Btg1b (BTG anti-proliferation factor 1B) - Rat Genome Database

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Gene: Btg1b (BTG anti-proliferation factor 1B) Rattus norvegicus
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Symbol: Btg1b
Name: BTG anti-proliferation factor 1B
RGD ID: 1598239
Description: Predicted to be involved in negative regulation of cell population proliferation. Predicted to be active in cytoplasm and nucleus; INTERACTS WITH epoxiconazole (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC367975; LOC367975; MGC156798; similar to B-cell translocation gene 1; uncharacterized protein LOC367975
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,665,324 - 121,671,141 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX121,665,449 - 121,672,111 (-)EnsemblGRCr8
mRatBN7.2X116,794,228 - 116,805,478 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,800,208 - 116,805,516 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX118,895,300 - 118,900,507 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X122,464,454 - 122,469,661 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X120,010,325 - 120,015,540 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X124,156,649 - 124,162,089 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX124,156,856 - 124,162,058 (-)Ensemblrn6Rnor6.0
Rnor_5.0X124,242,535 - 124,248,313 (-)NCBIRnor_5.0Rnor_5.0rn5
CeleraX116,018,928 - 116,024,124 (-)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Btg1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,665,324 - 121,671,141 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX121,665,449 - 121,672,111 (-)EnsemblGRCr8
mRatBN7.2X116,794,228 - 116,805,478 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,800,208 - 116,805,516 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX118,895,300 - 118,900,507 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X122,464,454 - 122,469,661 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X120,010,325 - 120,015,540 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X124,156,649 - 124,162,089 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX124,156,856 - 124,162,058 (-)Ensemblrn6Rnor6.0
Rnor_5.0X124,242,535 - 124,248,313 (-)NCBIRnor_5.0Rnor_5.0rn5
CeleraX116,018,928 - 116,024,124 (-)NCBICelera
Cytogenetic MapXq35NCBI
Btg1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X37,102,050 - 37,107,727 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX37,102,785 - 37,103,294 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 EnsemblX37,102,045 - 37,107,719 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X38,013,173 - 38,018,850 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX38,013,173 - 38,018,815 (-)Ensemblmm10GRCm38
MGSCv37X35,367,085 - 35,367,588 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X34,258,535 - 34,259,020 (-)NCBIMGSCv36mm8
CeleraX25,661,706 - 25,662,209 (-)NCBICelera
Cytogenetic MapXA3.3NCBI
cM MapX22.27NCBI

Variants

.
Variants in Btg1b
33 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X120028026141353710Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X120028026141353710Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X105468858125434318Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
4 4 18 29 51 41 35 8 35 3 136 41 13 53 49 6 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000071436   ⟹   ENSRNOP00000067299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX121,665,449 - 121,671,239 (-)Ensembl
mRatBN7.2 EnsemblX116,800,208 - 116,805,516 (-)Ensembl
Rnor_6.0 EnsemblX124,156,856 - 124,162,058 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093830   ⟹   ENSRNOP00000094842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX121,665,449 - 121,671,239 (-)Ensembl
mRatBN7.2 EnsemblX116,800,208 - 116,804,395 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128258   ⟹   ENSRNOP00000103757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX121,665,450 - 121,671,239 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154877   ⟹   ENSRNOP00000106143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX121,665,450 - 121,672,111 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000161146   ⟹   ENSRNOP00000100566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX121,665,449 - 121,671,239 (-)Ensembl
RefSeq Acc Id: NM_001079896   ⟹   NP_001073365
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,665,896 - 121,671,099 (-)NCBI
mRatBN7.2X116,800,247 - 116,805,450 (-)NCBI
Rnor_6.0X124,156,855 - 124,162,058 (-)NCBI
Rnor_5.0X124,242,535 - 124,248,313 (-)NCBI
CeleraX116,018,928 - 116,024,124 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257480   ⟹   XP_006257542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,665,324 - 121,671,141 (-)NCBI
mRatBN7.2X116,794,228 - 116,805,478 (-)NCBI
Rnor_6.0X124,156,649 - 124,162,089 (-)NCBI
Rnor_5.0X124,242,535 - 124,248,313 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001073365   ⟸   NM_001079896
- UniProtKB: A1L133 (UniProtKB/TrEMBL),   A6JMJ2 (UniProtKB/TrEMBL),   A0A8I6ANE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257542   ⟸   XM_006257480
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000067299   ⟸   ENSRNOT00000071436
Ensembl Acc Id: ENSRNOP00000094842   ⟸   ENSRNOT00000093830
Ensembl Acc Id: ENSRNOP00000100566   ⟸   ENSRNOT00000161146
Ensembl Acc Id: ENSRNOP00000103757   ⟸   ENSRNOT00000128258
Ensembl Acc Id: ENSRNOP00000106143   ⟸   ENSRNOT00000154877
Protein Domains
Anti-proliferative protein

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1L133-F1-model_v2 AlphaFold A1L133 1-161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701992
Promoter ID:EPDNEW_R12516
Type:single initiation site
Name:LOC367975_1
Description:similar to B-cell translocation gene 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X124,162,073 - 124,162,133EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598239 AgrOrtholog
BioCyc Gene G2FUF-1270 BioCyc
Ensembl Genes ENSRNOG00000047100 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071436 ENTREZGENE
  ENSRNOT00000071436.3 UniProtKB/TrEMBL
  ENSRNOT00000093830 ENTREZGENE
  ENSRNOT00000093830.2 UniProtKB/TrEMBL
  ENSRNOT00000128258.1 UniProtKB/TrEMBL
  ENSRNOT00000154877.1 UniProtKB/TrEMBL
  ENSRNOT00000161146.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.640.90 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132670 IMAGE-MGC_LOAD
InterPro Anti_prolifrtn UniProtKB/TrEMBL
  BTG UniProtKB/TrEMBL
  BTG-like_sf UniProtKB/TrEMBL
KEGG Report rno:367975 UniProtKB/TrEMBL
MGC_CLONE MGC:156798 IMAGE-MGC_LOAD
NCBI Gene 367975 ENTREZGENE
PANTHER PROTEIN BTG1 UniProtKB/TrEMBL
  PTHR22978 UniProtKB/TrEMBL
Pfam BTG UniProtKB/TrEMBL
PhenoGen Btg1b PhenoGen
PRINTS ANTIPRLFBTG1 UniProtKB/TrEMBL
PROSITE BTG_1 UniProtKB/TrEMBL
  BTG_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047100 RatGTEx
SMART btg1 UniProtKB/TrEMBL
Superfamily-SCOP SSF160696 UniProtKB/TrEMBL
UniProt A0A8I6ANE6 ENTREZGENE, UniProtKB/TrEMBL
  A1L133 ENTREZGENE, UniProtKB/TrEMBL
  A6JMJ2 ENTREZGENE
UniProt Secondary A6JMJ2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-21 Btg1b  BTG anti-proliferation factor 1B  LOC367975  similar to B-cell translocation gene 1  Name and Symbol changed 629549 APPROVED
2006-11-20 LOC367975  similar to B-cell translocation gene 1      Symbol and Name status set to provisional 70820 PROVISIONAL