Tedc1 (tubulin epsilon and delta complex 1) - Rat Genome Database

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Gene: Tedc1 (tubulin epsilon and delta complex 1) Rattus norvegicus
Analyze
Symbol: Tedc1
Name: tubulin epsilon and delta complex 1
RGD ID: 1596085
Description: Predicted to be involved in positive regulation of smoothened signaling pathway. Predicted to be located in centriole and cilium. Orthologous to human TEDC1 (tubulin epsilon and delta complex 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC690422; LOC690422; tubulin epsilon and delta complex protein 1; uncharacterized protein C14orf80 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86138,056,029 - 138,068,899 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6138,056,027 - 138,067,274 (+)EnsemblGRCr8
mRatBN7.26132,234,764 - 132,245,164 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6132,236,925 - 132,244,928 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6132,406,001 - 132,414,227 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,696,146 - 132,704,360 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06132,071,324 - 132,079,559 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,967,119 - 137,976,324 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,967,401 - 137,980,217 (+)Ensemblrn6Rnor6.0
Rnor_5.06146,961,451 - 146,970,728 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46138,163,267 - 138,170,396 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6129,773,145 - 129,782,350 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centriole  (IEA,ISO)
centrosome  (IEA,ISO)
cilium  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:29459677  


Genomics

Comparative Map Data
Tedc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86138,056,029 - 138,068,899 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6138,056,027 - 138,067,274 (+)EnsemblGRCr8
mRatBN7.26132,234,764 - 132,245,164 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6132,236,925 - 132,244,928 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6132,406,001 - 132,414,227 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,696,146 - 132,704,360 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06132,071,324 - 132,079,559 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,967,119 - 137,976,324 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,967,401 - 137,980,217 (+)Ensemblrn6Rnor6.0
Rnor_5.06146,961,451 - 146,970,728 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46138,163,267 - 138,170,396 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6129,773,145 - 129,782,350 (+)NCBICelera
Cytogenetic Map6q32NCBI
TEDC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,489,855 - 105,499,248 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,489,855 - 105,499,575 (+)Ensemblhg38GRCh38
GRCh3714105,956,192 - 105,965,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614105,028,749 - 105,036,610 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3414105,028,748 - 105,036,610NCBI
Celera1486,009,230 - 86,017,442 (+)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1486,154,352 - 86,163,741 (+)NCBIHuRef
CHM1_114105,893,909 - 105,903,298 (+)NCBICHM1_1
T2T-CHM13v2.01499,739,223 - 99,748,612 (+)NCBIT2T-CHM13v2.0
Tedc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,118,639 - 113,135,102 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,120,041 - 113,129,668 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812113,156,421 - 113,165,458 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,156,421 - 113,166,048 (+)Ensemblmm10GRCm38
MGSCv3712114,394,632 - 114,403,669 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612113,604,229 - 113,612,352 (+)NCBIMGSCv36mm8
Celera12114,372,288 - 114,381,309 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.62NCBI
Tedc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,688,509 - 3,696,674 (+)Ensembl
ChiLan1.0NW_0049555383,688,127 - 3,696,920 (+)NCBIChiLan1.0ChiLan1.0
TEDC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,677,732 - 106,687,174 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,894,237 - 105,903,673 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01486,153,559 - 86,159,324 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,916,696 - 105,925,911 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,916,697 - 105,925,911 (+)EnsemblpanPan2panpan1.1
TEDC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,787,754 - 72,795,593 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,788,592 - 72,795,326 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha872,297,958 - 72,307,691 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0873,075,739 - 73,085,470 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl873,030,867 - 73,083,556 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,756,434 - 72,766,161 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,804,284 - 72,814,011 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0873,195,759 - 73,205,487 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101966253
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,242,100 - 1,270,286 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493662170,667 - 98,388 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493662188,621 - 98,388 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493662171,057 - 98,853 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TEDC1
(Sus scrofa - pig)		 No map positions available.
TEDC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12483,389,035 - 83,396,908 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2483,389,037 - 83,398,548 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605370,847,661 - 70,855,562 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tedc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473443,289 - 51,824 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473443,462 - 53,378 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tedc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17130,759,686 - 130,766,852 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tedc1
53 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:46
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000029223
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
BE110196  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26132,243,714 - 132,243,873 (+)MAPPERmRatBN7.2
Rnor_6.06137,976,130 - 137,976,288NCBIRnor6.0
Rnor_5.06146,970,534 - 146,970,692UniSTSRnor5.0
RGSC_v3.46138,170,093 - 138,170,251UniSTSRGSC3.4
Celera6129,782,156 - 129,782,314UniSTS
RH 3.4 Map6783.9UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000029223   ⟹   ENSRNOP00000030430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6137,967,401 - 137,980,217 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101385   ⟹   ENSRNOP00000085075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6138,057,973 - 138,067,274 (+)Ensembl
mRatBN7.2 Ensembl6132,236,925 - 132,244,928 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143613   ⟹   ENSRNOP00000111593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6138,057,093 - 138,067,274 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149882   ⟹   ENSRNOP00000103807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6138,056,027 - 138,067,274 (+)Ensembl
RefSeq Acc Id: NM_001399144   ⟹   NP_001386073
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86138,057,977 - 138,066,216 (+)NCBI
mRatBN7.26132,236,925 - 132,245,164 (+)NCBI
RefSeq Acc Id: XM_039113425   ⟹   XP_038969353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86138,056,029 - 138,068,899 (+)NCBI
mRatBN7.26132,234,764 - 132,243,909 (+)NCBI
RefSeq Acc Id: XM_039113426   ⟹   XP_038969354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86138,056,032 - 138,068,899 (+)NCBI
mRatBN7.26132,236,771 - 132,245,164 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386073 (Get FASTA)   NCBI Sequence Viewer  
  XP_038969353 (Get FASTA)   NCBI Sequence Viewer  
  XP_038969354 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97388 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000085075
  ENSRNOP00000085075.1
  ENSRNOP00000103807
  ENSRNOP00000103807.1
  ENSRNOP00000111593.1
Ensembl Acc Id: ENSRNOP00000030430   ⟸   ENSRNOT00000029223
RefSeq Acc Id: XP_038969353   ⟸   XM_039113425
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038969354   ⟸   XM_039113426
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000085075   ⟸   ENSRNOT00000101385
RefSeq Acc Id: NP_001386073   ⟸   NM_001399144
- UniProtKB: A0A8I5ZZB2 (UniProtKB/TrEMBL),   A6KBZ3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103807   ⟸   ENSRNOT00000149882
Ensembl Acc Id: ENSRNOP00000111593   ⟸   ENSRNOT00000143613
Protein Domains
Tubulin epsilon and delta complex protein

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A8N6-F1-model_v2 AlphaFold D4A8N6 1-416 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596085 AgrOrtholog
BioCyc Gene G2FUF-35760 BioCyc
Ensembl Genes ENSRNOG00000005153 Ensembl
  ENSRNOG00000070355 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000101385 ENTREZGENE
  ENSRNOT00000101385.2 UniProtKB/TrEMBL
  ENSRNOT00000143613.1 UniProtKB/TrEMBL
  ENSRNOT00000149882 ENTREZGENE
  ENSRNOT00000149882.1 UniProtKB/TrEMBL
InterPro TEDC1 UniProtKB/TrEMBL
  TEDC1_dom UniProtKB/TrEMBL
NCBI Gene 690422 ENTREZGENE
PANTHER PTHR35076 UniProtKB/TrEMBL
  TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 1 UniProtKB/TrEMBL
Pfam TEDC1 UniProtKB/TrEMBL
PhenoGen Tedc1 PhenoGen
RatGTEx ENSRNOG00000005153 RatGTEx
  ENSRNOG00000070355 RatGTEx
UniProt A0A8I5ZZB2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LE30_RAT UniProtKB/TrEMBL
  A0ABK0M7T1_RAT UniProtKB/TrEMBL
  A6KBZ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Tedc1  tubulin epsilon and delta complex 1  Tedc1  tubulin epsilon and delta complex 1  Data merged from RGD:149736277 737654 PROVISIONAL
2021-08-09 Tedc1  tubulin epsilon and delta complex 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2017-08-02 Tedc1  tubulin epsilon and delta complex 1  LOC690422  hypothetical protein LOC690422  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC690422  hypothetical protein LOC690422  LOC684619  hypothetical protein LOC684619  Data merged from RGD:1587953 1643240 APPROVED
2006-11-20 LOC690422  hypothetical protein LOC690422      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684619  hypothetical protein LOC684619      Symbol and Name status set to provisional 70820 PROVISIONAL