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Gene: Tmem121 (transmembrane protein 121) Rattus norvegicus

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Symbol:

Tmem121

Name:

transmembrane protein 121

RGD ID:

1597216

Description:

Predicted to be located in membrane. Orthologous to human TMEM121 (transmembrane protein 121); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; copper atom.

Type:

protein-coding

RefSeq Status:

INFERRED

Previously known as:

LOC314484; LOC691678; similar to hole protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM121 (transmembrane protein 121)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tmem121 (transmembrane protein 121)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem121 (transmembrane protein 121)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM121 (transmembrane protein 121)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM121 (transmembrane protein 121)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM121 (transmembrane protein 121)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM121 (transmembrane protein 121)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem121 (transmembrane protein 121)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tmem121 (transmembrane protein 121)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TMEM121 (transmembrane protein 121)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TMEM121 (transmembrane protein 121)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tmem121 (transmembrane protein 121)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tmem121 (transmembrane protein 121)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem121aa	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem121ab	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem121ab	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tmem121	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	tmem121	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	138,083,239 - 138,086,848 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	138,082,863 - 138,103,060 (+)	Ensembl				GRCr8
mRatBN7.2	6	132,262,182 - 132,265,797 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	132,262,176 - 132,265,914 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	132,431,455 - 132,435,064 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	132,721,570 - 132,725,179 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	132,096,584 - 132,100,193 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	137,994,675 - 138,002,897 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	137,997,335 - 137,998,291 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	146,989,463 - 146,997,301 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	138,188,587 - 138,192,179 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	129,800,118 - 129,808,340 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

myoepithelioma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dicrotophos (ISO)

dimethyl sulfoxide (ISO)

fonofos (ISO)

genistein (ISO)

gentamycin (EXP)

lead(0) (ISO)

nitrofen (EXP)

paracetamol (ISO)

parathion (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

terbufos (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

trimellitic anhydride (ISO)

urethane (ISO)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
2.	Comprehensive gene review and curation	RGD comprehensive gene curation

Genomics

Comparative Map Data

Tmem121
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	138,083,239 - 138,086,848 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	138,082,863 - 138,103,060 (+)	Ensembl				GRCr8
mRatBN7.2	6	132,262,182 - 132,265,797 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	132,262,176 - 132,265,914 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	132,431,455 - 132,435,064 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	132,721,570 - 132,725,179 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	132,096,584 - 132,100,193 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	137,994,675 - 138,002,897 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	137,997,335 - 137,998,291 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	146,989,463 - 146,997,301 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	138,188,587 - 138,192,179 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	129,800,118 - 129,808,340 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

TMEM121
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	105,526,583 - 105,530,198 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	105,525,996 - 105,530,205 (+)	Ensembl			hg38	GRCh38
GRCh37	14	105,992,920 - 105,996,535 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	105,063,998 - 105,067,584 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	14	86,047,836 - 86,049,422 (+)	NCBI		Celera
Cytogenetic Map	14	q32.33	NCBI
HuRef	14	86,193,241 - 86,194,722 (+)	NCBI		HuRef
CHM1_1	14	105,930,717 - 105,934,303 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	99,778,054 - 99,781,666 (+)	NCBI		T2T-CHM13v2.0

Tmem121
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	113,149,523 - 113,153,143 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	113,149,550 - 113,153,143 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	113,185,903 - 113,189,523 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	113,185,930 - 113,189,523 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	114,424,114 - 114,427,734 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	113,633,738 - 113,637,331 (+)	NCBI		MGSCv36	mm8
Celera	12	114,396,101 - 114,397,650 (+)	NCBI		Celera
Cytogenetic Map	12	F1	NCBI
cM Map	12	61.76	NCBI

Tmem121
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955538	3,714,998 - 3,715,948 (+)	Ensembl
ChiLan1.0	NW_004955538	3,713,448 - 3,716,174 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMEM121
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	106,709,418 - 106,717,147 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	105,925,919 - 105,929,537 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	86,181,558 - 86,185,176 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

TMEM121
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	72,807,482 - 72,810,575 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	72,808,382 - 72,810,277 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	72,319,443 - 72,320,408 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	73,097,307 - 73,098,306 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	8	72,777,980 - 72,778,945 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	72,825,788 - 72,826,777 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	73,217,311 - 73,218,276 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

TMEM121
(Sus scrofa - pig)

No map positions available.

TMEM121
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	83,423,123 - 83,426,704 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	83,425,352 - 83,426,302 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666053	70,881,386 - 70,885,010 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem121
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	27,105 - 28,058 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624734	26,878 - 29,713 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tmem121
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	130,785,306 - 130,788,915 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tmem121
10 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	81
Count of miRNA genes:	69
Interacting mature miRNAs:	75
Transcripts:	ENSRNOT00000006872
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4145118	Mcs26	Mammary carcinoma susceptibility QTL 26		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	112483610	147156653	Rat
1331797	Bp213	Blood pressure QTL 213	3.291		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	114241077	147156653	Rat
1641917	Colcr5	Colorectal carcinoma resistance QTL 5	3.18	0.0009	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	6	98944780	143944780	Rat
71111	Iddm8	Insulin dependent diabetes mellitus QTL 8	1.9	0.002	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	6	110921244	147156653	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	79198463	144254945	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	106095977	147156653	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	93778632	138778632	Rat
737976	Pia24	Pristane induced arthritis QTL 24			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	6	118366855	147156653	Rat
2312560	Pur20	Proteinuria QTL 20	2.1	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	131392689	143944780	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	101593607	138161926	Rat
1298087	Iddm18	Insulin dependent diabetes mellitus QTL 18		0.0001	urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	6	122236101	147156653	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	101593607	146593607	Rat
2293085	Iddm29	Insulin dependent diabetes mellitus QTL 29	7.66		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	121444670	147156653	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	155	91	90	59	42	59	6	302	140	8	136	79	86	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001398696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002726782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006225896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240674	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001838593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001838594	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001844203	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001844204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006872 ⟹ ENSRNOP00000006872

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	138,083,300 - 138,087,929 (+)	Ensembl
mRatBN7.2 Ensembl	6	132,262,250 - 132,265,914 (+)	Ensembl
Rnor_6.0 Ensembl	6	137,997,335 - 137,998,291 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110911 ⟹ ENSRNOP00000077735

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	138,083,094 - 138,103,060 (+)	Ensembl
mRatBN7.2 Ensembl	6	132,262,176 - 132,265,914 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000122810 ⟹ ENSRNOP00000109559

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	138,082,863 - 138,089,248 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000127998 ⟹ ENSRNOP00000105423

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	138,083,237 - 138,088,604 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000169570 ⟹ ENSRNOP00000102234

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	138,082,969 - 138,093,182 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000170546 ⟹ ENSRNOP00000106861

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	138,082,969 - 138,093,182 (+)	Ensembl

RefSeq Acc Id:

NM_001398696 ⟹ NP_001385625

RefSeq Status:

INFERRED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	138,083,239 - 138,086,848 (+)	NCBI
mRatBN7.2	6	132,262,188 - 132,265,797 (+)	NCBI

RefSeq Acc Id:

XM_006240674 ⟹ XP_006240736

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	138,083,250 - 138,086,848 (+)	NCBI
mRatBN7.2	6	132,262,182 - 132,265,797 (+)	NCBI
Rnor_6.0	6	137,995,130 - 138,002,897 (+)	NCBI
Rnor_5.0	6	146,989,463 - 146,997,301 (+)	NCBI

Sequence:

