED
2010-05-06	LOC100360790	heat shock transcription factor 3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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