Glb1 (galactosidase, beta 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Glb1 (galactosidase, beta 1) Rattus norvegicus
Analyze
Symbol: Glb1
Name: galactosidase, beta 1
RGD ID: 1597145
Description: Enables beta-galactosidase activity and galactoside binding activity. Involved in galactose catabolic process; response to Thyroglobulin triiodothyronine; and response to cortisone. Predicted to be located in Golgi apparatus; extracellular space; and lysosome. Predicted to be active in vacuole. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis IV (multiple). Orthologous to human GLB1 (galactosidase beta 1); PARTICIPATES IN Fabry disease pathway; galactose metabolic pathway; galactosemia pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-galactosidase; galactosidase, beta 1 (mapped); Glb1_mapped
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88122,963,718 - 123,036,326 (+)NCBIGRCr8
mRatBN7.28114,085,508 - 114,158,127 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8114,085,508 - 114,158,127 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8119,702,274 - 119,775,293 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08117,901,534 - 117,974,533 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08115,744,315 - 115,817,349 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08122,439,328 - 122,511,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,439,328 - 122,511,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08121,752,146 - 121,824,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48118,791,550 - 118,864,281 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8113,332,049 - 113,404,466 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
amitrole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
azoxystrobin  (EXP)
baicalein  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
desferrioxamine B  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ferric ammonium citrate  (EXP,ISO)
ferrostatin-1  (EXP)
fipronil  (EXP)
flavokawain B  (ISO)
fluorometholone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
galactose  (ISO)
genistein  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
imidacloprid  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lithium chloride  (ISO)
LY294002  (ISO)
melatonin  (ISO)
melphalan  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
microcystin-LR  (ISO)
misonidazole  (EXP)
mitomycin C  (ISO)
myo-inositol hexakisphosphate  (EXP,ISO)
myrtenal  (EXP)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
nickel atom  (ISO)
nicotinamide  (EXP)
nitric oxide  (ISO)
NMN zwitterion  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perifosine  (ISO)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
pifithrin-?  (EXP)
pinostrobin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
pravastatin  (ISO)
pyrimidifen  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
rotenone  (ISO)
S-allylcysteine  (EXP)
SB 203580  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-caffeic acid  (EXP)
tremolite asbestos  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
wogonin  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Genetically controlled variation of "acid" beta-galactosidase detected in Rattus norvegicus by isoelectric focusing. Douglas TC, etal., Genetics. 1982 Mar;100(3):455-73.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Effect of cortisone or L-triiodothyronine administration to pregnant rats on the activity of fetal intestinal disaccharidases and lysosomal acid beta-galactosidase. Jumawan J, etal., Biol Neonate. 1977;32(3-4):211-7.
4. Hormonal control of postnatal development of ileal neuraminidase and acid beta-galactosidase. Leeper LL and Henning SJ, Biol Neonate. 1983;44(1):28-35.
5. Acrosomal and lysosomal isoenzymes of beta-galactosidase and N-acetyl-beta-glucosaminidase in rat testis. Majumder GC and Turkington RW, Biochemistry. 1974 Jul 2;13(14):2857-64.
6. New GLB1 mutation in siblings with Morquio type B disease presenting with mental regression. Mayer FQ, etal., Mol Genet Metab. 2009 Mar;96(3):148. doi: 10.1016/j.ymgme.2008.11.159. Epub 2008 Dec 16.
7. beta-galactosidase gene mutations affecting the lysosomal enzyme and the elastin-binding protein in GM1-gangliosidosis patients with cardiac involvement. Morrone A, etal., Hum Mutat. 2000;15(4):354-66.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Mutation analyses in 17 patients with deficiency in acid beta-galactosidase: three novel point mutations and high correlation of mutation W273L with Morquio disease type B. Paschke E, etal., Hum Genet. 2001 Aug;109(2):159-66.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. Alterations in certain lysosomal glycohydrolases and cathepsins in rats on dexamethasone administration. Rajashree S and Puvanakrishnan R, Mol Cell Biochem. 1996 Jan 26;154(2):165-70.
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Identification of 14 novel GLB1 mutations, including five deletions, in 19 patients with GM1 gangliosidosis from South America. Santamaria R, etal., Clin Genet. 2007 Mar;71(3):273-9.
16. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
17. Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan. Weismann CM, etal., Hum Mol Genet. 2015 Aug 1;24(15):4353-64. doi: 10.1093/hmg/ddv168. Epub 2015 May 10.