show sequence

TAAGCGCGGGGTGCAAGCGGCGGGACAGCAGGAGACGGGTGGCTGAGCCGAGCGGGTCGGCGGA
GCTGGGCGGTTCCGAGCTCGCCGGCCGGGAGCGGCAGCGCTCTCCGGGCAAGTGGACAAGTCCC
GCGCCCTGCTGCGCTGCGCCATGCCGGAGGGCTGAGCATCGGGGCCCGCTGCTCTTTGGGACAC
TGCAGGACCTCGTCCCGCTTTGCGTTGGGACTGCGCGCGCCAGGGCCGAGCCCGGGCCGCTGAC
CATGGTGCTGCCTCCTCCAGACCGGCGCCACGTGTGCCTGACCACGCTGGTGATCATGGGCAGT
ATGGCCGTCATGGACGCATACCTGGTGGAGCAAAACCAGGGCCCGCGCAAGATTGGCGTGTGCA
TAATTGTGTTGGTAGGCGATGTGTGCTTCCTGCTGGTGCTGCGCTATGTGGCCGTATGGGTGGG
TGCCGAGGTTCGCACGGCCAAGCGTGGCTACGCTATGATCCTCTGGTTCCTCTATATCTTCGTG
CTGGAGATCAAGCTCTATTTCATCTTTCAGAACTACAAGGCAGCGCGGCGCGGGGCGGCCGACC
CAGTGGCTCGCAAGGCATTGACACTGCTGCTGTCTGTGTGCGTGCCAGGCCTGTTCCTCTTGCT
TGTGGCACTAGATCGCATGGAATATGTGCGCACCTTCCGAAAGCGGGAGGACCTGCGGGGCCGC
CTCTTCTGGGTGGCCTTAGATCTGCTGGATCTGCTGGACATGCAGGCCAACCTCTGGGAACCGC
CACGCACTGGGTTGCCACTGTGGGCCGAAGGTCTCACCTTTTTCTATTGCTATATGCTGCTGTT
GGTGCTGCCCTGCGTAGCGCTCAGTGAGGTCAGTATGCAAGGGGAGCACATCGCACCGCAGAAG
ATGATGTTGTACCCGGTGCTCAGTCTCGCCACTGTCAATGTGGTGGCTGTGCTGGCTCGTGCCG
CCAACATGGCGCTCTTCCGCGATAGCCGAGTCTCAGCCATCTTCGTAGGCAAGAACGTGGTGGC
ACTGGCCACCAAGGCCTGCACGTTCCTCGAGTACCGACGCCAGGTTCGCGATTTTCCTCCACCT
GCGCTTGCACTTGAGCTGCAGCCACCGCCTTCCCAGCGCAACTCGGTGCCGCCTCCTCCACCAC
TGCATGGCCCGCCAGTGCGTCCACACGGGCCCTCACCCACGCGTGATGCGCTGGACACGTGACA
GCCCCCCCCTCCGCGGGCCGCACAGACGCTGGACTAGCTGCGCGCGGTTTGCATGGGATGGGAT
GGGGCAGGCTCCCTTTAGGGACAGGTGTTGTGAATACCTGTGCAGTGCCTGGGGCCACGTCTGC
TTCTTCATCTCAGGAATCTCTCGGACCACGGACCCTTAGCTTCCACCCCCAGTAGCTCACCTCG
AAGCACAGGGCAGCTGGTGAGGCCTGGTCTTGAGTGGAGATGGCTCAACCCCTACCTGAGGCTG
GCCTGCCAGGGTGGGAAGCGGGGGTCAGTGTTCCAGGAGATCTGGACCTGTGGTAGGGGCCTCT
GGCTCAGAGTTTGTGGCCAAGGAGGCCTCTGTCATTTTAAAGACTTGTGTTTACAGTTTTGTAC
CGAAAGCCTGGCTATTCTTCCTGTCTCATGAGTACCTTGCCCAACAGCTGACTAGAGTAGCAAG
GACTGGTGAGTGCTGGTGGCCATGGAGCAAGCAGGTATTTTCTCCAGGTGGTCCATTGTGGCCC
TGGGTTGGAGACACCCTCTTTTCTCCCACCTCACTGTGACTATCCCCACAGAATCTGCTTCTAC
TGAGGTATTTTGACCTCTGCCTCCCATTCCACCTCTCCACAGCCTCCCAGGCCTCATGCCCCTG
CCCTTTCCCAGCTCAGGTTCAGAAGTGTCCCTACACTTCCATCTCCTTCCTGTGCAAGCTTGCT
CTGCCTGTGGTGGTGGTGGGGGACTGGGGCTCATGACTGTCAATATCCAGTGGGAACAGGTGCC
AGCTTTGTTCCCAAGTTGAAGCTGCCTGAGCCAGAAGAGCAATTTGGCCTTGTGTCACCCCAGC
