Aqp8 (aquaporin 8) - Rat Genome Database

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Gene: Aqp8 (aquaporin 8) Rattus norvegicus
Analyze
Symbol: Aqp8
Name: aquaporin 8
RGD ID: 2146
Description: Enables ammonium channel activity; methylammonium channel activity; and water channel activity. Involved in several processes, including ammonium import across plasma membrane; canalicular bile acid transport; and hydrogen peroxide transmembrane transport. Located in apical plasma membrane; basolateral plasma membrane; and mitochondrial inner membrane. Biomarker of brain ischemia. Orthologous to human AQP8 (aquaporin 8); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol 17-glucosiduronic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AQP-8; aquaporin-8; MGC93492
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81187,424,314 - 187,430,243 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1187,424,417 - 187,430,242 (+)EnsemblGRCr8
mRatBN7.21177,993,313 - 177,999,158 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,993,305 - 177,999,158 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1186,329,480 - 186,335,292 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01193,515,484 - 193,521,296 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01186,193,169 - 186,198,970 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01193,424,818 - 193,430,665 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1193,424,812 - 193,430,676 (+)Ensemblrn6Rnor6.0
Rnor_5.01200,483,584 - 200,489,432 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41182,331,494 - 182,337,291 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1175,681,663 - 175,687,460 (+)NCBICelera
RGSC_v3.11182,471,745 - 182,477,543 (+)NCBI
Cytogenetic Map1q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Boldine  (EXP)
cadmium sulfate  (ISO)
capecitabine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dextran sulfate  (ISO)
dibenzofurans  (ISO)
diprotium oxide  (EXP,ISO)
diquat  (ISO)
epoxiconazole  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
glucose  (ISO)
graphene oxide  (ISO)
herbicide  (ISO)
hydrogen peroxide  (ISO)
leflunomide  (ISO)
leupeptin  (EXP)
lipopolysaccharide  (ISO)
mercury atom  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
ochratoxin A  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (ISO)
senecionine  (ISO)
sodium dichromate  (ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
water  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
ammonium channel activity  (IDA,IEA,ISO,ISS)
channel activity  (IEA)
methylammonium channel activity  (IDA,IEA,ISO)
protein binding  (ISO)
urea channel activity  (IEA,ISO,ISS)
water channel activity  (IBA,IDA,IEA,IMP,ISO,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression and regulation of aquaporins 1, 8, and 9 in the testis, efferent ducts, and epididymis of adult rats and during postnatal development. Badran HH and Hermo LS, J Androl 2002 May-Jun;23(3):358-73.
2. Possible involvement of aquaporin-7 and -8 in rat testis development and spermatogenesis. Calamita G, etal., Biochem Biophys Res Commun 2001 Nov 2;288(3):619-25.
3. Expression and immunolocalization of the aquaporin-8 water channel in rat gastrointestinal tract. Calamita G, etal., Eur J Cell Biol 2001 Nov;80(11):711-9.
4. The inner mitochondrial membrane has aquaporin-8 water channels and is highly permeable to water. Calamita G, etal., J Biol Chem. 2005 Apr 29;280(17):17149-53. doi: 10.1074/jbc.C400595200. Epub 2005 Mar 4.
5. Data of H2O2 release from AQP8-knockdown rat hepatocyte mitochondria. Danielli M, etal., Data Brief. 2019 Mar 6;23:103722. doi: 10.1016/j.dib.2019.103722. eCollection 2019 Apr.
6. Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways. Elkjaer ML, etal., Am J Physiol Renal Physiol 2001 Dec;281(6):F1047-57.
7. The water channel aquaporin-8 is mainly intracellular in rat hepatocytes, and its plasma membrane insertion is stimulated by cyclic AMP. Garcia F, etal., J Biol Chem 2001 Apr 13;276(15):12147-52.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes. Gradilone SA, etal., Hepatology 2003 Jun;37(6):1435-41.
11. NH3 and NH4+ permeability in aquaporin-expressing Xenopus oocytes. Holm LM, etal., Pflugers Arch. 2005 Sep;450(6):415-28. doi: 10.1007/s00424-005-1399-1. Epub 2005 Jun 30.
12. Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion. Huebert RC, etal., J Biol Chem 2002 Jun 21;277(25):22710-7.
13. Cloning and functional expression of a second new aquaporin abundantly expressed in testis. Ishibashi K, etal., Biochem Biophys Res Commun 1997 Aug 28;237(3):714-8.
14. AQP8 is a crucial H2O2 transporter in insulin-producing RINm5F cells. Krüger C, etal., Redox Biol. 2021 Jul;43:101962. doi: 10.1016/j.redox.2021.101962. Epub 2021 Apr 1.
15. Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon. Laforenza U, etal., J Nutr. 2005 Oct;135(10):2329-36. doi: 10.1093/jn/135.10.2329.
16. Purification and functional characterization of aquaporin-8. Liu K, etal., Biol Cell. 2006 Mar;98(3):153-61.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Fast and selective ammonia transport by aquaporin-8. Saparov SM, etal., J Biol Chem. 2007 Feb 23;282(8):5296-301. doi: 10.1074/jbc.M609343200. Epub 2006 Dec 21.
23. Aquaporin-8-facilitated mitochondrial ammonia transport. Soria LR, etal., Biochem Biophys Res Commun. 2010 Mar 5;393(2):217-21. doi: 10.1016/j.bbrc.2010.01.104. Epub 2010 Feb 2.
24. Ammonia detoxification via ureagenesis in rat hepatocytes involves mitochondrial aquaporin-8 channels. Soria LR, etal., Hepatology. 2013 May;57(5):2061-71. doi: 10.1002/hep.26236.
25. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
26. Immunolocalization of aquaporin-8 in rat digestive organs and testis. Tani T, etal., Arch Histol Cytol. 2001 May;64(2):159-68. doi: 10.1679/aohc.64.159.
27. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
28. Osmotic water permeability of rat intestinal brush border membrane vesicles: involvement of aquaporin-7 and aquaporin-8 and effect of metal ions. Tritto S, etal., Biochem Cell Biol. 2007 Dec;85(6):675-84. doi: 10.1139/o07-142.
29. Evidence that aquaporin-8 is located in the basolateral membrane of rat submandibular gland acinar cells. Wellner RB, etal., Pflugers Arch. 2000 Nov;441(1):49-56. doi: 10.1007/s004240000396.
30. Evidence from knockout mice against physiologically significant aquaporin 8-facilitated ammonia transport. Yang B, etal., Am J Physiol Cell Physiol. 2006 Sep;291(3):C417-23. doi: 10.1152/ajpcell.00057.2006. Epub 2006 Apr 19.
31. Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. Yang M, etal., Brain Res. 2009 Sep 22;1290:121-32. Epub 2009 Jul 16.
Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:7530250   PMID:9369468   PMID:9374520   PMID:9405233   PMID:9806845   PMID:9829975   PMID:10318966   PMID:10510269   PMID:10564231   PMID:11001937  
PMID:11034202   PMID:11076974   PMID:11573934   PMID:12084581   PMID:12717383   PMID:12801959   PMID:14701836   PMID:15489334   PMID:15647389   PMID:15682487   PMID:16311720   PMID:16596446  
PMID:17110522   PMID:17178220   PMID:17636236   PMID:18202181   PMID:18501347   PMID:18511455   PMID:18662282   PMID:18683753   PMID:18762715   PMID:19193945   PMID:20958229   PMID:21251984  
PMID:21713710   PMID:22622463   PMID:24286754   PMID:24642373   PMID:26194146   PMID:28525373   PMID:30579780   PMID:32115689  


Genomics

Comparative Map Data
Aqp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81187,424,314 - 187,430,243 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1187,424,417 - 187,430,242 (+)EnsemblGRCr8
mRatBN7.21177,993,313 - 177,999,158 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,993,305 - 177,999,158 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1186,329,480 - 186,335,292 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01193,515,484 - 193,521,296 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01186,193,169 - 186,198,970 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01193,424,818 - 193,430,665 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1193,424,812 - 193,430,676 (+)Ensemblrn6Rnor6.0
Rnor_5.01200,483,584 - 200,489,432 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41182,331,494 - 182,337,291 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1175,681,663 - 175,687,460 (+)NCBICelera
RGSC_v3.11182,471,745 - 182,477,543 (+)NCBI
Cytogenetic Map1q36NCBI
AQP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381625,216,947 - 25,228,932 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1625,215,731 - 25,228,932 (+)Ensemblhg38GRCh38
GRCh371625,228,268 - 25,240,253 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361625,135,786 - 25,147,754 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341625,135,785 - 25,147,753NCBI
Celera1624,008,196 - 24,020,163 (+)NCBICelera
Cytogenetic Map16p12.1NCBI
HuRef1623,321,042 - 23,333,010 (+)NCBIHuRef
CHM1_11626,242,508 - 26,254,476 (+)NCBICHM1_1
T2T-CHM13v2.01625,496,437 - 25,508,423 (+)NCBIT2T-CHM13v2.0
Aqp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397123,061,517 - 123,067,226 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7123,061,514 - 123,067,227 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387123,462,294 - 123,468,003 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7123,462,291 - 123,468,004 (+)Ensemblmm10GRCm38
MGSCv377130,605,808 - 130,611,517 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367123,253,460 - 123,259,134 (+)NCBIMGSCv36mm8
Celera7123,345,814 - 123,351,523 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map767.42NCBI
Aqp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554933,550,120 - 3,559,206 (+)Ensembl
ChiLan1.0NW_0049554933,550,697 - 3,558,875 (+)NCBIChiLan1.0ChiLan1.0
AQP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21826,625,618 - 26,639,032 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11631,146,930 - 31,160,329 (+)NCBINHGRI_mPanPan1
PanPan1.11625,456,998 - 25,469,713 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1625,458,165 - 25,469,713 (+)EnsemblpanPan2panpan1.1
AQP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1620,984,868 - 20,992,647 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl620,984,908 - 20,992,524 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha622,560,101 - 22,567,873 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0621,124,913 - 21,132,686 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl621,124,953 - 21,132,569 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1620,928,723 - 20,936,525 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0620,830,570 - 20,838,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0621,225,638 - 21,233,418 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aqp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344121,332,842 - 121,340,934 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365019,430,775 - 9,436,813 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365019,430,872 - 9,438,182 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl321,491,719 - 21,503,863 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1321,493,564 - 21,503,778 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2322,088,868 - 22,099,108 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1522,928,230 - 22,940,814 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl522,928,350 - 22,940,856 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660686,785,501 - 6,798,873 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aqp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478210,075,062 - 10,082,076 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478210,074,875 - 10,082,628 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Aqp8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1278,396,663 - 78,402,499 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aqp8
16 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:86
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000019939
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1182383862191260518Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
RH142181  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,998,862 - 177,999,027 (+)MAPPERmRatBN7.2
Rnor_6.01193,430,372 - 193,430,536NCBIRnor6.0
Rnor_5.01200,489,136 - 200,489,300UniSTSRnor5.0
RGSC_v3.41182,336,998 - 182,337,162UniSTSRGSC3.4
Celera1175,687,167 - 175,687,331UniSTS
Cytogenetic Map1q36UniSTS
RH136820  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,998,874 - 177,999,091 (+)MAPPERmRatBN7.2
Rnor_6.01193,430,384 - 193,430,600NCBIRnor6.0
Rnor_5.01200,489,148 - 200,489,364UniSTSRnor5.0
RGSC_v3.41182,337,010 - 182,337,226UniSTSRGSC3.4
Celera1175,687,179 - 175,687,395UniSTS
RH 3.4 Map11377.6UniSTS
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
16 7 49 78 83 86 59 22 59 6 214 88 2 63 45 92 27

Sequence


Ensembl Acc Id: ENSRNOT00000019939   ⟹   ENSRNOP00000019939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1187,424,417 - 187,430,241 (+)Ensembl
mRatBN7.2 Ensembl1177,993,305 - 177,999,158 (+)Ensembl
Rnor_6.0 Ensembl1193,424,812 - 193,430,676 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118056   ⟹   ENSRNOP00000092342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1187,424,627 - 187,430,242 (+)Ensembl
mRatBN7.2 Ensembl1177,993,543 - 177,999,158 (+)Ensembl
RefSeq Acc Id: NM_019158   ⟹   NP_062031
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,424,443 - 187,430,240 (+)NCBI
mRatBN7.21177,993,359 - 177,999,156 (+)NCBI
Rnor_6.01193,424,868 - 193,430,665 (+)NCBI
Rnor_5.01200,483,584 - 200,489,432 (+)NCBI
RGSC_v3.41182,331,494 - 182,337,291 (+)RGD
Celera1175,681,663 - 175,687,460 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230187   ⟹   XP_006230249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,424,314 - 187,430,243 (+)NCBI
mRatBN7.21177,993,313 - 177,999,158 (+)NCBI
Rnor_6.01193,424,818 - 193,430,395 (+)NCBI
Rnor_5.01200,483,584 - 200,489,432 (+)NCBI
Sequence:
RefSeq Acc Id: NP_062031   ⟸   NM_019158
- UniProtKB: P56405 (UniProtKB/Swiss-Prot),   A0A8I6GK50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230249   ⟸   XM_006230187
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000019939   ⟸   ENSRNOT00000019939
Ensembl Acc Id: ENSRNOP00000092342   ⟸   ENSRNOT00000118056

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56405-F1-model_v2 AlphaFold P56405 1-263 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690382
Promoter ID:EPDNEW_R907
Type:initiation region
Name:Aqp8_1
Description:aquaporin 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01193,424,911 - 193,424,971EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2146 AgrOrtholog
BioCyc Gene G2FUF-57520 BioCyc
Ensembl Genes ENSRNOG00000014652 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019939 ENTREZGENE
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7114305 IMAGE-MGC_LOAD
InterPro Aquaporin-like UniProtKB/Swiss-Prot
  Aquaporin_8 UniProtKB/Swiss-Prot
  Aquaporin_transptr UniProtKB/Swiss-Prot
  MIP UniProtKB/Swiss-Prot
  MIP_CS UniProtKB/Swiss-Prot
KEGG Report rno:29172 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93492 IMAGE-MGC_LOAD
NCBI Gene 29172 ENTREZGENE
PANTHER AQUAPORIN-8 UniProtKB/Swiss-Prot
  PTHR45665 UniProtKB/Swiss-Prot
Pfam MIP UniProtKB/Swiss-Prot
PhenoGen Aqp8 PhenoGen
PRINTS AQUAPORIN8 UniProtKB/Swiss-Prot
  MINTRINSICP UniProtKB/Swiss-Prot
PROSITE MIP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014652 RatGTEx
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot
TIGR TC219837
UniProt A0A0H2UHM1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GK50 ENTREZGENE, UniProtKB/TrEMBL
  A6I904 ENTREZGENE, UniProtKB/TrEMBL
  AQP8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Aqp8  aquaporin 8      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process increases cell membrane water permeability facilitating rapid movement of water in response to osmotic gradients 67930
gene_process contributes to water transport in cAMP-stimulated hepatocytes 67930