Cartpt (CART prepropeptide) - Rat Genome Database

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Gene: Cartpt (CART prepropeptide) Rattus norvegicus
Analyze
Symbol: Cartpt
Name: CART prepropeptide
RGD ID: 2272
Description: Predicted to enable neuropeptide hormone activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; regulation of circadian sleep/wake cycle; and regulation of secretion by cell. Located in cytoplasm; extracellular space; and neuronal cell body. Used to study cerebral infarction. Biomarker of amphetamine abuse; cognitive disorder (multiple); morphine dependence; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; and obesity. Orthologous to human CARTPT (CART prepropeptide); INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cart; cocaine and amphetamine regulated transcript; cocaine- and amphetamine-regulated transcript protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8232,989,215 - 32,991,794 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl232,989,215 - 32,999,712 (-)EnsemblGRCr8
mRatBN7.2231,255,098 - 31,257,452 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,255,098 - 31,290,713 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx238,333,324 - 38,335,346 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0236,427,667 - 36,429,691 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,220,463 - 31,222,481 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,125,249 - 30,127,408 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,125,249 - 30,127,269 (-)Ensemblrn6Rnor6.0
Rnor_5.0249,285,118 - 49,287,405 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4230,889,817 - 30,891,837 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera227,276,402 - 27,278,422 (-)NCBICelera
RGSC_v3.1230,810,185 - 30,812,206 (-)NCBI
Cytogenetic Map2q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(S)-nicotine  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2-naphthylamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
alpha-melanocyte stimulating hormone  (EXP)
AM-251  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arachidonyl-2'-chloroethylamide  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylparaben  (EXP)
C60 fullerene  (EXP)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
clozapine  (EXP)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
DDE  (EXP)
dichlorine  (EXP)
diprotium oxide  (EXP)
entinostat  (ISO)
enzacamene  (EXP)
ethanol  (ISO)
fluoxetine  (EXP)
fonofos  (ISO)
fructose  (EXP)
Glutathione ethyl ester  (EXP)
glycidol  (EXP)
hydrogen sulfide  (ISO)
icariin  (ISO)
KT 5720  (EXP)
linuron  (EXP)
lipopolysaccharide  (EXP)
malathion  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
morphine hydrochloride  (EXP)
nicotine  (EXP,ISO)
nitroprusside  (EXP)
ozone  (EXP)
paracetamol  (EXP)
parathion  (ISO)
PCB138  (ISO)
pirinixic acid  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP)
scopolamine  (EXP)
Soman  (EXP)
streptozocin  (EXP)
terbufos  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
water  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult feeding behavior  (IDA,IEA,ISO)
behavioral response to cocaine  (IDA)
cAMP biosynthetic process  (IDA)
cellular response to estradiol stimulus  (IEP)
cellular response to starvation  (IBA,IDA,IEA,ISO)
chemical synaptic transmission  (IEA)
circadian regulation of gene expression  (IDA)
circadian rhythm  (IEP)
conditioned place preference  (IDA)
detection of chemical stimulus involved in sensory perception of pain  (IDA)
detection of temperature stimulus involved in sensory perception of pain  (IDA)
drinking behavior  (IDA)
G protein-coupled receptor signaling pathway  (IDA,IEA,ISO)
gastric acid secretion  (TAS)
glucose metabolic process  (IDA)
intracellular calcium ion homeostasis  (IDA)
intracellular glucose homeostasis  (IEA,ISO,ISS)
negative regulation of appetite  (IBA,IDA,IEA,ISO)
negative regulation of bone resorption  (IEA,ISO)
negative regulation of cytosolic calcium ion concentration  (IDA)
negative regulation of D-glucose import across plasma membrane  (IDA)
