Spint3 (serine peptidase inhibitor, Kunitz type, 3) - Rat Genome Database

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Gene: Spint3 (serine peptidase inhibitor, Kunitz type, 3) Rattus norvegicus
Analyze
Symbol: Spint3
Name: serine peptidase inhibitor, Kunitz type, 3
RGD ID: 1597746
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human SPINT3 (serine peptidase inhibitor, Kunitz type 3); INTERACTS WITH 17beta-estradiol; bisphenol A; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kunitz-type protease inhibitor 3; LOC685136; similar to alpha 3 type VI collagen isoform 1 precursor
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,713,314 - 173,716,062 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3173,712,460 - 173,716,121 (-)EnsemblGRCr8
mRatBN7.23153,293,969 - 153,296,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,294,010 - 153,296,779 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3157,103,933 - 157,106,677 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,602,899 - 165,605,641 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,346,535 - 163,349,271 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,024,739 - 161,028,927 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,025,491 - 161,027,943 (-)Ensemblrn6Rnor6.0
Rnor_5.03167,204,567 - 167,208,044 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43155,589,217 - 155,591,507 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3151,902,801 - 151,906,977 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Spint3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,713,314 - 173,716,062 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3173,712,460 - 173,716,121 (-)EnsemblGRCr8
mRatBN7.23153,293,969 - 153,296,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,294,010 - 153,296,779 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3157,103,933 - 157,106,677 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,602,899 - 165,605,641 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,346,535 - 163,349,271 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,024,739 - 161,028,927 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,025,491 - 161,027,943 (-)Ensemblrn6Rnor6.0
Rnor_5.03167,204,567 - 167,208,044 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43155,589,217 - 155,591,507 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3151,902,801 - 151,906,977 (-)NCBICelera
Cytogenetic Map3q42NCBI
SPINT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,512,461 - 45,515,622 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,512,461 - 45,515,622 (-)Ensemblhg38GRCh38
GRCh372044,141,101 - 44,144,262 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362044,141,101 - 44,144,264 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2040,849,624 - 40,852,785 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,882,590 - 40,885,751 (-)NCBIHuRef
CHM1_12044,043,676 - 44,046,833 (-)NCBICHM1_1
T2T-CHM13v2.02047,248,342 - 47,251,497 (-)NCBIT2T-CHM13v2.0
Spint3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,411,641 - 164,415,355 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,411,615 - 164,415,379 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382164,569,695 - 164,573,456 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,569,695 - 164,573,459 (-)Ensemblmm10GRCm38
MGSCv372164,395,195 - 164,398,956 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362164,260,893 - 164,264,638 (-)NCBIMGSCv36mm8
MGSCv362165,518,814 - 165,522,581 (-)NCBIMGSCv36mm8
Celera2170,506,128 - 170,510,122 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.2NCBI
SPINT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22151,247,663 - 51,251,987 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12051,240,772 - 51,245,096 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,845,959 - 41,849,511 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,936,030 - 42,939,176 (-)NCBIPanPan1.1PanPan1.1panPan2
SPINT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,721,798 - 32,724,433 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,721,798 - 32,724,408 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2432,366,719 - 32,369,677 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02433,432,196 - 33,435,154 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,432,201 - 33,434,810 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,693,294 - 32,696,249 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,808,981 - 32,811,939 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,353,244 - 33,356,202 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100513767
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11747,755,665 - 47,759,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,422,329 - 53,426,557 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPINT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,320,557 - 18,324,159 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,320,887 - 18,323,976 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605066,962,136 - 66,965,418 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spint3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15153,399,473 - 153,402,053 (+)NCBIRrattus_CSIRO_v1


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 6 22 40 41 46 18 22 18 2 121 55 33 34 66 28 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000078633   ⟹   ENSRNOP00000073710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,712,460 - 173,716,121 (-)Ensembl
mRatBN7.2 Ensembl3153,294,010 - 153,296,779 (-)Ensembl
Rnor_6.0 Ensembl3161,025,491 - 161,027,943 (-)Ensembl
RefSeq Acc Id: NM_001399567   ⟹   NP_001386496
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,713,314 - 173,716,062 (-)NCBI
mRatBN7.23153,293,969 - 153,296,717 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386496 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073710
  ENSRNOP00000073710.3
Ensembl Acc Id: ENSRNOP00000073710   ⟸   ENSRNOT00000078633
RefSeq Acc Id: NP_001386496   ⟸   NM_001399567
- Peptide Label: precursor
- UniProtKB: A0A0G2K680 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K680-F1-model_v2 AlphaFold A0A0G2K680 1-88 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692661
Promoter ID:EPDNEW_R3182
Type:multiple initiation site
Name:Spint3_1
Description:serine peptidase inhibitor, Kunitz type, 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03161,027,956 - 161,028,016EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597746 AgrOrtholog
BioCyc Gene G2FUF-46848 BioCyc
Ensembl Genes ENSRNOG00000052294 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078633 ENTREZGENE
  ENSRNOT00000078633.3 UniProtKB/TrEMBL
Gene3D-CATH 4.10.410.10 UniProtKB/TrEMBL
InterPro Kunitz-type_SerProtInhib UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
NCBI Gene 685136 ENTREZGENE
PANTHER KUNITZ-TYPE PROTEASE INHIBITOR-RELATED UniProtKB/TrEMBL
  SERINE PEPTIDASE INHIBITOR, KUNITZ TYPE, 3 UniProtKB/TrEMBL
Pfam Kunitz_BPTI UniProtKB/TrEMBL
PhenoGen Spint3 PhenoGen
PRINTS BASICPTASE UniProtKB/TrEMBL
PROSITE BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052294 RatGTEx
SMART SM00131 UniProtKB/TrEMBL
Superfamily-SCOP SSF57362 UniProtKB/TrEMBL
UniProt A0A0G2K680 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-21 Spint3  serine peptidase inhibitor, Kunitz type, 3  LOC685136  similar to alpha 3 type VI collagen isoform 1 precursor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC685136  similar to alpha 3 type VI collagen isoform 1 precursor  LOC684688  similar to alpha 3 type VI collagen isoform 1 precursor  Data merged from RGD:1587886 1643240 APPROVED
2006-11-20 LOC685136  similar to alpha 3 type VI collagen isoform 1 precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684688  similar to alpha 3 type VI collagen isoform 1 precursor      Symbol and Name status set to provisional 70820 PROVISIONAL