Gzmn (granzyme N) - Rat Genome Database

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Gene: Gzmn (granzyme N) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gzmn
Name: granzyme N
RGD ID: 1597226
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be active in extracellular space. Orthologous to human GZMB (granzyme B); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: granzyme N-like; LOC502002; LOC691668; RGD1564878; similar to granzyme N; similar to natural killer cell protease 7
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,923,350 - 33,953,255 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,943,803 - 33,946,800 (-)EnsemblGRCr8
mRatBN7.21529,953,113 - 29,983,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,953,123 - 29,983,009 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,819,539 - 31,828,991 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,966,748 - 32,976,202 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,224,875 - 31,234,327 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01535,129,622 - 35,160,290 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1535,129,736 - 35,132,452 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1535,150,851 - 35,153,804 (-)Ensemblrn6Rnor6.0
Rnor_5.01539,016,569 - 39,047,242 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41534,661,907 - 34,664,860 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,547,722 - 29,550,675 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Gzmn
214 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:113
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000050660, ENSRNOT00000059672
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
BF387607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,973,602 - 29,973,796 (+)MAPPERmRatBN7.2
Rnor_6.01535,150,888 - 35,151,081NCBIRnor6.0
Rnor_5.01539,037,835 - 39,038,028UniSTSRnor5.0
RGSC_v3.41534,661,944 - 34,662,137UniSTSRGSC3.4
Celera1529,547,759 - 29,547,952UniSTS
RH 3.4 Map15213.88UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2 2 7 7 8 3 6 3 3 14 7 4 1 40 5 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000050660   ⟹   ENSRNOP00000051075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,943,803 - 33,946,800 (-)Ensembl
mRatBN7.2 Ensembl1529,973,566 - 29,983,009 (-)Ensembl
Rnor_6.0 Ensembl1535,150,851 - 35,153,804 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000059672   ⟹   ENSRNOP00000056424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,953,123 - 29,983,009 (-)Ensembl
Rnor_6.0 Ensembl1535,129,736 - 35,132,452 (-)Ensembl
RefSeq Acc Id: NM_001191116   ⟹   NP_001178045
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,943,803 - 33,953,255 (-)NCBI
mRatBN7.21529,973,566 - 29,983,018 (-)NCBI
Rnor_6.01535,150,851 - 35,153,804 (-)NCBI
Rnor_5.01539,016,569 - 39,047,242 (-)NCBI
Celera1529,547,722 - 29,550,675 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093666   ⟹   XP_038949594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,923,350 - 33,950,235 (-)NCBI
mRatBN7.21529,953,113 - 29,979,746 (-)NCBI
RefSeq Acc Id: XM_039093668   ⟹   XP_038949596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,923,350 - 33,953,254 (-)NCBI
mRatBN7.21529,953,113 - 29,983,017 (-)NCBI
RefSeq Acc Id: XM_039093669   ⟹   XP_038949597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,923,350 - 33,950,219 (-)NCBI
mRatBN7.21529,953,113 - 29,979,972 (-)NCBI
RefSeq Acc Id: XM_039093670   ⟹   XP_038949598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,923,350 - 33,951,054 (-)NCBI
mRatBN7.21529,953,113 - 29,980,765 (-)NCBI
RefSeq Acc Id: XM_039093671   ⟹   XP_038949599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,923,350 - 33,947,357 (-)NCBI
mRatBN7.21529,953,113 - 29,977,090 (-)NCBI
RefSeq Acc Id: XM_039093672   ⟹   XP_038949600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,943,803 - 33,951,022 (-)NCBI
mRatBN7.21529,973,541 - 29,978,403 (-)NCBI
RefSeq Acc Id: XM_039093674   ⟹   XP_038949602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,923,350 - 33,953,254 (-)NCBI
mRatBN7.21529,953,113 - 29,983,017 (-)NCBI
RefSeq Acc Id: XM_039093675   ⟹   XP_038949603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,923,350 - 33,950,235 (-)NCBI
mRatBN7.21529,953,113 - 29,979,988 (-)NCBI
RefSeq Acc Id: XM_039093676   ⟹   XP_038949604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,923,350 - 33,945,515 (-)NCBI
mRatBN7.21529,953,113 - 29,975,276 (-)NCBI
RefSeq Acc Id: XM_063274664   ⟹   XP_063130734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,923,350 - 33,953,219 (-)NCBI
RefSeq Acc Id: XM_063274665   ⟹   XP_063130735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,943,803 - 33,951,372 (-)NCBI
RefSeq Acc Id: XM_063274666   ⟹   XP_063130736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,923,350 - 33,953,254 (-)NCBI
RefSeq Acc Id: XM_063274667   ⟹   XP_063130737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,943,803 - 33,950,121 (-)NCBI
RefSeq Acc Id: XM_063274668   ⟹   XP_063130738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,924,492 - 33,953,254 (-)NCBI
RefSeq Acc Id: XM_063274669   ⟹   XP_063130739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,943,803 - 33,950,188 (-)NCBI
RefSeq Acc Id: XM_063274670   ⟹   XP_063130740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,943,803 - 33,950,189 (-)NCBI
RefSeq Acc Id: NP_001178045   ⟸   NM_001191116
- Peptide Label: precursor
- UniProtKB: D3ZRW9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056424   ⟸   ENSRNOT00000059672
Ensembl Acc Id: ENSRNOP00000051075   ⟸   ENSRNOT00000050660
RefSeq Acc Id: XP_038949602   ⟸   XM_039093674
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949596   ⟸   XM_039093668
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949598   ⟸   XM_039093670
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949603   ⟸   XM_039093675
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949597   ⟸   XM_039093669
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949594   ⟸   XM_039093666
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949599   ⟸   XM_039093671
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949604   ⟸   XM_039093676
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038949600   ⟸   XM_039093672
- Peptide Label: isoform X6
- UniProtKB: D3ZRW9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130736   ⟸   XM_063274666
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063130734   ⟸   XM_063274664
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063130738   ⟸   XM_063274668
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063130735   ⟸   XM_063274665
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063130740   ⟸   XM_063274670
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063130739   ⟸   XM_063274669
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063130737   ⟸   XM_063274667
- Peptide Label: isoform X6
- UniProtKB: D3ZRW9 (UniProtKB/TrEMBL)
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZY81-F1-model_v2 AlphaFold D3ZY81 1-254 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597226 AgrOrtholog
BioCyc Gene G2FUF-13660 BioCyc
Ensembl Genes ENSRNOG00000029860 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000049074 Ensembl
Ensembl Transcript ENSRNOT00000050660 ENTREZGENE
  ENSRNOT00000050660.5 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Pept_cys/ser_Trypsin-like UniProtKB/TrEMBL
  Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
KEGG Report rno:691668 UniProtKB/TrEMBL
NCBI Gene 691668 ENTREZGENE
PANTHER GRANZYME H UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Gzmn PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029860 RatGTEx
  ENSRNOG00000049074 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt D3ZRW9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Gzmn  granzyme N  RGD1564878  similar to natural killer cell protease 7  Data merged from RGD:1564878 737654 PROVISIONAL
2013-05-24 Gzmn  granzyme N  LOC100365914  granzyme N-like  Data merged from RGD:2318074 1643240 APPROVED
2010-05-05 LOC100365914  granzyme N-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1564878  similar to natural killer cell protease 7   RGD1564878_predicted  similar to natural killer cell protease 7 (predicted)  'predicted' is removed 2292626 APPROVED
2008-03-06 Gzmn  granzyme N  LOC691668  similar to granzyme N  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691668  similar to granzyme N  LOC681840  similar to granzyme N  Data merged from RGD:1590521 1643240 APPROVED
2006-11-20 LOC691668  similar to granzyme N      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC681840  similar to granzyme N      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1564878_predicted  similar to natural killer cell protease 7 (predicted)  LOC502002  similar to natural killer cell protease 7  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC502002  similar to natural killer cell protease 7      Symbol and Name status set to provisional 70820 PROVISIONAL