Actg2 (actin gamma 2, smooth muscle) - Rat Genome Database

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Gene: Actg2 (actin gamma 2, smooth muscle) Rattus norvegicus
Analyze
Symbol: Actg2
Name: actin gamma 2, smooth muscle
RGD ID: 2027
Description: Predicted to enable ATP binding activity and hydrolase activity. Involved in cellular response to acetaldehyde; cellular response to interleukin-6; and response to ethanol. Predicted to be located in several cellular components, including filopodium; lamellipodium; and myosin filament. Predicted to be active in actin cytoskeleton. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to human ACTG2 (actin gamma 2, smooth muscle); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ACTGE; Actin gamma 2 smooth muscle enteric; actin, gamma 2; actin, gamma 2, smooth muscle, enteric; actin, gamma-enteric smooth muscle; alpha-actin-3; alpha-smooth muscle actin; gamma-2-actin; gamma-enteric smooth muscle actin; MGC105507; SMGA; smooth muscle gamma-actin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,579,513 - 117,604,379 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4117,579,514 - 117,604,295 (-)EnsemblGRCr8
mRatBN7.24116,021,832 - 116,046,475 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4116,021,832 - 116,046,465 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4121,500,276 - 121,514,993 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04117,275,441 - 117,290,158 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,889,059 - 115,903,778 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04115,215,160 - 115,239,746 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4115,215,060 - 115,239,723 (-)Ensemblrn6Rnor6.0
Rnor_5.04179,805,782 - 179,830,362 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44117,732,482 - 117,747,006NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4105,015,569 - 105,030,100 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
9-cis-retinoic acid  (EXP)
acetaldehyde  (EXP)
acetamide  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
amitrole  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chromium(6+)  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cyclosporin A  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylcarbamazine  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP)
diuron  (EXP)
doramapimod  (EXP)
dorsomorphin  (ISO)
ethanol  (EXP)
fipronil  (EXP)
folic acid  (ISO)
genistein  (ISO)
glyphosate  (ISO)
Heliotrine  (EXP)
hesperidin  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
isoprenaline  (ISO)
ketamine  (EXP)
leflunomide  (ISO)
Leptin  (EXP)
lipopolysaccharide  (ISO)
losartan  (EXP)
mercaptopurine  (EXP)
mercury dibromide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mitoxantrone  (ISO)
Monobutylphthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
senecionine  (EXP)
serpentine asbestos  (ISO)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sorafenib  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thymoquinone  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
XL147  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Antifibrotic effect of diethylcarbamazine combined with hesperidin against ethanol induced liver fibrosis in rats. El-Sisi AEE, etal., Biomed Pharmacother. 2017 May;89:1196-1206. doi: 10.1016/j.biopha.2017.03.013. Epub 2017 Mar 14.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Leptin and acetaldehyde synergistically promotes αSMA expression in hepatic stellate cells by an interleukin 6-dependent mechanism. Liu Y, etal., Alcohol Clin Exp Res. 2011 May;35(5):921-8. doi: 10.1111/j.1530-0277.2010.01422.x. Epub 2011 Feb 5.
4. The development expression of the rat alpha-vascular and gamma-enteric smooth muscle isoactins: isolation and characterization of a rat gamma-enteric actin cDNA. McHugh KM and Lessard JL, Mol Cell Biol 1988 Dec;8(12):5224-31.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. [Complex evaluation of the health status indicators of military personnel]. Poliakov LE, etal., Voen Med Zh. 1978 Nov;(11):15-20.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Polski tygodnik lekarski (Warsaw, Poland : 1960) Woyton A Pol Tyg Lek 1978 Aug 7;33(32):1263-4.
Additional References at PubMed
PMID:3597426   PMID:12040017   PMID:12477932   PMID:12482893   PMID:15489334   PMID:15591055   PMID:15972885   PMID:16259921   PMID:16493181   PMID:16533564   PMID:19797053   PMID:22165288  
PMID:22516433   PMID:23533145   PMID:23580065   PMID:25002582   PMID:29476059   PMID:31484043  


