Paep (progestagen associated endometrial protein) - Rat Genome Database

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Gene: Paep (progestagen associated endometrial protein) Rattus norvegicus
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Symbol: Paep
Name: progestagen associated endometrial protein
RGD ID: 2293817
Description: Predicted to enable small molecule binding activity. Predicted to be involved in several processes, including negative regulation of sperm capacitation; positive regulation of granulocyte macrophage colony-stimulating factor production; and regulation of binding activity of sperm to zona pellucida. Predicted to be located in extracellular region. Orthologous to human PAEP (progestagen associated endometrial protein); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Lcn11; lipocalin 11
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,929,252 - 28,932,592 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.238,531,136 - 8,534,430 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,531,138 - 8,534,430 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,637,821 - 11,641,115 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,224,058 - 20,227,352 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,413,894 - 18,417,188 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,935,396 - 2,938,883 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.038,599,189 - 8,602,477 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,883,332 - 3,886,626 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,431,983 - 3,435,265 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:3667877   PMID:12672671   PMID:15883155   PMID:17192260   PMID:18996219   PMID:19945098   PMID:23451353  


Genomics

Comparative Map Data
Paep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,929,252 - 28,932,592 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.238,531,136 - 8,534,430 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,531,138 - 8,534,430 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,637,821 - 11,641,115 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,224,058 - 20,227,352 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,413,894 - 18,417,188 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,935,396 - 2,938,883 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.038,599,189 - 8,602,477 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,883,332 - 3,886,626 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,431,983 - 3,435,265 (+)NCBICelera
Cytogenetic Map3p13NCBI
PAEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389135,561,756 - 135,566,955 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9135,561,756 - 135,566,955 (+)Ensemblhg38GRCh38
GRCh379138,453,602 - 138,458,801 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369137,593,425 - 137,598,443 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349135,679,548 - 135,684,567NCBI
Celera9108,970,476 - 108,975,523 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9107,915,451 - 107,920,498 (+)NCBIHuRef
CHM1_19138,602,185 - 138,607,211 (+)NCBICHM1_1
T2T-CHM13v2.09147,789,564 - 147,794,795 (+)NCBIT2T-CHM13v2.0
Lcn11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,667,029 - 25,670,291 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,667,029 - 25,670,291 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38225,777,017 - 25,780,279 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,777,017 - 25,780,279 (+)Ensemblmm10GRCm38
MGSCv37225,632,537 - 25,635,799 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36225,599,026 - 25,602,288 (+)NCBIMGSCv36mm8
Celera225,503,112 - 25,506,377 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.02NCBI
PAEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2113,775,974 - 3,783,383 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan193,778,307 - 3,785,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09106,669,550 - 106,681,918 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19135,667,342 - 135,672,464 (+)NCBIPanPan1.1PanPan1.1panPan2
LOC491263
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,663,646 - 49,667,034 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,916,053 - 48,919,441 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
PAEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21308,664,373 - 308,669,075 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1122,624,894 - 2,630,817 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl122,625,017 - 2,630,602 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660582,528,029 - 2,535,826 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Paep
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:39
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000065658
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
8 1 10 16 7 4 1 6 35 13 2 9 14 42 4

Sequence


Ensembl Acc Id: ENSRNOT00000084196   ⟹   ENSRNOP00000075567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,531,138 - 8,534,430 (-)Ensembl
RefSeq Acc Id: NM_001135809   ⟹   NP_001129281
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,929,252 - 28,932,546 (-)NCBI
mRatBN7.238,531,136 - 8,534,430 (-)NCBI
Rnor_6.032,935,396 - 2,938,883 (-)NCBI
Rnor_5.038,599,189 - 8,602,477 (+)NCBI
RGSC_v3.433,883,332 - 3,886,626 (-)RGD
Celera33,431,983 - 3,435,265 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063282941   ⟹   XP_063139011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,929,252 - 28,932,592 (-)NCBI
RefSeq Acc Id: XM_063282942   ⟹   XP_063139012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,929,252 - 28,932,592 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001129281 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139011 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139012 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABG24238 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075567
  ENSRNOP00000075567.1
RefSeq Acc Id: NP_001129281   ⟸   NM_001135809
- Peptide Label: precursor
- UniProtKB: B3EY86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075567   ⟸   ENSRNOT00000084196
RefSeq Acc Id: XP_063139012   ⟸   XM_063282942
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063139011   ⟸   XM_063282941
- Peptide Label: isoform X1
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B3EY86-F1-model_v2 AlphaFold B3EY86 1-177 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2293817 AgrOrtholog
BioCyc Gene G2FUF-50423 BioCyc
Ensembl Genes ENSRNOG00000070613 Ensembl
  ENSRNOG00000073207 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084196 ENTREZGENE
  ENSRNOT00000084196.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/TrEMBL
InterPro Calycin UniProtKB/TrEMBL
  Lipocalin UniProtKB/TrEMBL
  Lipocln_cytosolic_FA_bd UniProtKB/TrEMBL
KEGG Report rno:100169711 UniProtKB/TrEMBL
NCBI Gene 100169711 ENTREZGENE
PANTHER LIPOCALIN 11 UniProtKB/TrEMBL
  PTHR11430 UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/TrEMBL
PhenoGen Paep PhenoGen
RatGTEx ENSRNOG00000070613 RatGTEx
  ENSRNOG00000073207 RatGTEx
Superfamily-SCOP Calycin UniProtKB/TrEMBL
UniProt B3EY86 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-09 Paep  progestagen associated endometrial protein  Lcn11  lipocalin 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-13 Lcn11  lipocalin 11      Symbol and Name status set to provisional 70820 PROVISIONAL