Cox7b2 (cytochrome c oxidase subunit 7B2) - Rat Genome Database

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Gene: Cox7b2 (cytochrome c oxidase subunit 7B2) Rattus norvegicus
Analyze
Symbol: Cox7b2
Name: cytochrome c oxidase subunit 7B2
RGD ID: 2319120
Description: Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to act upstream of or within spermatogenesis. Predicted to be located in mitochondrial respirasome. Orthologous to human COX7B2 (cytochrome c oxidase subunit 7B2); INTERACTS WITH atrazine; decabromodiphenyl ether; glyphosate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytochrome c oxidase subunit 7B, mitochondrial; cytochrome c oxidase subunit VIIb2; LOC100361960; rCG57154-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81437,047,081 - 37,159,288 (+)NCBIGRCr8
mRatBN7.21436,693,120 - 36,805,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1436,693,105 - 36,805,523 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1437,037,834 - 37,150,080 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01438,342,592 - 38,454,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01436,830,931 - 36,943,258 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01439,256,685 - 39,368,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1439,368,530 - 39,368,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01439,068,181 - 39,180,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41439,267,491 - 39,267,844 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1435,915,908 - 36,028,099 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Cox7b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81437,047,081 - 37,159,288 (+)NCBIGRCr8
mRatBN7.21436,693,120 - 36,805,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1436,693,105 - 36,805,523 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1437,037,834 - 37,150,080 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01438,342,592 - 38,454,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01436,830,931 - 36,943,258 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01439,256,685 - 39,368,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1439,368,530 - 39,368,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01439,068,181 - 39,180,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41439,267,491 - 39,267,844 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1435,915,908 - 36,028,099 (+)NCBICelera
Cytogenetic Map14p11NCBI
COX7B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38446,734,827 - 46,909,245 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl446,734,827 - 46,909,245 (-)EnsemblGRCh38hg38GRCh38
GRCh37446,736,844 - 46,911,262 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36446,431,601 - 46,606,009 (-)NCBINCBI36Build 36hg18NCBI36
Build 34446,577,776 - 46,735,051NCBI
Celera447,185,698 - 47,295,989 (-)NCBICelera
Cytogenetic Map4p12NCBI
HuRef446,055,726 - 46,230,199 (-)NCBIHuRef
CHM1_1446,736,036 - 46,910,437 (-)NCBICHM1_1
T2T-CHM13v2.0446,701,990 - 46,876,576 (-)NCBIT2T-CHM13v2.0
Cox7b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39571,600,166 - 71,705,548 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl571,600,167 - 71,705,548 (-)EnsemblGRCm39 Ensembl
GRCm38571,442,823 - 71,548,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl571,442,824 - 71,548,205 (-)EnsemblGRCm38mm10GRCm38
MGSCv37571,834,062 - 71,939,444 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36571,721,959 - 71,827,340 (-)NCBIMGSCv36mm8
Celera568,711,387 - 68,812,814 (-)NCBICelera
Cytogenetic Map5C3.2NCBI
cM Map537.98NCBI
LOC102030009
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554431,650,087 - 1,768,318 (+)NCBIChiLan1.0ChiLan1.0
LOC100982199
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2380,960,773 - 81,131,252 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1481,222,393 - 81,392,846 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0475,248,761 - 75,419,165 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1485,979,748 - 86,149,145 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl486,148,780 - 86,149,025 (+)Ensemblpanpan1.1panPan2
COX7B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11342,739,856 - 42,831,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1342,739,976 - 42,740,221 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1342,689,694 - 42,829,675 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01343,345,645 - 43,485,296 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1343,345,765 - 43,346,010 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11343,023,052 - 43,163,061 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01343,084,951 - 43,224,540 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01343,438,753 - 43,578,514 (-)NCBIUU_Cfam_GSD_1.0
LOC101969650
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528533,209,089 - 33,347,627 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648212,950,597 - 12,951,029 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100517408
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl836,736,352 - 36,736,597 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1836,736,233 - 36,856,176 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2838,606,863 - 38,731,780 (-)NCBISscrofa10.2Sscrofa10.2susScr3
COX7B2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1273,353,319 - 3,503,408 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl273,503,043 - 3,503,285 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604749,570,372 - 49,570,775 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101719726
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476120,336,164 - 20,336,517 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cox7b2
591 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat

Markers in Region
RH138249  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21436,805,095 - 36,805,259 (+)MAPPERmRatBN7.2
Rnor_6.01439,368,659 - 39,368,822NCBIRnor6.0
Rnor_5.01439,180,134 - 39,180,297UniSTSRnor5.0
RGSC_v3.41439,267,620 - 39,267,783UniSTSRGSC3.4
Celera1436,027,872 - 36,028,035UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 7
Medium 11
Low 4 1 2 2 17 9 1 2
Below cutoff 1 4 9 5 6 5 2 3 22 6 3 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000084367   ⟹   ENSRNOP00000073886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1436,693,105 - 36,805,523 (+)Ensembl
Rnor_6.0 Ensembl1439,368,530 - 39,368,769 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100762   ⟹   ENSRNOP00000077116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1436,693,105 - 36,805,523 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107991   ⟹   ENSRNOP00000089141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1436,693,105 - 36,805,523 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108234   ⟹   ENSRNOP00000079507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1436,693,105 - 36,805,523 (+)Ensembl
RefSeq Acc Id: NM_001399572   ⟹   NP_001386501
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81437,047,081 - 37,159,288 (+)NCBI
mRatBN7.21436,693,120 - 36,805,323 (+)NCBI
RefSeq Acc Id: XM_063272794   ⟹   XP_063128864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81437,047,086 - 37,159,285 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386501 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128864 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90006 (Get FASTA)   NCBI Sequence Viewer  
  EDL90007 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073886
  ENSRNOP00000073886.1
  ENSRNOP00000077116.1
  ENSRNOP00000079507.1
  ENSRNOP00000089141.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000073886   ⟸   ENSRNOT00000084367
RefSeq Acc Id: ENSRNOP00000077116   ⟸   ENSRNOT00000100762
RefSeq Acc Id: ENSRNOP00000079507   ⟸   ENSRNOT00000108234
RefSeq Acc Id: ENSRNOP00000089141   ⟸   ENSRNOT00000107991
RefSeq Acc Id: NP_001386501   ⟸   NM_001399572
- UniProtKB: A0A0G2K6P0 (UniProtKB/TrEMBL),   A6JD85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128864   ⟸   XM_063272794
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K6P0-F1-model_v2 AlphaFold A0A0G2K6P0 1-80 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2319120 AgrOrtholog
BioCyc Gene G2FUF-15836 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
  PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
  PWY-7279 BioCyc
Ensembl Genes ENSRNOG00000057953 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084367 ENTREZGENE
  ENSRNOT00000084367.2 UniProtKB/TrEMBL
  ENSRNOT00000100762.1 UniProtKB/TrEMBL
  ENSRNOT00000107991.1 UniProtKB/TrEMBL
  ENSRNOT00000108234.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.51.10 UniProtKB/TrEMBL
InterPro Cyt_c_oxidase_suVIIB UniProtKB/TrEMBL
  Cyt_c_oxidase_suVIIB_dom UniProtKB/TrEMBL
KEGG Report rno:100361960 UniProtKB/TrEMBL
NCBI Gene 100361960 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 7B2, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR16716 UniProtKB/TrEMBL
Pfam COX7B UniProtKB/TrEMBL
PhenoGen Cox7b2 PhenoGen
RatGTEx ENSRNOG00000057953 RatGTEx
Superfamily-SCOP SSF81423 UniProtKB/TrEMBL
UniProt A0A0G2K6P0 ENTREZGENE, UniProtKB/TrEMBL
  A6JD85 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Cox7b2  cytochrome c oxidase subunit 7B2  Cox7b2  cytochrome c oxidase subunit VIIb2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-24 Cox7b2  cytochrome c oxidase subunit VIIb2  LOC100361960  rCG57154-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361960  rCG57154-like      Symbol and Name status set to provisional 70820 PROVISIONAL