CTGGCCCTGCCCCAGACACTGACCAGTCCCGCAGTGCCCTGACCCAGTGCAGAGGCCTTGAAGT
CTGTCGGCAGGTGGTCTCTCCCTGACCTCTACCCTGCATGGCGAATCCATGGCCAAATTCACCA
GGCCATGGAGTGTCTCTCGGTGGCATCTGGGGGGGAGGGGGAGGGCTTTATGAAGCTGTTTGAG
GAGCCTTATCCATGAGGGGCGATGGCTACATAGACTCCCGACCTGGCGTCTGCAGCGCTGTGCA
GACATACTGTGCAGACATACGGCCTGCCAGGCCTGCGCTCACTGCGTGGCCTGGTCCTTGCACC
ATCGCCCTGAAGCAAGGATCCACGCTGCTGAGATCCAGAGCCAGGGTTTTTACTGTCCAGTCAG
TCTATCACTAGCGGTTGAGGGGTGTAGATCCAGCTGTGCACAGTAGGGTAGCTCCATTCCTGTG
CCCACCTCTGGATGCACCAACTGCTCCCTTCTCTACCCAGAGAACTGCTTTACCACCGAGTCTG
GGCTTTGAGTCACCTGTTTTGCAAGCAGCTGTCCTTGGAGACCATTCTCTCCATGGGTACAGGG
ACCACCCATGGCTATACCCCTGACCTGGTAGAGTATGATGGTGCCCCCCCCCCATCCTGGACCA
TCACGTCCTCTGCAGTGCCTGATGAGCAACCTGGAAACCTTGGCTTTGAGTTCCACACTCCCGA
GACGCTGCAGCCCACCGACGGGCCTTAGAGAGTGGAGGCCTATGGTATGTAGGGCAGTGACCCT
TTACATATGGAGATGGTTCCACCAATTCCTCAGCTGGTAGGCGGACCCAGGCTCTGTGAGGTGT
TGGGTGGGGATCACAGCCCAAGGAATGAGCTCCAATTTGCAGTGTCTGGGCTGCTGCCTGTGCC
CTTCTCTTGCTTAAGCCAGGGCCATCCCACCTTGCTGGTCTCTTGTCTCTGTGGCCCCACTTGC
TAAAGGGTCAGATTTATCTAGCTGCATCTAGCCATCTCCTTCCTAACTTCTTGAGGTGGCCTGT
TTGGCCAGATATAGTGGAGAAGGGAACTAGGGGGTCCCTTGTCCTCATAGTTTATTCCTGCTCA
TAAATCCTGGTGCTAGGCTGCTGACCTTGACCTAAAATCCTTAAGAGGACTGGTTCCGATGAGC
ACCTGGGACCAACACTGGGCAGATCTGGTCCTTGGGACATGGAAGGAAATTGGATTTGGGCCCT
CCAACAGCAAGCATGTCAGGGCTGTGAGTGGTCCTGTGGAAAGATTACTGTACGAGGCTGGAGG
ATAGCTGTGGTCATGGGGACACCCAGTGAATACCTCAGGAGAAGGGTTGGGTAAGTCAGATGAC
TGCCAAAGGGCAGGGAGGTGGGCGGTGAACAGACCAGGGGTGGGATGGGGGCACTCCCTTTGAG
GCAGATCAGTATGGAGAATTCTTCCTGGGCTCCAGCCCTCAGGTGGGCTTTAGAGGAATGACGT
GTCAAGGCATGCTTGCCGTGAGGATCCTGAAATGGATTTCGTGTCTGTTTCAGACGAGGATTCT
GAGACTGTACACAGCATAAAGTGTAACACATCAAAGGCTAAGCTCCCAGAGTGCTTTAGATGTG
TGGGCCAAACAGCAACGGAGGCTCAAGAAAAGACGGGAGCTGTGGCTTGGCAGTGGAGGGGAAG
TGCTGGAAGTGCCTGTGTGGGCCGGGGGGAGAAAGGCTCCCTGAGACTTGGGCAAAAGAGTCAG
GATGCAAAGACAGCACAGGCAGCCAGTTCTTCGGACCCTTTGTAGGGAGTGGAGGAAGAGTAAT
GGACAATAAGGCCGGGGCCAGGGCTATCCCCAAGTGCTATGTCCTTCCAAGGAGTTGACCCACC
TCTGATGTCATCAGGAGCATAGCCGCCCCCTCCAGCTTCTCCTCCAGTGCAACACCACACGTTT
CCAGCTTACGTGACAAGGGCTTAATGAAGGATCGGAGAAGCTCCTATCTGGATACACTAACCAC
CTATGCCCATGTCCCCGAGTGGGACCTACTGTGTGCTCGACCTCTTCTGTCCTGGTAGAGAGTC
