Gzmbl3 (Granzyme B-like 3) - Rat Genome Database

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Gene: Gzmbl3 (Granzyme B-like 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gzmbl3
Name: Granzyme B-like 3
RGD ID: 2320502
Description: Orthologous to human GZMB (granzyme B); INTERACTS WITH amphetamine; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: granzyme B; granzyme-like protein 1; granzyme-like protein I; granzyme-like protein III; LOC100361261; rCG23560-like; uncharacterized protein LOC100361261; uncharacterized protein LOC120766154
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81534,337,656 - 34,339,888 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1534,337,656 - 34,340,883 (-)EnsemblGRCr8
mRatBN7.21530,173,712 - 30,176,441 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1530,087,127 - 30,206,702 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1532,060,086 - 32,062,852 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01533,207,100 - 33,209,866 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,465,215 - 31,467,981 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01536,111,884 - 36,114,917 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1536,111,986 - 36,114,752 (-)Ensemblrn6Rnor6.0
Rnor_5.01539,971,750 - 39,974,679 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41534,900,532 - 34,903,394 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,782,316 - 29,785,343 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8150084   PMID:8508925   PMID:11790262  


Genomics

Variants

.
Variants in Gzmbl3
5 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:27
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000045209
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 2 10 10 38 47 22 24 22 2 76 38 4 5 11 25

Sequence


Ensembl Acc Id: ENSRNOT00000045209   ⟹   ENSRNOP00000043259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1536,111,986 - 36,114,752 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100039   ⟹   ENSRNOP00000082283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1530,087,127 - 30,206,702 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000129171   ⟹   ENSRNOP00000112576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1534,337,656 - 34,340,883 (-)Ensembl
RefSeq Acc Id: NM_001329880   ⟹   NP_001316809
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81534,337,656 - 34,339,888 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001316809 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000112576
  ENSRNOP00000112576.1
Ensembl Acc Id: ENSRNOP00000043259   ⟸   ENSRNOT00000045209
Ensembl Acc Id: ENSRNOP00000082283   ⟸   ENSRNOT00000100039
RefSeq Acc Id: NP_001316809   ⟸   NM_001329880
- UniProtKB: A6KH92 (UniProtKB/TrEMBL),   M0R4W8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112576   ⟸   ENSRNOT00000129171
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0A0MY24-F1-model_v2 AlphaFold A0A0A0MY24 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699709
Promoter ID:EPDNEW_R10232
Type:single initiation site
Name:Gzmbl3_1
Description:Granzyme B-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01536,114,816 - 36,114,876EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2320502 AgrOrtholog
BioCyc Gene G2FUF-13649 BioCyc
Ensembl Genes ENSRNOG00000046301 Ensembl
  ENSRNOG00000090964 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000129171 ENTREZGENE
  ENSRNOT00000129171.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1 UniProtKB/TrEMBL
  Peptidase_S1_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin-like_Pept_dom UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:120766154 UniProtKB/TrEMBL
NCBI Gene Gzmbl3 ENTREZGENE
PANTHER GRANZYME B UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Gzmbl3 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046301 RatGTEx
  ENSRNOG00000090964 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt A0ABK0LNJ0_RAT UniProtKB/TrEMBL
  A6KH92 ENTREZGENE, UniProtKB/TrEMBL
  M0R4W8 ENTREZGENE
  Q63224_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-22 Gzmbl3  Granzyme B-like 3  LOC100361261  rCG23560-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361261  rCG23560-like      Symbol and Name status set to provisional 70820 PROVISIONAL