Acp5 (acid phosphatase 5, tartrate resistant) - Rat Genome Database

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Gene: Acp5 (acid phosphatase 5, tartrate resistant) Rattus norvegicus
Analyze
Symbol: Acp5
Name: acid phosphatase 5, tartrate resistant
RGD ID: 2022
Description: Enables acid phosphatase activity. Involved in several processes, including bone resorption; cellular response to zinc ion starvation; and response to L-ascorbic acid. Located in extracellular space. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia. Orthologous to human ACP5 (acid phosphatase 5, tartrate resistant); PARTICIPATES IN rheumatoid arthritis pathway; riboflavin metabolic pathway; INTERACTS WITH (20S)-ginsenoside Rg3; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acid phosphatase 5; Acid phosphatase 5 tartrate resistant; acid phosphatase type V; tartrate-resistant acid ATPase; tartrate-resistant acid phosphatase type 5; TR-AP; Trap; trATPase; TTRRAP; type 5 acid phosphatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,939,984 - 28,946,639 (-)NCBIGRCr8
mRatBN7.2820,663,984 - 20,670,604 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,663,985 - 20,667,929 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,693,289 - 24,698,588 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,990,432 - 22,995,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,893,525 - 20,899,471 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0823,142,733 - 23,149,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl823,142,734 - 23,148,396 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0823,197,095 - 23,202,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera822,052,728 - 22,058,674 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-matairesinol  (ISO)
(20S)-ginsenoside Rg3  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,4-dichlorobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-aminopurine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
amitrole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
azadirachtin A  (ISO)
beclomethasone  (ISO)
belinostat  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (EXP,ISO)
Bergenin  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chromium atom  (EXP)
cisapride  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
crocin-1  (ISO)
cyclosporin A  (ISO)
Cyclosporin H  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diethylstilbestrol  (ISO)
diosgenin  (ISO)
diosmetin  (ISO)
dioxygen  (EXP)
dithionite(2-)  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ferric ammonium citrate  (EXP)
fluoxetine  (ISO)
formononetin  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
guanethidine  (EXP)
Heptachlor epoxide  (ISO)
indometacin  (EXP)
iron dichloride  (EXP,ISO)
ivermectin  (ISO)
KN-93  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
Maxacalcitol  (ISO)
methimazole  (EXP)
methylglyoxal  (EXP,ISO)
microcystin-LR  (EXP)
modafinil  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Morroniside  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naringin  (ISO)
niclosamide  (ISO)
nitric acid  (EXP)
nitrofen  (EXP)
NMN zwitterion  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
phenethyl caffeate  (EXP)
poly(ethylene)  (ISO)
poly(methyl methacrylate) macromolecule  (ISO)
potassium dichromate  (EXP)
propiconazole  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sclareol  (ISO)
silibinin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
stevioside  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tacrolimus hydrate  (ISO)
telmisartan  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
theophylline  (EXP)
thioacetamide  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tungsten  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vitamin D  (ISO)
zinc atom  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IDA)
lysosome  (IEA,ISO)

Molecular Function
acid phosphatase activity  (IBA,IDA,IEA,ISO,TAS)
ferric iron binding  (IBA,IEA,ISO,ISS)
ferrous iron binding  (IBA,IEA,ISO,ISS)
hydrolase activity  (IDA)
metal ion binding  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
2. Evaluation of tartrate-resistant acid phosphatase (TRAP) 5b as serum marker of bone metastases in human breast cancer. Capeller B, etal., Anticancer Res 2003 Mar-Apr;23(2A):1011-5.
3. Characterization and expression of tartrate-resistant acid phosphatase (TRAP) in hematopoietic cells. Drexler HG and Gignac SM, Leukemia 1994 Mar;8(3):359-68.
4. Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase. Ek-Rylander B and Andersson G, Exp Cell Res. 2009 Oct 23.
5. Cloning, sequence, and developmental expression of a type 5, tartrate-resistant, acid phosphatase of rat bone. Ek-Rylander B, etal., J Biol Chem 1991 Dec 25;266(36):24684-9.
6. The effects of systemic stress on orthodontic tooth movement. Gameiro GH, etal., Aust Orthod J. 2008 Nov;24(2):121-8.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Dietary zinc reduces osteoclast resorption activities and increases markers of osteoblast differentiation, matrix maturation, and mineralization in the long bones of growing rats. Hadley KB, etal., J Nutr Biochem. 2009 Apr 13.
10. Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action. Hanayama R, etal., Int J Mol Med. 2009 May;23(5):581-8.
11. Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes. Hie M and Tsukamoto I, Int J Mol Med. 2010 Oct;26(4):611-8. doi: 10.3892/ijmm_00000506.
12. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
13. Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes. Hie M, etal., Eur J Pharmacol. 2009 Oct 25;621(1-3):1-9. Epub 2009 Aug 21.
14. Ethanol increases osteoclastogenesis associated with the increased expression of RANK, PU.1 and MITF in vitro and in vivo. Iitsuka N, etal., Int J Mol Med. 2012 Jul;30(1):165-72. doi: 10.3892/ijmm.2012.974. Epub 2012 Apr 20.
15. Phosphatase and oxygen radical-generating activities of mammalian purple acid phosphatase are functionally independent. Kaija H, etal., Biochem Biophys Res Commun 2002 Mar 22;292(1):128-32.
16. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
17. Dioxins interfere with differentiation of osteoblasts and osteoclasts. Korkalainen M, etal., Bone. 2009 Jun;44(6):1134-42. Epub 2009 Mar 2.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Expressions of RANKL/RANK and M-CSF/c-fms in root resorption lacunae in rat molar by heavy orthodontic force. Nakano Y, etal., Eur J Orthod. 2011 Aug;33(4):335-43. doi: 10.1093/ejo/cjq068. Epub 2010 Sep 10.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. [Osteosynthesis of the tubular bones using a polymeric pin]. Plakhotin MV, etal., Veterinariia. 1978 Dec;(12):89-90.
24. Evidence-based assessment of antiosteoporotic activity of petroleum-ether extract of Cissus quadrangularis Linn. on ovariectomy-induced osteoporosis. Potu BK, etal., Ups J Med Sci. 2009;114(3):140-8.
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Primary structure of rat secretory acid phosphatase and comparison to other acid phosphatases. Roiko K, etal., Gene 1990 May 14;89(2):223-9.
29. Vitamin C intake inhibits serum lipid peroxidation and osteoclast differentiation on alveolar bone in rats fed on a high-cholesterol diet. Sanbe T, etal., Arch Oral Biol. 2009 Mar;54(3):235-40. Epub 2008 Dec 24.
30. Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female rats. Shen CL, etal., Osteoporos Int. 2010 Jan 13.
31. Bone formation in a rat calvarial defect model after transplanting autogenous bone marrow with beta-tricalcium phosphate. Shirasu N, etal., Acta Histochem. 2009 Apr 27.
32. RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNF-alpha or anti-IL-1 therapies. Stolina M, etal., Arthritis Res Ther. 2009 Dec 11;11(6):R187.
33. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
34. Microdamage Repair and Remodeling Requires Mechanical Loading. Waldorff EI, etal., J Bone Miner Res. 2009 Oct 12.
35. Effects of berberine on differentiation and bone resorption of osteoclasts derived from rat bone marrow cells. Wei P, etal., Zhong Xi Yi Jie He Xue Bao. 2009 Apr;7(4):342-8.
36. Administration of colony stimulating factor-1 to toothless osteopetrotic rats normalizes osteoblast, but not osteoclast, gene expression. Wisner-Lynch LA, etal., Bone. 1995 Jun;16(6):611-8. doi: 10.1016/8756-3282(95)00114-s.