Additional References at PubMed
PMID:1914521   PMID:4830244   PMID:7203014   PMID:11927518   PMID:19056867   PMID:19710420   PMID:20849834   PMID:22128166   PMID:23376485   PMID:23533145   PMID:24737316   PMID:25936995  
PMID:29514215   PMID:32423114  


Genomics

Comparative Map Data
Glb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88122,963,718 - 123,036,326 (+)NCBIGRCr8
mRatBN7.28114,085,508 - 114,158,127 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8114,085,508 - 114,158,127 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8119,702,274 - 119,775,293 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08117,901,534 - 117,974,533 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08115,744,315 - 115,817,349 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08122,439,328 - 122,511,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,439,328 - 122,511,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08121,752,146 - 121,824,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48118,791,550 - 118,864,281 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8113,332,049 - 113,404,466 (+)NCBICelera
Cytogenetic Map8q32NCBI
GLB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38332,961,108 - 33,097,146 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl332,996,609 - 33,097,202 (-)EnsemblGRCh38hg38GRCh38
GRCh37333,002,600 - 33,138,638 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36333,013,104 - 33,113,698 (-)NCBINCBI36Build 36hg18NCBI36
Build 34333,013,234 - 33,113,632NCBI
Celera332,980,743 - 33,081,754 (-)NCBICelera
Cytogenetic Map3p22.3NCBI
HuRef332,977,821 - 33,078,667 (-)NCBIHuRef
CHM1_1332,988,097 - 33,088,744 (-)NCBICHM1_1
T2T-CHM13v2.0332,962,888 - 33,098,917 (-)NCBIT2T-CHM13v2.0
Glb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399114,230,146 - 114,303,447 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9114,230,144 - 114,303,966 (+)EnsemblGRCm39 Ensembl
GRCm389114,401,078 - 114,474,379 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9114,401,076 - 114,474,898 (+)EnsemblGRCm38mm10GRCm38
MGSCv379114,310,237 - 114,383,495 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369114,249,817 - 114,323,075 (+)NCBIMGSCv36mm8
Celera9114,872,858 - 114,948,660 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map964.4NCBI
Glb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955421231,076 - 312,500 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955421230,957 - 311,504 (-)NCBIChiLan1.0ChiLan1.0
GLB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2232,943,061 - 33,083,071 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1332,947,825 - 33,088,024 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0332,892,039 - 33,031,959 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1333,231,208 - 33,336,804 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl333,231,209 - 33,336,804 (-)Ensemblpanpan1.1panPan2
GLB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1233,721,768 - 3,814,209 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl233,732,040 - 3,814,191 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha233,776,393 - 3,858,177 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0233,992,209 - 4,074,051 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl233,992,152 - 4,074,337 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,826,915 - 3,908,721 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0233,954,230 - 4,036,008 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0233,927,851 - 4,009,519 (+)NCBIUU_Cfam_GSD_1.0
Glb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118190,209,844 - 190,301,836 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647323,348,416 - 23,440,196 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647323,348,431 - 23,440,271 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1318,878,612 - 18,953,146 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11318,878,407 - 18,978,999 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GLB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11577,480,895 - 77,592,130 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1577,480,598 - 77,592,120 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604150,859,532 - 50,971,400 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478810,970,652 - 11,111,722 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478810,970,657 - 11,110,839 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Glb1
412 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:81
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000013632
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1599689Iddm24Insulin dependent diabetes mellitus QTL 244.720.001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)8112834440118649220Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