Genomics

Comparative Map Data
Actg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,579,513 - 117,604,379 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4117,579,514 - 117,604,295 (-)EnsemblGRCr8
mRatBN7.24116,021,832 - 116,046,475 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4116,021,832 - 116,046,465 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4121,500,276 - 121,514,993 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04117,275,441 - 117,290,158 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,889,059 - 115,903,778 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04115,215,160 - 115,239,746 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4115,215,060 - 115,239,723 (-)Ensemblrn6Rnor6.0
Rnor_5.04179,805,782 - 179,830,362 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44117,732,482 - 117,747,006NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4105,015,569 - 105,030,100 (-)NCBICelera
Cytogenetic Map4q34NCBI
ACTG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38273,893,008 - 73,919,865 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl273,892,232 - 73,919,865 (+)Ensemblhg38GRCh38
GRCh37274,120,135 - 74,146,992 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36273,973,601 - 74,000,288 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34274,031,789 - 74,058,434NCBI
Celera273,951,347 - 73,978,043 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef273,854,905 - 73,882,444 (+)NCBIHuRef
CHM1_1274,049,434 - 74,076,040 (+)NCBICHM1_1
T2T-CHM13v2.0273,901,172 - 73,928,327 (+)NCBIT2T-CHM13v2.0
Actg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,489,891 - 83,513,233 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,489,887 - 83,513,247 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38683,512,909 - 83,536,251 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,512,905 - 83,536,265 (-)Ensemblmm10GRCm38
MGSCv37683,462,903 - 83,486,245 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36683,478,568 - 83,501,883 (-)NCBIMGSCv36mm8
Celera685,494,063 - 85,517,393 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Actg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,779,597 - 11,802,446 (-)Ensembl
ChiLan1.0NW_00495542411,779,805 - 11,802,446 (-)NCBIChiLan1.0ChiLan1.0
ACTG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21252,464,021 - 52,490,974 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A52,466,775 - 52,493,728 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A73,966,939 - 73,993,862 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A75,476,877 - 75,503,658 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,476,877 - 75,503,658 (+)EnsemblpanPan2panpan1.1
ACTG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11749,144,184 - 49,168,872 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1749,104,546 - 49,168,782 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1748,784,850 - 48,810,117 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01750,003,715 - 50,028,411 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1750,003,722 - 50,028,328 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11749,019,875 - 49,044,569 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01749,087,331 - 49,111,998 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,645,142 - 49,670,439 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Actg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,517,808 - 10,563,374 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556174,602 - 220,285 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936556174,602 - 220,088 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl369,096,782 - 69,121,351 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1369,097,366 - 69,121,542 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,251,872 - 72,257,786 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,363,170 - 33,390,710 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1433,363,023 - 33,390,937 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604578,776,828 - 78,804,281 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474929,566,380 - 29,588,705 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474929,566,613 - 29,588,572 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Actg2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1662,695,111 - 62,709,259 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Actg2
132 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000042699
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat

Markers in Region
PMC20960P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,665,621 - 11,665,967 (+)MAPPERmRatBN7.2
Rnor_6.01213,718,353 - 13,718,698NCBIRnor6.0
Rnor_5.01215,748,366 - 15,748,711UniSTSRnor5.0
RGSC_v3.41212,049,580 - 12,049,925UniSTSRGSC3.4
Celera1213,454,953 - 13,455,298UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic Map4q34UniSTS
STS_ADH2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23100,812,851 - 100,813,988 (+)MAPPERmRatBN7.2
mRatBN7.2437,621,193 - 37,621,465 (+)MAPPERmRatBN7.2
Rnor_6.0435,593,637 - 35,593,908NCBIRnor6.0
Rnor_6.03105,508,268 - 105,509,404NCBIRnor6.0
Rnor_5.0435,451,038 - 35,451,309UniSTSRnor5.0
Rnor_5.03112,081,718 - 112,082,854UniSTSRnor5.0
RGSC_v3.4399,901,887 - 99,903,023UniSTSRGSC3.4
RGSC_v3.4434,652,200 - 34,652,471UniSTSRGSC3.4
Celera433,105,107 - 33,105,378UniSTS
Celera399,782,375 - 99,783,511UniSTS
Cytogenetic Map3q35UniSTS
Cytogenetic Map4q21UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 148 91 90 59 34 59 6 282 134 11 125 65 92 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000042699   ⟹   ENSRNOP00000050322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,579,514 - 117,604,295 (-)Ensembl
mRatBN7.2 Ensembl4116,021,832 - 116,046,465 (-)Ensembl
Rnor_6.0 Ensembl4115,215,060 - 115,239,723 (-)Ensembl
RefSeq Acc Id: NM_012893   ⟹   NP_037025
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,579,513 - 117,594,039 (-)NCBI
mRatBN7.24116,021,832 - 116,036,358 (-)NCBI
Rnor_6.04115,215,160 - 115,229,684 (-)NCBI
Rnor_5.04179,805,782 - 179,830,362 (-)NCBI
RGSC_v3.44117,732,482 - 117,747,006 (-)RGD
Celera4105,015,569 - 105,030,100 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236728   ⟹   XP_006236790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,579,513 - 117,604,379 (-)NCBI
mRatBN7.24116,021,832 - 116,046,475 (-)NCBI
Rnor_6.04115,215,160 - 115,239,746 (-)NCBI
Rnor_5.04179,805,782 - 179,830,362 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_037025 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236790 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40672 (Get FASTA)   NCBI Sequence Viewer  
  AAH87689 (Get FASTA)   NCBI Sequence Viewer  
  EDL91149 (Get FASTA)   NCBI Sequence Viewer  
  EDL91150 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050322
  ENSRNOP00000050322.2
GenBank Protein P63269 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037025   ⟸   NM_012893
- UniProtKB: P63269 (UniProtKB/Swiss-Prot),   A6IAN1 (UniProtKB/TrEMBL),   A0A0G2K4M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236790   ⟸   XM_006236728
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000050322   ⟸   ENSRNOT00000042699

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63269-F1-model_v2 AlphaFold P63269 1-376 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693181
Promoter ID:EPDNEW_R3705
Type:multiple initiation site
Name:Actg2_1
Description:actin, gamma 2, smooth muscle, enteric
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04115,239,689 - 115,239,749EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2027 AgrOrtholog
BioCyc Gene G2FUF-44003 BioCyc
Ensembl Genes ENSRNOG00000029401 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000042699 ENTREZGENE
  ENSRNOT00000042699.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7310913 IMAGE-MGC_LOAD
InterPro Actin UniProtKB/Swiss-Prot
  Actin/actin-like_CS UniProtKB/Swiss-Prot
  Actin_CS UniProtKB/Swiss-Prot
  ATPase_NBD UniProtKB/Swiss-Prot
KEGG Report rno:25365 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105507 IMAGE-MGC_LOAD
NCBI Gene 25365 ENTREZGENE
PANTHER PTHR11937 UniProtKB/Swiss-Prot
Pfam Actin UniProtKB/Swiss-Prot
PhenoGen Actg2 PhenoGen
PRINTS ACTIN UniProtKB/Swiss-Prot
PROSITE ACTINS_1 UniProtKB/Swiss-Prot
  ACTINS_2 UniProtKB/Swiss-Prot
  ACTINS_ACT_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029401 RatGTEx
SMART ACTIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot
TIGR TC217240
UniProt A0A0G2K4M6 ENTREZGENE, UniProtKB/TrEMBL
  A6IAN1 ENTREZGENE, UniProtKB/TrEMBL
  A6IAN2_RAT UniProtKB/TrEMBL
  ACTH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P12718 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-25 Actg2  actin gamma 2, smooth muscle  Actg2  actin, gamma 2, smooth muscle, enteric  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-14 Actg2  actin, gamma 2, smooth muscle, enteric  Actg2  actin, gamma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Actg2  actin, gamma 2    Actin, gamma 2, smooth muscle, enteric  Name updated 625702 APPROVED
2002-06-10 Actg2  Actin, gamma 2, smooth muscle, enteric      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in stomach smooth muscle 631723
gene_homology mature protein is nearly identical to that of the chicken gizzard gamma actin sequence with one differing amino acid 631723
gene_product member of the actin family 631723