Tedc2 (tubulin epsilon and delta complex 2) - Rat Genome Database

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Gene: Tedc2 (tubulin epsilon and delta complex 2) Rattus norvegicus
Analyze
Symbol: Tedc2
Name: tubulin epsilon and delta complex 2
RGD ID: 2293499
Description: Predicted to be involved in positive regulation of smoothened signaling pathway. Predicted to be located in centriole and cilium. Orthologous to human TEDC2 (tubulin epsilon and delta complex 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC100158225; LOC100158225; MGC188077; tubulin epsilon and delta complex protein 2; uncharacterized protein C16orf59 homolog; uncharacterized protein LOC100158225
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,750,586 - 13,755,775 (-)NCBIGRCr8
mRatBN7.21013,246,032 - 13,251,196 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,246,037 - 13,251,124 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,990,957 - 17,996,048 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,479,796 - 17,484,887 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,978,519 - 12,983,612 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,586,852 - 13,591,938 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,586,648 - 13,591,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,402,883 - 13,407,969 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,466,825 - 13,471,910 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1012,931,940 - 12,937,026 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centriole  (ISO)
cilium  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:29459677  


Genomics

Comparative Map Data
Tedc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,750,586 - 13,755,775 (-)NCBIGRCr8
mRatBN7.21013,246,032 - 13,251,196 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,246,037 - 13,251,124 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,990,957 - 17,996,048 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,479,796 - 17,484,887 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,978,519 - 12,983,612 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,586,852 - 13,591,938 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,586,648 - 13,591,953 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,402,883 - 13,407,969 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,466,825 - 13,471,910 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1012,931,940 - 12,937,026 (-)NCBICelera
Cytogenetic Map10q12NCBI
TEDC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,460,109 - 2,464,963 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,460,086 - 2,464,963 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,510,110 - 2,514,964 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,450,116 - 2,454,965 (+)NCBINCBI36Build 36hg18NCBI36
Celera162,724,490 - 2,729,339 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,435,738 - 2,440,587 (+)NCBIHuRef
CHM1_1162,510,009 - 2,514,858 (+)NCBICHM1_1
T2T-CHM13v2.0162,482,238 - 2,487,092 (+)NCBIT2T-CHM13v2.0
Tedc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,434,028 - 24,439,825 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,434,028 - 24,439,825 (-)EnsemblGRCm39 Ensembl
GRCm381724,215,054 - 24,220,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,215,054 - 24,220,851 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,351,999 - 24,357,714 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361723,942,654 - 23,948,369 (-)NCBIMGSCv36mm8
Celera1724,720,495 - 24,726,198 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.32NCBI
Tedc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,856,269 - 14,862,338 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,856,517 - 14,862,391 (-)NCBIChiLan1.0ChiLan1.0
TEDC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,961,311 - 2,966,189 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,742,330 - 6,747,198 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,316,181 - 1,321,075 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,559,493 - 2,564,370 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,559,493 - 2,564,370 (+)Ensemblpanpan1.1panPan2
TEDC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,567,365 - 38,571,451 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,567,547 - 38,571,341 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,805,559 - 39,809,622 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,876,432 - 38,880,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,875,289 - 38,880,446 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,561,556 - 38,565,618 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,534,190 - 38,538,253 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,010,339 - 39,014,403 (-)NCBIUU_Cfam_GSD_1.0
Tedc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,113,543 - 105,118,054 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,590,919 - 1,595,719 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,591,392 - 1,595,693 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TEDC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,580,199 - 39,584,380 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,580,181 - 39,584,414 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,635,334 - 42,639,548 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TEDC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,338,246 - 2,343,171 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,338,341 - 2,342,825 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,694,362 - 28,699,320 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tedc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624824209,879 - 218,659 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624824209,758 - 215,362 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tedc2
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:226
Count of miRNA genes:157
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000047734
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat

Markers in Region
RH131745  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,249,389 - 13,249,594 (+)MAPPERmRatBN7.2
Rnor_6.01013,590,210 - 13,590,414NCBIRnor6.0
Rnor_5.01013,406,241 - 13,406,445UniSTSRnor5.0
RGSC_v3.41013,470,182 - 13,470,386UniSTSRGSC3.4
Celera1012,935,298 - 12,935,502UniSTS
RH 3.4 Map10170.6UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 22 22 16 12 16 43 17 31 4
Low 2 21 35 25 7 25 8 11 31 18 10 7 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000047734   ⟹   ENSRNOP00000046320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,246,037 - 13,251,124 (-)Ensembl
Rnor_6.0 Ensembl1013,586,648 - 13,591,953 (-)Ensembl
RefSeq Acc Id: NM_001127606   ⟹   NP_001121078
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,750,586 - 13,755,672 (-)NCBI
mRatBN7.21013,246,032 - 13,251,118 (-)NCBI
Rnor_6.01013,586,852 - 13,591,938 (-)NCBI
Rnor_5.01013,402,883 - 13,407,969 (-)NCBI
RGSC_v3.41013,466,825 - 13,471,910 (-)RGD
Celera1012,931,940 - 12,937,026 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084981   ⟹   XP_038940909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,750,586 - 13,755,775 (-)NCBI
mRatBN7.21013,246,411 - 13,251,196 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001121078 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940909 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66509 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046320
  ENSRNOP00000046320.3
RefSeq Acc Id: NP_001121078   ⟸   NM_001127606
- UniProtKB: B2GV34 (UniProtKB/TrEMBL),   A6HCR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000046320   ⟸   ENSRNOT00000047734
RefSeq Acc Id: XP_038940909   ⟸   XM_039084981
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GV34-F1-model_v2 AlphaFold B2GV34 1-434 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697005
Promoter ID:EPDNEW_R7530
Type:single initiation site
Name:LOC100158225_1
Description:hypothetical protein LOC100158225
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01013,591,972 - 13,592,032EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2293499 AgrOrtholog
BioCyc Gene G2FUF-25870 BioCyc
Ensembl Genes ENSRNOG00000007436 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047734 ENTREZGENE
  ENSRNOT00000047734.5 UniProtKB/TrEMBL
InterPro DUF4693 UniProtKB/TrEMBL
KEGG Report rno:100158225 UniProtKB/TrEMBL
NCBI Gene 100158225 ENTREZGENE
PANTHER PTHR14870 UniProtKB/TrEMBL
  TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 2 UniProtKB/TrEMBL
Pfam DUF4693 UniProtKB/TrEMBL
PhenoGen Tedc2 PhenoGen
RatGTEx ENSRNOG00000007436 RatGTEx
UniProt A6HCR0 ENTREZGENE, UniProtKB/TrEMBL
  B2GV34 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-05 Tedc2  tubulin epsilon and delta complex 2  LOC100158225  hypothetical protein LOC100158225  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-30 LOC100158225  hypothetical protein LOC100158225      Symbol and Name status set to provisional 70820 PROVISIONAL