Krtap10-2 (keratin associated protein 10-2) - Rat Genome Database

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Gene: Krtap10-2 (keratin associated protein 10-2) Rattus norvegicus
Analyze
Symbol: Krtap10-2 (Ensembl: LOC690460)
Name: keratin associated protein 10-2 (Ensembl:similar to keratin associated protein 10-7)
RGD ID: 1596048
Description: Orthologous to human KRTAP10-2 (keratin associated protein 10-2); INTERACTS WITH benzo[a]pyrene (ortholog); cadmium dichloride (ortholog); resveratrol (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: keratin associated protein 10-7-like; LOC690460; similar to keratin associated protein 10-7
RGD Orthologs
Human
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,888,197 - 10,888,995 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.22010,888,588 - 10,889,386 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2011,588,113 - 11,588,911 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,949,064 - 10,949,862 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,420,826 - 11,421,624 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,604,790 - 11,605,588 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,604,790 - 11,605,588 (+)Ensemblrn6Rnor6.0
Rnor_5.02013,770,872 - 13,771,670 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42011,267,201 - 11,267,999 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2012,391,161 - 12,391,959 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Krtap10-2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,888,197 - 10,888,995 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.22010,888,588 - 10,889,386 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2011,588,113 - 11,588,911 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,949,064 - 10,949,862 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,420,826 - 11,421,624 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,604,790 - 11,605,588 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,604,790 - 11,605,588 (+)Ensemblrn6Rnor6.0
Rnor_5.02013,770,872 - 13,771,670 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42011,267,201 - 11,267,999 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2012,391,161 - 12,391,959 (+)NCBICelera
Cytogenetic Map20p12NCBI
KRTAP10-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,550,357 - 44,551,505 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,550,357 - 44,551,505 (-)Ensemblhg38GRCh38
GRCh372145,970,240 - 45,971,388 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,794,746 - 44,795,816 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2131,077,991 - 31,079,046 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,344,141 - 31,345,196 (-)NCBIHuRef
CHM1_12145,530,920 - 45,531,990 (-)NCBICHM1_1
T2T-CHM13v2.02142,910,748 - 42,911,896 (-)NCBIT2T-CHM13v2.0
LOC117977362
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22240,593,651 - 40,604,828 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12135,467,535 - 35,468,805 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,842,558 - 30,844,819 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12144,147,028 - 44,147,768 (-)NCBIPanPan1.1PanPan1.1panPan2

Variants

.
Variants in Krtap10-2
10 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:64
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000065418
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20904109911115921Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
1 1 3 1 2 2 5 3 1 1 8

Sequence


Ensembl Acc Id: ENSRNOT00000065418   ⟹   ENSRNOP00000063279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2011,604,790 - 11,605,588 (+)Ensembl
RefSeq Acc Id: NM_001109593   ⟹   NP_001103063
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,888,197 - 10,888,995 (+)NCBI
mRatBN7.22010,888,588 - 10,889,386 (+)NCBI
Rnor_6.02011,604,790 - 11,605,588 (+)NCBI
Rnor_5.02013,770,872 - 13,771,670 (+)NCBI
RGSC_v3.42011,267,201 - 11,267,999 (+)RGD
Celera2012,391,161 - 12,391,959 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103063 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97084 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001103063   ⟸   NM_001109593
- UniProtKB: A6JK68 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063279   ⟸   ENSRNOT00000065418

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUG4-F1-model_v2 AlphaFold D3ZUG4 1-251 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701497
Promoter ID:EPDNEW_R12019
Type:single initiation site
Name:LOC690460_1
Description:similar to keratin associated protein 10-7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02011,604,721 - 11,604,781EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596048 AgrOrtholog
BioCyc Gene G2FUF-4254 BioCyc
Ensembl Genes ENSRNOG00000042797 Ensembl
InterPro KAP UniProtKB/TrEMBL
KEGG Report rno:690460 UniProtKB/TrEMBL
NCBI Gene 690460 ENTREZGENE
PANTHER KERATIN ASSOCIATED PROTEIN UniProtKB/TrEMBL
  KERATIN-ASSOCIATED PROTEIN 10-6 UniProtKB/TrEMBL
Pfam Keratin_B2_2 UniProtKB/TrEMBL
PhenoGen Krtap10-2 PhenoGen
RatGTEx ENSRNOG00000042797 RatGTEx
UniProt A6JK68 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Krtap10-2  keratin associated protein 10-2  LOC690460  similar to keratin associated protein 10-7  Symbol and Name Changed 1299863 APPROVED
2006-11-20 LOC690460  similar to keratin associated protein 10-7      Symbol and Name status set to provisional 70820 PROVISIONAL