Spaca7 (sperm acrosome associated 7) - Rat Genome Database

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Gene: Spaca7 (sperm acrosome associated 7) Rattus norvegicus
Analyze
Symbol: Spaca7
Name: sperm acrosome associated 7
RGD ID: 1597409
Description: Predicted to act upstream of or within negative regulation of cell adhesion and single fertilization. Predicted to be located in acrosomal vesicle. Orthologous to human SPACA7 (sperm acrosome associated 7); INTERACTS WITH bisphenol A; 1,2-dimethylhydrazine (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC686769; hypothetical protein LOC689077; LOC689077; sperm acrosome-associated protein 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81683,630,735 - 83,657,669 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1683,630,705 - 83,657,665 (-)EnsemblGRCr8
mRatBN7.21676,928,611 - 76,955,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,928,581 - 76,955,543 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1682,209,132 - 82,236,068 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01685,661,724 - 85,688,666 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,911,875 - 80,938,824 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01682,261,120 - 82,288,091 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1682,262,673 - 82,288,022 (-)Ensemblrn6Rnor6.0
Rnor_5.01681,745,898 - 81,772,901 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41681,787,243 - 81,812,661 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1674,732,673 - 74,759,646 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
acrosomal vesicle  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22495889   PMID:24307706   PMID:36462395  


Genomics

Comparative Map Data
Spaca7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81683,630,735 - 83,657,669 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1683,630,705 - 83,657,665 (-)EnsemblGRCr8
mRatBN7.21676,928,611 - 76,955,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,928,581 - 76,955,543 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1682,209,132 - 82,236,068 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01685,661,724 - 85,688,666 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,911,875 - 80,938,824 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01682,261,120 - 82,288,091 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1682,262,673 - 82,288,022 (-)Ensemblrn6Rnor6.0
Rnor_5.01681,745,898 - 81,772,901 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41681,787,243 - 81,812,661 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1674,732,673 - 74,759,646 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
SPACA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813112,376,355 - 112,434,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13112,376,355 - 112,434,689 (+)Ensemblhg38GRCh38
GRCh3713113,030,669 - 113,089,003 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613112,078,670 - 112,137,002 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1393,856,057 - 93,914,326 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1393,472,184 - 93,530,513 (+)NCBIHuRef
CHM1_113112,996,281 - 113,054,892 (+)NCBICHM1_1
T2T-CHM13v2.013111,623,523 - 111,681,824 (+)NCBIT2T-CHM13v2.0
Spaca7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39812,623,038 - 12,650,744 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl812,623,029 - 12,650,744 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38812,573,036 - 12,600,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl812,573,029 - 12,600,744 (+)Ensemblmm10GRCm38
MGSCv37812,573,049 - 12,600,738 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36812,573,026 - 12,600,715 (+)NCBIMGSCv36mm8
Celera812,741,376 - 12,768,613 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.73NCBI
Spaca7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554041,050,098 - 1,077,184 (-)NCBIChiLan1.0ChiLan1.0
SPACA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214113,867,309 - 113,925,787 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113112,552,729 - 112,611,179 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01393,505,639 - 93,564,287 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113112,593,729 - 112,651,826 (+)NCBIPanPan1.1PanPan1.1panPan2
SPACA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,106,719 - 60,135,916 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,106,763 - 60,135,759 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2259,819,553 - 59,822,020 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
Spaca7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945193,933,197 - 193,949,770 (-)NCBIHiC_Itri_2
SPACA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11177,367,299 - 77,378,342 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SPACA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1390,454,316 - 90,482,525 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl390,455,290 - 90,482,383 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604647,373,539 - 47,400,921 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spaca7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11371,097,473 - 71,124,086 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spaca7
397 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 5 2 15 9 7 2 8 2 26 15 11 1 21 5

Sequence


Ensembl Acc Id: ENSRNOT00000078609   ⟹   ENSRNOP00000069078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,929,331 - 76,955,543 (-)Ensembl
Rnor_6.0 Ensembl1682,262,673 - 82,288,022 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107465   ⟹   ENSRNOP00000096482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1683,630,705 - 83,657,665 (-)Ensembl
mRatBN7.2 Ensembl1676,928,581 - 76,955,543 (-)Ensembl
RefSeq Acc Id: NM_001399279   ⟹   NP_001386208
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,630,735 - 83,657,669 (-)NCBI
mRatBN7.21676,928,611 - 76,955,547 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386208 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000096482
  ENSRNOP00000096482.1
GenBank Protein QHI05887 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000069078   ⟸   ENSRNOT00000078609
Ensembl Acc Id: ENSRNOP00000096482   ⟸   ENSRNOT00000107465
RefSeq Acc Id: NP_001386208   ⟸   NM_001399279
- Peptide Label: precursor
- UniProtKB: A0A6B9RW43 (UniProtKB/TrEMBL),   A0A0G2JUF4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JUF4-F1-model_v2 AlphaFold A0A0G2JUF4 1-176 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700242
Promoter ID:EPDNEW_R10763
Type:initiation region
Name:Spaca7_1
Description:sperm acrosome associated 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01682,288,053 - 82,288,113EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597409 AgrOrtholog
BioCyc Gene G2FUF-10690 BioCyc
Ensembl Genes ENSRNOG00000054006 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000107465 ENTREZGENE
  ENSRNOT00000107465.2 UniProtKB/TrEMBL
InterPro SPACA7 UniProtKB/TrEMBL
NCBI Gene 689077 ENTREZGENE
Pfam SPACA7 UniProtKB/TrEMBL
PhenoGen Spaca7 PhenoGen
RatGTEx ENSRNOG00000054006 RatGTEx
UniProt A0A0G2JUF4 ENTREZGENE
  A0A6B9RW43 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Spaca7  sperm acrosome associated 7  LOC686769  hypothetical protein LOC686769  Data merged from RGD:1593693 1643240 APPROVED
2011-08-02 Spaca7  sperm acrosome associated 7  LOC689077  hypothetical protein LOC689077  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC689077  hypothetical protein LOC689077      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC686769  hypothetical protein LOC686769      Symbol and Name status set to provisional 70820 PROVISIONAL