Nrn1l (neuritin 1-like) - Rat Genome Database

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Gene: Nrn1l (neuritin 1-like) Rattus norvegicus
Analyze
Symbol: Nrn1l
Name: neuritin 1-like
RGD ID: 2301010
Description: Predicted to enable identical protein binding activity. Predicted to act upstream of or within neuron projection extension. Predicted to be located in axon; extracellular space; and plasma membrane. Orthologous to human NRN1L (neuritin 1 like); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,696,281 - 50,697,741 (+)NCBIGRCr8
mRatBN7.21933,786,419 - 33,787,879 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1940,601,963 - 40,603,423 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,255,278 - 41,256,738 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,553,597 - 43,555,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,865,016 - 37,866,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01948,731,784 - 48,733,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,731,663 - 35,733,123 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1933,213,979 - 33,215,439 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090   PMID:18265009  


Genomics

Comparative Map Data
Nrn1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,696,281 - 50,697,741 (+)NCBIGRCr8
mRatBN7.21933,786,419 - 33,787,879 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1940,601,963 - 40,603,423 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,255,278 - 41,256,738 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,553,597 - 43,555,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,865,016 - 37,866,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01948,731,784 - 48,733,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,731,663 - 35,733,123 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1933,213,979 - 33,215,439 (+)NCBICelera
Cytogenetic Map19q12NCBI
NRN1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,884,885 - 67,888,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,884,885 - 67,888,855 (+)EnsemblGRCh38hg38GRCh38
GRCh371667,918,788 - 67,922,758 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,476,282 - 66,477,772 (+)NCBINCBI36Build 36hg18NCBI36
Celera1652,427,193 - 52,428,683 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,791,872 - 53,793,362 (+)NCBIHuRef
CHM1_11669,326,963 - 69,328,453 (+)NCBICHM1_1
T2T-CHM13v2.01673,680,658 - 73,684,628 (+)NCBIT2T-CHM13v2.0
Nrn1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,620,199 - 106,621,655 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,620,199 - 106,621,655 (+)EnsemblGRCm39 Ensembl
GRCm388105,893,567 - 105,895,023 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,893,567 - 105,895,023 (+)EnsemblGRCm38mm10GRCm38
MGSCv378108,417,470 - 108,418,915 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,782,699 - 108,784,144 (+)NCBIMGSCv36mm8
Celera8110,121,331 - 110,122,776 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.06NCBI
Nrn1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554848,818,852 - 8,820,203 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554848,818,768 - 8,820,477 (-)NCBIChiLan1.0ChiLan1.0
NRN1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21877,411,615 - 77,415,765 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11683,322,950 - 83,327,194 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01648,226,206 - 48,230,470 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,613,100 - 67,617,429 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,613,293 - 67,614,881 (+)Ensemblpanpan1.1panPan2
NRN1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,600,442 - 81,602,175 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,600,547 - 81,601,940 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,587,744 - 81,592,108 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0582,033,148 - 82,037,512 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,035,885 - 82,037,278 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,859,348 - 81,863,711 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,541,412 - 81,545,774 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,183,647 - 82,188,012 (-)NCBIUU_Cfam_GSD_1.0
Nrn1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,342,811 - 41,344,346 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,244,844 - 18,246,196 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,244,787 - 18,246,303 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRN1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,501,697 - 28,503,347 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,501,664 - 28,506,234 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,628,956 - 25,630,700 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NRN1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,551,441 - 59,553,214 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604722,273,785 - 22,278,144 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrn1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,490,760 - 18,492,130 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474618,490,582 - 18,492,300 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:46
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000006345
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat

Markers in Region
SHGC-74292  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,785,639 - 33,785,905 (+)MAPPERmRatBN7.2
mRatBN7.26131,169,237 - 131,170,711 (+)MAPPERmRatBN7.2
Rnor_6.06136,674,643 - 136,676,116NCBIRnor6.0
Rnor_6.01937,864,237 - 37,864,502NCBIRnor6.0
Rnor_5.01948,731,005 - 48,731,270UniSTSRnor5.0
Rnor_5.06145,684,439 - 145,685,912UniSTSRnor5.0
RGSC_v3.46136,901,771 - 136,903,244UniSTSRGSC3.4
RGSC_v3.41935,730,884 - 35,731,149UniSTSRGSC3.4
Celera1933,213,200 - 33,213,465UniSTS
Celera6128,721,828 - 128,723,301UniSTS
Cytogenetic Map19q12UniSTS
RH128383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,785,708 - 33,785,919 (+)MAPPERmRatBN7.2
Rnor_6.01937,864,306 - 37,864,516NCBIRnor6.0
Rnor_5.01948,731,074 - 48,731,284UniSTSRnor5.0
RGSC_v3.41935,730,953 - 35,731,163UniSTSRGSC3.4
Celera1933,213,269 - 33,213,479UniSTS
RH 3.4 Map19330.2UniSTS
Cytogenetic Map19q12UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001135006   ⟹   NP_001128478
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,696,281 - 50,697,741 (+)NCBI
mRatBN7.21933,786,419 - 33,787,879 (+)NCBI
Rnor_6.01937,865,016 - 37,866,476 (+)NCBI
Rnor_5.01948,731,784 - 48,733,244 (+)NCBI
RGSC_v3.41935,731,663 - 35,733,123 (+)RGD
Celera1933,213,979 - 33,215,439 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128478 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92415 (Get FASTA)   NCBI Sequence Viewer  
  EDL92416 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001128478   ⟸   NM_001135006
- Peptide Label: precursor
- UniProtKB: A6IYT7 (UniProtKB/TrEMBL)
- Sequence:


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2301010 AgrOrtholog
BioCyc Gene G2FUF-5803 BioCyc
InterPro Neuritin_fam UniProtKB/TrEMBL
KEGG Report rno:100189544 UniProtKB/TrEMBL
NCBI Gene 100189544 ENTREZGENE
PANTHER NEURITIN-LIKE PROTEIN UniProtKB/TrEMBL
  NEURITIN-RELATED UniProtKB/TrEMBL
Pfam NRN1 UniProtKB/TrEMBL
PhenoGen Nrn1l PhenoGen
UniProt A6IYT7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-20 Nrn1l  neuritin 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL