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Gene: Esco1 (establishment of sister chromatid cohesion N-acetyltransferase 1) Rattus norvegicus

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Symbol:

Esco1

Name:

establishment of sister chromatid cohesion N-acetyltransferase 1

RGD ID:

1596873

Description:

Predicted to enable identical protein binding activity; protein-lysine-acetyltransferase activity; and zinc ion binding activity. Predicted to be involved in mitotic sister chromatid cohesion; protein acetylation; and regulation of DNA replication. Predicted to be located in chromosome. Predicted to be active in chromatin and nucleus. Orthologous to human ESCO1 (establishment of sister chromatid cohesion N-acetyltransferase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

establishment of cohesion 1 homolog 1; establishment of cohesion 1 homolog 1 (S. cerevisiae); LOC680014; N-acetyltransferase ESCO1; similar to N-acetyltransferase ESCO1 (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Related Pseudogenes:

Esco1-ps1

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	1,904,748 - 1,959,609 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	1,904,762 - 1,959,805 (-)	Ensembl				GRCr8
mRatBN7.2	18	1,630,560 - 1,686,803 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	1,631,954 - 1,686,942 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	1,861,141 - 1,899,061 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	2,648,833 - 2,686,753 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	1,863,033 - 1,900,953 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	18	2,278,285 - 2,316,257 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	18	1,871,845 - 1,909,801 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	18	1,871,399 - 1,909,356 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	18	1,908,337 - 1,946,259 (-)	NCBI		F344_StmMcwi
Rnor_6.0	18	1,789,796 - 1,857,271 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	1,789,900 - 1,828,606 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	1,823,872 - 1,890,134 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	1,935,297 - 1,991,046 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	1,514,223 - 1,552,131 (-)	NCBI		Celera
Cytogenetic Map	18	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

chloroprene (EXP)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clorgyline (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

DDE (ISO)

dicrotophos (ISO)

diuron (EXP)

dorsomorphin (ISO)

epoxiconazole (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

geldanamycin (ISO)

gentamycin (EXP)

GSK-J4 (ISO)

hydrogen cyanide (ISO)

hypochlorous acid (ISO)

L-methionine (ISO)

leflunomide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methidathion (ISO)

methylmercury chloride (ISO)

O-methyleugenol (EXP)

paracetamol (EXP)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

potassium cyanide (ISO)

potassium dichromate (ISO)

promethazine (EXP)

rac-lactic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP,ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitotic sister chromatid cohesion (IBA)

peptidyl-lysine acetylation (ISO)

post-translational protein acetylation (ISO)

regulation of DNA replication (IEA,ISO)

Cellular Component

chromatin (IBA,IEA,ISO)

chromosome (IEA,ISO)

nucleus (IBA,IEA)

Molecular Function

acetyltransferase activity (IEA,ISO)

acyltransferase activity (IEA)

identical protein binding (ISO)

metal ion binding (IEA)

N-acetyltransferase activity (IEA,ISO)

protein-lysine-acetyltransferase activity (IBA,IEA,ISO)

transferase activity (IEA)

zinc ion binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15958495	PMID:19907496	PMID:21111234	PMID:27112597	PMID:27803161

Genomics

Comparative Map Data

Esco1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	1,904,748 - 1,959,609 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	1,904,762 - 1,959,805 (-)	Ensembl				GRCr8
mRatBN7.2	18	1,630,560 - 1,686,803 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	1,631,954 - 1,686,942 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	1,861,141 - 1,899,061 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	2,648,833 - 2,686,753 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	1,863,033 - 1,900,953 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	18	2,278,285 - 2,316,257 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	18	1,871,845 - 1,909,801 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	18	1,871,399 - 1,909,356 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	18	1,908,337 - 1,946,259 (-)	NCBI		F344_StmMcwi
Rnor_6.0	18	1,789,796 - 1,857,271 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	1,789,900 - 1,828,606 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	1,823,872 - 1,890,134 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	1,935,297 - 1,991,046 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	1,514,223 - 1,552,131 (-)	NCBI		Celera
Cytogenetic Map	18	p13	NCBI

ESCO1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	21,529,284 - 21,600,704 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	21,529,041 - 21,600,966 (-)	Ensembl			hg38	GRCh38
GRCh37	18	19,109,245 - 19,180,665 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	17,363,260 - 17,434,691 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	18	17,363,259 - 17,434,627	NCBI
Celera	18	15,915,246 - 15,986,667 (-)	NCBI		Celera
Cytogenetic Map	18	q11.2	NCBI
HuRef	18	15,956,007 - 16,027,812 (-)	NCBI		HuRef
CHM1_1	18	19,036,317 - 19,107,811 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	21,714,377 - 21,786,047 (-)	NCBI		T2T-CHM13v2.0

Esco1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	10,566,507 - 10,610,863 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	10,566,507 - 10,610,352 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	10,566,507 - 10,610,863 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	10,566,507 - 10,610,352 (-)	Ensembl			mm10	GRCm38
MGSCv37	18	10,566,510 - 10,610,350 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	10,566,510 - 10,610,350 (-)	NCBI		MGSCv36	mm8
Celera	18	10,596,416 - 10,640,352 (-)	NCBI		Celera
Cytogenetic Map	18	A1	NCBI
cM Map	18	5.21	NCBI

Esco1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	10,207,527 - 10,262,995 (-)	Ensembl
ChiLan1.0	NW_004955402	10,207,621 - 10,257,363 (-)	NCBI	ChiLan1.0	ChiLan1.0

ESCO1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	38,946,690 - 39,018,645 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	24,639,042 - 24,711,297 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	14,767,377 - 14,839,978 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	18,406,773 - 18,477,786 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

ESCO1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	66,429,492 - 66,502,232 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	66,445,041 - 66,502,094 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	65,883,514 - 65,956,457 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	66,493,911 - 66,566,913 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	66,494,017 - 66,566,913 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	66,159,353 - 66,232,273 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	66,182,982 - 66,256,163 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	66,484,395 - 66,557,386 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Esco1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	62,498,850 - 62,572,707 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936550	1,245,931 - 1,292,263 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936550	1,244,891 - 1,317,271 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ESCO1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	106,697,988 - 106,752,135 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	106,697,975 - 106,789,445 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	99,204,547 - 99,260,031 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ESCO1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	58,887,158 - 58,957,605 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	58,900,663 - 58,956,545 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	33,668,553 - 33,741,519 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Esco1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624770	10,153,506 - 10,219,745 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Esco1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	15	33,506,899 - 33,558,662 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Esco1
342 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	303
Count of miRNA genes:	192
Interacting mature miRNAs:	233
Transcripts:	ENSRNOT00000033312
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331781	Scl28	Serum cholesterol level QTL 28	3.995		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	1	25071266	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	31610627	Rat
6903356	Bp354	Blood pressure QTL 354	4.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	15642423	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34566578	Rat
8552968	Pigfal19	Plasma insulin-like growth factor 1 level QTL 19	11.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	18	1	26032889	Rat
9590248	Scort10	Serum corticosterone level QTL 10	19.71	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	1	26032889	Rat
6903347	Bp350	Blood pressure QTL 350	4.4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	31610627	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	44930869	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	54490981	Rat
1641910	Colcr3	Colorectal carcinoma resistance QTL 3	5.02	0.000007	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	1	25022372	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34566578	Rat

Markers in Region

RH131290

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	27,441,206 - 27,441,390 (+)	MAPPER	mRatBN7.2
mRatBN7.2	18	1,632,137 - 1,632,321 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	1,790,084 - 1,790,267	NCBI	Rnor6.0
Rnor_6.0	13	31,849,291 - 31,849,474	NCBI	Rnor6.0
Rnor_5.0	18	1,824,057 - 1,824,240	UniSTS	Rnor5.0
Rnor_5.0	13	36,988,252 - 36,988,435	UniSTS	Rnor5.0
RGSC_v3.4	18	1,935,583 - 1,935,766	UniSTS	RGSC3.4
RGSC_v3.4	13	17,641,634 - 17,641,817	UniSTS	RGSC3.4
Celera	13	27,183,620 - 27,183,803	UniSTS
Celera	18	1,514,408 - 1,514,591	UniSTS
Cytogenetic Map	18	p13	UniSTS

RH124285

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	1,640,155 - 1,640,553 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	1,798,548 - 1,798,945	NCBI	Rnor6.0
Rnor_5.0	18	1,832,219 - 1,832,616	UniSTS	Rnor5.0
RGSC_v3.4	18	1,943,962 - 1,944,359	UniSTS	RGSC3.4
Celera	18	1,522,041 - 1,522,438	UniSTS
Cytogenetic Map	18	p13	UniSTS

UniSTS:237739

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	1,632,088 - 1,632,325 (+)	MAPPER	mRatBN7.2
mRatBN7.2	13	27,441,157 - 27,441,394 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	31,849,242 - 31,849,478	NCBI	Rnor6.0
Rnor_6.0	18	1,790,035 - 1,790,271	NCBI	Rnor6.0
Rnor_5.0	18	1,824,008 - 1,824,244	UniSTS	Rnor5.0
Rnor_5.0	13	36,988,203 - 36,988,439	UniSTS	Rnor5.0
RGSC_v3.4	18	1,935,534 - 1,935,770	UniSTS	RGSC3.4
RGSC_v3.4	13	17,641,585 - 17,641,821	UniSTS	RGSC3.4
Celera	13	27,183,571 - 27,183,807	UniSTS
Celera	18	1,514,359 - 1,514,595	UniSTS
Cytogenetic Map	18	p13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001126299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006254415	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277577	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277578	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277579	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277580	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001842030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166441	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000033312 ⟹ ENSRNOP00000032270

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	1,904,762 - 1,943,100 (-)	Ensembl
mRatBN7.2 Ensembl	18	1,631,971 - 1,670,973 (-)	Ensembl
Rnor_6.0 Ensembl	18	1,789,900 - 1,828,606 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096461 ⟹ ENSRNOP00000084239

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	1,904,762 - 1,943,102 (-)	Ensembl
mRatBN7.2 Ensembl	18	1,631,954 - 1,670,295 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100138 ⟹ ENSRNOP00000079439

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	1,904,762 - 1,959,805 (-)	Ensembl
mRatBN7.2 Ensembl	18	1,631,956 - 1,686,942 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118344 ⟹ ENSRNOP00000076410

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	1,904,762 - 1,943,100 (-)	Ensembl
mRatBN7.2 Ensembl	18	1,631,954 - 1,670,918 (-)	Ensembl

RefSeq Acc Id:

NM_001126299 ⟹ NP_001119771

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	1,904,761 - 1,943,100 (-)	NCBI
mRatBN7.2	18	1,631,953 - 1,670,293 (-)	NCBI
Dahl_SR_JrHsd	18	2,278,285 - 2,316,257 (-)	NCBI
Lyon_Normotensive	18	1,871,845 - 1,909,801 (-)	NCBI
Lyon_Hypertensive	18	1,871,399 - 1,909,356 (-)	NCBI
F344_StmMcwi	18	1,908,337 - 1,946,259 (-)	NCBI
Rnor_6.0	18	1,789,899 - 1,828,606 (-)	NCBI
Rnor_5.0	18	1,823,872 - 1,890,134 (-)	NCBI
RGSC_v3.4	18	1,935,297 - 1,991,046 (-)	RGD
Celera	18	1,514,223 - 1,552,131 (-)	NCBI

Sequence:

show sequence

GTTACAGATTCATCAACGTCCAGTAGCTGTAGACTTCAGAAGAAAAAACTTTTCAGAAATTTTG
TCAAAGCAGACAGGTCAGTGATAAATAACTACTCTAGTAATAGGGTTAGGCCGGAAACTAATCG
TAATTAAAACAAATTGGATCTGAATGAAGTTTTTTTTCATTAAAAAAATAAAAACTTCTGAAAA
TATTAAGTTAGAGTTTTCTTCAGATTTTCATTTCCCTATCCAGCAGAAAGCAAATATCTTTCAA
CATTCATGCTAGCTTTTCTCATGTCTTAGAAATTGCCAAGAGCAACCTTACTTGAAACAACCTG
GTATTTTTGTTGGAAATGTACATCAGTATAAGTTAAAGTCTATTTTTAAAAGATCTACTCCTTA
GTGATAATACTAAGTACTTAGCATCTGCATCTACCTGGACACAGTCCTCAACTCTTCAGAAAGA
AAGACATTACTCAGGAATAATGTCCATTCAGGAGAAATCAAAAGAAAATTCCTCCAAAGTTATT
AAAGAAAGTGAAGGTGAGAATTTAGAACAAGAAATCGAAGGTTCTCAAAACAGCCTAGCAAAGA
AATCAGGCTCCAAGGAAGCTGGAAAGTCAGCGGTTAGATTTTCCAACAAAAGTAAAGTAAATCA
GTCTGAAATTGGAACACGAATGAGTACAAGGTCAGCATCATGTTCAGCTGATAAAAATGCTACT
AACTCCATTAATAAAAATATGGTATCTGTGAAGGGACAATCACAAGAATCTTTAAAAAAGAAGA
AATTATGTCAGGAAAAATTATCATTTGGAACCTTCAAAGGGAGTGAGCAACTTAACCGCAGATC
ACAAAGACTACAACAGTTAACGGAGTCTTTAACTAGGTCTTTGCGCAGTAGAGAGATTCAGGGT
CAAATTCAAACAGTAAAACAGAATTTGCAACCAGCAAGAAGAGAACAGTGTAACAGTACTCAAA
GTAAATGTAATAAAGTAAATCAAAAGCATGTGAAAAGAAAAGTGCTTGAAATAAAGTCTGATTG
TAAGGAGGACAGACATTCAGTTACAAATGAAGTAATAAATTCTCCCAAAGGAAAGAAGCGCAAA
GTACAGCATCAGACAACTTCTACTTGTAGTTCTCAGTGCATCCAAGGATCTGAAAAATGTCTCC
AGAAGACTATTAGAAAAGAAGAAACAAAACCTGTGCCTGTAACTGCTGAGATTAGAAAACTAAA
AACAGCTACATCAGTGGTCTCTAAAAGGAATGAACTGAGGAAATCAGCTCATACACAAGTGAGT
GCTAGCACAAAGTTTCCCCAAATCCCACTGCCGTTAGTGCCTGAACACAGTGTTGACCATGAAT
TGGAGCAACCTGGAAAGAGCAAAAGAGGCAGCATTCTCCAACTTTGTGAAGAGATTGCTGGAGA
AATTGAATCAGACACTGTAGAGGTAAAAAAGGAATCCTGTGTGGAAAGTGTAAAGGAGGAGAAG
CCTGCAGAAGTAAAATTGGAAGAGACTGATGCTGAAAGACAAACACTCCATCAGAAAGAAACAA
ACCAGGACGTGCAGTGCAATCGTTTCTTTCCCAGTAGGAAAACAAAGCCTGTGAAATGTGTACT
AAATGGAATAAATAGTTCAACTAAGAAGAACTCCAACTGGACTAAAATTAAACTCTCAAAATTT
AACTCTGTGCATCAACATAAATTGGACTCTCAAGTGTCTCCTAAGTTGAGCTTATTACAAACTT
TTTTGTCACCACCAGTTTTAGAAATGCCTCATCCAGTGTCTCAAAGCACGTTTTTAGAGATGAA
ACCGCATGGTACTGTAACTTGCCAACAAGATAAAATGAAAGGAATTAAATCTGAAGATGTTAAA
ATTAATAATATTGCAATTGAAATTAATAAAGCCACAAAAAGGGCTCCTGGAAATTGTAATTTGG
ATAATCATATTAAACCCTCTTCTGACTCATCATTGGATAATCAGATGAAACATTCTTGTGAGTC
AGCACCAGATCAGAATTTCAGCATATGTTCAGCGTCAGAGGTGGAGACTAATCCACTAGAAAAC
ACTGCTGCTGTCTCAACTCTTCTCAGTCAAGCTAGGATTGATGGGGACAGAAAATTTCCAGGTT
CAGCTCCTAATCAGCAGCACAGTATACTCAGTAATGAAGCATCTATCAACAGAAAGAACAGAGA
TACACCGCCAAATCATTCTCAGCTGAAGTGTAATTCTAATCTAGAGATAACAATTCCAAAGTCC
TTAAAACTGAAAGACTCAGAGAAAGTGGATGAAAAACAGCTGGTTATAGATGCAGGACACAAAA
GATTTGGAGCAGTGTCCTGTAATATCTGTGGGATGCTTTATACAGCTTCAAATCCAGAAGATGA
AACCCAGCACCTGCTTTTCCACAACCAGTTTATAAGTGCTGTAAAGTATGTGGGCTGGAAAAAA
GAAAGAATTCTGGCTGAATATCCTGACGGTAGGATAATAATGGTTCTCCCTGAAGATCCAAAGT
ATGCCCTGAAAAAGGTTGATGAAATTAGAGAGATGGTTGACAATGATCTGGGTTTCCAACAGGC
TCCATTAATGTGCTATTCCAGAACTAAAACACTTCTCTTTATTTCTAATGACAAAAAAGTAGTT
GGTTGCCTAATTGCAGAACATATCCAGTGGGGCTATCGAGTTATAGAAGAGAAACTTCCAGTTA
TCAGATCAGAAGAAGAAAAAGTCCGATTTGAAAGGCAAAAAGCCTGGTGCTGCTCAACATTGCC
AGAGCCTGCAATATGTGGGATCAGTCGAATTTGGGTGTTCAGCATGATGCGACGGAAAAAGATA
GCTTCTCGCATGATTGAATGCCTAAGGAGTAACTTTATTTATGGCTCATATTTGAGTAAAGAAG
AAATTGCTTTCTCAGATCCCACTCCTGATGGAAAGCTGTTTGCAACACAGTACTGTGGCACTGG
TCAGTTTCTGGTCTATAATTTTATCAATGGACAGAATACCACCTAATACCGATCCTGCTTACTG
TGCCAGAAGACATCTTTGAAGAGAAAGAATTGGTTGCTGACTTTATCCAGGAACTAGGGCCATT
TTTTTACAAATGAACTCAGGACTGGCAACAACCATATGGTTGTTCCATTTTCATAAAATTGGAA
ACAATGCAGTAATAGCTTATTATTGTTTTGTTTTTTTAAAGAAGATATTTTATTATCTTTTACA
GAAATTTATGATTGTATTTTATCTATAGTTATTTAGACATGTTTACATGCAGCAGATAATTGTT
CATAGTGGACTGAAAATTAATGCAAGGACTATGGTCTCAGTGATAAGTATATTTTGAAGTTCTT
AATATGGAAATATACCAGTGTAGCTTGGTACTGTATTTTTTTATATTGATCTACCGATACCAGT
TATAGGTTTAAAGACTGTATTTTCAAAGTGAAAAACCAATGCTTTTGAGTTACTATTCAAAGAG
AGTACAGTATTACACATTTAAGAATTTGAAGTTACTAAAGTATACTCTAAGGAGACCCCACAGG
AAAGGAGAGCTCCAAGTAAAAGAACTTGTATAATAGCAAGTGTCTCCATTGCTTATGTTTGTGA
CACTGATGGTGGCAGGGGAAGCTCTCTGATGTGGAGCCATAAATGACTAGAGTCACAAAGAACT
ATAGCATAGTTGTAAACTAAATGTGGATGGCTTGTTGGTATCTGCATTGTTACTCCTCAGAAAT
ACTGCACTGAGTATACACCCTCATTACTGGACTTCATCTTGATACTTGTCTGTCCTTCATAGTG
CCCTCTACTTTTAAAGGGTTATGTATTGAAAAACTGCTGTGGCCTTTTATGACCTGTATATAAT
GTAGAATAAAATAATAAAATACTTGATAGCTTTTTCTAAGTGAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039097119 ⟹ XP_038953047

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	1,904,748 - 1,943,786 (-)	NCBI
mRatBN7.2	18	1,630,560 - 1,686,803 (-)	NCBI

RefSeq Acc Id:

XM_039097120 ⟹ XP_038953048

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	1,905,659 - 1,943,786 (-)	NCBI
mRatBN7.2	18	1,632,960 - 1,686,803 (-)	NCBI

RefSeq Acc Id:

XM_063277577 ⟹ XP_063133647

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	1,904,748 - 1,943,786 (-)	NCBI

RefSeq Acc Id:

XM_063277578 ⟹ XP_063133648

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	1,920,105 - 1,943,786 (-)	NCBI

RefSeq Acc Id:

XM_063277579 ⟹ XP_063133649

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	1,930,465 - 1,958,945 (-)	NCBI

RefSeq Acc Id:

XM_063277580 ⟹ XP_063133650

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	1,904,748 - 1,959,609 (-)	NCBI

RefSeq Acc Id:

XM_063277581 ⟹ XP_063133651

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	1,904,748 - 1,959,604 (-)	NCBI

RefSeq Acc Id:

XM_063277582 ⟹ XP_063133652

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	1,904,748 - 1,959,043 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001119771	(Get FASTA)	NCBI Sequence Viewer
	XP_038953047	(Get FASTA)	NCBI Sequence Viewer
	XP_038953048	(Get FASTA)	NCBI Sequence Viewer
	XP_063133647	(Get FASTA)	NCBI Sequence Viewer
	XP_063133648	(Get FASTA)	NCBI Sequence Viewer
	XP_063133649	(Get FASTA)	NCBI Sequence Viewer
	XP_063133650	(Get FASTA)	NCBI Sequence Viewer
	XP_063133651	(Get FASTA)	NCBI Sequence Viewer
	XP_063133652	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66441	(Get FASTA)	NCBI Sequence Viewer
	EDL86670	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000032270
	ENSRNOP00000032270.4
	ENSRNOP00000076410
	ENSRNOP00000076410.2
	ENSRNOP00000079439
	ENSRNOP00000079439.2
	ENSRNOP00000084239.1

RefSeq Acc Id:

NP_001119771 ⟸ NM_001126299

- UniProtKB:

B2GUX2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSIQEKSKENSSKVIKESEGENLEQEIEGSQNSLAKKSGSKEAGKSAVRFSNKSKVNQSEIGTR
MSTRSASCSADKNATNSINKNMVSVKGQSQESLKKKKLCQEKLSFGTFKGSEQLNRRSQRLQQL
TESLTRSLRSREIQGQIQTVKQNLQPARREQCNSTQSKCNKVNQKHVKRKVLEIKSDCKEDRHS
VTNEVINSPKGKKRKVQHQTTSTCSSQCIQGSEKCLQKTIRKEETKPVPVTAEIRKLKTATSVV
SKRNELRKSAHTQVSASTKFPQIPLPLVPEHSVDHELEQPGKSKRGSILQLCEEIAGEIESDTV
EVKKESCVESVKEEKPAEVKLEETDAERQTLHQKETNQDVQCNRFFPSRKTKPVKCVLNGINSS
TKKNSNWTKIKLSKFNSVHQHKLDSQVSPKLSLLQTFLSPPVLEMPHPVSQSTFLEMKPHGTVT
CQQDKMKGIKSEDVKINNIAIEINKATKRAPGNCNLDNHIKPSSDSSLDNQMKHSCESAPDQNF
SICSASEVETNPLENTAAVSTLLSQARIDGDRKFPGSAPNQQHSILSNEASINRKNRDTPPNHS
QLKCNSNLEITIPKSLKLKDSEKVDEKQLVIDAGHKRFGAVSCNICGMLYTASNPEDETQHLLF
HNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYS
RTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICG
ISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYN
FINGQNTT

hide sequence

Ensembl Acc Id:

ENSRNOP00000032270 ⟸ ENSRNOT00000033312

RefSeq Acc Id:	XP_038953047 ⟸ XM_039097119
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038953048 ⟸ XM_039097120
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000084239 ⟸ ENSRNOT00000096461

Ensembl Acc Id:

ENSRNOP00000076410 ⟸ ENSRNOT00000118344

Ensembl Acc Id:

ENSRNOP00000079439 ⟸ ENSRNOT00000100138

RefSeq Acc Id:	XP_063133650 ⟸ XM_063277580
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I5Y5R8 (UniProtKB/TrEMBL), A0A8I6GBM2 (UniProtKB/TrEMBL), A6KNE2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133651 ⟸ XM_063277581
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I5Y5R8 (UniProtKB/TrEMBL), A0A8I6GBM2 (UniProtKB/TrEMBL), A6KNE2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133652 ⟸ XM_063277582
- Peptide Label:	isoform X6
- UniProtKB:	A0A8I5Y5R8 (UniProtKB/TrEMBL), A0A8I6GBM2 (UniProtKB/TrEMBL), A6KNE2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133647 ⟸ XM_063277577
- Peptide Label:	isoform X1
- UniProtKB:	B2GUX2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133648 ⟸ XM_063277578
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063133649 ⟸ XM_063277579
- Peptide Label:	isoform X5

Protein Domains

N-acetyltransferase ESCO acetyl-transferase N-acetyltransferase ESCO zinc-finger

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2GUX2-F1-model_v2	AlphaFold	B2GUX2	1-840	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1596873	AgrOrtholog
BioCyc Gene	G2FUF-8414	BioCyc
Ensembl Genes	ENSRNOG00000014031	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000033312	ENTREZGENE
	ENSRNOT00000033312.7	UniProtKB/TrEMBL
	ENSRNOT00000096461.2	UniProtKB/TrEMBL
	ENSRNOT00000100138	ENTREZGENE
	ENSRNOT00000100138.2	UniProtKB/TrEMBL
	ENSRNOT00000118344	ENTREZGENE
	ENSRNOT00000118344.2	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7461161	IMAGE-MGC_LOAD
InterPro	AcTrfase_ESCO_Znf_dom	UniProtKB/TrEMBL
	ESCO_Acetyltransf_dom	UniProtKB/TrEMBL
KEGG Report	rno:680014	UniProtKB/TrEMBL
MGC_CLONE	MGC:187566	IMAGE-MGC_LOAD
NCBI Gene	680014	ENTREZGENE
PANTHER	N-ACETYLTRANSFERASE ECO	UniProtKB/TrEMBL
	PTHR45884:SF1	UniProtKB/TrEMBL
Pfam	Acetyltransf_13	UniProtKB/TrEMBL
	zf-C2H2_3	UniProtKB/TrEMBL
PhenoGen	Esco1	PhenoGen
RatGTEx	ENSRNOG00000014031	RatGTEx
UniProt	A0A8I5Y5R8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G3B1_RAT	UniProtKB/TrEMBL
	A0A8I6GBM2	ENTREZGENE, UniProtKB/TrEMBL
	A6KNE2	ENTREZGENE, UniProtKB/TrEMBL
	B2GUX2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-09-16	Esco1	establishment of sister chromatid cohesion N-acetyltransferase 1	Esco1	establishment of cohesion 1 homolog 1 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-07-08	Esco1	establishment of cohesion 1 homolog 1 (S. cerevisiae)	LOC682499	similar to N-acetyltransferase ESCO1 (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1)	Data merged from RGD:1583393	1643240	APPROVED
2008-03-05	Esco1	establishment of cohesion 1 homolog 1 (S. cerevisiae)	LOC680014	similar to N-acetyltransferase ESCO1 (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC680014	similar to N-acetyltransferase ESCO1 (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1)			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC682499	similar to N-acetyltransferase ESCO1 (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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