Kcnmb3 (potassium large conductance calcium-activated channel, subfamily M, beta member 3) - Rat Genome Database

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Gene: Kcnmb3 (potassium large conductance calcium-activated channel, subfamily M, beta member 3) Mus musculus
Analyze
Symbol: Kcnmb3
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 3
RGD ID: 1621871
MGI Page MGI
Description: Predicted to enable calcium-activated potassium channel activity and potassium channel regulator activity. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human KCNMB3 (potassium calcium-activated channel subfamily M regulatory beta subunit 3).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium-activated potassium channel subunit beta-3; calcium-activated potassium channel subunit beta-3-like; EG435726; Gm5707; potassium large conductance calcium-activated channel, subfamily M, beta member 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,518,995 - 32,557,045 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl332,525,737 - 32,546,380 (-)EnsemblGRCm39 Ensembl
GRCm38332,465,146 - 32,502,896 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,471,588 - 32,492,231 (-)EnsemblGRCm38mm10GRCm38
MGSCv37332,371,243 - 32,390,891 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36332,371,243 - 32,390,891 (-)NCBIMGSCv36mm8
Celera332,382,266 - 32,401,903 (-)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14610273   PMID:21873635   PMID:27241733  


Genomics

Comparative Map Data
Kcnmb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39332,518,995 - 32,557,045 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl332,525,737 - 32,546,380 (-)EnsemblGRCm39 Ensembl
GRCm38332,465,146 - 32,502,896 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl332,471,588 - 32,492,231 (-)EnsemblGRCm38mm10GRCm38
MGSCv37332,371,243 - 32,390,891 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36332,371,243 - 32,390,891 (-)NCBIMGSCv36mm8
Celera332,382,266 - 32,401,903 (-)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.73NCBI
KCNMB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383179,239,703 - 179,267,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3179,236,691 - 179,267,002 (-)EnsemblGRCh38hg38GRCh38
GRCh373178,957,491 - 178,984,838 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363180,443,246 - 180,467,532 (-)NCBINCBI36Build 36hg18NCBI36
Build 343180,443,257 - 180,452,347NCBI
Celera3177,388,403 - 177,415,818 (-)NCBICelera
Cytogenetic Map3q26.32NCBI
HuRef3176,360,809 - 176,387,906 (-)NCBIHuRef
CHM1_13178,920,451 - 178,947,744 (-)NCBICHM1_1
T2T-CHM13v2.03182,043,540 - 182,070,887 (-)NCBIT2T-CHM13v2.0
Kcnmb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82117,184,165 - 117,198,519 (-)NCBIGRCr8
mRatBN7.22115,255,788 - 115,270,142 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2115,253,761 - 115,270,142 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2121,869,547 - 121,883,891 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02119,982,186 - 119,996,529 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02114,683,159 - 114,697,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02118,868,225 - 118,882,562 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2118,868,225 - 118,882,562 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02138,528,371 - 138,542,202 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42118,679,363 - 118,693,857 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12118,622,752 - 118,638,633 (-)NCBI
Celera2110,366,829 - 110,381,168 (-)NCBICelera
Cytogenetic Map2q24NCBI
Kcnmb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554208,435,179 - 8,445,676 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554208,428,823 - 8,445,940 (-)NCBIChiLan1.0ChiLan1.0
KCNMB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22177,105,544 - 177,135,691 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13177,112,640 - 177,140,408 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03176,272,381 - 176,299,463 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13184,444,118 - 184,473,394 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3184,444,118 - 184,473,394 (-)Ensemblpanpan1.1panPan2
KCNMB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13412,683,658 - 12,708,516 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3412,681,574 - 12,707,956 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3416,828,564 - 16,851,672 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03412,581,969 - 12,605,051 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3412,578,627 - 12,604,959 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13412,636,833 - 12,659,895 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03412,616,723 - 12,639,792 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,856,014 - 12,879,143 (-)NCBIUU_Cfam_GSD_1.0
Kcnmb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602109,302,138 - 109,317,515 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365663,903,272 - 3,915,094 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365663,903,272 - 3,918,741 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNMB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13117,283,631 - 117,309,863 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113117,283,505 - 117,370,306 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213126,368,594 - 126,392,879 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNMB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11510,187,551 - 10,218,110 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1510,202,426 - 10,210,325 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606319,069,820 - 19,098,218 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnmb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473056,974,812 - 56,987,731 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473056,970,854 - 57,074,148 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnmb3
1199 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:243
Count of miRNA genes:222
Interacting mature miRNAs:237
Transcripts:ENSMUST00000164954
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1300559Thypr3_mthymocyte proliferative response 3 (mouse)Not determined3452541938525519Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
1301358Eae20_mexperimental allergic encephalomyelitis 20 (mouse)Not determined31163045345630591Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
4142092Tgq13_mtriglyceride QTL 13 (mouse)Not determined1828816852288168Mouse
1301114Ssial2_msusceptibility to sialadenitis 2 (mouse)Not determined32017486254180103Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33183785465837997Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000164954   ⟹   ENSMUSP00000130177
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl332,525,737 - 32,546,380 (-)Ensembl
GRCm38.p6 Ensembl332,471,588 - 32,492,231 (-)Ensembl
RefSeq Acc Id: NM_001195074   ⟹   NP_001182003
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39332,526,470 - 32,546,118 (-)NCBI
GRCm38332,472,321 - 32,491,969 (-)NCBI
Celera332,382,266 - 32,401,903 (-)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011249654   ⟹   XP_011247956
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39332,518,995 - 32,556,956 (-)NCBI
GRCm38332,465,146 - 32,502,807 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319414   ⟹   XP_017174903
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39332,518,995 - 32,557,045 (-)NCBI
GRCm38332,465,146 - 32,502,896 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001182003 (Get FASTA)   NCBI Sequence Viewer  
  XP_011247956 (Get FASTA)   NCBI Sequence Viewer  
  XP_017174903 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000130177
  ENSMUSP00000130177.2
RefSeq Acc Id: NP_001182003   ⟸   NM_001195074
- UniProtKB: E9Q7U0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011247956   ⟸   XM_011249654
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017174903   ⟸   XM_017319414
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000130177   ⟸   ENSMUST00000164954

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9Q7U0-F1-model_v2 AlphaFold E9Q7U0 1-239 view protein structure

Promoters
RGD ID:6833994
Promoter ID:MM_KWN:33996
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney
Transcripts:DT.103571886_KCNMB3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36332,372,321 - 32,373,322 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3612244 AgrOrtholog
Ensembl Genes ENSMUSG00000091091 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000164954 ENTREZGENE
  ENSMUST00000164954.3 UniProtKB/TrEMBL
InterPro K_chnl_Ca-activ_BK_bsu UniProtKB/TrEMBL
KEGG Report mmu:100502876 UniProtKB/TrEMBL
MGD MGI:3612244 ENTREZGENE
NCBI Gene 100502876 ENTREZGENE
PANTHER BK_channel_beta UniProtKB/TrEMBL
  CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-3 UniProtKB/TrEMBL
Pfam CaKB UniProtKB/TrEMBL
PhenoGen Kcnmb3 PhenoGen
UniProt E9Q7U0 ENTREZGENE, UniProtKB/TrEMBL