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Gene: Iqsec1 (IQ motif and Sec7 domain ArfGEF 1) Rattus norvegicus

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Symbol:

Iqsec1

Name:

IQ motif and Sec7 domain ArfGEF 1

RGD ID:

1596313

Description:

Predicted to enable guanyl-nucleotide exchange factor activity and protein kinase binding activity. Involved in positive regulation of synapse assembly; regulation of ARF protein signal transduction; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in nucleus; postsynaptic density; and synaptic vesicle. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities and lung adenocarcinoma. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1); INTERACTS WITH atrazine; bisphenol A; flutamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1; LOC108350819; LOC686590; similar to IQ motif and Sec7 domain 1; uncharacterized LOC108350819; uncharacterized protein LOC108350819

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)	HGNC	Ensembl, HomoloGene, NCBI, Panther
Mus musculus (house mouse):	Iqsec1 (IQ motif and Sec7 domain 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Iqsec1 (IQ motif and Sec7 domain ArfGEF 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Iqsec1 (IQ motif and Sec7 domain ArfGEF 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Iqsec1 (IQ motif and Sec7 domain ArfGEF 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GALNT2 (polypeptide N-acetylgalactosaminyltransferase 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Iqsec1 (IQ motif and Sec7 domain 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Iqsec1 (IQ motif and Sec7 domain 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	iqsec1a (IQ motif and Sec7 domain 1a)	Alliance	DIOPT (PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	iqsec1b (IQ motif and Sec7 domain 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	bris-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	siz	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	siz	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SYT1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	iqsec1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	iqsec1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	124,725,917 - 125,045,351 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	124,725,917 - 125,045,550 (-)	Ensembl				GRCr8
mRatBN7.2	4	123,168,719 - 123,488,300 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	123,168,719 - 123,488,172 (-)	Ensembl				mRatBN7.2
Rnor_6.0	4	123,400,717 - 123,454,656 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	123,307,624 - 123,453,478 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	187,091,489 - 187,212,029 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	4	112,091,878 - 112,411,666 (-)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Developmental Disease (ISO)

intellectual developmental disorder with short stature and behavioral abnormalities (ISO)

Liver Metastasis (ISO)

lung adenocarcinoma (ISO)

lung metastasis (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

chrysene (ISO)

clobetasol (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

flutamide (EXP)

FR900359 (ISO)

fulvestrant (ISO)

hydrogen sulfide (ISO)

Indeno[1,2,3-cd]pyrene (ISO)

ivermectin (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

nickel dichloride (ISO)

ozone (ISO)

paracetamol (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dendritic spine development (ISO)

positive regulation of focal adhesion disassembly (ISO)

positive regulation of keratinocyte migration (ISO)

positive regulation of synapse assembly (IMP)

postsynaptic modulation of chemical synaptic transmission (ISO)

regulation of ARF protein signal transduction (IEA,IGI)

regulation of postsynaptic neurotransmitter receptor internalization (IBA,IMP,ISO)

regulation of small GTPase mediated signal transduction (IEA)

vesicle-mediated transport (IBA)

Cellular Component

cytoplasm (IEA)

cytoplasmic vesicle (IEA)

cytosol (ISO)

glutamatergic synapse (ISO)

nucleoplasm (ISO)

nucleus (IEA)

postsynaptic density (IEA)

postsynaptic density membrane (IBA)

postsynaptic density, intracellular component (ISO)

Schaffer collateral - CA1 synapse (ISO)

synaptic vesicle (IEA)

Molecular Function

guanyl-nucleotide exchange factor activity (IBA,IEA)

lipid binding (IEA)

protein binding (ISO)

protein kinase binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays.	Dmitriev AA, etal., Epigenetics. 2012 May;7(5):502-13. doi: 10.4161/epi.19801. Epub 2012 May 1.
2.	Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation.	Elagabani MN, etal., J Biol Chem. 2016 Apr 22;291(17):9105-18. doi: 10.1074/jbc.M115.691717. Epub 2016 Feb 16.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma.	Menju T, etal., PLoS One. 2011;6(9):e25301. doi: 10.1371/journal.pone.0025301. Epub 2011 Sep 22.
5.	GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.	Morishige M, etal., Nat Cell Biol. 2008 Jan;10(1):85-92. doi: 10.1038/ncb1672. Epub 2007 Dec 16.
6.	Epidermal growth factor receptor-GEP100-Arf6 axis affects the prognosis of lung adenocarcinoma.	Oka S, etal., Oncology. 2014;86(5-6):263-70. doi: 10.1159/000360089. Epub 2014 Jun 4.
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Down-regulation of GEP100 causes increase in E-cadherin levels and inhibits pancreatic cancer cell invasion.	Xie CG, etal., PLoS One. 2012;7(5):e37854. doi: 10.1371/journal.pone.0037854. Epub 2012 May 25.

Additional References at PubMed

PMID:19946888	PMID:20547133	PMID:22886754	PMID:25490267

Genomics

Comparative Map Data

Iqsec1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	124,725,917 - 125,045,351 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	124,725,917 - 125,045,550 (-)	Ensembl				GRCr8
mRatBN7.2	4	123,168,719 - 123,488,300 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	123,168,719 - 123,488,172 (-)	Ensembl				mRatBN7.2
Rnor_6.0	4	123,400,717 - 123,454,656 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	123,307,624 - 123,453,478 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	187,091,489 - 187,212,029 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	4	112,091,878 - 112,411,666 (-)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

IQSEC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	12,897,043 - 13,283,257 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	12,897,043 - 13,283,281 (-)	Ensembl			hg38	GRCh38
GRCh37	3	12,938,542 - 13,324,757 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	12,914,374 - 12,983,960 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	12,914,373 - 12,983,960	NCBI
Celera	3	12,877,006 - 13,052,894 (-)	NCBI		Celera
Cytogenetic Map	3	p25.2-p25.1	NCBI
HuRef	3	12,872,445 - 13,048,384 (-)	NCBI		HuRef
CHM1_1	3	12,888,737 - 13,064,773 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	12,898,545 - 13,283,599 (-)	NCBI		T2T-CHM13v2.0

Iqsec1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	90,636,578 - 90,965,766 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	90,633,070 - 90,965,667 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	90,659,596 - 90,988,480 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	90,656,088 - 90,988,685 (-)	Ensembl			mm10	GRCm38
MGSCv37	6	90,609,592 - 90,760,117 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	90,625,102 - 90,627,792 (-)	NCBI		MGSCv36	mm8
Celera	6	92,543,472 - 92,701,358 (-)	NCBI		Celera
Cytogenetic Map	6	D1	NCBI
cM Map	6	40.16	NCBI

Iqsec1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	13,246,294 - 13,376,568 (+)	Ensembl
ChiLan1.0	NW_004955429	13,246,585 - 13,373,189 (+)	NCBI	ChiLan1.0	ChiLan1.0

IQSEC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	12,879,847 - 13,262,286 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	12,884,608 - 13,267,048 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	12,820,552 - 13,202,925 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	13,165,134 - 13,235,377 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	13,167,299 - 13,235,285 (-)	Ensembl			panPan2	panpan1.1

IQSEC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	3,241,058 - 3,403,394 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	3,241,052 - 3,522,859 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	3,275,721 - 3,653,100 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	3,257,657 - 3,635,203 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	3,258,323 - 3,424,924 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	2,976,955 - 3,354,374 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	3,299,223 - 3,676,904 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	3,264,034 - 3,641,876 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Iqsec1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	19,241,464 - 19,372,429 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936898	337,400 - 425,859 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936898	318,564 - 425,785 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IQSEC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	71,031,001 - 71,366,684 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	71,203,967 - 71,366,685 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	78,945,020 - 78,992,150 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IQSEC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	48,873,240 - 49,050,666 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	48,872,925 - 49,050,625 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	117,225,297 - 117,615,790 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Iqsec1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	55,939,370 - 56,256,777 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Iqsec1
1645 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	232
Count of miRNA genes:	114
Interacting mature miRNAs:	129
Transcripts:	ENSRNOT00000071259, ENSRNOT00000073503, ENSRNOT00000074004
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582232	Gluco25	Glucose level QTL 25	3.6	0.0023	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	86583980	149763391	Rat
631689	Scl4	Serum cholesterol level QTL 4	1.9	0.008	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	96731383	141731383	Rat
1578655	Bmd11	Bone mineral density QTL 11	11		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	4	92406430	137406430	Rat
1300116	Hrtrt5	Heart rate QTL 5	3.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	117737142	152833657	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	123870974	168870974	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	106848959	168870974	Rat
731165	Uae21	Urinary albumin excretion QTL 21	2.4	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	108206096	153206096	Rat
1549832	Bss3	Bone structure and strength QTL 3	11		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	4	111383604	156383604	Rat
70177	Xhs1	X-ray hypersensitivity QTL 1	25.1		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	82944895	154403548	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
61476	Aia3	Adjuvant induced arthritis QTL 3	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	75939858	140508796	Rat
1641919	Alc22	Alcohol consumption QTL 22		0.0005	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	65060960	127749483	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	45429897	149763204	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
1578670	Bss14	Bone structure and strength QTL 14	16.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	4	88883695	133883695	Rat
70201	Gcr1	Gastric cancer resistance QTL 1	2.7		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	4	103834277	148834277	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	57613339	151163960	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
1578662	Bss15	Bone structure and strength QTL 15	19.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	4	88883695	133883695	Rat
2302049	Pia32	Pristane induced arthritis QTL 32	5.1	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)	4	107346299	152346299	Rat
6478763	Anxrr46	Anxiety related response QTL 46		0.07428	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
6478760	Anxrr45	Anxiety related response QTL 45		0.06717	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	112427331	157427331	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	117559384	162559384	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
7207480	Bss105	Bone structure and strength QTL 105	8.1		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	4	111383604	156383604	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	94638356	168870820	Rat
631646	Stl4	Serum triglyceride level QTL 4	6.5	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	4	74169813	134199155	Rat
634334	Xhs3	X-ray hypersensitivity QTL 3	10		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	86058928	131411333	Rat
61406	Scwia1	Streptococcal cell wall induced arthritis QTL 1	2.3		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	4	75939858	140508796	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	45429897	149763204	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	124700988	169700988	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
631662	Hcar2	Hepatocarcinoma resistance QTL 2	3.1	0.0003	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	84349032	129349032	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63245026	129846354	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	86709649	168870974	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	57664252	127749483	Rat
2306899	Bp338	Blood pressure QTL 338		0.071	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	82336765	127336765	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
2293840	Kiddil9	Kidney dilation QTL 9	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	4	113634167	149763391	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	116184844	161184844	Rat
12798523	Anxrr56	Anxiety related response QTL 56	2.83	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	86583980	131583980	Rat
12798527	Anxrr58	Anxiety related response QTL 58	4.11	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	121020385	148834277	Rat

Markers in Region

RH134634

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	123,168,858 - 123,169,068 (-)	MAPPER	mRatBN7.2
Rnor_6.0	4	123,454,307 - 123,454,516	NCBI	Rnor6.0
Rnor_5.0	4	187,091,627 - 187,091,836	UniSTS	Rnor5.0
Celera	4	112,092,018 - 112,092,227	UniSTS

RH141156

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	123,169,578 - 123,169,761 (-)	MAPPER	mRatBN7.2
Rnor_6.0	4	123,453,614 - 123,453,796	NCBI	Rnor6.0
Rnor_5.0	4	187,092,347 - 187,092,529	UniSTS	Rnor5.0
Celera	4	112,092,738 - 112,092,920	UniSTS
RH 3.4 Map	4	734.31	UniSTS

UniSTS:235495

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	123,171,312 - 123,171,523 (-)	MAPPER	mRatBN7.2
Rnor_6.0	4	123,451,852 - 123,452,062	NCBI	Rnor6.0
Rnor_5.0	4	187,094,081 - 187,094,291	UniSTS	Rnor5.0
Celera	4	112,094,472 - 112,094,682	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001408959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001408960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108749	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108750	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108753	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108759	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108760	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286693	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063286696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000085466 ⟹ ENSRNOP00000069092

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	124,728,250 - 124,872,797 (-)	Ensembl
mRatBN7.2 Ensembl	4	123,176,855 - 123,337,047 (-)	Ensembl
Rnor_6.0 Ensembl	4	123,307,624 - 123,453,478 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098236 ⟹ ENSRNOP00000081495

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	124,725,917 - 124,827,602 (-)	Ensembl
mRatBN7.2 Ensembl	4	123,172,706 - 123,270,715 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000104320 ⟹ ENSRNOP00000095381

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	124,726,200 - 124,894,275 (-)	Ensembl
mRatBN7.2 Ensembl	4	123,168,719 - 123,488,172 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105189 ⟹ ENSRNOP00000077923

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	124,725,917 - 124,845,445 (-)	Ensembl
mRatBN7.2 Ensembl	4	123,175,947 - 123,221,274 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113793 ⟹ ENSRNOP00000081156

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	124,725,917 - 124,872,797 (-)	Ensembl
mRatBN7.2 Ensembl	4	123,168,719 - 123,315,644 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114697 ⟹ ENSRNOP00000085130

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	124,725,917 - 124,779,352 (-)	Ensembl
mRatBN7.2 Ensembl	4	123,168,721 - 123,222,208 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000150411 ⟹ ENSRNOP00000107769

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	124,725,917 - 124,894,275 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000152016 ⟹ ENSRNOP00000111646

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	124,725,917 - 125,045,550 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000170289 ⟹ ENSRNOP00000101372

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	124,725,917 - 124,894,383 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000170859 ⟹ ENSRNOP00000105733

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	124,725,917 - 124,872,634 (-)	Ensembl

RefSeq Acc Id:

NM_001408959 ⟹ NP_001395888

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,917 - 124,827,602 (-)	NCBI
mRatBN7.2	4	123,168,719 - 123,270,405 (-)	NCBI

RefSeq Acc Id:

NM_001408960 ⟹ NP_001395889

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,917 - 124,872,797 (-)	NCBI
mRatBN7.2	4	123,168,719 - 123,315,600 (-)	NCBI

RefSeq Acc Id:

XM_006236890 ⟹ XP_006236952

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 124,779,413 (-)	NCBI
mRatBN7.2	4	123,169,955 - 123,222,214 (-)	NCBI
Rnor_6.0	4	123,400,717 - 123,453,376 (+)	NCBI
Rnor_5.0	4	187,091,489 - 187,212,029 (-)	NCBI

Sequence:

show sequence

TCCTGGCCATAAAGGGTGTGTGAATATATGTTTTGAGAGAAACAAATCTTTTTCCACCAGATTT
GGGATAGGTGCACCACAGTCCTGGAACTTGTTGCTCCGCTGTTTGAGTCGCAAAGTTGTGTACA
CTGAAGCCAGTCGGGATTGGCGTACAACTGAGGTTTTGCAGCGAGTTCTACTTGTTGCGCTTAC
AAGTGGGGAAGATACCCAGTACAGCACCCAGTACAGCAAGCCTGGGATTCTGGGATTCTGCTGT
TATGGGAACAAGAGCAGAATCTGCGCTCCTCCCGGAACTCATGGTTCTGGCCCCGCCCCCACAA
GAGCCCCACCTCCGCCCCTTCGGCCCCGCCTCCTCCCGACCACATTCCTCCGGCCGGACTTGAG
CTACGCCAAGCGGGCGGCGGCGAAAGGGTCGCGCCAGGCGGGTGATTGGACTTGCGGGCCTAGG
GCTGCGTGGACTTGCGGGCGCAAGGCCAGGAAGATCCGTGAAGGCTCGTGGCGGGTAGACGGGT
TTTCCGGGATCGGCCCCAAGGTCCGGCGGCTGCTCGGGGGAGTCGCGGGCGCGCGGCTCGGCCT
GGGTCCCGGGGCGCCGGCCCGGGCCGCTCTTGCGGCGGTCGACATGTGGTGCCTGCACTGCAAC
TCAGAGAGGACCCAGTCCTTGCTGGAGTTGGAGCTTGACAGCGGTGTTGAGGGCGAGGCTCCCA
GCAGCGAGACTGGCACATCGCTGGACAGCCCGTCAGCCTACCATCAGGGTCCCCTGGTACCTGG
TTCCAGCCTGAGTCCAGACCACTACGAGCACACGTCAGTGGGCGCCTATGGGCTGTACGCAGGG
CCAGGACCACAACAGCGCACACGGAGGCCTCGGCTGCAGCACTCGACCTCAGTCCTGCGCAAGC
AGGCTGAGGAGGAGGCCATCAAGCGCTCTCGGTCACTCTCTGAGAGCTATGAGCTCTCTTCAGA
TCTGCAAGACAAGCAGGTGGAAATGCTAGAACGCAAGTATGGGGGACGCCTCGTGACCCGCCAT
GCAGCCCGCACCATCCAGACGGCGTTCCGCCAGTACCAGATGAACAAGAACTTTGAGCGCCTGC
GTAGCTCCATGTCGGAGAACCGCATGTCACGCCGCATTGTGCTGTCCAACATGAGGATGCAGTT
CTCCTTCGAGGGCCCCGAGAAGGTGCACAGCTCCTACTTCGAGGGAAAACAGGTTTCTGTGACC
AATGATGGCTCCCAGCTGGGGGCCCTGGTGCCATCAGAATGTGGAGACCTTAGTGACCCAGCCC
TCAAGTCTCCAGCCCCCTCCAGTGACTTTGCAGATGCCATCACGGAACTGGAGGATGCCTTCTC
CAGGCAGGTGAAATCCCTGGCTGAATCCATTGATGATGCCCTTAATTGCCGCAGCCTACACAGT
GAGGAGGTGCCAGCCTCAGACACGGCCCGGGCTCGGGACACTGAGCCCAAACCAGGCCTGCATG
GCATGGACCACCGCAAATTGGATGAGATGACAGCCTCGTATAGTGATGTCACCCTCTACATTGA
TGAGGAAGAGCTGTCACCGCCTCTACCACTCTCACAGGCTGGTGATCGGCCTTCTAGCACCGAG
TCGGACCTGCGGCTGAGGTCTGGGGGTGCAGCCCAGGACTACTGGGCCTTGGCCCACAAAGAGG
ACAAGGCTGACACGGACACAAGCTGCCGAAGCACACCTTCACTGGAGCGGCCAGAGCCACGGCT
GCGGGTGGAGCACCTGCCCCTGCTTACCATTGAGCCGCCCAGTGATAGCTCCGTGGAACTCAGT
GACCGCTCGGATCGCAGCTCACTCAAGAGGCAGAGTGCCTATGAGCGCAGCCTCGGTGGGCAGC
AGGGCAGCCCCAAGCACGGCCCCCACGGTGGCCCCCCCAAAGGCCTCCCCCGGGAGGAACCTGA
ATTGCGACCTCGACCCCCCAGACCTCTTGAGAGTCACCTAGCCATCAATGGTTCAGCCAACCGG
CAGAGCAAATCTGAGTCTGACTACTCAGACGGGGACAATGACAGCATCAACAGCACGTCCAACT
CCAATGACACCATAAACTGCAGCTCCGAGTCCTCATCTCGGGACAGCCTGCGGGAACAGACACT
CAGCAAGCAGACATACCACAAGGAGACCCGCAACAGCTGGGACTCGCCAGCTTTCAGCAATGAT
GTCATCCGTAAGAGGCATTACCGAATTGGCCTGAACCTCTTCAACAAGAAGCCTGAGAAGGGCA
TCCAGTATCTCATTGAGCGCGGCTTCGTGCCCGACACGCCAGTGGGAGTGGCCCACTTCCTGCT
GCAGCGCAAGGGCCTCAGCCGCCAGATGATCGGTGAGTTCCTGGGAAACCGGCAGAAGCAGTTC
AACCGTGATGTACTCGACTGTGTTGTGGACGAGATGGACTTCTCCGCCATGGAGCTAGATGAAG
CCCTCCGGAAGTTCCAGGCACACATCCGAGTCCAAGGGGAGGCTCAGAAAGTGGAGCGGCTCAT
CGAGGCATTCAGCCAGCGGTACTGTGTCTGCAATCCTGGGGTGGTGCGACAGTTCCGGAACCCA
GACACCATCTTCATCCTGGCCTTCGCCATCATCCTGCTCAACACAGACATGTACAGCCCCAATG
TCAAGCCAGAGCGCAAAATGAAGCTGGAGGACTTTGTCAAGAACCTCCGAGGTGTTGATGACGG
TGAAGACATTCCCCGGGAGACACTAATTGGGATCTATGAGCGGATCCGTAAGCGAGAACTGAAG
ACCAACGAGGACCACGTGTCCCAGGTGCAGAAGGTTGAGAAGCTCATCGTGGGCAAAAAGCCGA
TTGGATCCTTGCATCATGGTCTTGGCTGTGTGCTCTCTCTTCCCCATCGACGACTGGTCTGCTA
CTGCCGGCTTTTTGAAGTTCCTGACCCCAACAAACCCCAGAAGCTGGGACTGCACCAGCGAGAG
ATCTTCCTGTTCAATGACCTCCTGGTGGTCACCAAGATCTTCCAGAAGAAGAAGAACTCGGTGA
CGTACAGCTTCCGGCAGTCCTTCTCCCTCTACGGCATGCAGGTCCTGCTCTTCGAGAACCAGTA
CTACCCCAATGGCATCCGGCTGACGTCTGCTGTCCCTGGAGCAGATATCAAAGTGCTAATAAAC
TTCAACGCTCCCAATCCTCAGGACCGGAAGAAGTTCACTGATGACCTACGGGAGTCTGTCGCTG
AAGTGCAAGAGATGGAGAAACACCGGATAGAGTCGGAGCTCGAGAAGCAGAAAGGTGTCGTGCG
GCCCAGCATGTCACAATGTTCCAGCCTCAAAAAGGAGTCAGGCAACGGGACACTGAGCAGAGCT
TGCCTGGATGACAGCTATGCCAGTGGCGAGGGCCTCAAGCGCAGCGCCCTCAGCAGCTCACTGA
GAGACCTCTCAGAAGCGGGGAAGCGAGGGCGTCGCAGCAGTGCGGGATCGCTAGAGAGCAATGT
GGAATTTCAGCCCTTCCAGCCATCACAGCCTCCAGTGCTGTGCTCCTAAGCCTAGGACCTGAGG
ACTGCCTGTGGTCTCTGCCTGCGCGGAGGCCCTTTCAGAATGGAAGGAGCTGCCGCCTGACCGT
GGGCTGCGTCTAGGACC

hide sequence

RefSeq Acc Id:

XM_039108748 ⟹ XP_038964676

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 125,045,351 (-)	NCBI
mRatBN7.2	4	123,168,719 - 123,488,300 (-)	NCBI

RefSeq Acc Id:

XM_039108749 ⟹ XP_038964677

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 125,045,351 (-)	NCBI
mRatBN7.2	4	123,168,719 - 123,488,296 (-)	NCBI

RefSeq Acc Id:

XM_039108750 ⟹ XP_038964678

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 125,045,351 (-)	NCBI
mRatBN7.2	4	123,168,719 - 123,488,295 (-)	NCBI

RefSeq Acc Id:

XM_039108751 ⟹ XP_038964679

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 124,779,413 (-)	NCBI
mRatBN7.2	4	123,168,719 - 123,222,216 (-)	NCBI

RefSeq Acc Id:

XM_039108753 ⟹ XP_038964681

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 124,845,922 (-)	NCBI
mRatBN7.2	4	123,168,719 - 123,288,166 (-)	NCBI

RefSeq Acc Id:

XM_039108754 ⟹ XP_038964682

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 124,876,154 (-)	NCBI
mRatBN7.2	4	123,168,719 - 123,315,599 (-)	NCBI

RefSeq Acc Id:

XM_039108756 ⟹ XP_038964684

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 124,893,995 (-)	NCBI
mRatBN7.2	4	123,168,719 - 123,336,750 (-)	NCBI

RefSeq Acc Id:

XM_039108758 ⟹ XP_038964686

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 125,045,351 (-)	NCBI
mRatBN7.2	4	123,168,719 - 123,488,292 (-)	NCBI

RefSeq Acc Id:

XM_039108759 ⟹ XP_038964687

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 125,045,351 (-)	NCBI
mRatBN7.2	4	123,169,955 - 123,488,292 (-)	NCBI

RefSeq Acc Id:

XM_039108760 ⟹ XP_038964688

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 125,045,351 (-)	NCBI
mRatBN7.2	4	123,171,907 - 123,488,290 (-)	NCBI

RefSeq Acc Id:

XM_039108762 ⟹ XP_038964690

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 124,821,312 (-)	NCBI
mRatBN7.2	4	123,168,719 - 123,264,123 (-)	NCBI

RefSeq Acc Id:

XM_063286693 ⟹ XP_063142763

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 124,779,413 (-)	NCBI

RefSeq Acc Id:

XM_063286694 ⟹ XP_063142764

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 124,827,932 (-)	NCBI

RefSeq Acc Id:

XM_063286695 ⟹ XP_063142765

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 124,876,154 (-)	NCBI

RefSeq Acc Id:

XM_063286696 ⟹ XP_063142766

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	124,725,919 - 124,779,413 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001395888	(Get FASTA)	NCBI Sequence Viewer
	NP_001395889	(Get FASTA)	NCBI Sequence Viewer
	XP_006236952	(Get FASTA)	NCBI Sequence Viewer
	XP_038964676	(Get FASTA)	NCBI Sequence Viewer
	XP_038964677	(Get FASTA)	NCBI Sequence Viewer
	XP_038964678	(Get FASTA)	NCBI Sequence Viewer
	XP_038964679	(Get FASTA)	NCBI Sequence Viewer
	XP_038964681	(Get FASTA)	NCBI Sequence Viewer
	XP_038964682	(Get FASTA)	NCBI Sequence Viewer
	XP_038964684	(Get FASTA)	NCBI Sequence Viewer
	XP_038964686	(Get FASTA)	NCBI Sequence Viewer
	XP_038964687	(Get FASTA)	NCBI Sequence Viewer
	XP_038964688	(Get FASTA)	NCBI Sequence Viewer
	XP_038964690	(Get FASTA)	NCBI Sequence Viewer
	XP_063142763	(Get FASTA)	NCBI Sequence Viewer
	XP_063142764	(Get FASTA)	NCBI Sequence Viewer
	XP_063142765	(Get FASTA)	NCBI Sequence Viewer
	XP_063142766	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A0A0G2JUG7	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000077923
	ENSRNOP00000081156
	ENSRNOP00000081495
	ENSRNOP00000085130
	ENSRNOP00000095381
	ENSRNOP00000107769
	ENSRNOP00000111646

RefSeq Acc Id:	XP_006236952 ⟸ XM_006236890
- Peptide Label:	isoform X12
- UniProtKB:	A0A0G2JUG7 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MWCLHCNSERTQSLLELELDSGVEGEAPSSETGTSLDSPSAYHQGPLVPGSSLSPDHYEHTSVG AYGLYAGPGPQQRTRRPRLQHSTSVLRKQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYG GRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFE GKQVSVTNDGSQLGALVPSECGDLSDPALKSPAPSSDFADAITELEDAFSRQVKSLAESIDDAL NCRSLHSEEVPASDTARARDTEPKPGLHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAG DRPSSTESDLRLRSGGAAQDYWALAHKEDKADTDTSCRSTPSLERPEPRLRVEHLPLLTIEPPS DSSVELSDRSDRSSLKRQSAYERSLGGQQGSPKHGPHGGPPKGLPREEPELRPRPPRPLESHLA INGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKETRNSWD SPAFSNDVIRKRHYRIGLNLFNKKPEKGIQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFL GNRQKQFNRDVLDCVVDEMDFSAMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCVCNPGV VRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFVKNLRGVDDGEDIPRETLIGIYER IRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHHGLGCVLSLPHRRLVCYCRLFEVPDPNKPQK LGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSAVPGA DIKVLINFNAPNPQDRKKFTDDLRESVAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESG NGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFQPSQPPVLC S hide sequence

Ensembl Acc Id:

ENSRNOP00000069092 ⟸ ENSRNOT00000085466

RefSeq Acc Id:	XP_038964676 ⟸ XM_039108748
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038964677 ⟸ XM_039108749
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038964678 ⟸ XM_039108750
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038964686 ⟸ XM_039108758
- Peptide Label:	isoform X8
- UniProtKB:	A0A8L2R061 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964684 ⟸ XM_039108756
- Peptide Label:	isoform X7
- UniProtKB:	A0A0G2JUG7 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038964682 ⟸ XM_039108754
- Peptide Label:	isoform X6
- UniProtKB:	A0A0G2JUG7 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038964681 ⟸ XM_039108753
- Peptide Label:	isoform X5
- UniProtKB:	A0A0G2JUG7 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038964690 ⟸ XM_039108762
- Peptide Label:	isoform X16
- UniProtKB:	A6IB89 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964679 ⟸ XM_039108751
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5YC35 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964687 ⟸ XM_039108759
- Peptide Label:	isoform X9
- UniProtKB:	A0A0G2JUG7 (UniProtKB/Swiss-Prot), A0A8I6ANF6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038964688 ⟸ XM_039108760
- Peptide Label:	isoform X10
- UniProtKB:	A0A8L2R061 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000095381 ⟸ ENSRNOT00000104320

Ensembl Acc Id:

ENSRNOP00000081156 ⟸ ENSRNOT00000113793

Ensembl Acc Id:

ENSRNOP00000081495 ⟸ ENSRNOT00000098236

Ensembl Acc Id:

ENSRNOP00000085130 ⟸ ENSRNOT00000114697

Ensembl Acc Id:

ENSRNOP00000077923 ⟸ ENSRNOT00000105189

RefSeq Acc Id:	NP_001395889 ⟸ NM_001408960
- Peptide Label:	isoform 2
- UniProtKB:	A0A0G2JUG7 (UniProtKB/Swiss-Prot), A0A8I6G7L1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001395888 ⟸ NM_001408959
- Peptide Label:	isoform 1
- UniProtKB:	A0A8I5ZSW3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063142765 ⟸ XM_063286695
- Peptide Label:	isoform X14
- UniProtKB:	A0A0G2JUG7 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063142764 ⟸ XM_063286694
- Peptide Label:	isoform X13
- UniProtKB:	A0A0G2JUG7 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063142763 ⟸ XM_063286693
- Peptide Label:	isoform X11
- UniProtKB:	A0A8I5YC35 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063142766 ⟸ XM_063286696
- Peptide Label:	isoform X15
- UniProtKB:	A0A8I6GBT6 (UniProtKB/TrEMBL), A0A8I5YC35 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000105733 ⟸ ENSRNOT00000170859

Ensembl Acc Id:

ENSRNOP00000107769 ⟸ ENSRNOT00000150411

Ensembl Acc Id:

ENSRNOP00000111646 ⟸ ENSRNOT00000152016

Ensembl Acc Id:

ENSRNOP00000101372 ⟸ ENSRNOT00000170289

Protein Domains

IQ PH SEC7

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JUG7-F1-model_v2	AlphaFold	A0A0G2JUG7	1-962	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1596313	AgrOrtholog
BioCyc Gene	G2FUF-43729	BioCyc
Ensembl Genes	ENSRNOG00000060350	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000098236	ENTREZGENE
	ENSRNOT00000104320	ENTREZGENE
	ENSRNOT00000105189	ENTREZGENE
	ENSRNOT00000113793	ENTREZGENE
	ENSRNOT00000114697	ENTREZGENE
	ENSRNOT00000150411	ENTREZGENE
	ENSRNOT00000152016	ENTREZGENE
Gene3D-CATH	1.10.1000.11	UniProtKB/Swiss-Prot
	1.10.220.20	UniProtKB/Swiss-Prot
	2.30.29.30	UniProtKB/Swiss-Prot
InterPro	IQSEC_PH	UniProtKB/Swiss-Prot
	PH-like_dom_sf	UniProtKB/Swiss-Prot
	Sec7_C_sf	UniProtKB/Swiss-Prot
	Sec7_dom	UniProtKB/Swiss-Prot
	Sec7_dom_sf	UniProtKB/Swiss-Prot
NCBI Gene	686590	ENTREZGENE
PANTHER	GUANYL-NUCLEOTIDE EXCHANGE FACTOR	UniProtKB/Swiss-Prot
	PTHR10663:SF327	UniProtKB/Swiss-Prot
Pfam	IQ_SEC7_PH	UniProtKB/Swiss-Prot
	Sec7	UniProtKB/Swiss-Prot
PhenoGen	Iqsec1	PhenoGen
PROSITE	PS50096	UniProtKB/Swiss-Prot
	SEC7	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000060350	RatGTEx
SMART	Sec7	UniProtKB/Swiss-Prot
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot
	SSF48425	UniProtKB/Swiss-Prot
UniProt	A0A0G2JUG7	ENTREZGENE
	A0A8I5YC35	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZSW3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ANF6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G7L1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GBT6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2R061	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L0A1_RAT	UniProtKB/TrEMBL
	A0ABK0LB71_RAT	UniProtKB/TrEMBL
	A0ABK0LQ16_RAT	UniProtKB/TrEMBL
	A0ABK0M7V6_RAT	UniProtKB/TrEMBL
	A6IB89	ENTREZGENE, UniProtKB/TrEMBL
	IQEC1_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Iqsec1	IQ motif and Sec7 domain ArfGEF 1	LOC108350819	uncharacterized LOC108350819	Data merged from RGD:11435432	737654	PROVISIONAL
2019-09-13	Iqsec1	IQ motif and Sec7 domain ArfGEF 1	Iqsec1	IQ motif and Sec7 domain 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-08-02	LOC108350819	uncharacterized LOC108350819			Symbol and Name status set to provisional	70820	PROVISIONAL
2013-08-16	Iqsec1	IQ motif and Sec7 domain 1	LOC686590	similar to IQ motif and Sec7 domain 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC686590	similar to IQ motif and Sec7 domain 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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