Pip5kl1 (phosphatidylinositol-4-phosphate 5-kinase-like 1) - Rat Genome Database

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Gene: Pip5kl1 (phosphatidylinositol-4-phosphate 5-kinase-like 1) Rattus norvegicus
Analyze
Symbol: Pip5kl1
Name: phosphatidylinositol-4-phosphate 5-kinase-like 1
RGD ID: 1597527
Description: Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in several processes, including negative regulation of mitochondrial membrane potential; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and phosphatidylinositol phosphate biosynthetic process. Predicted to be located in cell projection and cytosol. Predicted to be active in plasma membrane. Orthologous to human PIP5KL1 (phosphatidylinositol-4-phosphate 5-kinase like 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC687758; phosphatidylinositol 4-phosphate 5-kinase-like protein 1; similar to phosphatidylinositol-4-phosphate 5-kinase-like 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,258,141 - 36,266,902 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl336,258,102 - 36,266,888 (+)EnsemblGRCr8
mRatBN7.2315,860,493 - 15,869,264 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,855,946 - 15,869,165 (+)EnsemblmRatBN7.2
Rnor_6.0311,592,156 - 11,597,513 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,593,655 - 11,597,410 (+)Ensemblrn6Rnor6.0
Rnor_5.0316,941,608 - 16,947,929 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera310,600,220 - 10,608,899 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14701839   PMID:16751333   PMID:19680787  


Genomics

Comparative Map Data
Pip5kl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,258,141 - 36,266,902 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl336,258,102 - 36,266,888 (+)EnsemblGRCr8
mRatBN7.2315,860,493 - 15,869,264 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,855,946 - 15,869,165 (+)EnsemblmRatBN7.2
Rnor_6.0311,592,156 - 11,597,513 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,593,655 - 11,597,410 (+)Ensemblrn6Rnor6.0
Rnor_5.0316,941,608 - 16,947,929 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera310,600,220 - 10,608,899 (+)NCBICelera
Cytogenetic Map3p11NCBI
PIP5KL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,920,881 - 127,930,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,920,881 - 127,930,785 (-)Ensemblhg38GRCh38
GRCh379130,683,160 - 130,693,056 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,723,629 - 129,729,591 (-)NCBIBuild 36Build 36hg18NCBI36
Build 349127,763,361 - 127,769,324NCBI
Celera9101,335,032 - 101,344,303 (-)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,300,746 - 100,310,021 (-)NCBIHuRef
CHM1_19130,836,106 - 130,845,374 (-)NCBICHM1_1
T2T-CHM13v2.09140,128,656 - 140,138,557 (-)NCBIT2T-CHM13v2.0
Pip5kl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,465,238 - 32,473,799 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,464,809 - 32,473,794 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38232,575,226 - 32,583,787 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,574,797 - 32,583,782 (+)Ensemblmm10GRCm38
MGSCv37232,431,339 - 32,439,299 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36232,397,828 - 32,405,788 (+)NCBIMGSCv36mm8
Celera232,281,603 - 32,289,592 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Pip5kl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419745,344 - 753,819 (+)Ensembl
ChiLan1.0NW_004955419745,400 - 753,819 (+)NCBIChiLan1.0ChiLan1.0
PIP5KL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,422,581 - 11,432,558 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,420,766 - 11,434,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,041,687 - 99,051,031 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,712,944 - 127,722,332 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,712,944 - 127,722,332 (-)EnsemblpanPan2panpan1.1
PIP5KL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,490,881 - 55,499,755 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,490,942 - 55,498,891 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha954,684,983 - 54,693,829 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0956,412,941 - 56,421,788 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,413,002 - 56,420,828 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,172,948 - 55,181,794 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,487,663 - 55,496,508 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,578,889 - 55,587,737 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pip5kl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,785,445 - 195,793,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,554,565 - 15,562,131 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,554,565 - 15,562,131 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIP5KL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,408,448 - 268,417,944 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11268,409,113 - 268,417,580 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,331,469 - 302,339,378 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIP5KL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,191,317 - 10,201,268 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,191,818 - 10,200,949 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660796,016,840 - 6,027,165 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pip5kl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,642,577 - 7,651,083 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247607,642,551 - 7,650,321 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pip5kl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v153,059,504 - 3,068,328 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pip5kl1
75 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:59
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000074122
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH144018  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera310,608,652 - 10,608,803UniSTS
RH 3.4 Map372.4UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 11 52 144 58 58 27 75 27 6 261 149 128 63 85 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000074122   ⟹   ENSRNOP00000067014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,258,102 - 36,266,888 (+)Ensembl
mRatBN7.2 Ensembl315,855,946 - 15,869,165 (+)Ensembl
Rnor_6.0 Ensembl311,593,655 - 11,597,410 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109105   ⟹   ENSRNOP00000092836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,258,102 - 36,266,888 (+)Ensembl
RefSeq Acc Id: XM_039106178   ⟹   XP_038962106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,258,141 - 36,266,902 (+)NCBI
mRatBN7.2315,860,493 - 15,869,264 (+)NCBI
RefSeq Acc Id: XM_039106179   ⟹   XP_038962107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,258,141 - 36,266,902 (+)NCBI
mRatBN7.2315,860,493 - 15,869,264 (+)NCBI
RefSeq Acc Id: XM_039106180   ⟹   XP_038962108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,258,250 - 36,266,657 (+)NCBI
mRatBN7.2315,860,493 - 15,868,931 (+)NCBI
Ensembl Acc Id: ENSRNOP00000067014   ⟸   ENSRNOT00000074122
RefSeq Acc Id: XP_038962106   ⟸   XM_039106178
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038962107   ⟸   XM_039106179
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038962108   ⟸   XM_039106180
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000092836   ⟸   ENSRNOT00000109105
Protein Domains
PIPK

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RBR8-F1-model_v2 AlphaFold M0RBR8 1-302 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597527 AgrOrtholog
BioCyc Gene G2FUF-50132 BioCyc
Ensembl Genes ENSRNOG00000048676 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074122 ENTREZGENE
  ENSRNOT00000074122.4 UniProtKB/TrEMBL
  ENSRNOT00000109105 ENTREZGENE
Gene3D-CATH 2-Layer Sandwich UniProtKB/TrEMBL
  3.30.800.10 UniProtKB/TrEMBL
InterPro PInositol-4-P-4/5-kinase_C_sf UniProtKB/TrEMBL
  PInositol-4-P-5-kinase UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_core UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_N UniProtKB/TrEMBL
NCBI Gene 687758 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE-LIKE PROTEIN 1 UniProtKB/TrEMBL
  PTHR23086 UniProtKB/TrEMBL
Pfam PIP5K UniProtKB/TrEMBL
PhenoGen Pip5kl1 PhenoGen
PROSITE PIPK UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048676 RatGTEx
SMART PIPKc UniProtKB/TrEMBL
Superfamily-SCOP SAICAR synthase-like UniProtKB/TrEMBL
UniProt A6JU69 ENTREZGENE, UniProtKB/TrEMBL
  M0RBR8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-16 Pip5kl1  phosphatidylinositol-4-phosphate 5-kinase-like 1  LOC687758  similar to phosphatidylinositol-4-phosphate 5-kinase-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687758  similar to phosphatidylinositol-4-phosphate 5-kinase-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL