C14h2orf74 (similar to human chromosome 2 open reading frame 74) - Rat Genome Database

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Gene: C14h2orf74 (similar to human chromosome 2 open reading frame 74) Rattus norvegicus
Analyze
Symbol: C14h2orf74
Name: similar to human chromosome 2 open reading frame 74
RGD ID: 1597336
Description: Orthologous to human C2orf74 (chromosome 2 open reading frame 74); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); arsenite(3-) (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC690352; LOC690352; uncharacterized protein C2orf74 homolog; uncharacterized protein LOC690352
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,694,721 - 101,697,842 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl14101,694,721 - 101,697,398 (-)EnsemblGRCr8
mRatBN7.21497,493,579 - 97,496,697 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,493,658 - 97,496,679 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14101,825,814 - 101,828,841 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014103,070,175 - 103,073,202 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,541,741 - 99,544,768 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014108,281,908 - 108,285,008 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,281,907 - 108,285,008 (-)Ensemblrn6Rnor6.0
Rnor_5.014105,117,765 - 105,120,865 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414104,443,532 - 104,446,553 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1496,470,624 - 96,473,645 (-)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
C14h2orf74
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,694,721 - 101,697,842 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl14101,694,721 - 101,697,398 (-)EnsemblGRCr8
mRatBN7.21497,493,579 - 97,496,697 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,493,658 - 97,496,679 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14101,825,814 - 101,828,841 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014103,070,175 - 103,073,202 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,541,741 - 99,544,768 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014108,281,908 - 108,285,008 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,281,907 - 108,285,008 (-)Ensemblrn6Rnor6.0
Rnor_5.014105,117,765 - 105,120,865 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414104,443,532 - 104,446,553 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1496,470,624 - 96,473,645 (-)NCBICelera
Cytogenetic Map14q22NCBI
C2orf74
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38261,145,116 - 61,164,828 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl261,145,068 - 61,164,828 (+)Ensemblhg38GRCh38
GRCh37261,372,251 - 61,391,963 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36261,225,792 - 61,245,468 (+)NCBIBuild 36Build 36hg18NCBI36
Celera261,215,846 - 61,236,014 (+)NCBICelera
Cytogenetic Map2p15NCBI
HuRef261,113,262 - 61,133,063 (+)NCBIHuRef
CHM1_1261,302,780 - 61,322,493 (+)NCBICHM1_1
T2T-CHM13v2.0261,150,976 - 61,170,676 (+)NCBIT2T-CHM13v2.0
1700093K21Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391123,466,203 - 23,471,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1123,466,203 - 23,471,155 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381123,516,202 - 23,521,319 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1123,516,203 - 23,521,155 (-)Ensemblmm10GRCm38
MGSCv371123,416,203 - 23,419,942 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361123,416,203 - 23,419,195 (-)NCBIMGSCv36mm8
Celera1125,643,964 - 25,647,707 (-)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.32NCBI
CUNH2orf74
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542422,709,676 - 22,712,178 (-)NCBIChiLan1.0ChiLan1.0
C12H2orf74
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21265,212,265 - 65,232,116 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A65,216,227 - 65,236,067 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A61,236,580 - 61,256,389 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A62,377,116 - 62,395,225 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A62,392,633 - 62,395,225 (+)EnsemblpanPan2panpan1.1
C10H2orf74
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11061,199,711 - 61,231,862 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1061,229,922 - 61,231,834 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1061,089,577 - 61,121,728 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01062,208,401 - 62,240,704 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1062,238,753 - 62,240,667 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11061,911,317 - 61,943,472 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01062,195,570 - 62,228,168 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01062,491,291 - 62,523,461 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CUNH2orf74
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629221,913,425 - 21,917,216 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364916,654,380 - 6,657,560 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364916,654,389 - 6,657,560 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C3H2orf74
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl380,626,159 - 80,648,230 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1380,626,056 - 80,651,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2384,514,795 - 84,517,948 (+)NCBISscrofa10.2Sscrofa10.2susScr3
C14H2orf74
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11445,819,831 - 45,824,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1445,820,129 - 45,822,162 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604565,963,324 - 65,981,598 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH2orf74
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624833746,124 - 749,415 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624833746,419 - 748,845 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
C11H2orf74
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11193,420,111 - 93,423,117 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in C14h2orf74
55 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 3 20 102 44 47 17 31 17 6 124 72 5 84 24 62 30 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000078814   ⟹   ENSRNOP00000073410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl14108,281,907 - 108,284,619 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087501   ⟹   ENSRNOP00000071771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl14101,694,721 - 101,697,398 (-)Ensembl
mRatBN7.2 Ensembl1497,493,658 - 97,496,679 (-)Ensembl
Rnor_6.0 Ensembl14108,281,987 - 108,285,008 (-)Ensembl
RefSeq Acc Id: NM_001419355   ⟹   NP_001406284
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814101,694,721 - 101,697,398 (-)NCBI
mRatBN7.21497,493,579 - 97,496,256 (-)NCBI
RefSeq Acc Id: XM_006251550   ⟹   XP_006251612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814101,694,754 - 101,697,842 (-)NCBI
mRatBN7.21497,493,579 - 97,496,697 (-)NCBI
Rnor_6.014108,281,908 - 108,284,969 (-)NCBI
Rnor_5.014105,117,765 - 105,120,865 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001406284 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251612 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97991 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071771
  ENSRNOP00000071771.1
RefSeq Acc Id: XP_006251612   ⟸   XM_006251550
- Peptide Label: isoform X1
- UniProtKB: D3ZLU7 (UniProtKB/TrEMBL),   A6JQ74 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071771   ⟸   ENSRNOT00000087501
Ensembl Acc Id: ENSRNOP00000073410   ⟸   ENSRNOT00000078814
RefSeq Acc Id: NP_001406284   ⟸   NM_001419355
- UniProtKB: D3ZLU7 (UniProtKB/TrEMBL),   A6JQ74 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLU7-F1-model_v2 AlphaFold D3ZLU7 1-199 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699528
Promoter ID:EPDNEW_R10046
Type:multiple initiation site
Name:LOC690352_1
Description:hypothetical protein LOC690352
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014108,284,585 - 108,284,645EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597336 AgrOrtholog
BioCyc Gene G2FUF-14770 BioCyc
Ensembl Genes ENSRNOG00000051590 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087501 ENTREZGENE
  ENSRNOT00000087501.3 UniProtKB/TrEMBL
InterPro DUF4642 UniProtKB/TrEMBL
NCBI Gene 690352 ENTREZGENE
PANTHER PTHR37882 UniProtKB/TrEMBL
Pfam DUF4642 UniProtKB/TrEMBL
PhenoGen C14h2orf74 PhenoGen
RatGTEx ENSRNOG00000051590 RatGTEx
UniProt A6JQ74 ENTREZGENE, UniProtKB/TrEMBL
  D3ZLU7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-29 C14h2orf74  similar to human chromosome 2 open reading frame 74  LOC690352  hypothetical protein LOC690352  Name and Symbol changed 629549 APPROVED
2008-01-09 LOC690352  hypothetical protein LOC690352  LOC682682  hypothetical protein LOC682682  Data merged from RGD:1596611 1643240 APPROVED
2006-11-20 LOC690352  hypothetical protein LOC690352      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC682682  hypothetical protein LOC682682      Symbol and Name status set to provisional 70820 PROVISIONAL