C1h6orf118 (similar to human chromosome 6 open reading frame 118) - Rat Genome Database

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Gene: C1h6orf118 (similar to human chromosome 6 open reading frame 118) Rattus norvegicus
Analyze
Symbol: C1h6orf118 (Ensembl: MGC94891)
Name: similar to human chromosome 6 open reading frame 118 (Ensembl:hypothetical protein LOC681210)
RGD ID: 1598061
Description: Orthologous to human C6orf118 (chromosome 6 open reading frame 118); INTERACTS WITH bisphenol A; 4,4'-sulfonyldiphenol (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC681210; MGC94891; uncharacterized protein C6orf118 homolog; uncharacterized protein LOC681210
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,287,934 - 54,311,640 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl154,287,936 - 54,311,847 (-)EnsemblGRCr8
mRatBN7.2151,740,328 - 51,764,041 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl151,740,330 - 51,763,989 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx152,446,230 - 52,469,878 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0158,433,683 - 58,457,325 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0152,521,810 - 52,545,454 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,330,530 - 52,354,155 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,330,443 - 52,354,175 (-)Ensemblrn6Rnor6.0
Rnor_5.0153,587,608 - 53,611,289 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4146,361,376 - 46,386,858 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera147,509,830 - 47,533,279 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15632090  


Genomics

Comparative Map Data
C1h6orf118
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8154,287,934 - 54,311,640 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl154,287,936 - 54,311,847 (-)EnsemblGRCr8
mRatBN7.2151,740,328 - 51,764,041 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl151,740,330 - 51,763,989 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx152,446,230 - 52,469,878 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0158,433,683 - 58,457,325 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0152,521,810 - 52,545,454 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,330,530 - 52,354,155 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,330,443 - 52,354,175 (-)Ensemblrn6Rnor6.0
Rnor_5.0153,587,608 - 53,611,289 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4146,361,376 - 46,386,858 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera147,509,830 - 47,533,279 (-)NCBICelera
Cytogenetic Map1q12NCBI
C6orf118
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386165,279,664 - 165,309,605 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6165,279,664 - 165,309,605 (-)Ensemblhg38GRCh38
GRCh376165,693,153 - 165,723,094 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366165,613,143 - 165,643,101 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346165,663,575 - 165,693,509NCBI
Celera6166,431,264 - 166,461,218 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6163,154,651 - 163,184,602 (-)NCBIHuRef
CHM1_16165,956,097 - 165,986,054 (-)NCBICHM1_1
T2T-CHM13v2.06166,645,732 - 166,675,678 (-)NCBIT2T-CHM13v2.0
1700010I14Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39179,207,152 - 9,227,151 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl179,207,165 - 9,230,781 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38178,988,320 - 9,008,319 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl178,988,333 - 9,011,949 (+)Ensemblmm10GRCm38
MGSCv37179,181,198 - 9,201,184 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36178,826,535 - 8,846,490 (+)NCBIMGSCv36mm8
Celera179,032,544 - 9,052,547 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map175.53NCBI
CUNH6orf118
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543916,386,453 - 16,404,184 (+)Ensembl
ChiLan1.0NW_00495543916,386,460 - 16,404,123 (+)NCBIChiLan1.0ChiLan1.0
C5H6orf118
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25185,447,756 - 185,497,491 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16183,343,508 - 183,393,657 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06163,229,435 - 163,256,848 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16168,215,707 - 168,242,293 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6168,189,392 - 168,242,553 (-)EnsemblpanPan2panpan1.1
C1H6orf118
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1153,416,602 - 53,445,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl153,416,762 - 53,445,813 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha154,203,009 - 54,229,562 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0153,593,095 - 53,620,064 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl153,593,255 - 53,623,663 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1153,490,606 - 53,517,448 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0153,338,001 - 53,365,087 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0153,971,421 - 53,997,968 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CUNH6orf118
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946148,120,738 - 148,135,768 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648915,373,836 - 15,387,735 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648915,374,148 - 15,387,735 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C1H6orf118
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113,403,704 - 3,426,919 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214,753,311 - 4,776,373 (+)NCBISscrofa10.2Sscrofa10.2susScr3
C13H6orf118
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11392,969,136 - 92,993,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1392,967,038 - 92,993,467 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604064,791,192 - 64,815,641 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH6orf118
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478513,892,713 - 13,923,376 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
C2H6orf118
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12187,819,887 - 187,843,727 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in C1h6orf118
180 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:211
Count of miRNA genes:150
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000015010
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
BF403295  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2151,740,393 - 51,740,513 (+)MAPPERmRatBN7.2
Rnor_6.0152,330,596 - 52,330,715NCBIRnor6.0
Rnor_5.0153,587,674 - 53,587,793UniSTSRnor5.0
RGSC_v3.4146,361,442 - 46,361,561UniSTSRGSC3.4
Celera147,509,896 - 47,510,015UniSTS
RH 3.4 Map1608.4UniSTS
Cytogenetic Map1q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2 5 6 109 22 23 3 3 3 3 61 22 97 30 65 20 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000015010   ⟹   ENSRNOP00000015010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl151,740,330 - 51,763,989 (-)Ensembl
Rnor_6.0 Ensembl152,330,443 - 52,354,175 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097954   ⟹   ENSRNOP00000080881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl154,287,936 - 54,311,847 (-)Ensembl
mRatBN7.2 Ensembl151,740,330 - 51,760,511 (-)Ensembl
RefSeq Acc Id: NM_001044277   ⟹   NP_001037742
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8154,287,934 - 54,311,591 (-)NCBI
mRatBN7.2151,740,328 - 51,763,989 (-)NCBI
Rnor_6.0152,330,530 - 52,354,155 (-)NCBI
Rnor_5.0153,587,608 - 53,611,289 (-)NCBI
RGSC_v3.4146,361,376 - 46,386,858 (-)RGD
Celera147,509,830 - 47,533,279 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090606   ⟹   XP_038946534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8154,298,048 - 54,311,640 (-)NCBI
mRatBN7.2151,750,442 - 51,764,041 (-)NCBI
RefSeq Acc Id: NP_001037742   ⟸   NM_001044277
- UniProtKB: F7EWN2 (UniProtKB/TrEMBL),   Q5XI71 (UniProtKB/TrEMBL),   A6KK12 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015010   ⟸   ENSRNOT00000015010
RefSeq Acc Id: XP_038946534   ⟸   XM_039090606
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000080881   ⟸   ENSRNOT00000097954
Protein Domains
Translin-associated factor X-interacting protein