negative regulation of eating behavior  (IMP)
negative regulation of glucagon secretion  (IDA)
negative regulation of locomotion  (IDA)
negative regulation of relaxation of smooth muscle  (IDA)
negative regulation of type B pancreatic cell apoptotic process  (IDA)
neuropeptide signaling pathway  (IEA)
operant conditioning  (IDA,IMP)
positive regulation of blood pressure  (IEA,ISO,ISS)
positive regulation of cell communication  (IEA)
positive regulation of epinephrine secretion  (IEA,ISO,ISS)
positive regulation of exocytosis  (IMP)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IDA,IMP)
positive regulation of MAPK cascade  (IDA,IEA,ISO)
positive regulation of transmission of nerve impulse  (IEA,ISO,ISS)
positive regulation of type B pancreatic cell proliferation  (IDA)
regulation of bone remodeling  (ISO)
regulation of circadian sleep/wake cycle, non-REM sleep  (IDA)
regulation of circadian sleep/wake cycle, REM sleep  (IDA)
regulation of circadian sleep/wake cycle, wakefulness  (IDA)
regulation of exocytosis  (IDA)
regulation of heart rate by chemical signal  (IDA)
regulation of insulin secretion  (IDA)
regulation of lipid biosynthetic process  (IDA)
regulation of lipid catabolic process  (IDA)
regulation of locomotion involved in locomotory behavior  (IDA)
regulation of systemic arterial blood pressure by neurotransmitter  (IDA)
response to corticosterone  (IEP)
response to corticotropin-releasing hormone  (IEP)
response to ethanol  (IEP)
response to food  (IEP)
response to glucocorticoid  (IEP)
response to glucose  (IEP)
response to insulin  (IEP)
response to morphine  (IEP)
response to starvation  (IEP)
signal transduction  (IEA)
somatostatin secretion  (IDA)

Cellular Component
cytoplasm  (IDA)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO,ISS)
neuronal cell body  (IDA)
secretory granule  (IEA,ISO)
synapse  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion. Abels M, etal., Diabetologia. 2016 Sep;59(9):1928-37. doi: 10.1007/s00125-016-4020-6. Epub 2016 Jun 23.
2. Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. Albertson DN, etal., J Neurochem. 2004 Mar;88(5):1211-9. doi: 10.1046/j.1471-4159.2003.02247.x.
3. Evaluation of the CART peptide expression in morphine sensitization in male rats. Bakhtazad A, etal., Eur J Pharmacol. 2017 May 5;802:52-59. doi: 10.1016/j.ejphar.2017.02.040. Epub 2017 Feb 24.
4. CART peptide and opioid addiction: Expression changes in male rat brain. Bakhtazad A, etal., Neuroscience. 2016 Jun 14;325:63-73. doi: 10.1016/j.neuroscience.2016.02.071. Epub 2016 Mar 5.
5. The effect of microinjection of CART 55-102 into the nucleus accumbens shell on morphine-induced conditioned place preference in rats: Involvement of the NMDA receptor. Bakhtazad A, etal., Peptides. 2020 Jul;129:170319. doi: 10.1016/j.peptides.2020.170319. Epub 2020 Apr 23.
6. Effects of adrenalectomy on CART expression in the rat arcuate nucleus. Balkan B, etal., Synapse. 2003 Oct;50(1):14-9. doi: 10.1002/syn.10213.
7. Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis. Banke E, etal., Regul Pept. 2013 Mar 10;182:35-40. doi: 10.1016/j.regpep.2012.12.011. Epub 2013 Jan 11.
8. Early and transient ontogenetic expression of the cocaine- and amphetamine-regulated transcript peptide in the rat mesencephalon: correlation with tyrosine hydroxylase expression. Brischoux F, etal., J Neurobiol 2002 Sep 5;52(3):221-9.
9. Cocaine and amphetamine regulated transcript (CART) gene in the comorbidity of schizophrenia with alcohol use disorders and nicotine dependence. Busto A, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):834-6. doi: 10.1016/j.pnpbp.2010.03.030. Epub 2010 Mar 30.
10. Production of recombinant CART peptides in Escherichia coli with agonist and antagonist effects on food intake in rats. Couceyro PR and Fritz T, Protein Expr Purif. 2003 Dec;32(2):185-93. doi: 10.1016/j.pep.2003.08.015.
11. Antinociceptive effects of supraspinal rat cart (55-102) peptide in mice. Damaj MI, etal., Brain Res. 2003 Sep 5;983(1-2):233-6. doi: 10.1016/s0006-8993(03)03094-4.
