Wfdc6a (WAP four-disulfide core domain 6A) - Rat Genome Database

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Gene: Wfdc6a (WAP four-disulfide core domain 6A) Rattus norvegicus
Analyze
Symbol: Wfdc6a
Name: WAP four-disulfide core domain 6A
RGD ID: 1597730
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Orthologous to human WFDC6 (WAP four-disulfide core domain 6); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC685153; similar to WAP four-disulfide core 6-like 1; WAP four-disulfide core domain protein 6a
RGD Orthologs
Human
Mouse
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,724,681 - 173,728,489 (-)NCBIGRCr8
mRatBN7.23153,305,336 - 153,309,144 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,305,336 - 153,309,144 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,115,318 - 157,119,126 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,614,282 - 165,618,090 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,357,913 - 163,361,721 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,036,703 - 161,040,511 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,036,703 - 161,040,511 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,215,812 - 167,219,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,600,267 - 155,604,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3151,914,750 - 151,918,558 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21796715  


Genomics

Comparative Map Data
Wfdc6a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,724,681 - 173,728,489 (-)NCBIGRCr8
mRatBN7.23153,305,336 - 153,309,144 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,305,336 - 153,309,144 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,115,318 - 157,119,126 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,614,282 - 165,618,090 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,357,913 - 163,361,721 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,036,703 - 161,040,511 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,036,703 - 161,040,511 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,215,812 - 167,219,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,600,267 - 155,604,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3151,914,750 - 151,918,558 (-)NCBICelera
Cytogenetic Map3q42NCBI
WFDC6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,534,196 - 45,539,482 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,534,196 - 45,539,482 (-)EnsemblGRCh38hg38GRCh38
GRCh372044,162,835 - 44,168,121 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,596,250 - 43,601,548 (-)NCBINCBI36Build 36hg18NCBI36
Build 342043,596,249 - 43,601,548NCBI
Celera2040,871,355 - 40,876,654 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,904,308 - 40,909,607 (-)NCBIHuRef
CHM1_12044,065,402 - 44,070,698 (-)NCBICHM1_1
T2T-CHM13v2.02047,270,055 - 47,275,339 (-)NCBIT2T-CHM13v2.0
Wfdc6a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,421,439 - 164,427,704 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,421,439 - 164,427,367 (-)EnsemblGRCm39 Ensembl
GRCm382164,579,519 - 164,585,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,579,519 - 164,585,447 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,405,019 - 164,410,947 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,270,725 - 164,276,382 (-)NCBIMGSCv36mm8
Celera2170,516,185 - 170,522,113 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.21NCBI
PTI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,773,060 - 47,779,703 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,773,060 - 47,780,746 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,401,274 - 53,408,962 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WFDC6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,296,865 - 18,298,961 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605066,938,427 - 66,943,694 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Wfdc6a
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:210
Count of miRNA genes:140
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000037518
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10
Low 1 3 18 14 5 14 1 1 23 14 26 11 1
Below cutoff 2 34 36 25 14 25 7 10 45 19 4 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000037518   ⟹   ENSRNOP00000036161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,305,336 - 153,309,144 (-)Ensembl
Rnor_6.0 Ensembl3161,036,703 - 161,040,511 (-)Ensembl
RefSeq Acc Id: NM_001246283   ⟹   NP_001233212
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,724,681 - 173,728,489 (-)NCBI
mRatBN7.23153,305,336 - 153,309,144 (-)NCBI
Rnor_6.03161,036,703 - 161,040,511 (-)NCBI
Rnor_5.03167,215,812 - 167,219,620 (-)NCBI
Celera3151,914,750 - 151,918,558 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001233212 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADK26530 (Get FASTA)   NCBI Sequence Viewer  
  EDL96510 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036161
  ENSRNOP00000036161.5
Reference Protein Sequences
RefSeq Acc Id: NP_001233212   ⟸   NM_001246283
- Peptide Label: precursor
- UniProtKB: A6JX99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036161   ⟸   ENSRNOT00000037518
Protein Domains
BPTI/Kunitz inhibitor   WAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LVU2-F1-model_v2 AlphaFold F1LVU2 1-147 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597730 AgrOrtholog
BioCyc Gene G2FUF-46847 BioCyc
Ensembl Genes ENSRNOG00000042526 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037518 ENTREZGENE
  ENSRNOT00000037518.6 UniProtKB/TrEMBL
Gene3D-CATH 4.10.410.10 UniProtKB/TrEMBL
  4.10.75.10 UniProtKB/TrEMBL
InterPro Elafin-like_sf UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  Prot_inh_Kunz-m UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
  Whey_acidic_protein_4-diS_core UniProtKB/TrEMBL
NCBI Gene 685153 ENTREZGENE
PANTHER EPPIN UniProtKB/TrEMBL
  WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 6A UniProtKB/TrEMBL
Pfam Kunitz_BPTI UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
PhenoGen Wfdc6a PhenoGen
PRINTS BASICPTASE UniProtKB/TrEMBL
PROSITE BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
  WAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042526 RatGTEx
SMART SM00131 UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_Kunz-m UniProtKB/TrEMBL
  SSF57256 UniProtKB/TrEMBL
UniProt A6JX99 ENTREZGENE, UniProtKB/TrEMBL
  F1LVU2_RAT UniProtKB/TrEMBL
  F6JRF6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Wfdc6a  WAP four-disulfide core domain 6A  LOC685153  similar to WAP four-disulfide core 6-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC685153  similar to WAP four-disulfide core 6-like 1  LOC684696  similar to WAP four-disulfide core 6-like 1  Data merged from RGD:1587878 1643240 APPROVED
2006-11-20 LOC685153  similar to WAP four-disulfide core 6-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684696  similar to WAP four-disulfide core 6-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL