Ackr1 (atypical chemokine receptor 1) - Rat Genome Database

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Gene: Ackr1 (atypical chemokine receptor 1) Rattus norvegicus
Analyze
Symbol: Ackr1
Name: atypical chemokine receptor 1
RGD ID: 1596198
Description: Predicted to enable C-C chemokine binding activity. Predicted to be involved in chemokine-mediated signaling pathway. Predicted to act upstream of or within inflammatory response and regulation of chemokine production. Predicted to be located in early endosome; membrane; and recycling endosome. Human ortholog(s) of this gene implicated in Plasmodium vivax malaria and malaria. Orthologous to human ACKR1 (atypical chemokine receptor 1 (Duffy blood group)); INTERACTS WITH bisphenol A; oxaliplatin; topotecan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Darc; Duffy blood group, atypical chemokine receptor; Duffy blood group, chemokine receptor; LOC689105; similar to Duffy antigen/chemokine receptor (CD234 antigen)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,314,735 - 88,316,354 (-)NCBIGRCr8
mRatBN7.21385,782,396 - 85,784,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,782,398 - 85,783,983 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1388,280,493 - 88,282,115 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,680,769 - 89,682,391 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,865,497 - 86,867,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,827,310 - 91,828,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01396,341,756 - 96,345,047 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41389,534,621 - 89,536,179 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1385,386,251 - 85,389,650 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Duffy antigen / receptor for chemokines correlates with inflammatory reaction in rats with venous hypertension: implication for the pathogenesis of primary chronic venous disease. Huang W, etal., Vasa. 2014 Jan;43(1):47-54. doi: 10.1024/0301-1526/a000327.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:7517217   PMID:10961863   PMID:20643340   PMID:22800956  


Genomics

Comparative Map Data
Ackr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,314,735 - 88,316,354 (-)NCBIGRCr8
mRatBN7.21385,782,396 - 85,784,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,782,398 - 85,783,983 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1388,280,493 - 88,282,115 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,680,769 - 89,682,391 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,865,497 - 86,867,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,827,310 - 91,828,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01396,341,756 - 96,345,047 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41389,534,621 - 89,536,179 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1385,386,251 - 85,389,650 (-)NCBICelera
Cytogenetic Map13q24NCBI
ACKR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,204,875 - 159,206,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,204,875 - 159,206,500 (+)EnsemblGRCh38hg38GRCh38
GRCh371159,174,665 - 159,176,290 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,441,134 - 157,442,914 (+)NCBINCBI36Build 36hg18NCBI36
Build 341155,987,582 - 155,989,361NCBI
Celera1132,244,749 - 132,246,528 (+)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1130,530,942 - 130,533,428 (+)NCBIHuRef
CHM1_11160,569,233 - 160,571,720 (+)NCBICHM1_1
T2T-CHM13v2.01158,341,901 - 158,343,525 (+)NCBIT2T-CHM13v2.0
Ackr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391173,159,457 - 173,161,079 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1173,159,453 - 173,161,317 (-)EnsemblGRCm39 Ensembl
GRCm381173,331,886 - 173,333,503 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1173,331,886 - 173,333,750 (-)EnsemblGRCm38mm10GRCm38
MGSCv371175,262,017 - 175,263,634 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,168,486 - 175,170,119 (-)NCBIMGSCv36mm8
Celera1176,180,941 - 176,182,560 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map180.33NCBI
Ackr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546810,995,941 - 11,001,094 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546810,994,372 - 10,997,434 (+)NCBIChiLan1.0ChiLan1.0
ACKR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2190,648,921 - 90,652,222 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1190,386,157 - 90,389,458 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01134,554,406 - 134,557,386 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11138,352,086 - 138,354,733 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1138,352,086 - 138,354,733 (+)Ensemblpanpan1.1panPan2
ACKR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,762,584 - 22,765,330 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3822,758,013 - 22,763,958 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3822,775,538 - 22,777,427 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03822,886,250 - 22,888,134 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3822,886,254 - 22,887,680 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13822,650,929 - 22,652,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03823,186,096 - 23,187,980 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03823,616,605 - 23,618,488 (-)NCBIUU_Cfam_GSD_1.0
Ackr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050585,455,886 - 5,459,211 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367401,295,319 - 1,296,812 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367401,295,299 - 1,298,441 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACKR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl491,224,139 - 91,225,850 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1491,224,089 - 91,225,610 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2499,221,386 - 99,222,907 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACKR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1204,742,326 - 4,746,615 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660383,888,960 - 3,891,604 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ackr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247942,120,786 - 2,122,232 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247942,055,917 - 2,124,815 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ackr1
7 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
1302791Stl29Serum triglyceride level QTL 293.30.0011blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)138473078886800898Rat

Markers in Region
RH138358  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21385,784,946 - 85,785,089 (+)MAPPERmRatBN7.2
Rnor_6.01391,829,851 - 91,829,993NCBIRnor6.0
Rnor_5.01396,344,297 - 96,344,439UniSTSRnor5.0
RGSC_v3.41389,537,172 - 89,537,314UniSTSRGSC3.4
Celera1385,388,802 - 85,388,944UniSTS
RH 3.4 Map13563.9UniSTS
Cytogenetic Map13q24UniSTS
BE095854  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21385,782,468 - 85,782,631 (+)MAPPERmRatBN7.2
Rnor_6.01391,827,383 - 91,827,545NCBIRnor6.0
Rnor_5.01396,341,829 - 96,341,991UniSTSRnor5.0
RGSC_v3.41389,534,694 - 89,534,856UniSTSRGSC3.4
Celera1385,386,324 - 85,386,486UniSTS
RH 3.4 Map13563.9UniSTS
Cytogenetic Map13q24UniSTS
AA162249  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21385,782,563 - 85,782,729 (+)MAPPERmRatBN7.2
Rnor_6.01391,827,478 - 91,827,643NCBIRnor6.0
Rnor_5.01396,341,924 - 96,342,089UniSTSRnor5.0
RGSC_v3.41389,534,789 - 89,534,954UniSTSRGSC3.4
Celera1385,386,419 - 85,386,584UniSTS
Cytogenetic Map13q24UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000095663   ⟹   ENSRNOP00000095417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1385,782,737 - 85,783,983 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117393   ⟹   ENSRNOP00000078656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1385,782,398 - 85,783,983 (-)Ensembl
RefSeq Acc Id: NM_001398729   ⟹   NP_001385658
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81388,314,735 - 88,316,354 (-)NCBI
mRatBN7.21385,782,396 - 85,784,015 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385658 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94741 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078656
  ENSRNOP00000078656.1
  ENSRNOP00000095417.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000095417   ⟸   ENSRNOT00000095663
RefSeq Acc Id: ENSRNOP00000078656   ⟸   ENSRNOT00000117393
RefSeq Acc Id: NP_001385658   ⟸   NM_001398729
- UniProtKB: A0A8I5ZL85 (UniProtKB/TrEMBL),   A6JG85 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596198 AgrOrtholog
BioCyc Gene G2FUF-17277 BioCyc
Ensembl Genes ENSRNOG00000069330 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095663.1 UniProtKB/TrEMBL
  ENSRNOT00000117393 ENTREZGENE
  ENSRNOT00000117393.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Duffy_chemokine_rcpt UniProtKB/TrEMBL
NCBI Gene 689105 ENTREZGENE
PANTHER ATYPICAL CHEMOKINE RECEPTOR 1 UniProtKB/TrEMBL
  PTHR14181 UniProtKB/TrEMBL
PhenoGen Ackr1 PhenoGen
PRINTS DUFFYANTIGEN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000069330 RatGTEx
UniProt A0A8I5ZL85 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQG3_RAT UniProtKB/TrEMBL
  A6JG85 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Ackr1  atypical chemokine receptor 1  Ackr1  atypical chemokine receptor 1  Data merged from RGD:149736278 737654 PROVISIONAL
2021-08-09 Ackr1  atypical chemokine receptor 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2014-04-16 Ackr1  atypical chemokine receptor 1  Darc  Duffy blood group, atypical chemokine receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-01 Darc  Duffy blood group, atypical chemokine receptor  Darc  Duffy blood group, chemokine receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-02 Darc  Duffy blood group, chemokine receptor  LOC689105  similar to Duffy antigen/chemokine receptor (CD234 antigen)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC689105  similar to Duffy antigen/chemokine receptor (CD234 antigen)      Symbol and Name status set to provisional 70820 PROVISIONAL