CCATTACTGTAGGGAGCTTGACCTTGCCAACATCTGAGATCTTAATCAGAGTCCAGACAGGTTC
AGCCTGGAGCCTAGCCTGGTGCTCAAGACCCACAAATCAAATCCTCTGCAAGTGCACCAAGCTC
TCTCAGCTTTCTCAACTGTTAGGTTTTGAGACGAGGGTCTCATATTGTCACACAGATTGGGTCC
AAACTCCTGGGCTCAAGTGCTGTTCCCGCCTCAGTCTCCAGAGTAGCTGACAATATAGGCGCCA
CCCTCCTGACTTCAGTTTGTCTGTTGGATTGTTTATTGAGATCGGGCCTCACGTACCCTAGGCT
GTCCTTGAATGCACTGAGTGGCTGAGGATGATGGCCTTGAACTACTGATCCTCTTGCCCCTACC
CTTCCAGAGCTGGGATTATAGACGTGGGCACTATGCTCACCACCCTTTTAAAAGAGCAGTGCTG
TACGAAACCCAGGCTCCATGCATGGCCTGCAAGCATTGTACCAACGGAACTACATCTTCAGCTC
CCCCTCCCCCCTTAAAGGTAGGCTGCCATTTTCTCCCTTTTGGCAAAGCCATGGAATAACCCTA
CTGTTGGCCCTTTTCTGGTGCAGGTGAGAAGGCTGCACTCATTAGGGCCCCTTTGCTCCATCTT
CCTCTAGCCCGGCTTTGGTCAGGGGTGATGGCAGCGAGGACTGCTGTCTGCTGTGGTGCGCCAA
GCCCCGGGCAGACCGCCAAGATCTCAGTGTTGATGCCGCACTATGTACAGTCGGAGGAGGTGGG
CTGTGGTGAGTTGCGTTGGGCGGCCCCTTGCTGACCCTCACTGTCTCGCTTAGGCTGGGCCTGT
GGGCAGGAGGAAACAATACCCTCAAGCTATTAGGTGCTACTTGCTGGGCTGGGGAAATGCTGCA
TCTTGGGCTCAAGAGTCAGTGTTTTCCCTGGCCTCTTGACACAGGGGCAGGCTCTCAAAGTCAA
ATCCCAGATATGGCCAAGAAAGGGAGCATCACAAGAAGAGGCTGTCCCAGCAGCTAGATGAGAT
CCTGGGTCCCAAGCGAGGGCTTCTGAGGAGGGAGGGACACTTAGAAATGCTGCTTTGGAGTGAC
GTTGGAACAGGGGCAGACTGCCTTTGCCAGTCCGGTCCCACCACAGGGGAACGTCTGGACCTGT
GTGACCTTTCACCTTCCACTCTAAAGCAAACTCACGTTTACTGTAGGAAAATGGCGTCTGAATG
ATGAGACCCGAATTCTTCAAAATCAAGCCCACTTAACAGGTGAAAGTTCCTGTGATCTGATTCC
TCTGAGCAAAGAAACTAGGAGAGGCACCGCCCTCAGAAAAGCCGTCGACGCTGTCATCTTTTAG
GTGGATCCTTTTAGGGGTTCCTTTGCTAATAGCCCAGGATGAAGAAACAAGGAGGGGTTAACTA
CCCTCATGGTAAGGCATGACAAACTGCACCCGTGAAACAAGACAGGAAATAATTGCAATGGGCT
CCTCAACCAGAGGTGGGCAAGGAGCTCTCACCCCCGTGGCTCAATGTGCGTGGGGCAGGTGTGG
CTATAGGTAGGTGGCAGTTCTTTGCTGGCAGGACTGTACCTGTACTTGATGTGCTGGGCCCATC
AAGAAGCACAGCTTTGGATGGGTGAAGAGGTTGGGGGTCACTGGGGACGAGACAGGATAGAGGG
CAGAAGGCAGAGGGTAACCATTGCTGTGATAAACACTGAGTAAAAGCAACTTGAGAACAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001385625	(Get FASTA)	NCBI Sequence Viewer
	XP_006240736	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006872
	ENSRNOP00000006872.1
	ENSRNOP00000077735.1
	ENSRNOP00000102234.1
	ENSRNOP00000105423.1
	ENSRNOP00000106861.1
	ENSRNOP00000109559
	ENSRNOP00000109559.1

