Krtcap3 (keratinocyte associated protein 3) - Rat Genome Database

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Pathways
Gene: Krtcap3 (keratinocyte associated protein 3) Rattus norvegicus
Analyze
Symbol: Krtcap3
Name: keratinocyte associated protein 3
RGD ID: 1596516
Description: Predicted to be located in membrane. Orthologous to human KRTCAP3 (keratinocyte associated protein 3); INTERACTS WITH acrylamide; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: KCP-3; keratinocyte-associated protein 3; LOC683980; similar to keratinocytes associated protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Krtcap3em3Mcwi
Genetic Models: WKY-Krtcap3em3Mcwi-/-
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,840,906 - 30,842,500 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl630,840,906 - 30,842,475 (-)EnsemblGRCr8
mRatBN7.2625,120,938 - 25,122,522 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,120,938 - 25,122,507 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx625,421,776 - 25,423,345 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,737,668 - 25,739,237 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,217,026 - 25,218,605 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,485,126 - 26,486,695 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,485,126 - 26,486,695 (-)Ensemblrn6Rnor6.0
Rnor_5.0636,304,329 - 36,305,898 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera624,613,034 - 24,614,603 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
Krtcap3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,840,906 - 30,842,500 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl630,840,906 - 30,842,475 (-)EnsemblGRCr8
mRatBN7.2625,120,938 - 25,122,522 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,120,938 - 25,122,507 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx625,421,776 - 25,423,345 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,737,668 - 25,739,237 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,217,026 - 25,218,605 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,485,126 - 26,486,695 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,485,126 - 26,486,695 (-)Ensemblrn6Rnor6.0
Rnor_5.0636,304,329 - 36,305,898 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera624,613,034 - 24,614,603 (-)NCBICelera
Cytogenetic Map6q14NCBI
KRTCAP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,442,381 - 27,446,481 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,442,337 - 27,446,481 (+)Ensemblhg38GRCh38
GRCh37227,665,248 - 27,669,348 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,518,767 - 27,520,668 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34227,576,913 - 27,578,814NCBI
Celera227,511,407 - 27,515,522 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,407,121 - 27,411,236 (+)NCBIHuRef
CHM1_1227,595,145 - 27,599,260 (+)NCBICHM1_1
T2T-CHM13v2.0227,484,734 - 27,488,837 (+)NCBIT2T-CHM13v2.0
Krtcap3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,409,050 - 31,410,541 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,409,035 - 31,410,546 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38531,251,670 - 31,253,202 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,251,691 - 31,253,202 (+)Ensemblmm10GRCm38
MGSCv37531,554,079 - 31,555,570 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36531,528,297 - 31,529,778 (+)NCBIMGSCv36mm8
Celera528,730,858 - 28,732,349 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.27NCBI
Krtcap3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,416,732 - 9,418,523 (+)Ensembl
ChiLan1.0NW_0049554699,416,732 - 9,418,523 (+)NCBIChiLan1.0ChiLan1.0
KRTCAP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,066,444 - 99,068,404 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,070,412 - 99,072,372 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,446,103 - 27,448,063 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,534,580 - 27,536,458 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,534,571 - 27,536,458 (+)EnsemblpanPan2panpan1.1
KRTCAP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,387,682 - 21,389,385 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,387,781 - 21,389,383 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1721,279,465 - 21,281,151 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01721,709,066 - 21,710,751 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,709,148 - 21,710,749 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,395,667 - 21,397,353 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,405,146 - 21,406,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,453,403 - 21,455,088 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Krtcap3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,692,737 - 65,694,328 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,142,970 - 5,146,778 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,145,237 - 5,146,904 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRTCAP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,718,584 - 111,720,207 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13111,718,581 - 111,720,245 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23118,753,140 - 118,754,315 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRTCAP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,171,335 - 80,173,295 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,167,492 - 80,174,059 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604531,980,831 - 31,991,039 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krtcap3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,508,599 - 9,509,970 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247389,508,571 - 9,510,376 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Krtcap3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1722,827,264 - 22,828,830 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Krtcap3
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:43
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000073236
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat

Markers in Region
RH92034  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8630,840,509 - 30,840,772 (+)Marker Load Pipeline
mRatBN7.2625,120,541 - 25,120,804 (+)MAPPERmRatBN7.2
Rnor_6.0626,484,730 - 26,484,992NCBIRnor6.0
Rnor_5.0636,303,933 - 36,304,195UniSTSRnor5.0
Celera624,612,638 - 24,612,900UniSTS
RH131827  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8630,840,938 - 30,841,223 (+)Marker Load Pipeline
mRatBN7.2625,120,970 - 25,121,255 (+)MAPPERmRatBN7.2
Rnor_6.0626,485,159 - 26,485,443NCBIRnor6.0
Rnor_5.0636,304,362 - 36,304,646UniSTSRnor5.0
Celera624,613,067 - 24,613,351UniSTS


Genetic Models
This gene Krtcap3 is modified in the following models/strains:


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 59 145 91 90 59 77 59 6 329 165 7 124 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000073236   ⟹   ENSRNOP00000063910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl630,840,906 - 30,842,475 (-)Ensembl
mRatBN7.2 Ensembl625,120,938 - 25,122,507 (-)Ensembl
Rnor_6.0 Ensembl626,485,126 - 26,486,695 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101414   ⟹   ENSRNOP00000084894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl630,841,111 - 30,842,475 (-)Ensembl
mRatBN7.2 Ensembl625,121,143 - 25,122,507 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117566   ⟹   ENSRNOP00000082458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl630,840,906 - 30,842,475 (-)Ensembl
mRatBN7.2 Ensembl625,120,938 - 25,122,507 (-)Ensembl
RefSeq Acc Id: NM_001109674   ⟹   NP_001103144
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8630,840,906 - 30,842,475 (-)NCBI
mRatBN7.2625,120,938 - 25,122,507 (-)NCBI
Rnor_6.0626,485,126 - 26,486,695 (-)NCBI
Rnor_5.0636,304,329 - 36,305,898 (-)NCBI
Celera624,613,034 - 24,614,603 (-)RGD
Sequence:
RefSeq Acc Id: XM_039112927   ⟹   XP_038968855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8630,840,907 - 30,842,500 (-)NCBI
mRatBN7.2625,120,940 - 25,122,522 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001103144 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968855 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI00634 (Get FASTA)   NCBI Sequence Viewer  
  EDM02918 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063910
  ENSRNOP00000063910.1
  ENSRNOP00000082458
GenBank Protein Q497B3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001103144   ⟸   NM_001109674
- UniProtKB: Q497B3 (UniProtKB/Swiss-Prot),   A6HA63 (UniProtKB/TrEMBL),   A0A8I5ZZ03 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063910   ⟸   ENSRNOT00000073236
RefSeq Acc Id: XP_038968855   ⟸   XM_039112927
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZX93 (UniProtKB/TrEMBL),   A0A8I5ZZ03 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082458   ⟸   ENSRNOT00000117566
Ensembl Acc Id: ENSRNOP00000084894   ⟸   ENSRNOT00000101414

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q497B3-F1-model_v2 AlphaFold Q497B3 1-240 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694437
Promoter ID:EPDNEW_R4962
Type:multiple initiation site
Name:Krtcap3_1
Description:keratinocyte associated protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,486,702 - 26,486,762EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596516 AgrOrtholog
BioCyc Gene G2FUF-38354 BioCyc
Ensembl Genes ENSRNOG00000047941 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073236 ENTREZGENE
  ENSRNOT00000073236.2 UniProtKB/Swiss-Prot
  ENSRNOT00000117566 ENTREZGENE
IMAGE_CLONE IMAGE:5622000 IMAGE-MGC_LOAD
InterPro Beta-casein-like UniProtKB/Swiss-Prot
KEGG Report rno:683980 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124654 IMAGE-MGC_LOAD
NCBI Gene 683980 ENTREZGENE
PANTHER KERATINOCYTE-ASSOCIATED PROTEIN 3 UniProtKB/Swiss-Prot
  PTHR31258 UniProtKB/Swiss-Prot
Pfam BCLP UniProtKB/Swiss-Prot
PhenoGen Krtcap3 PhenoGen
RatGTEx ENSRNOG00000047941 RatGTEx
UniProt A0A8I5ZX93 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZ03 ENTREZGENE, UniProtKB/TrEMBL
  A6HA63 ENTREZGENE, UniProtKB/TrEMBL
  KCP3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-12-09 Krtcap3  keratinocyte associated protein 3  LOC683980  similar to keratinocytes associated protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC683980  similar to keratinocytes associated protein 3      Symbol and Name status set to provisional 70820 PROVISIONAL