Serpina1fl1 (serpin family A member 1F like 1) - Rat Genome Database

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Gene: Serpina1fl1 (serpin family A member 1F like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Serpina1fl1
Name: serpin family A member 1F like 1
RGD ID: 1597369
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in response to cytokine. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human SERPINA2 (serpin family A member 2 (gene/pseudogene)).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-1-antiproteinase-like; alpha-1-antitrypsin-related protein-like; LOC690319; similar to Alpha-1-antitrypsin-related protein precursor
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,611,592 - 128,623,601 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.26122,846,808 - 122,858,814 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,846,749 - 122,876,546 (-)EnsemblmRatBN7.2
Rnor_6.06127,590,734 - 127,608,412 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06136,809,348 - 136,819,433 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46127,979,108 - 127,987,196 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6120,326,887 - 120,344,565 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Variants

.
Variants in Serpina1fl1
153 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

circulatory system
ectoderm
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
3 11 13 12 9 2 1 30 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000114342   ⟹   ENSRNOP00000087558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6122,846,749 - 122,876,546 (-)Ensembl
RefSeq Acc Id: XM_039113355   ⟹   XP_038969283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,611,592 - 128,623,601 (-)NCBI
mRatBN7.26122,846,808 - 122,858,814 (-)NCBI
RefSeq Acc Id: XM_039113356   ⟹   XP_038969284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,611,592 - 128,623,601 (-)NCBI
mRatBN7.26122,846,808 - 122,858,814 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038969283 (Get FASTA)   NCBI Sequence Viewer  
  XP_038969284 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000087558.2
RefSeq Acc Id: XP_038969284   ⟸   XM_039113356
- UniProtKB: A0A8I6A8Z3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969283   ⟸   XM_039113355
- UniProtKB: A0A8I6A8Z3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087558   ⟸   ENSRNOT00000114342

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597369 AgrOrtholog
BioCyc Gene G2FUF-36402 BioCyc
Ensembl Genes ENSRNOG00000032669 UniProtKB/TrEMBL
  ENSRNOG00000063912 Ensembl
Ensembl Transcript ENSRNOT00000114342.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
NCBI Gene 690319 ENTREZGENE
PANTHER ALPHA-1-ANTITRYPSIN UniProtKB/TrEMBL
  PTHR11461 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpina1fl1 PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032669 RatGTEx
  ENSRNOG00000063912 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A8I6A8Z3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Serpina1fl1  serpin family A member 1F like 1  LOC690319  similar to Alpha-1-antitrypsin-related protein precursor  Symbol and Name Changed 1299863 APPROVED
2008-01-09 LOC690319  similar to Alpha-1-antitrypsin-related protein precursor  LOC683730  similar to Alpha-1-antitrypsin-related protein precursor  Data merged from RGD:1583362 1643240 APPROVED
2006-11-20 LOC690319  similar to Alpha-1-antitrypsin-related protein precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683730  similar to Alpha-1-antitrypsin-related protein precursor      Symbol and Name status set to provisional 70820 PROVISIONAL