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7EWN2-F1-model_v2 AlphaFold F7EWN2 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689627
Promoter ID:EPDNEW_R151
Type:initiation region
Name:MGC94891_1
Description:hypothetical protein LOC681210
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0152,354,149 - 52,354,209EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598061 AgrOrtholog
BioCyc Gene G2FUF-61521 BioCyc
Ensembl Genes ENSRNOG00000011243 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097954 ENTREZGENE
  ENSRNOT00000097954.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111103 IMAGE-MGC_LOAD
InterPro TSNAXIP1_N UniProtKB/TrEMBL
KEGG Report rno:681210 UniProtKB/TrEMBL
MGC_CLONE MGC:94891 IMAGE-MGC_LOAD
NCBI Gene 681210 ENTREZGENE
PANTHER GI:13385330 UniProtKB/TrEMBL
  GI:13385330 UniProtKB/TrEMBL
Pfam TSNAXIP1_N UniProtKB/TrEMBL
PhenoGen C1h6orf118 PhenoGen
RatGTEx ENSRNOG00000011243 RatGTEx
UniProt A0A8I5ZRV0_RAT UniProtKB/TrEMBL
  A6KK12 ENTREZGENE, UniProtKB/TrEMBL
  F7EWN2 ENTREZGENE
  Q5XI71 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-02-04 C1h6orf118  similar to human chromosome 6 open reading frame 118  MGC94891  hypothetical protein LOC681210  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 MGC94891  hypothetical protein LOC681210      Symbol and Name status set to provisional 70820 PROVISIONAL