Additional References at PubMed
PMID:1830446   PMID:8200916   PMID:8889548   PMID:8898228   PMID:9308894   PMID:10388567   PMID:10438611   PMID:11168643   PMID:11731469   PMID:14696961   PMID:15489334   PMID:15761664  
PMID:15929988   PMID:15975830   PMID:15993892   PMID:17916452   PMID:19821118   PMID:22878484   PMID:23376485   PMID:23868496   PMID:24223830   PMID:24395179  


Genomics

Comparative Map Data
Acp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,939,984 - 28,946,639 (-)NCBIGRCr8
mRatBN7.2820,663,984 - 20,670,604 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,663,985 - 20,667,929 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx824,693,289 - 24,698,588 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,990,432 - 22,995,731 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,893,525 - 20,899,471 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0823,142,733 - 23,149,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl823,142,734 - 23,148,396 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0823,197,095 - 23,202,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera822,052,728 - 22,058,674 (-)NCBICelera
Cytogenetic Map8q13NCBI
ACP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,574,660 - 11,578,975 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,574,653 - 11,579,993 (-)EnsemblGRCh38hg38GRCh38
GRCh371911,685,475 - 11,689,790 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,546,477 - 11,549,496 (-)NCBINCBI36Build 36hg18NCBI36
Build 341911,546,476 - 11,549,496NCBI
Celera1911,580,213 - 11,584,539 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,259,840 - 11,264,071 (-)NCBIHuRef
CHM1_11911,685,335 - 11,689,664 (-)NCBICHM1_1
T2T-CHM13v2.01911,702,190 - 11,706,505 (-)NCBIT2T-CHM13v2.0
Acp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39922,038,023 - 22,047,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl922,038,023 - 22,047,007 (-)EnsemblGRCm39 Ensembl
GRCm38922,126,727 - 22,135,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl922,126,727 - 22,135,711 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,931,171 - 21,940,190 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36921,877,148 - 21,881,056 (-)NCBIMGSCv36mm8
Celera919,395,697 - 19,404,716 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map98.38NCBI
Acp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,418,364 - 2,421,538 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554952,418,113 - 2,421,181 (+)NCBIChiLan1.0ChiLan1.0
ACP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,486,997 - 16,495,640 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,482,421 - 15,489,613 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01911,120,451 - 11,125,167 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,832,575 - 11,836,881 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,832,575 - 11,835,203 (-)Ensemblpanpan1.1panPan2
ACP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,812,444 - 49,816,262 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,814,032 - 49,816,260 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,684,989 - 49,687,385 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02050,330,836 - 50,334,545 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,332,449 - 50,334,544 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,542,471 - 49,544,878 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,968,636 - 49,971,025 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,211,593 - 50,213,981 (+)NCBIUU_Cfam_GSD_1.0
Acp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,712,098 - 208,756,454 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,598,177 - 1,600,262 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,598,252 - 1,642,615 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,206,162 - 70,208,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1270,206,159 - 70,209,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2270,615,520 - 70,616,019 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q12-q21NCBI
ACP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,488,572 - 10,493,508 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,488,460 - 10,491,519 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660749,350,068 - 9,354,653 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,307,635 - 3,310,547 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,305,913 - 3,309,983 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acp5
60 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:54
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000075237
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat

Markers in Region
RH133500  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,664,061 - 20,664,276 (+)MAPPERmRatBN7.2
Rnor_6.0823,142,811 - 23,143,025NCBIRnor6.0
Rnor_5.0823,197,173 - 23,197,387UniSTSRnor5.0
Celera822,052,806 - 22,053,020UniSTS
RH 3.4 Map8206.61UniSTS
RH94519  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,664,045 - 20,664,190 (+)MAPPERmRatBN7.2
Rnor_6.0823,142,795 - 23,142,939NCBIRnor6.0
Rnor_5.0823,197,157 - 23,197,301UniSTSRnor5.0
Celera822,052,790 - 22,052,934UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 40 31 19 31 27 24 11
Low 39 17 10 10 8 11 72 8 17 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075237   ⟹   ENSRNOP00000066364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,663,985 - 20,667,822 (-)Ensembl
Rnor_6.0 Ensembl823,142,734 - 23,148,396 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092200   ⟹   ENSRNOP00000074001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,663,985 - 20,667,929 (-)Ensembl
Rnor_6.0 Ensembl823,142,734 - 23,146,689 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120171   ⟹   ENSRNOP00000090921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,663,985 - 20,667,812 (-)Ensembl
RefSeq Acc Id: NM_001270889   ⟹   NP_001257818
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,939,984 - 28,945,930 (-)NCBI
mRatBN7.2820,663,984 - 20,669,930 (-)NCBI
Rnor_6.0823,142,733 - 23,148,396 (-)NCBI
Rnor_5.0823,197,095 - 23,202,903 (-)NCBI
Celera822,052,728 - 22,058,674 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019144   ⟹   NP_062017
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,939,984 - 28,943,929 (-)NCBI
mRatBN7.2820,663,984 - 20,667,929 (-)NCBI
Rnor_6.0823,142,733 - 23,146,689 (-)NCBI
Rnor_5.0823,197,095 - 23,202,903 (-)NCBI
Celera822,052,728 - 22,056,673 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242692   ⟹   XP_006242754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,939,998 - 28,946,601 (-)NCBI
mRatBN7.2820,663,984 - 20,670,601 (-)NCBI
Rnor_6.0823,142,745 - 23,149,067 (-)NCBI
Rnor_5.0823,197,095 - 23,202,903 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242693   ⟹   XP_006242755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,939,998 - 28,946,631 (-)NCBI
mRatBN7.2820,663,996 - 20,670,602 (-)NCBI
Rnor_6.0823,142,745 - 23,149,067 (-)NCBI
Rnor_5.0823,197,095 - 23,202,903 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242694   ⟹   XP_006242756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,939,998 - 28,945,914 (-)NCBI
mRatBN7.2820,663,996 - 20,669,914 (-)NCBI
Rnor_6.0823,142,745 - 23,148,380 (-)NCBI
Rnor_5.0823,197,095 - 23,202,903 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595487   ⟹   XP_017450976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,939,998 - 28,946,639 (-)NCBI
mRatBN7.2820,663,984 - 20,670,604 (-)NCBI
Rnor_6.0823,142,745 - 23,149,067 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063264983   ⟹   XP_063121053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,939,998 - 28,946,601 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_062017   ⟸   NM_019144
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A0G2K6Z6 (UniProtKB/TrEMBL),   A6JNZ1 (UniProtKB/TrEMBL),   A0A8L2QYB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257818   ⟸   NM_001270889
- Peptide Label: isoform 2 precursor
- UniProtKB: P29288 (UniProtKB/Swiss-Prot),   A6JNZ2 (UniProtKB/TrEMBL),   A0A8L2QYB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242754   ⟸   XM_006242692
- Peptide Label: isoform X2
- UniProtKB: P29288 (UniProtKB/Swiss-Prot),   A6JNZ2 (UniProtKB/TrEMBL),   A0A8L2QYB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242755   ⟸   XM_006242693
- Peptide Label: isoform X2
- UniProtKB: P29288 (UniProtKB/Swiss-Prot),   A6JNZ2 (UniProtKB/TrEMBL),   A0A8L2QYB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242756   ⟸   XM_006242694
- Peptide Label: isoform X2
- UniProtKB: P29288 (UniProtKB/Swiss-Prot),   A6JNZ2 (UniProtKB/TrEMBL),   A0A8L2QYB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450976   ⟸   XM_017595487
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6Z6 (UniProtKB/TrEMBL),   A6JNZ1 (UniProtKB/TrEMBL),   A0A8L2QYB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074001   ⟸   ENSRNOT00000092200
RefSeq Acc Id: ENSRNOP00000066364   ⟸   ENSRNOT00000075237
RefSeq Acc Id: ENSRNOP00000090921   ⟸   ENSRNOT00000120171
RefSeq Acc Id: XP_063121053   ⟸   XM_063264983
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6Z6 (UniProtKB/TrEMBL),   A6JNZ1 (UniProtKB/TrEMBL)
Protein Domains
Calcineurin-like phosphoesterase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29288-F1-model_v2 AlphaFold P29288 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695807
Promoter ID:EPDNEW_R6330
Type:initiation region
Name:Acp5_1
Description:acid phosphatase 5, tartrate resistant
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0823,146,647 - 23,146,707EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2022 AgrOrtholog
BioCyc Gene G2FUF-31387 BioCyc
Ensembl Genes ENSRNOG00000046261 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075237.3 UniProtKB/TrEMBL
  ENSRNOT00000092200 ENTREZGENE
  ENSRNOT00000092200.2 UniProtKB/TrEMBL
  ENSRNOT00000120171.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110955 IMAGE-MGC_LOAD
InterPro Acid_PPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25732 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93494 IMAGE-MGC_LOAD
NCBI Gene 25732 ENTREZGENE
PANTHER TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5 UniProtKB/Swiss-Prot
  TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5 UniProtKB/Swiss-Prot
  TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5 UniProtKB/TrEMBL
  TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5 UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acp5 PhenoGen
PIRSF Acid_Ptase_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046261 RatGTEx
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6Z6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AF87_RAT UniProtKB/TrEMBL
  A0A8L2QYB7 ENTREZGENE, UniProtKB/TrEMBL
  A6JNZ1 ENTREZGENE, UniProtKB/TrEMBL
  A6JNZ2 ENTREZGENE, UniProtKB/TrEMBL
  P29288 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Acp5  acid phosphatase 5, tartrate resistant    acid phosphatase 5  Name updated 1299863 APPROVED
2002-11-06 Acp5  acid phosphatase 5    Acid phosphatase 5, tartrate resistant  Name updated 625702 APPROVED
2002-06-10 Acp5  Acid phosphatase 5, tartrate resistant      Symbol and Name status set to approved 70586 APPROVED