RefSeq Acc Id:	XP_006240736 ⟸ XM_006240674
- Peptide Label:	isoform X1
- UniProtKB:	D3ZMR5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVLPPPDRRHVCLTTLVIMGSMAVMDAYLVEQNQGPRKIGVCIIVLVGDVCFLLVLRYVAVWVG AEVRTAKRGYAMILWFLYIFVLEIKLYFIFQNYKAARRGAADPVARKALTLLLSVCVPGLFLLL VALDRMEYVRTFRKREDLRGRLFWVALDLLDLLDMQANLWEPPRTGLPLWAEGLTFFYCYMLLL VLPCVALSEVSMQGEHIAPQKMMLYPVLSLATVNVVAVLARAANMALFRDSRVSAIFVGKNVVA LATKACTFLEYRRQVRDFPPPALALELQPPPSQRNSVPPPPPLHGPPVRPHGPSPTRDALDT hide sequence

Ensembl Acc Id:

ENSRNOP00000006872 ⟸ ENSRNOT00000006872

Ensembl Acc Id:

ENSRNOP00000077735 ⟸ ENSRNOT00000110911

RefSeq Acc Id:	NP_001385625 ⟸ NM_001398696
- UniProtKB:	D3ZMR5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000109559 ⟸ ENSRNOT00000122810

Ensembl Acc Id:

ENSRNOP00000105423 ⟸ ENSRNOT00000127998

Ensembl Acc Id:

ENSRNOP00000102234 ⟸ ENSRNOT00000169570

Ensembl Acc Id:

ENSRNOP00000106861 ⟸ ENSRNOT00000170546

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZMR5-F1-model_v2	AlphaFold	D3ZMR5	1-318	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694863

Promoter ID:

EPDNEW_R5387

Type:

single initiation site

Name:

Tmem121_1

Description:

transmembrane protein 121

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	137,997,265 - 137,997,325	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1597216	AgrOrtholog
BioCyc Gene	G2FUF-35759	BioCyc
Ensembl Genes	ENSRNOG00000005174	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000006872	ENTREZGENE
	ENSRNOT00000006872.4	UniProtKB/TrEMBL
	ENSRNOT00000110911.2	UniProtKB/TrEMBL
	ENSRNOT00000122810	ENTREZGENE
	ENSRNOT00000122810.1	UniProtKB/TrEMBL
	ENSRNOT00000127998.1	UniProtKB/TrEMBL
	ENSRNOT00000169570.1	UniProtKB/TrEMBL
	ENSRNOT00000170546.1	UniProtKB/TrEMBL
InterPro	CECR6/TMEM121	UniProtKB/TrEMBL
	TMEM121	UniProtKB/TrEMBL
NCBI Gene	691678	ENTREZGENE
PANTHER	PTHR31046	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEIN 121	UniProtKB/TrEMBL
Pfam	CECR6_TMEM121	UniProtKB/TrEMBL
PhenoGen	Tmem121	PhenoGen
RatGTEx	ENSRNOG00000005174	RatGTEx
UniProt	A0ABK0LUX0_RAT	UniProtKB/TrEMBL
	D3ZMR5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Tmem121	transmembrane protein 121	LOC691678	similar to hole protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC691678	similar to hole protein	RGD1311091_predicted	similar to chromosome 14 open reading frame 80 (predicted)	Data merged from RGD:1311091	1643240	APPROVED
2006-11-20	LOC691678	similar to hole protein			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-20	RGD1311091_predicted	similar to chromosome 14 open reading frame 80 (predicted)	LOC314484_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC314484_predicted	similar to chromosome 14 open reading frame 80 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar