Capn1 (calpain 1) - Rat Genome Database

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Gene: Capn1 (calpain 1) Rattus norvegicus
Analyze
Symbol: Capn1
Name: calpain 1
RGD ID: 2267
Description: Enables several functions, including calcium ion binding activity; calcium-dependent cysteine-type endopeptidase activity; and cytoskeletal protein binding activity. Involved in several processes, including negative regulation of non-canonical NF-kappaB signal transduction; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of leukocyte tethering or rolling. Is active in glutamatergic synapse; postsynaptic density; and presynapse. Biomarker of acute kidney failure; aortic atherosclerosis; epilepsy; sciatic neuropathy; and traumatic brain injury. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1); PARTICIPATES IN the proteolytic pathway involving calcium-dependent proteases; Alzheimer's disease pathway; apoptotic cell death pathway; INTERACTS WITH (S)-colchicine; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium-activated neutral proteinase 1; calpain 1, (mu/I) large subunit; calpain mu-type; calpain-1 catalytic subunit; calpain-1 large subunit; CANP 1; micromolar-calpain; muCANP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,705,219 - 212,736,134 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1212,705,222 - 212,729,445 (-)EnsemblGRCr8
mRatBN7.21203,275,912 - 203,300,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,277,344 - 203,300,177 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1211,629,235 - 211,653,778 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,721,298 - 218,745,531 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,412,355 - 211,436,597 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,346,081 - 221,370,965 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,346,066 - 221,370,322 (-)Ensemblrn6Rnor6.0
Rnor_5.01228,280,716 - 228,306,187 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41208,620,286 - 208,645,007 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1200,809,826 - 200,833,901 (-)NCBICelera
RGSC_v3.11208,773,739 - 208,798,460 (-)NCBI
Cytogenetic Map1q43NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-dimethoxyphenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aloxistatin  (ISO)
alprazolam  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium acetate  (EXP)
caffeine  (ISO)
calcium atom  (EXP,ISO)
calcium carbonate  (ISO)
calcium(0)  (EXP,ISO)
Calpeptin  (EXP,ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon disulfide  (EXP)
casticin  (ISO)
chloroacetic acid  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
dantrolene  (EXP)
DDE  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP)
diuron  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
excitatory amino acid agonist  (ISO)
Fexofenadine hydrochloride  (ISO)
fisetin  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furans  (ISO)
furfural  (ISO)
gallic acid  (ISO)
genistein  (ISO)
glimepiride  (ISO)
glucose  (EXP,ISO)
glyphosate  (EXP,ISO)
heparin  (ISO)
hydrogen cyanide  (ISO)
indometacin  (EXP,ISO)
isoflurane  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (EXP,ISO)
lumacaftor  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
MDL-28170  (EXP,ISO)
melatonin  (EXP,ISO)
memantine  (ISO)
Mesaconitine  (EXP)
methimazole  (EXP)
methoxychlor  (ISO)
methylcobalamin  (EXP)
N-acetyl-L-cysteine  (ISO)
N-Acetylleucyl-leucyl-methioninal  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
NS-398  (EXP)
Nutlin-3  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
procaine  (ISO)
quercetin  (EXP,ISO)
sarin  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
simvastatin  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfur dioxide  (EXP)
surfactin  (ISO)
surfactin C  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP)
Triptolide  (ISO)
undecane  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cornified envelope  (ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (ISO,ISS)
glutamatergic synapse  (IDA,IMP)
lysosome  (ISO)
membrane  (ISO)
mitochondrion  (ISO)
plasma membrane  (IEA,ISO,ISS)
postsynapse  (IDA,IMP)
postsynaptic density  (IDA)
presynapse  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity. Briz V, etal., J Neurosci. 2015 Feb 4;35(5):2269-82. doi: 10.1523/JNEUROSCI.2302-14.2015.
2. Proteomic study of calpain interacting proteins during skeletal muscle aging. Brulé C, etal., Biochimie. 2010 Dec;92(12):1923-33. doi: 10.1016/j.biochi.2010.09.003. Epub 2010 Sep 17.
3. Calpain/calpastatin activities and substrate depletion patterns during hindlimb unweighting and reweighting in skeletal muscle. Enns DL, etal., Eur J Appl Physiol. 2007 Jul;100(4):445-55. Epub 2007 Apr 12.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis. Jiang L, etal., Hypertension. 2012 Nov;60(5):1192-9. doi: 10.1161/HYPERTENSIONAHA.112.196840. Epub 2012 Sep 24.