RH130801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28114,157,310 - 114,157,530 (+)MAPPERmRatBN7.2
Rnor_6.08122,511,123 - 122,511,342NCBIRnor6.0
Rnor_5.08121,823,977 - 121,824,196UniSTSRnor5.0
RGSC_v3.48118,863,465 - 118,863,684UniSTSRGSC3.4
Celera8113,403,642 - 113,403,861UniSTS
RH 3.4 Map81203.8UniSTS
Cytogenetic Map8q32UniSTS
RH134983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28114,095,665 - 114,095,863 (+)MAPPERmRatBN7.2
Rnor_6.08122,449,487 - 122,449,684NCBIRnor6.0
Rnor_5.08121,762,341 - 121,762,538UniSTSRnor5.0
RGSC_v3.48118,801,709 - 118,801,906UniSTSRGSC3.4
Celera8113,342,195 - 113,342,392UniSTS
RH 3.4 Map81202.0UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000013632   ⟹   ENSRNOP00000013632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8114,085,508 - 114,158,127 (+)Ensembl
Rnor_6.0 Ensembl8122,439,328 - 122,511,939 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095071   ⟹   ENSRNOP00000080740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8114,100,165 - 114,158,127 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112983   ⟹   ENSRNOP00000080639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8114,085,508 - 114,158,127 (+)Ensembl
RefSeq Acc Id: NM_001108192   ⟹   NP_001101662
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88122,963,718 - 123,036,326 (+)NCBI
mRatBN7.28114,085,508 - 114,158,127 (+)NCBI
Rnor_6.08122,439,328 - 122,511,939 (+)NCBI
Rnor_5.08121,752,146 - 121,824,793 (+)NCBI
RGSC_v3.48118,791,550 - 118,864,281 (+)RGD
Celera8113,332,049 - 113,404,466 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101662 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL76992 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013632.5
  ENSRNOP00000080639.1
  ENSRNOP00000080740.1
RefSeq Acc Id: NP_001101662   ⟸   NM_001108192
- Peptide Label: precursor
- UniProtKB: D3ZUM4 (UniProtKB/TrEMBL),   A6I3N5 (UniProtKB/TrEMBL),   A0A8I6G4Z3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013632   ⟸   ENSRNOT00000013632
Ensembl Acc Id: ENSRNOP00000080740   ⟸   ENSRNOT00000095071
Ensembl Acc Id: ENSRNOP00000080639   ⟸   ENSRNOT00000112983
Protein Domains
Beta-galactosidase 1-like first all-beta   Beta-galactosidase galactose-binding   Glycoside hydrolase 35 catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUM4-F1-model_v2 AlphaFold D3ZUM4 1-647 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696354
Promoter ID:EPDNEW_R6879
Type:initiation region
Name:Glb1_1
Description:galactosidase, beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08122,439,360 - 122,439,420EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597145 AgrOrtholog
BioCyc Gene G2FUF-28928 BioCyc
Ensembl Genes ENSRNOG00000010196 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013632.6 UniProtKB/TrEMBL
  ENSRNOT00000095071.1 UniProtKB/TrEMBL
  ENSRNOT00000112983.1 UniProtKB/TrEMBL
Gene3D-CATH Galactose-binding domain-like UniProtKB/TrEMBL
  Glycosidases UniProtKB/TrEMBL
InterPro B-gal_1-like UniProtKB/TrEMBL
  BetaGal1-like_ABD1 UniProtKB/TrEMBL
  BetaGal_gal-bd UniProtKB/TrEMBL
  Galactose-bd-like UniProtKB/TrEMBL
  Gly_Hdrlase_35_cat UniProtKB/TrEMBL
  Glyco_hydro_35_CS UniProtKB/TrEMBL
  Glyco_hydro_catalytic_core UniProtKB/TrEMBL
  Glycoside_Hdrlase_35 UniProtKB/TrEMBL
KEGG Report rno:316033 UniProtKB/TrEMBL
NCBI Gene 316033 ENTREZGENE
PANTHER BETA-GALACTOSIDASE UniProtKB/TrEMBL
  Glyco_hydro_35 UniProtKB/TrEMBL
Pfam BetaGal_ABD_1 UniProtKB/TrEMBL
  BetaGal_gal-bd UniProtKB/TrEMBL
  Glyco_hydro_35 UniProtKB/TrEMBL
PhenoGen Glb1 PhenoGen
PIRSF B-gal UniProtKB/TrEMBL
PRINTS GLHYDRLASE35 UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F35 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010196 RatGTEx
Superfamily-SCOP Gal_bind_like UniProtKB/TrEMBL
  Glyco_hydro_cat UniProtKB/TrEMBL
UniProt A0A8I5ZR79_RAT UniProtKB/TrEMBL
  A0A8I6G4Z3 ENTREZGENE, UniProtKB/TrEMBL
  A6I3N5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUM4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Glb1  galactosidase, beta 1   Glb1_predicted  galactosidase, beta 1 (predicted)  'predicted' is removed 2292626 APPROVED
2007-04-11 Glb1_predicted  galactosidase, beta 1 (predicted)  Glb1_mapped  galactosidase, beta 1 (mapped)  Data merged from RGD:2699 737654 APPROVED
2007-01-09 Glb1_predicted  galactosidase, beta 1 (predicted)  Glb1  galactosidase, beta 1  Gene type set to predicted; nomenclature changed appropriately 1299863 APPROVED
2007-01-09   galactosidase, beta 1  Glb1  galactosidase, beta 1 (mapped)  Name updated 1299863 APPROVED
2006-11-20 Glb1  galactosidase, beta 1 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Glb1_mapped  galactosidase, beta 1 (mapped)      Symbol and Name updated 1556543 APPROVED
2002-06-10 Glb1  Galactosidase, beta 1      Symbol and Name status set to approved 70586 APPROVED