Ambn (ameloblastin) - Rat Genome Database

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Gene: Ambn (ameloblastin) Rattus norvegicus
Analyze
Symbol: Ambn
Name: ameloblastin
RGD ID: 2101
Description: Predicted to enable growth factor activity. Predicted to be involved in cell adhesion and regulation of cell population proliferation. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1F. Orthologous to human AMBN (ameloblastin); INTERACTS WITH ammonium chloride; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amelin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81419,885,802 - 19,898,422 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1419,885,743 - 19,898,433 (-)EnsemblGRCr8
mRatBN7.21419,601,761 - 19,614,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1419,601,702 - 19,614,393 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1419,591,037 - 19,603,705 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01420,909,907 - 20,922,580 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01419,612,560 - 19,625,205 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,239,887 - 21,252,534 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,240,398 - 21,252,538 (-)Ensemblrn6Rnor6.0
Rnor_5.01421,151,232 - 21,164,256 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41421,183,338 - 21,196,650 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1418,940,192 - 18,974,478 (-)NCBICelera
RGSC_v3.11421,183,341 - 21,196,650 (-)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A novel gene expressed in rat ameloblasts codes for proteins with cell binding domains. Cerny R, etal., J Bone Miner Res 1996 Jul;11(7):883-91.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Full-length sequence, localization, and chromosomal mapping of ameloblastin. A novel tooth-specific gene. Krebsbach PH, etal., J Biol Chem 1996 Feb 23;271(8):4431-5.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12803485   PMID:16674693   PMID:17184233   PMID:18281204   PMID:19648121   PMID:20854943   PMID:21149578   PMID:27193486  


Genomics

Comparative Map Data
Ambn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81419,885,802 - 19,898,422 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1419,885,743 - 19,898,433 (-)EnsemblGRCr8
mRatBN7.21419,601,761 - 19,614,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1419,601,702 - 19,614,393 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1419,591,037 - 19,603,705 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01420,909,907 - 20,922,580 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01419,612,560 - 19,625,205 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,239,887 - 21,252,534 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,240,398 - 21,252,538 (-)Ensemblrn6Rnor6.0
Rnor_5.01421,151,232 - 21,164,256 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41421,183,338 - 21,196,650 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1418,940,192 - 18,974,478 (-)NCBICelera
RGSC_v3.11421,183,341 - 21,196,650 (-)NCBI
Cytogenetic Map14p22NCBI
AMBN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38470,592,256 - 70,607,288 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl470,592,256 - 70,607,288 (+)Ensemblhg38GRCh38
GRCh37471,457,973 - 71,473,005 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36471,492,590 - 71,507,594 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34471,638,760 - 71,653,762NCBI
Celera468,816,162 - 68,831,378 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef467,260,447 - 67,275,390 (+)NCBIHuRef
CHM1_1471,493,982 - 71,509,012 (+)NCBICHM1_1
T2T-CHM13v2.0473,933,220 - 73,948,252 (+)NCBIT2T-CHM13v2.0
Ambn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39588,603,850 - 88,616,390 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl588,603,850 - 88,616,390 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38588,455,991 - 88,468,531 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl588,455,991 - 88,468,531 (+)Ensemblmm10GRCm38
MGSCv37588,885,036 - 88,897,556 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36589,530,572 - 89,543,092 (+)NCBIMGSCv36mm8
Celera586,604,818 - 86,617,344 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.63NCBI
Ambn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554472,363,240 - 2,374,827 (-)Ensembl
ChiLan1.0NW_0049554472,363,240 - 2,374,827 (-)NCBIChiLan1.0ChiLan1.0
AMBN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2359,477,321 - 59,492,343 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1459,672,192 - 59,687,203 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0453,616,553 - 53,631,566 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1459,961,939 - 59,976,750 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl459,961,939 - 59,976,750 (-)EnsemblpanPan2panpan1.1
AMBN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11359,899,968 - 59,912,699 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1359,899,960 - 59,912,655 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1359,634,149 - 59,647,121 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01360,705,599 - 60,718,555 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1360,705,595 - 60,718,250 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11360,320,956 - 60,333,943 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01359,812,504 - 59,825,448 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01360,959,429 - 60,972,465 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ambn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528515,702,487 - 15,715,557 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365984,155,061 - 4,167,497 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365984,154,801 - 4,166,565 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMBN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl867,381,137 - 67,394,394 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1867,381,137 - 67,394,394 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2871,288,922 - 71,302,169 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AMBN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1719,107,182 - 19,121,992 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl719,107,299 - 19,122,285 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660843,763,200 - 3,778,295 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ambn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248901,942,559 - 1,954,490 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248901,943,471 - 1,954,948 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ambn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1111,952,005 - 1,964,959 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ambn
83 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:63
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000005003
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 2 1 52 31 30 5 33 5 67 45 1 42 9 27 25 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000005003   ⟹   ENSRNOP00000005003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1419,885,802 - 19,898,422 (-)Ensembl
mRatBN7.2 Ensembl1419,601,765 - 19,614,386 (-)Ensembl
Rnor_6.0 Ensembl1421,240,398 - 21,252,538 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105630   ⟹   ENSRNOP00000087626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1419,885,743 - 19,898,433 (-)Ensembl
mRatBN7.2 Ensembl1419,601,702 - 19,614,393 (-)Ensembl
RefSeq Acc Id: NM_012900   ⟹   NP_037032
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81419,885,802 - 19,898,422 (-)NCBI
mRatBN7.21419,601,761 - 19,614,382 (-)NCBI
Rnor_6.01421,239,887 - 21,252,534 (-)NCBI
Rnor_5.01421,151,232 - 21,164,256 (-)NCBI
RGSC_v3.41421,183,338 - 21,196,650 (-)RGD
Celera1418,940,192 - 18,974,478 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037032 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52428 (Get FASTA)   NCBI Sequence Viewer  
  CAA90414 (Get FASTA)   NCBI Sequence Viewer  
  CAA90415 (Get FASTA)   NCBI Sequence Viewer  
  EDL88511 (Get FASTA)   NCBI Sequence Viewer  
  EDL88512 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000087626
  ENSRNOP00000087626.1
GenBank Protein Q62840 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037032   ⟸   NM_012900
- Peptide Label: precursor
- UniProtKB: Q540J9 (UniProtKB/Swiss-Prot),   Q63043 (UniProtKB/Swiss-Prot),   Q62840 (UniProtKB/Swiss-Prot),   A6KKJ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005003   ⟸   ENSRNOT00000005003
Ensembl Acc Id: ENSRNOP00000087626   ⟸   ENSRNOT00000105630

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62840-F1-model_v2 AlphaFold Q62840 1-422 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2101 AgrOrtholog
BioCyc Gene G2FUF-16157 BioCyc
Ensembl Genes ENSRNOG00000003718 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000105630 ENTREZGENE
  ENSRNOT00000105630.1 UniProtKB/Swiss-Prot
InterPro Amelin UniProtKB/Swiss-Prot
KEGG Report rno:25376 UniProtKB/Swiss-Prot
NCBI Gene 25376 ENTREZGENE
PANTHER AMELOBLASTIN UniProtKB/Swiss-Prot
  PTHR14115 UniProtKB/Swiss-Prot
Pfam Amelin UniProtKB/Swiss-Prot
PhenoGen Ambn PhenoGen
RatGTEx ENSRNOG00000003718 RatGTEx
SMART Amelin UniProtKB/Swiss-Prot
UniProt A0A8L2Q1Q4_RAT UniProtKB/TrEMBL
  A6KKJ8_RAT UniProtKB/TrEMBL
  A6KKJ9 ENTREZGENE, UniProtKB/TrEMBL
  AMBN_RAT UniProtKB/Swiss-Prot
  Q540J9 ENTREZGENE
  Q62840 ENTREZGENE
  Q63043 ENTREZGENE
UniProt Secondary Q540J9 UniProtKB/Swiss-Prot
  Q63043 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ambn  Ameloblastin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains integrin recognition sequence DGEA 632199
gene_expression expressed in ameloblasts during enamel matrix formation 632199
gene_process may serve as a structural component of the enamel matrix 632199
gene_protein encodes two variant forms containing 407 and 324 amino acids 632199