7. Increased proteolytic activity in lymphocytes from patients with early onset Alzheimer's disease. Karlsson JO, etal., Neurobiol Aging. 1995 Nov-Dec;16(6):901-6.
8. High glucose-induced Ca2+ overload and oxidative stress contribute to apoptosis of cardiac cells through mitochondrial dependent and independent pathways. Kumar S, etal., Biochim Biophys Acta. 2012 Jul;1820(7):907-20. doi: 10.1016/j.bbagen.2012.02.010. Epub 2012 Feb 28.
9. [Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models]. Li MQ, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Mar;46(2):201-4.
10. [Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and cdk5/p25]. Li X, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2014 Mar;32(3):202-6.
11. Calpain 1 and Calpastatin expression is developmentally regulated in rat brain. Li Y, etal., Exp Neurol. 2009 Dec;220(2):316-9. Epub 2009 Sep 12.
12. Calpain-mediated degradation of PSD-95 in developing and adult rat brain. Lu X, etal., Neurosci Lett. 2000 Jun 2;286(2):149-53. doi: 10.1016/s0304-3940(00)01101-0.
13. Influence of electrical stimulation on calpain and ubiquitin-proteasome systems in the denervated and unloaded rat tibialis anterior muscles. Matsumoto A, etal., Acta Histochem. 2014 Jun;116(5):936-42. doi: 10.1016/j.acthis.2014.03.006. Epub 2014 Apr 16.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. A Ca(2+) switch aligns the active site of calpain. Moldoveanu T, etal., Cell 2002 Mar 8;108(5):649-60.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. ERp57-associated mitochondrial micro-calpain truncates apoptosis-inducing factor. Ozaki T, etal., Biochim Biophys Acta. 2008 Oct;1783(10):1955-63. doi: 10.1016/j.bbamcr.2008.05.011. Epub 2008 May 24.
18. Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria. Ozaki T, etal., Biochim Biophys Acta. 2009 Dec;1793(12):1848-59. doi: 10.1016/j.bbamcr.2009.10.002. Epub 2009 Oct 13.
19. The ultrastructural localization of calcium-activated protease "calpain" in rat brain. Perlmutter LS, etal., Synapse. 1988;2(1):79-88. doi: 10.1002/syn.890020111.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Effects of injury severity on regional and temporal mRNA expression levels of calpains and caspases after traumatic brain injury in rats. Ringger NC, etal., J Neurotrauma. 2004 Jul;21(7):829-41.
25. A novel role for calpain in the endothelial dysfunction induced by activation of angiotensin II type 1 receptor signaling. Scalia R, etal., Circ Res. 2011 Apr 29;108(9):1102-11. doi: 10.1161/CIRCRESAHA.110.229393. Epub 2011 Mar 17.
26. Calpain expression and infiltration of activated T cells in experimental allergic encephalomyelitis over time: increased calpain activity begins with onset of disease. Schaecher K, etal., J Neuroimmunol 2002 Aug;129(1-2):1-9.
27. Primary sequences of rat mu-calpain large and small subunits are, respectively, moderately and highly similar to those of human. Sorimachi H, etal., Biochim Biophys Acta 1996 Nov 11;1309(1-2):37-41.
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. Taniguchi S, etal., FEBS Lett. 2001 Jan 26;489(1):46-50.
30. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
31. Perspective on rhabdomyolysis-induced acute kidney injury and new treatment options. Ulusoy S, etal., Am J Nephrol. 2013;38(5):368-78. doi: 10.1159/000355537. Epub 2013 Oct 22.
32. Marking synaptic activity in dendritic spines with a calpain substrate exhibiting fluorescence resonance energy transfer. Vanderklish PW, etal., Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2253-8. doi: 10.1073/pnas.040565597.
33. Differential localization of autolyzed calpains 1 and 2 in slow and fast skeletal muscles in the early phase of atrophy. Vermaelen M, etal., Am J Physiol Cell Physiol. 2007 May;292(5):C1723-31. Epub 2006 Dec 20.
34. Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons. Wang CF and Huang YS, Mol Cell Biol. 2012 Aug;32(16):3321-32. doi: 10.1128/MCB.00296-12. Epub 2012 Jun 18.
35. Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration. Wang Y, etal., J Neurosci. 2013 Nov 27;33(48):18880-92. doi: 10.1523/JNEUROSCI.3293-13.2013.
36. Calpain 1 knockdown improves tissue sparing and functional outcomes after spinal cord injury in rats. Yu CG, etal., J Neurotrauma. 2013 Mar 15;30(6):427-33. doi: 10.1089/neu.2012.2561. Epub 2013 Mar 26.
37. Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study. Zhao X, etal., J Cereb Blood Flow Metab. 1998 Feb;18(2):161-7. doi: 10.1097/00004647-199802000-00006.
Additional References at PubMed
PMID:2400579   PMID:2407243   PMID:8769305   PMID:8954105   PMID:9271093   PMID:12014988   PMID:12150984   PMID:12534936   PMID:14559243   PMID:14656436   PMID:15101113   PMID:15132950  
PMID:15191812   PMID:15489334   PMID:15640140   PMID:15680332   PMID:15979593   PMID:16107503   PMID:16356733   PMID:16411745   PMID:16758583   PMID:16857710   PMID:16959224   PMID:16981728  
PMID:17121855   PMID:17334225   PMID:17513494   PMID:17529984   PMID:17953355   PMID:18053648   PMID:18055215   PMID:18070881   PMID:18088374   PMID:18157632   PMID:18258589   PMID:18289510  
PMID:18395616   PMID:18420382   PMID:18493299   PMID:18495118   PMID:18590784   PMID:18627259   PMID:19022302   PMID:19056867   PMID:19162106   PMID:19199708   PMID:19295178   PMID:19318376  
PMID:19608740   PMID:20473717   PMID:20945043   PMID:21071702   PMID:21423176   PMID:21490676   PMID:21531719   PMID:21613375   PMID:21765948   PMID:22427928   PMID:22496446   PMID:22547201  
PMID:22555453   PMID:23376485   PMID:23400779   PMID:23408424   PMID:23533145   PMID:23919677   PMID:23994487   PMID:25319025   PMID:25336645   PMID:25416777   PMID:25756858   PMID:25895366  
PMID:26047104   PMID:26086870   PMID:26297661   PMID:26818429   PMID:26974309   PMID:27622212   PMID:27956030   PMID:28342779   PMID:28447745   PMID:28714350   PMID:28754591   PMID:28821652  
PMID:29249590   PMID:29772491   PMID:30423475   PMID:30796971   PMID:31278888   PMID:31815668   PMID:31904090   PMID:35597151   PMID:36382482   PMID:36430329   PMID:37325630   PMID:37602925  
PMID:38291756  


Genomics

Comparative Map Data
Capn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,705,219 - 212,736,134 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1212,705,222 - 212,729,445 (-)EnsemblGRCr8
mRatBN7.21203,275,912 - 203,300,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1203,277,344 - 203,300,177 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1211,629,235 - 211,653,778 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,721,298 - 218,745,531 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,412,355 - 211,436,597 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,346,081 - 221,370,965 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,346,066 - 221,370,322 (-)Ensemblrn6Rnor6.0
Rnor_5.01228,280,716 - 228,306,187 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41208,620,286 - 208,645,007 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1200,809,826 - 200,833,901 (-)NCBICelera
RGSC_v3.11208,773,739 - 208,798,460 (-)NCBI
Cytogenetic Map1q43NCBI
CAPN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,181,373 - 65,212,006 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,180,566 - 65,212,006 (+)Ensemblhg38GRCh38
GRCh371164,948,844 - 64,979,477 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361164,705,919 - 64,736,052 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341164,705,918 - 64,736,052NCBI
Celera1162,275,660 - 62,305,793 (+)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,275,919 - 61,306,719 (+)NCBIHuRef
CHM1_11164,832,312 - 64,863,095 (+)NCBICHM1_1
T2T-CHM13v2.01165,174,678 - 65,205,290 (+)NCBIT2T-CHM13v2.0
Capn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,038,573 - 6,065,855 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,038,573 - 6,065,927 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38195,988,545 - 6,015,825 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,988,545 - 6,015,897 (-)Ensemblmm10GRCm38
MGSCv37195,988,545 - 6,015,825 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36195,988,545 - 6,015,151 (-)NCBIMGSCv36mm8
Celera195,858,975 - 5,885,371 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.34NCBI
Capn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,004,426 - 20,025,708 (-)Ensembl
ChiLan1.0NW_00495542220,006,448 - 20,026,984 (-)NCBIChiLan1.0ChiLan1.0
CAPN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2966,416,231 - 66,447,116 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,459,271 - 67,490,086 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01160,545,837 - 60,576,631 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11163,884,451 - 63,916,731 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,886,015 - 63,916,021 (+)EnsemblpanPan2panpan1.1
CAPN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,983,266 - 52,010,831 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,983,824 - 52,010,757 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1850,591,530 - 50,619,992 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01853,024,769 - 53,053,236 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,941,097 - 53,053,224 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,121,242 - 52,149,446 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,694,854 - 51,723,087 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01852,489,182 - 52,517,646 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Capn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,736,614 - 7,759,589 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,178,901 - 4,201,052 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,178,963 - 4,201,037 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,997,985 - 7,022,684 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.126,997,513 - 7,024,410 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,129,549 - 6,155,985 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAPN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,014,087 - 9,050,389 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,014,084 - 9,049,804 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038106,399,098 - 106,431,434 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Capn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476721,146,999 - 21,169,957 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476721,146,310 - 21,169,593 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Capn1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v121,684,705 - 1,710,075 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Capn1
176 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:290
Count of miRNA genes:162
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000028431
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat

Markers in Region
D1Got194  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,293,397 - 203,293,528 (+)MAPPERmRatBN7.2
Rnor_6.01221,363,524 - 221,363,653NCBIRnor6.0
Rnor_5.01228,298,093 - 228,298,222UniSTSRnor5.0
RGSC_v3.41208,638,027 - 208,638,156UniSTSRGSC3.4
RGSC_v3.41208,638,026 - 208,638,156RGDRGSC3.4
Celera1200,827,149 - 200,827,278UniSTS
RGSC_v3.11208,791,480 - 208,791,609RGD
RH 3.4 Map11535.8UniSTS
RH 3.4 Map11535.8RGD
RH 2.0 Map11144.1RGD
Cytogenetic Map1q43UniSTS
RH128571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,275,935 - 203,276,143 (+)MAPPERmRatBN7.2
Rnor_6.01221,346,105 - 221,346,311NCBIRnor6.0
Rnor_5.01228,280,740 - 228,280,946UniSTSRnor5.0
RGSC_v3.41208,620,310 - 208,620,516UniSTSRGSC3.4
Celera1200,809,850 - 200,810,056UniSTS
RH 3.4 Map11538.0UniSTS
Cytogenetic Map1q43UniSTS
AU048692  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,285,403 - 203,285,685 (+)MAPPERmRatBN7.2
Rnor_6.01221,355,534 - 221,355,815NCBIRnor6.0
Rnor_5.01228,290,103 - 228,290,384UniSTSRnor5.0
RGSC_v3.41208,630,037 - 208,630,318UniSTSRGSC3.4
Celera1200,819,158 - 200,819,439UniSTS
Cytogenetic Map1q43UniSTS
MARC_2595-2596:1027009134:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21203,277,766 - 203,278,793 (+)MAPPERmRatBN7.2
Rnor_6.01221,347,908 - 221,348,932NCBIRnor6.0
Rnor_5.01228,282,842 - 228,283,866UniSTSRnor5.0
RGSC_v3.41208,622,533 - 208,623,557UniSTSRGSC3.4
Celera1200,811,505 - 200,812,529UniSTS
Cytogenetic Map1q43UniSTS
MARC_4751-4752:996679637:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81212,708,087 - 212,708,931 (+)Marker Load Pipeline
mRatBN7.21203,278,786 - 203,279,630 (+)MAPPERmRatBN7.2
Rnor_6.01221,348,926 - 221,349,769NCBIRnor6.0
Rnor_5.01228,283,860 - 228,284,703UniSTSRnor5.0
RGSC_v3.41208,623,551 - 208,624,394UniSTSRGSC3.4
Celera1200,812,523 - 200,813,366UniSTS
Cytogenetic Map1q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028431   ⟹   ENSRNOP00000028431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1212,706,974 - 212,729,445 (-)Ensembl
mRatBN7.2 Ensembl1203,277,344 - 203,300,177 (-)Ensembl
Rnor_6.0 Ensembl1221,346,066 - 221,370,322 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000132675   ⟹   ENSRNOP00000105278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1212,705,571 - 212,729,445 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156162   ⟹   ENSRNOP00000112486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1212,705,222 - 212,729,054 (-)Ensembl
RefSeq Acc Id: NM_019152   ⟹   NP_062025
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,705,219 - 212,729,445 (-)NCBI
mRatBN7.21203,275,912 - 203,300,152 (-)NCBI
Rnor_6.01221,346,081 - 221,370,276 (-)NCBI
Rnor_5.01228,280,716 - 228,306,187 (-)NCBI
RGSC_v3.41208,620,286 - 208,645,007 (-)RGD
Celera1200,809,826 - 200,833,901 (-)RGD
Sequence:
RefSeq Acc Id: XM_063282744   ⟹   XP_063138814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,705,219 - 212,736,134 (-)NCBI
RefSeq Acc Id: XM_063282746   ⟹   XP_063138816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,705,219 - 212,729,770 (-)NCBI
RefSeq Acc Id: XM_063282747   ⟹   XP_063138817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,705,219 - 212,729,505 (-)NCBI
RefSeq Acc Id: XM_063282748   ⟹   XP_063138818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,708,971 - 212,729,528 (-)NCBI
RefSeq Acc Id: NP_062025   ⟸   NM_019152
- UniProtKB: P97571 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028431   ⟸   ENSRNOT00000028431
RefSeq Acc Id: XP_063138814   ⟸   XM_063282744
- Peptide Label: isoform X1
- UniProtKB: P97571 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063138816   ⟸   XM_063282746
- Peptide Label: isoform X1
- UniProtKB: P97571 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063138817   ⟸   XM_063282747
- Peptide Label: isoform X1
- UniProtKB: P97571 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063138818   ⟸   XM_063282748
- Peptide Label: isoform X2
- UniProtKB: P97571 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000105278   ⟸   ENSRNOT00000132675
Ensembl Acc Id: ENSRNOP00000112486   ⟸   ENSRNOT00000156162
Protein Domains
Calpain catalytic   EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97571-F1-model_v2 AlphaFold P97571 1-713 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690678
Promoter ID:EPDNEW_R1202
Type:multiple initiation site
Name:Capn1_1
Description:calpain 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01221,370,307 - 221,370,367EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2267 AgrOrtholog
BioCyc Gene G2FUF-56636 BioCyc
Ensembl Genes ENSRNOG00000020935 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000156162 ENTREZGENE
Gene3D-CATH 2.60.120.380 UniProtKB/Swiss-Prot
  Cysteine proteinases UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599301 IMAGE-MGC_LOAD
InterPro C2_III UniProtKB/Swiss-Prot
  Calpain_cysteine_protease UniProtKB/Swiss-Prot
  Calpain_domain_III UniProtKB/Swiss-Prot
  Calpain_III UniProtKB/Swiss-Prot
  Calpain_III_sf UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_cys_AS UniProtKB/Swiss-Prot
  Peptidase_C2_calpain_cat UniProtKB/Swiss-Prot
KEGG Report rno:29153 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72486 IMAGE-MGC_LOAD
NCBI Gene 29153 ENTREZGENE
PANTHER CALPAIN UniProtKB/Swiss-Prot
  PTHR10183:SF284 UniProtKB/Swiss-Prot
Pfam Calpain_III UniProtKB/Swiss-Prot
  EF-hand_8 UniProtKB/Swiss-Prot
  Peptidase_C2 UniProtKB/Swiss-Prot
PhenoGen Capn1 PhenoGen
PRINTS CALPAIN UniProtKB/Swiss-Prot
PROSITE CALPAIN_CAT UniProtKB/Swiss-Prot
  EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020935 RatGTEx
SMART calpain_III UniProtKB/Swiss-Prot
  CysPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
  SSF49758 UniProtKB/Swiss-Prot
  SSF54001 UniProtKB/Swiss-Prot
TIGR TC206297
UniProt A0ABK0L5W3_RAT UniProtKB/TrEMBL
  A0ABK0M8P9_RAT UniProtKB/TrEMBL
  A6HZB9_RAT UniProtKB/TrEMBL
  CAN1_RAT UniProtKB/Swiss-Prot
  F1LS29_RAT UniProtKB/TrEMBL
  P97571 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Capn1  calpain 1  Capn1  calpain 1, (mu/I) large subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-06 Capn1  calpain 1, (mu/I) large subunit  Capn1  calpain 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Capn1  calpain 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in experimental allergic encephalomyelitis (EAE) 634693
gene_domains contains nine putative protease inhibitor domains, four EGF repeats, and a laminin domain III homology region 632164
gene_expression expressed in inflammatory cells, activated microglia, and astrocytes 634693
gene_function Ca2+ dependent protease 70442