12. Maternal ethanol exposure reshapes CART system in the rat brain: Correlation with development of anxiety, depression and memory deficits. Dandekar MP, etal., Neuroscience. 2019 May 15;406:126-139. doi: 10.1016/j.neuroscience.2019.02.010. Epub 2019 Feb 28.
13. Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. del Giudice EM, etal., Diabetes. 2001 Sep;50(9):2157-60.
14. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. Douglass J, etal., J Neurosci 1995 Mar;15(3 Pt 2):2471-81.
15. Expression and activity of cocaine- and amphetamine-regulated transcript peptide(1-39) in the rat. Dun SL, etal., Regul Pept. 2007 Apr 5;140(1-2):47-54. doi: 10.1016/j.regpep.2006.11.010. Epub 2006 Dec 21.
16. Sequence variants in the human cocaine and amphetamine-regulated transcript (CART) gene in subjects with early onset obesity. Echwald SM, etal., Obes Res. 1999 Nov;7(6):532-6.
17. Cocaine- and amphetamine-regulated transcript: distribution and function in rat gastrointestinal tract. Ekblad E, etal., Neurogastroenterol Motil. 2003 Oct;15(5):545-57. doi: 10.1046/j.1365-2982.2003.00437.x.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Colocalization of CART peptide with prodynorphin and dopamine D1 receptors in the rat nucleus accumbens. Hubert GW and Kuhar MJ, Neuropeptides. 2006 Dec;40(6):409-15. Epub 2006 Oct 24.
20. Cocaine-and-Amphetamine Regulated Transcript (CART) peptide attenuates dopamine- and cocaine-mediated locomotor activity in both male and female rats: lack of sex differences. Job MO, etal., Neuropeptides. 2014 Apr;48(2):75-81. doi: 10.1016/j.npep.2014.01.002. Epub 2014 Jan 10.
21. Association between polymorphism in intron 1 of cocaine- and amphetamine-regulated transcript gene with alcoholism, but not with bipolar disorder and schizophrenia in Korean population. Jung SK, etal., Neurosci Lett. 2004 Jul 15;365(1):54-7. doi: 10.1016/j.neulet.2004.04.036.
22. Wake promoting effects of cocaine and amphetamine-regulated transcript (CART). Keating GL, etal., Neuropeptides. 2010 Jun;44(3):241-6. doi: 10.1016/j.npep.2009.12.013. Epub 2010 Feb 8.
23. CART peptide 55-102 microinjected into the nucleus accumbens inhibits the expression of behavioral sensitization by amphetamine. Kim S, etal., Regul Pept. 2007 Dec 4;144(1-3):6-9. doi: 10.1016/j.regpep.2007.07.003. Epub 2007 Jul 17.
24. Compulsive methamphetamine taking in the presence of punishment is associated with increased oxytocin expression in the nucleus accumbens of rats. Krasnova IN, etal., Sci Rep. 2017 Aug 21;7(1):8331. doi: 10.1038/s41598-017-08898-8.
25. Hypothalamic CART is a new anorectic peptide regulated by leptin. Kristensen P, etal., Nature. 1998 May 7;393(6680):72-6.
26. Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors. Lakatos A, etal., Neurosci Lett. 2005 Aug 12-19;384(1-2):198-202.
27. Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain. Lee SJ, etal., Cell Rep. 2020 Feb 11;30(6):2028-2039.e4. doi: 10.1016/j.celrep.2020.01.045.
28. Altered R-spondin 1/CART neurocircuit in the hypothalamus contributes to hyperphagia in diabetes. Li JY, etal., J Neurophysiol. 2019 Mar 1;121(3):928-939. doi: 10.1152/jn.00413.2018. Epub 2019 Jan 16.
29. Traumatic stress affects alcohol‑drinking behavior through cocaine‑ and amphetamine‑regulated transcript 55‑102 in the paraventricular nucleus in rats. Liu J, etal., Mol Med Rep. 2018 Jan;17(1):1157-1165. doi: 10.3892/mmr.2017.7989. Epub 2017 Nov 6.
30. The neuroprotective effect of NeuroAid on morphine-induced amnesia with respect to the expression of TFAM, PGC-1α, ΔfosB and CART genes in the hippocampus of male Wistar rats. Malboosi N, etal., Gene. 2020 Jun 5;742:144601. doi: 10.1016/j.gene.2020.144601. Epub 2020 Mar 19.
31. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
32. Cocaine- and amphetamine-regulated transcript in the nucleus accumbens shell attenuates context-induced reinstatement of alcohol seeking. Millan EZ and McNally GP, Behav Neurosci. 2012 Oct;126(5):690-8. doi: 10.1037/a0029953.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Cocaine-amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotropin-releasing factor system. Okumura T, etal., Endocrinology 2000 Aug;141(8):2854-60.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. A cocaine-and-amphetamine-regulated-transcript peptide projection from the lateral hypothalamus to the ventral tegmental area. Philpot KB, etal., Neuroscience. 2005;135(3):915-25. doi: 10.1016/j.neuroscience.2005.06.064. Epub 2005 Sep 8.
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Ethanol enhancement of cocaine- and amphetamine-regulated transcript mRNA and peptide expression in the nucleus accumbens. Salinas A, etal., J Neurochem. 2006 Apr;97(2):408-15. doi: 10.1111/j.1471-4159.2006.03745.x. Epub 2006 Mar 15.
40. Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation. Sathanoori R, etal., J Biol Chem. 2013 Feb 1;288(5):3208-18. doi: 10.1074/jbc.M112.437145. Epub 2012 Dec 16.
41. Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes. Shcherbina L, etal., Mol Cell Endocrinol. 2017 May 15;447:52-60. doi: 10.1016/j.mce.2017.02.027. Epub 2017 Feb 24.
42. Testosterone (T)-induced changes in arcuate nucleus cocaine-amphetamine-regulated transcript and NPY mRNA are attenuated in old compared to young male brown Norway rats: contribution of T to age-related changes in cocaine-amphetamine-regulated transcript and NPY gene expression. Sohn EH, etal., Endocrinology 2002 Mar;143(3):954-63.
43. Regulation of rat pituitary cocaine- and amphetamine-regulated transcript (CART) by CRH and glucocorticoids. Stanley SA, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E583-90. doi: 10.1152/ajpendo.00576.2003. Epub 2004 May 11.
44. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
45. CART peptide diurnal rhythm in brain and effect of fasting. Vicentic A, etal., Brain Res. 2005 Jan 25;1032(1-2):111-5.
46. Effect of corticosterone on CART peptide levels in rat blood. Vicentic A, etal., Peptides. 2005 Mar;26(3):531-3. doi: 10.1016/j.peptides.2004.10.023.
47. A polymorphism in the gene encoding CART is not associated with obesity in Pima Indians. Walder K, etal., Int J Obes Relat Metab Disord. 2000 Apr;24(4):520-1.
48. Cocaine and amphetamine regulated transcript (CART) signalling in the central nucleus of the amygdala modulates stress-induced alcohol seeking. Walker LC, etal., Neuropsychopharmacology. 2021 Jan;46(2):325-333. doi: 10.1038/s41386-020-00807-4. Epub 2020 Aug 21.
49. CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats. Wierup N, etal., Diabetes. 2006 Feb;55(2):305-11.
50. Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection. Xu Y, etal., Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14489-94. doi: 10.1073/pnas.0602932103. Epub 2006 Sep 13.
51. Cocaine- and amphetamine-regulated transcript peptide modulation of voltage-gated Ca2+ signaling in hippocampal neurons. Yermolaieva O, etal., J Neurosci. 2001 Oct 1;21(19):7474-80. doi: 10.1523/JNEUROSCI.21-19-07474.2001.
Additional References at PubMed
PMID:9654146   PMID:11711504   PMID:11841916   PMID:12147208   PMID:12147209   PMID:12468444   PMID:12490674   PMID:12559087   PMID:12588509   PMID:12591118   PMID:12732339   PMID:12933358  
PMID:14691017   PMID:14698680   PMID:14700744   PMID:14730586   PMID:14764627   PMID:15155577   PMID:15271883   PMID:15380921   PMID:15572204   PMID:15720470   PMID:15724149   PMID:15874973  
PMID:15890775   PMID:15908130   PMID:15978559   PMID:16339196   PMID:16374620   PMID:16614075   PMID:16644010   PMID:16684132   PMID:16879170   PMID:17023531   PMID:17105939   PMID:17434149  
PMID:17616293   PMID:17634068   PMID:17669377   PMID:17880396   PMID:18078990   PMID:18384674   PMID:18472225   PMID:18554810   PMID:18624928   PMID:18645412   PMID:18719668   PMID:18823957  
PMID:19005467   PMID:19046951   PMID:19070636   PMID:19254763   PMID:19258027   PMID:19426783   PMID:19490082   PMID:19533109   PMID:19632277   PMID:19704931   PMID:19755135   PMID:19825396  
PMID:19854189   PMID:20528087   PMID:20595030   PMID:20626417   PMID:20810898   PMID:20883668   PMID:20886038   PMID:21167239   PMID:21407156   PMID:21452228   PMID:21539900   PMID:21589937  
PMID:21624661   PMID:21821286   PMID:21903152   PMID:22137563   PMID:22887004   PMID:22960117   PMID:23155622   PMID:23206801   PMID:23211962   PMID:23538212   PMID:23545074   PMID:23736294  
PMID:23770418   PMID:23907376   PMID:24549602   PMID:24647922   PMID:24939825   PMID:24989426   PMID:25151991   PMID:25256086   PMID:25552080   PMID:25825358   PMID:26008155   PMID:26150151  
PMID:26771081   PMID:27258934   PMID:27349817   PMID:27822503   PMID:27823935   PMID:28300671   PMID:28984394   PMID:30610873   PMID:31830460   PMID:33098940   PMID:34043767   PMID:36539163  
PMID:37859350  


Genomics

Comparative Map Data
Cartpt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8232,989,215 - 32,991,794 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl232,989,215 - 32,999,712 (-)EnsemblGRCr8
mRatBN7.2231,255,098 - 31,257,452 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,255,098 - 31,290,713 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx238,333,324 - 38,335,346 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0236,427,667 - 36,429,691 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,220,463 - 31,222,481 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,125,249 - 30,127,408 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,125,249 - 30,127,269 (-)Ensemblrn6Rnor6.0
Rnor_5.0249,285,118 - 49,287,405 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4230,889,817 - 30,891,837 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera227,276,402 - 27,278,422 (-)NCBICelera
RGSC_v3.1230,810,185 - 30,812,206 (-)NCBI
Cytogenetic Map2q12NCBI
CARTPT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38571,719,275 - 71,721,045 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl571,719,275 - 71,721,048 (+)Ensemblhg38GRCh38
GRCh37571,015,102 - 71,016,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36571,050,750 - 71,052,628 (+)NCBIBuild 36Build 36hg18NCBI36
Celera566,910,678 - 66,912,563 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef566,220,931 - 66,222,816 (+)NCBIHuRef
CHM1_1570,447,686 - 70,449,571 (+)NCBICHM1_1
T2T-CHM13v2.0572,200,597 - 72,202,367 (+)NCBIT2T-CHM13v2.0
Cartpt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,034,991 - 100,037,191 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,034,997 - 100,037,599 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381399,898,483 - 99,910,179 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1399,898,489 - 99,901,091 (-)Ensemblmm10GRCm38
MGSCv3713100,668,439 - 100,670,638 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613100,998,914 - 101,000,892 (-)NCBIMGSCv36mm8
Celera13103,550,272 - 103,552,922 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.9NCBI
Cartpt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955575551,991 - 555,149 (+)Ensembl
ChiLan1.0NW_004955575551,991 - 555,118 (+)NCBIChiLan1.0ChiLan1.0
CARTPT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2443,593,184 - 43,595,366 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1541,746,812 - 41,748,989 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0543,591,683 - 43,593,586 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1544,236,114 - 44,238,229 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl544,236,114 - 44,238,229 (-)EnsemblpanPan2panpan1.1
CARTPT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,865,043 - 54,867,410 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,865,298 - 54,867,158 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha251,831,747 - 51,833,904 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0255,380,658 - 55,382,812 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl255,380,662 - 55,382,560 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,441,398 - 52,443,555 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0253,208,304 - 53,210,460 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0254,099,675 - 54,101,833 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cartpt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213186,139,406 - 186,141,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365494,717,771 - 4,719,395 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365494,717,337 - 4,719,523 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CARTPT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1648,043,492 - 48,045,592 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11648,043,558 - 48,045,592 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,989,808 - 51,991,843 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CARTPT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1466,058,755 - 66,060,635 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl466,058,769 - 66,061,112 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604914,805,312 - 14,807,192 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cartpt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905751,223 - 752,845 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624905751,032 - 753,012 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cartpt
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13196,704,124 - 196,706,379 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cartpt
15 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:134
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000023869
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 1 19 127 36 33 6 10 6 1 72 43 112 10 28 27 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023869   ⟹   ENSRNOP00000023869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl232,989,215 - 32,999,712 (-)Ensembl
mRatBN7.2 Ensembl231,255,098 - 31,290,713 (-)Ensembl
Rnor_6.0 Ensembl230,125,249 - 30,127,269 (-)Ensembl
RefSeq Acc Id: NM_017110   ⟹   NP_058806
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8232,989,215 - 32,991,235 (-)NCBI
mRatBN7.2231,255,098 - 31,257,120 (-)NCBI
Rnor_6.0230,125,249 - 30,127,269 (-)NCBI
Rnor_5.0249,285,118 - 49,287,405 (-)NCBI
RGSC_v3.4230,889,817 - 30,891,837 (-)RGD
Celera227,276,402 - 27,278,422 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231843   ⟹   XP_006231905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8232,989,474 - 32,991,794 (-)NCBI
mRatBN7.2231,255,099 - 31,257,452 (-)NCBI
Rnor_6.0230,125,252 - 30,127,408 (-)NCBI
Rnor_5.0249,285,118 - 49,287,405 (-)NCBI
Sequence:
RefSeq Acc Id: NP_058806   ⟸   NM_017110
- Peptide Label: precursor
- UniProtKB: P49192 (UniProtKB/Swiss-Prot),   A6I575 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231905   ⟸   XM_006231843
- Peptide Label: isoform X1
- UniProtKB: P49192 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023869   ⟸   ENSRNOT00000023869

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49192-F1-model_v2 AlphaFold P49192 1-129 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691099
Promoter ID:EPDNEW_R1624
Type:single initiation site
Name:Cartpt_1
Description:CART prepropeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0230,127,269 - 30,127,329EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2272 AgrOrtholog
BioCyc Gene G2FUF-54681 BioCyc
Ensembl Genes ENSRNOG00000017712 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023869 ENTREZGENE
  ENSRNOT00000023869.3 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.40.30 UniProtKB/Swiss-Prot
InterPro CART UniProtKB/Swiss-Prot
  CART_C_sf UniProtKB/Swiss-Prot
KEGG Report rno:29131 UniProtKB/Swiss-Prot
NCBI Gene 29131 ENTREZGENE
PANTHER COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT PROTEIN UniProtKB/Swiss-Prot
  PTHR16655 UniProtKB/Swiss-Prot
Pfam CART UniProtKB/Swiss-Prot
PhenoGen Cartpt PhenoGen
RatGTEx ENSRNOG00000017712 RatGTEx
Superfamily-SCOP SSF64546 UniProtKB/Swiss-Prot
TIGR TC234475
UniProt A6I575 ENTREZGENE, UniProtKB/TrEMBL
  CART_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-15 Cartpt  CART prepropeptide  Cart  cocaine and amphetamine regulated transcript  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cart  cocaine and amphetamine regulated transcript      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in mesencephalon of central nervous system 634696
gene_process may have a role in the development of specific regions of the rat brain 634696
gene_regulation expression may be regulated by testosterone 1299848