Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of DERL3 mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of DERL3 mRNA] | CTD | PMID:22206623 | 1,2-dimethylhydrazine | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of DERL3 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of DERL3 mRNA and [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of DERL3 mRNA | CTD | PMID:26496021 and PMID:32741896 | 17beta-estradiol | multiple interactions | ISO | DERL3 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of DERL3 mRNA | CTD | PMID:30165855 | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of DERL3 mRNA | CTD | PMID:32741896 | 1H-pyrazole | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | pyrazole results in increased expression of DERL3 mRNA | CTD | PMID:17945193 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | DERL3 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin affects the expression of DERL3 mRNA | CTD | PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of DERL3 mRNA | CTD | PMID:32109520 | 4,4'-sulfonyldiphenol | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | bisphenol S results in increased expression of DERL3 mRNA | CTD | PMID:34850234 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of DERL3 mRNA | CTD | PMID:24780913 and PMID:25825206 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of DERL3 mRNA | CTD | PMID:28959563 | acrylamide | decreases expression | ISO | DERL3 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of DERL3 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of DERL3 mRNA | CTD | PMID:25378103 | aldehydo-D-glucose | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of DERL3 mRNA | CTD | PMID:37567420 | aristolochic acid A | decreases expression | ISO | DERL3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of DERL3 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of DERL3 mRNA | CTD | PMID:32417428 | benzo[a]pyrene | increases expression | ISO | DERL3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of DERL3 mRNA | CTD | PMID:30453624 | benzo[a]pyrene | increases methylation | ISO | DERL3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of DERL3 5' UTR and Benzo(a)pyrene results in increased methylation of DERL3 promoter | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | [corannulene co-treated with Benzo(a)pyrene] results in decreased expression of DERL3 mRNA | CTD | PMID:32417428 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | Diethylhexyl Phthalate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of DERL3 mRNA] | CTD | PMID:33484791 | bis(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in increased expression of DERL3 mRNA | CTD | PMID:36005737 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of DERL3 mRNA | CTD | PMID:28085963 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of DERL3 mRNA | CTD | PMID:26496021 | bisphenol A | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of DERL3 mRNA | CTD | PMID:32156529 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of DERL3 mRNA | CTD | PMID:25181051 | bromobenzene | decreases expression | EXP | | 6480464 | bromobenzene results in decreased expression of DERL3 mRNA | CTD | PMID:32479839 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of DERL3 promoter | CTD | PMID:22457795 | calcitriol | decreases expression | ISO | DERL3 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of DERL3 mRNA | CTD | PMID:26485663 | carbon nanotube | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | ciguatoxin CTX1B | affects expression | ISO | Derl3 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of DERL3 mRNA | CTD | PMID:18353800 | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of DERL3 mRNA | CTD | PMID:30556269 | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of DERL3 mRNA | CTD | PMID:30556269 | copper(II) chloride | decreases expression | ISO | DERL3 (Homo sapiens) | 6480464 | cupric chloride results in decreased expression of DERL3 mRNA | CTD | PMID:34921933 | cyclosporin A | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | Cyclosporine results in increased expression of DERL3 mRNA | CTD | PMID:25270620 | D-glucose | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of DERL3 mRNA | CTD | PMID:37567420 | dextran sulfate | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | Dextran Sulfate results in increased expression of DERL3 mRNA | CTD | PMID:23894361 | dibutyl phthalate | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of DERL3 mRNA | CTD | PMID:21266533 | dichloroacetic acid | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | Dichloroacetic Acid results in decreased expression of DERL3 mRNA | CTD | PMID:28962523 | diclofenac | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | Diclofenac results in increased expression of DERL3 mRNA | CTD | PMID:26934552 | dioxygen | multiple interactions | EXP | | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of DERL3 mRNA | CTD | PMID:33729688 | endosulfan | affects expression | EXP | | 6480464 | Endosulfan affects the expression of DERL3 mRNA | CTD | PMID:29391264 | epoxiconazole | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of DERL3 mRNA | CTD | PMID:35436446 | folic acid | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of DERL3 mRNA] | CTD | PMID:22206623 | fructose | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of DERL3 mRNA | CTD | PMID:37567420 | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of DERL3 mRNA | CTD | PMID:26194646 | genistein | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | Genistein results in decreased expression of DERL3 mRNA | CTD | PMID:32186404 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of DERL3 mRNA | CTD | PMID:33387578 | glucose | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of DERL3 mRNA | CTD | PMID:37567420 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of DERL3 mRNA | CTD | PMID:21396975 | indole-3-methanol | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of DERL3 mRNA | CTD | PMID:22129741 | isoprenaline | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | Isoproterenol results in decreased expression of DERL3 mRNA | CTD | PMID:21823215 | luteolin | increases expression | EXP | | 6480464 | Luteolin results in increased expression of DERL3 mRNA | CTD | PMID:31201582 | mono(2-ethylhexyl) phthalate | affects expression | ISO | Derl3 (Mus musculus) | 6480464 | mono-(2-ethylhexyl)phthalate affects the expression of DERL3 mRNA | CTD | PMID:21195148 | Monobutylphthalate | affects expression | ISO | Derl3 (Mus musculus) | 6480464 | monobutyl phthalate affects the expression of DERL3 mRNA | CTD | PMID:21195148 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | Derl3 (Mus musculus) | 6480464 | Ethylnitrosourea results in increased mutagenesis of DERL3 mRNA | CTD | PMID:27776689 | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of DERL3 mRNA | CTD | PMID:28801915 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of DERL3 mRNA | CTD | PMID:22129741 | paracetamol | affects expression | ISO | Derl3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of DERL3 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of DERL3 mRNA | CTD | PMID:33387578 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of DERL3 mRNA | CTD | PMID:32479839 | paracetamol | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | Acetaminophen results in increased expression of DERL3 mRNA | CTD | PMID:29246445 | paracetamol | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of DERL3 mRNA] | CTD | PMID:29246445 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of DERL3 mRNA | CTD | PMID:36331819 | pioglitazone | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of DERL3 mRNA | CTD | PMID:27935865 | pirinixic acid | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of DERL3 mRNA | CTD | PMID:20813756 and PMID:23811191 | pravastatin | decreases expression | EXP | | 6480464 | Pravastatin results in decreased expression of DERL3 mRNA | CTD | PMID:27225895 | pravastatin | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | Pravastatin results in decreased expression of DERL3 mRNA | CTD | PMID:27225895 | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in decreased expression of DERL3 mRNA | CTD | PMID:28903501 | quercetin | affects expression | EXP | | 6480464 | Quercetin affects the expression of DERL3 mRNA | CTD | PMID:18178720 | quercetin | increases expression | EXP | | 6480464 | Quercetin results in increased expression of DERL3 mRNA | CTD | PMID:31201582 | resveratrol | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | Resveratrol inhibits the reaction [titanium dioxide results in increased expression of DERL3 mRNA] | CTD | PMID:31298478 | silicon dioxide | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of DERL3 mRNA | CTD | PMID:29341224 | sodium arsenite | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of DERL3 mRNA | CTD | PMID:37682722 | streptozocin | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | [Streptozocin co-treated with Dietary Fats] results in increased expression of DERL3 mRNA and Diethylhexyl Phthalate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of DERL3 mRNA] | CTD | PMID:33484791 | sunitinib | increases expression | ISO | DERL3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of DERL3 mRNA | CTD | PMID:31533062 | tebuconazole | decreases expression | ISO | DERL3 (Homo sapiens) | 6480464 | tebuconazole results in decreased expression of DERL3 mRNA | CTD | PMID:30458266 | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of DERL3 mRNA | CTD | PMID:32741896 | testosterone | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | Testosterone deficiency results in decreased expression of DERL3 mRNA | CTD | PMID:33848595 | testosterone | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:33848595 | tetrachloromethane | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of DERL3 mRNA | CTD | PMID:25270620 | tetrachloromethane | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of DERL3 mRNA | CTD | PMID:29987408 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of DERL3 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of DERL3 mRNA] | CTD | PMID:31150632 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of DERL3 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | Derl3 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of DERL3 mRNA | CTD | PMID:23557971 more ... | titanium dioxide | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | Resveratrol inhibits the reaction [titanium dioxide results in increased expression of DERL3 mRNA] | CTD | PMID:31298478 | trichloroethene | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | Trichloroethylene results in decreased expression of DERL3 mRNA | CTD | PMID:25549359 | triclosan | decreases expression | ISO | DERL3 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of DERL3 mRNA | CTD | PMID:30510588 | tunicamycin | increases expression | ISO | DERL3 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of DERL3 mRNA | CTD | PMID:29453283 | valproic acid | affects expression | ISO | Derl3 (Mus musculus) | 6480464 | Valproic Acid affects the expression of DERL3 mRNA | CTD | PMID:17292431 | valproic acid | decreases expression | ISO | DERL3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of DERL3 mRNA | CTD | PMID:29154799 | XL147 | multiple interactions | ISO | Derl3 (Mus musculus) | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of DERL3 mRNA | CTD | PMID:27935865 | zaragozic acid A | decreases expression | EXP | | 6480464 | squalestatin 1 results in decreased expression of DERL3 mRNA | CTD | PMID:27225895 | zaragozic acid A | decreases expression | ISO | Derl3 (Mus musculus) | 6480464 | squalestatin 1 results in decreased expression of DERL3 mRNA | CTD | PMID:27225895 | |